Telomerase promoter mutations in cancer: an emerging molecular biomarker? (Q38232447)

31 August 2017

Telomerase promoter mutations in cancer: an emerging molecular biomarker? (English)

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31 August 2017

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13

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31 August 2017

Telmo Catarino

8

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Marta Reis

Marta Reis

4

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Paula Boaventura

Paula Boaventura

6

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Helena Pópulo

Helena Pópulo

5

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Ricardo Celestino

Ricardo Celestino

3

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Miguel Melo

Miguel Melo

7

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João Vinagre

João Vinagre

1

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Jorge Lima

Jorge Lima

9

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José Manuel Lopes

José Manuel Lopes

10

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Manuel Sobrinho Simões

Manuel Sobrinho-Simões

12

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Vasco Sampaio-Pinto

2

Vasco Pinto

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31 August 2017

11

Valdemar Máximo

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31 August 2017

22 July 2014

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31 August 2017

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31 August 2017

465

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31 August 2017

119-133

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2

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https://scigraph.springernature.com/pub.10.1007/s00428-014-1608-4

31 August 2017

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cites work

Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome

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https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomere length and risk of melanoma, squamous cell carcinoma, and basal cell carcinoma.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Flow cytometry and FISH to measure the average length of telomeres (flow FISH).

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Genes and pathways downstream of telomerase in melanoma metastasis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Extensive allelic variation and ultrashort telomeres in senescent human cells.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Structure and function of telomeres

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

The somatic genomic landscape of glioblastoma

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

The role of telomeres in the ageing of human skin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomere length and the risk of cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Is telomerase a viable target in cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomere abnormalities and chromosome fragility in patients affected by familial papillary thyroid cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomeres and thyroid cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomerase activity in prognostic histopathologic features of melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomere measurement by quantitative PCR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Alternative lengthening of telomeres: models, mechanisms and implications

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

21 January 2018

Telomerase regulation

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

A highly selective telomerase inhibitor limiting human cancer cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Selective cytotoxicity and telomere damage in leukemia cells using the telomerase inhibitor BIBR1532.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Human diseases of telomerase dysfunction: insights into tissue aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

21 January 2018

Telomerase is processive

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

TERT promoter mutations are frequent in cutaneous basal cell carcinoma and squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

The role of telomeres in stem cells and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

A prospective study of telomere length and the risk of skin cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomerase activity in the regenerative basal layer of the epidermis inhuman skin and in immortal and carcinoma-derived skin keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

The serial cultivation of human diploid cell strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Altered telomeres in tumors with ATRX and DAXX mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

TERT promoter mutations in familial and sporadic melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

A syndrome of progressive pancytopenia with microcephaly, cerebellar hypoplasia and growth failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Highly recurrent TERT promoter mutations in human melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomere length and telomerase reverse transcriptase gene copy number in patients with papillary thyroid carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Specific association of human telomerase activity with immortal cells and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

TERT promoter mutations occur early in urothelial neoplasia and are biomarkers of early disease and disease recurrence in urine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Biosensor Techniques Used for Determination of Telomerase Activity in Cancer Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomerase activity in human brain tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

No association between telomere length in peripheral blood leukocytes and the risk of nonmelanoma skin cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

The absence of TERT promoter mutations in primary gastric cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Highly prevalent TERT promoter mutations in aggressive thyroid cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Highly prevalent TERT promoter mutations in bladder cancer and glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Prognostic significance of telomerase-associated parameters in glioblastoma: effect of patient age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Dyskeratosis congenita: telomerase, telomeres and anticipation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomerase and the search for the end of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomere dysfunction and chromosome instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Shorter telomeres associate with a reduced risk of melanoma development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Finding the end: recruitment of telomerase to telomeres

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

TERT promoter mutations in primary and secondary glioblastomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomerase activity in melanoma and non-melanoma skin cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

The different telomere lengths in basal and squamous cell carcinomas also differ between the nontransplant and renal transplant population

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

DNA vaccination against tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Progressive increase in telomerase activity from benign melanocytic conditions to malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Novel anticancer therapeutics targeting telomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomerase activity in melanocytic lesions: A potential marker of tumor biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomerase activity of basal cell carcinoma in patients living in North Queensland, Australia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomerase activity in 144 brain tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

How I treat acquired aplastic anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

A survey of telomerase activity in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Genome-wide association study identifies five susceptibility loci for glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Genetic alterations in poorly differentiated and undifferentiated thyroid carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomere length as a biological marker in malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Cloning yeast telomeres on linear plasmid vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Detection of telomerase activity in malignant and nonmalignant skin conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Frequency of TERT promoter mutations in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

TERT promoter mutations in renal cell carcinomas and upper tract urothelial carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomerase reverse transcriptase gene promoter mutations help discern the origin of urogenital tumors: a genomic and molecular study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Fine-mapping of a region of chromosome 5p15.33 (TERT-CLPTM1L) suggests a novel locus in TERT and a CLPTM1L haplotype are associated with glioma susceptibility in a Chinese population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Assays for human telomerase activity: progress and prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Idiopathic Pulmonary Fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00428-014-1608-4

Telomerase expression and proliferative activity suggest a stem cell role for thyroid solid cell nests.

21 January 2018

1 reference

12 December 2020

Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma

1 reference

12 December 2020

Telomerase activity in human bladder cancer

1 reference

12 December 2020

The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas

1 reference

12 December 2020

Telomerase activity in bladder cancer tissue

1 reference

12 December 2020

Evidence for UV-associated activation of telomerase in human skin.

1 reference

12 December 2020

Absence of TERT promoter mutations in esophageal adenocarcinoma.

1 reference

12 December 2020

Telomerase expression in benign and malignant skin neoplasms: comparison of three major subunits.

1 reference

12 December 2020

Telomere length in neoplastic and nonneoplastic tissues of patients with familial and sporadic papillary thyroid cancer

1 reference

12 December 2020

Telomerase in cancer immunotherapy

1 reference

12 December 2020

Melanomas of unknown primary frequently harbor TERT-promoter mutations

1 reference

12 December 2020

Increase in telomerase activity during progression of melanocytic cells from melanocytic naevi to malignant melanomas

1 reference

12 December 2020

Telomere dysfunction in human diseases: the long and short of it!

1 reference

12 December 2020

Low frequency of TERT promoter mutations in a large cohort of gallbladder and gastric cancers

1 reference

12 December 2020

Relationship between dyskerin expression and telomerase activity in human breast cancer.

1 reference

12 December 2020

A robust assay for alternative lengthening of telomeres in tumors shows the significance of alternative lengthening of telomeres in sarcomas and astrocytomas.

1 reference

12 December 2020

Overexpression and promoter mutation of the TERT gene in malignant pleural mesothelioma.

1 reference

12 December 2020

TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomas

1 reference

12 December 2020

Evaluation of telomerase activity in cutaneous melanocytic proliferations

1 reference

12 December 2020

TERT promoter mutations are frequent in atypical fibroxanthomas and pleomorphic dermal sarcomas

1 reference

12 December 2020

Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths

1 reference

12 December 2020

TERT promoter mutation is uncommon in acral lentiginous melanoma.

1 reference

12 December 2020

Assays for detection of telomerase activity.

1 reference

12 December 2020

TERT promoter mutations in skin cancer: the effects of sun exposure and X-irradiation.

1 reference

12 December 2020

High incidence of activating TERT promoter mutations in meningiomas undergoing malignant progression.

1 reference

12 December 2020

The genetics and clinical manifestations of telomere biology disorders

1 reference

12 December 2020

Immunoexpression and prognostic role of hTERT and cyclin D1 in urothelial carcinoma

1 reference

12 December 2020

Telomerase activity is correlated with lower grade and lower stage bladder carcinomas.

1 reference

12 December 2020

Telomerase activity and alterations in telomere length in human brain tumors

1 reference

12 December 2020

TERT promoter mutations predict worse survival in laryngeal cancer patients

1 reference

12 December 2020

Inhibition of Telomerase Activity by a Hammerhead Ribozyme Targeting the RNA Component of Telomerase in Human Melanoma Cells

1 reference

12 December 2020

TERT promoter mutations and their association with BRAF V600E mutation and aggressive clinicopathological characteristics of thyroid cancer

1 reference

12 December 2020

p63 expression in solid cell nests of the thyroid: further evidence for a stem cell origin

1 reference

12 December 2020

Low frequency of TERT promoter somatic mutation in 313 sporadic esophageal squamous cell carcinomas

1 reference

12 December 2020

Mutation frequencies of GNAQ, GNA11, BAP1, SF3B1, EIF1AX and TERT in uveal melanoma: detection of an activating mutation in the TERT gene promoter in a single case of uveal melanoma

1 reference

12 December 2020

10.1007/S00428-014-1608-4

Identifiers

DOI

1 reference

31 August 2017

1 reference

PubMed ID

25048572