Therapeutic applications of lipoic acid: a patent review (2011 - 2014). (Q38237714)

31 August 2017

Therapeutic applications of lipoic acid: a patent review (2011 - 2014). (English)

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31 August 2017

Maria Koufaki

1

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PubMed ID

25101925

31 August 2017

language of work or name

English

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publication date

7 August 2014

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Expert Opinion on Therapeutic Patents

31 August 2017

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31 August 2017

24

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31 August 2017

9

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31 August 2017

993-1005

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alpha-Lipoic acid as a biological antioxidant

31 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.937425

The pharmacology of the antioxidant lipoic acid

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Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid

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Lipoic acid: a multifunctional antioxidant

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Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling

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Lipoic acid as a novel treatment for Alzheimer's disease and related dementias.

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Evidence for using alpha-lipoic acid in reducing lipoprotein and inflammatory related atherosclerotic risk

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Lipoic acid prevents fructose-induced changes in liver carbohydrate metabolism: role of oxidative stress

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Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential

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Multifunctional lipoic acid conjugates

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Design and synthesis of antioxidant alpha-lipoic acid hybrids

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Novel potent inhibitors of lipid peroxidation with protective effects against reperfusion arrhythmias

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Synthesis of chroman analogues of lipoic acid and evaluation of their activity against reperfusion arrhythmias

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Attenuation of oxidative stress in HL-1 cardiomyocytes improves mitochondrial function and stabilizes Hif-1alpha

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Lipoic acid analogs with enhanced pharmacological activity

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Synthesis and pharmacological evaluation of new 1,2-dithiolane based antioxidants

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Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration

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Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks

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Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties

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L-dopa- and dopamine-(R)-alpha-lipoic acid conjugates as multifunctional codrugs with antioxidant properties.

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Design and synthesis of 1,2-dithiolane derivatives and evaluation of their neuroprotective activity

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Design and synthesis of novel neuroprotective 1,2-dithiolane/chroman hybrids

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Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C ε-mediated metalloproteinase 2 and 9 levels in β-amyloid infused Alzheimer's disease rat model.

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A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells

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Identification of N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate as a new anti-Parkinson's agent possessing a dopamine D2 and serotonin 5-HT1A dual-agonist profile

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Design and synthesis of new bifunctional sigma-1 selective ligands with antioxidant activity.

21 January 2018

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Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases

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Design and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and anti-inflammatory agents.

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Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts

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NOSH-Aspirin: A Novel Nitric Oxide-Hydrogen Sulfide-Releasing Hybrid: A New Class of Anti-inflammatory Pharmaceuticals

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Synthesis and characterization of new and potent alpha-lipoic acid derivatives

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Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds

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Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects

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Synthesis and cytotoxic activity of diosgenyl saponin analogues

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Synthesis and anticancer evaluation of alpha-lipoic acid derivatives

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Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells.

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Design, synthesis and evaluation of PEGylated lipoic acid derivatives with functionality as potent anti-melanogenic agents.

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Hyaluronic acid lipoate: synthesis and physicochemical properties.

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Synthesis of new antioxidant conjugates and their in vitro hydrolysis with Stratum corneum enzymes

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Electrochemical analysis of HIV-1 reverse transcriptase serum level: exploiting protein binding to a functionalized nanostructured surface.

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Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis

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Alpha-lipoic acid supplementation and diabetes

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Alpha-lipoic Acid and diabetic neuropathy

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Diabetes and alpha lipoic Acid.

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Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

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Sodium dependent multivitamin transporter (SMVT): a potential target for drug delivery

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Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study

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Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial.

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Effects of alpha-lipoic Acid on body weight in obese subjects

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Efficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial

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Effects of α-lipoic acid on mtDNA damage after isolated muscle contractions

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A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain

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Carbonic Anhydrase Activators: Gold Nanoparticles Coated with Derivatized Histamine, Histidine, and Carnosine Show Enhanced Activatory Effects on Several Mammalian Isoforms

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10.1517/13543776.2014.937425

21 January 2018

Identifiers

DOI

1 reference

31 August 2017

1 reference

PubMed ID

25101925