DICER1: mutations, microRNAs and mechanisms (Q38245164)

31 August 2017

DICER1: mutations, microRNAs and mechanisms (English)

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31 August 2017

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William David Foulkes

series ordinal

1

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31 August 2017

John R Priest

2

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31 August 2017

Thomas F Duchaine

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3

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31 August 2017

language of work or name

English

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publication date

1 September 2014

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31 August 2017

Nature Reviews Cancer

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31 August 2017

14

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31 August 2017

10

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31 August 2017

662-672

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https://scigraph.springernature.com/pub.10.1038/nrc3802

31 August 2017

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cites work

Role for a bidentate ribonuclease in the initiation step of RNA interference

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Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

31 March 2020

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A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

31 March 2020

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Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

31 March 2020

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A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans

31 March 2020

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RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

31 March 2020

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RNA interference is mediated by 21- and 22-nucleotide RNAs

31 March 2020

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A human, ATP-independent, RISC assembly machine fueled by pre-miRNA

31 March 2020

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Molecular requirements for RNA-induced silencing complex assembly in the Drosophila RNA interference pathway.

31 March 2020

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Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways

31 March 2020

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Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways

31 March 2020

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Regulation of microRNA biogenesis

31 March 2020

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The Microprocessor complex mediates the genesis of microRNAs

31 March 2020

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The Drosha-DGCR8 complex in primary microRNA processing

31 March 2020

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The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis

31 March 2020

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The nuclear RNase III Drosha initiates microRNA processing

31 March 2020

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Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

31 March 2020

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Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs

31 March 2020

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Nuclear export of microRNA precursors

31 March 2020

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Human RISC couples microRNA biogenesis and posttranscriptional gene silencing

31 March 2020

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Molecular mechanisms of RNA interference

31 March 2020

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The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.

31 March 2020

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Snapshot: endogenous RNAi [corrected] pathways

31 March 2020

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Endogenous small interfering RNAs in animals

31 March 2020

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Small RNAs correspond to centromere heterochromatic repeats

31 March 2020

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Characterization of Dicer-deficient murine embryonic stem cells.

31 March 2020

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Dicer is essential for formation of the heterochromatin structure in vertebrate cells

31 March 2020

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Loss of Dicer fowls up centromeres

31 March 2020

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DICER- and AGO3-dependent generation of retinoic acid-induced DR2 Alu RNAs regulates human stem cell proliferation

31 March 2020

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Structural insights into RNA processing by the human RISC-loading complex

31 March 2020

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The molecular architecture of human Dicer

31 March 2020

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Structural basis for double-stranded RNA processing by Dicer

31 March 2020

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A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer

31 March 2020

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Single processing center models for human Dicer and bacterial RNase III

31 March 2020

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Dicer's helicase domain discriminates dsRNA termini to promote an altered reaction mode

31 March 2020

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A role for the Dicer helicase domain in the processing of thermodynamically unstable hairpin RNAs

31 March 2020

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Autoinhibition of human dicer by its internal helicase domain

31 March 2020

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Requirement for the ERI/DICER complex in endogenous RNA interference and sperm development in Caenorhabditis elegans

31 March 2020

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Dicer recognizes the 5' end of RNA for efficient and accurate processing

31 March 2020

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TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing

31 March 2020

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Multiple sensors ensure guide strand selection in human RNAi pathways

31 March 2020

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Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing

31 March 2020

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Reduced expression of Dicer associated with poor prognosis in lung cancer patients.

31 March 2020

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Dicer, Drosha, and outcomes in patients with ovarian cancer

31 March 2020

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Down-regulation of dicer expression in ovarian cancer tissues.

31 March 2020

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Expression levels of the microRNA processing enzymes Drosha and dicer in epithelial skin cancer

31 March 2020

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Down-regulation of the miRNA master regulators Drosha and Dicer is associated with specific subgroups of breast cancer

31 March 2020

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Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma

31 March 2020

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Global microRNA profiles in cervical squamous cell carcinoma depend on Drosha expression levels.

31 March 2020

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RNASEN regulates cell proliferation and affects survival in esophageal cancer patients

31 March 2020

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Overexpression of Dicer in precursor lesions of lung adenocarcinoma

31 March 2020

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Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells

31 March 2020

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Dicer and outcomes in patients with acute myeloid leukemia (AML).

31 March 2020

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RETRACTED: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function

31 March 2020

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A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells

31 March 2020

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DICER1 mutations in familial pleuropulmonary blastoma

31 March 2020

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Pleuropulmonary blastoma: a marker for familial disease

31 March 2020

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Familial pleuropulmonary blastoma in Australia

31 March 2020

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Pulmonary cysts in early childhood and the risk of malignancy.

31 March 2020

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Familial cystic nephroma and pleuropulmonary blastoma

31 March 2020

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Familial association of pleuropulmonary blastoma with cystic nephroma and other renal tumors: a report from the International Pleuropulmonary Blastoma Registry

31 March 2020

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Nasal chondromesenchymal hamartoma in children with pleuropulmonary blastoma--A report from the International Pleuropulmonary Blastoma Registry registry

31 March 2020

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Ciliary body medulloepithelioma: four cases associated with pleuropulmonary blastoma--a report from the International Pleuropulmonary Blastoma Registry

31 March 2020

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DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome

31 March 2020

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Extending the phenotypes associated with DICER1 mutations.

31 March 2020

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Exploring the association Between DICER1 mutations and differentiated thyroid carcinoma.

31 March 2020

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DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors

31 March 2020

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Ovarian sex cord-stromal tumors, pleuropulmonary blastoma and DICER1 mutations: a report from the International Pleuropulmonary Blastoma Registry

31 March 2020

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DICER1 mutations in childhood cystic nephroma and its relationship to DICER1-renal sarcoma

31 March 2020

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Germline DICER1 mutations and familial cystic nephroma.

31 March 2020

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DICER1 mutations in embryonal rhabdomyosarcomas from children with and without familial PPB-tumor predisposition syndrome.

31 March 2020

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Pituitary blastoma: a pathognomonic feature of germ-line DICER1 mutations

31 March 2020

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Germline DICER1 mutation and associated loss of heterozygosity in a pineoblastoma

31 March 2020

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Biallelic DICER1 mutations in sporadic pleuropulmonary blastoma

31 March 2020

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Exome sequencing of pleuropulmonary blastoma reveals frequent biallelic loss of TP53 and two hits in DICER1 resulting in retention of 5p-derived miRNA hairpin loop sequences

31 March 2020

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Judicious DICER1 testing and surveillance imaging facilitates early diagnosis and cure of pleuropulmonary blastoma

31 March 2020

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31 March 2020

Cancer genome landscapes

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Biallelic DICER1 mutations occur in Wilms tumours.

31 March 2020

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Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers.

31 March 2020

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Germ-line and somatic DICER1 mutations in pineoblastoma

31 March 2020

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Refining the relation between 'first hits' and 'second hits' at the APC locus: the 'loose fit' model and evidence for differences in somatic mutation spectra among patients.

31 March 2020

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Expanding the phenotype of mutations in DICER1: mosaic missense mutations in the RNase IIIb domain of DICER1 cause GLOW syndrome.

31 March 2020

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Cancer-associated somatic DICER1 hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage.

31 March 2020

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In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs

31 March 2020

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Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour

31 March 2020

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Serum levels of mature microRNAs in DICER1-mutated pleuropulmonary blastoma

31 March 2020

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MicroRNA expression profiles classify human cancers

31 March 2020

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let-7 regulates self renewal and tumorigenicity of breast cancer cells

31 March 2020

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Impaired microRNA processing enhances cellular transformation and tumorigenesis

31 March 2020

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Characterization of microRNA expression levels and their biological correlates in human cancer cell lines

31 March 2020

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Dicer1 functions as a haploinsufficient tumor suppressor

31 March 2020

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A dosage-dependent pleiotropic role of Dicer in prostate cancer growth and metastasis

31 March 2020

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Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation

31 March 2020

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DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer

31 March 2020

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Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing

31 March 2020

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Impaired DICER1 function promotes stemness and metastasis in colon cancer.

31 March 2020

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Familial arrhenoblastoma and thyroid adenoma

31 March 2020

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Multinodular Goiter in children: an important pointer to a germline DICER1 mutation

31 March 2020

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Primary pulmonary rhabdomyosarcoma of the lung in children. Report of two cases presenting with spontaneous pneumothorax

31 March 2020

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Nasal chondromesenchymal hamartoma: an upper respiratory tract analogue of the chest wall mesenchymal hamartoma

31 March 2020

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Medulloepithelioma in DICER1 syndrome treated with resection

31 March 2020

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Cerebral metastasis and other central nervous system complications of pleuropulmonary blastoma

31 March 2020

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31 March 2020

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Pituitary blastoma: a unique embryonal tumor.

31 March 2020

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Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

31 March 2020

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Bilateral progressive cystic nephroma in a 9-month-old male infant requiring renal replacement therapy.

31 March 2020

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Pleuropulmonary blastoma: a rare pathology with an even rarer presentation

31 March 2020

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Syndromic presentation of a pleuropulmonary blastoma associated with congenital cystic adenomatoid malformation. A case report

31 March 2020

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Prenatal presentation and outcome of children with pleuropulmonary blastoma

31 March 2020

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Type I pleuropulmonary blastoma: pathology and biology study of 51 cases from the international pleuropulmonary blastoma registry

31 March 2020

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Anaplastic sarcoma of the kidney: a clinicopathologic study of 20 cases of a new entity with polyphenotypic features

31 March 2020

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Treatment of high risk Sertoli-Leydig cell tumors of the ovary using a gonadotropin releasing hormone (GnRH) analog

31 March 2020

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Pleuropulmonary blastoma: a clinicopathologic study of 50 cases

31 March 2020

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12 December 2020

Dicer ablation impairs prostate stem cell activity and causes prostate atrophy

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12 December 2020

Pleuropulmonary blastoma is THE pulmonary blastoma of childhood

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12 December 2020

Radiographic screening of infants and young children with genetic predisposition for rare malignancies: DICER1 mutations and pleuropulmonary blastoma

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12 December 2020

An unusual case of pleuropulmonary blastoma in a child with jejunal hamartomas

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12 December 2020

Identifiers

DOI

10.1038/NRC3802

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Dimensions Publication ID

31 August 2017

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