Heavy metals and metalloids as a cause for protein misfolding and aggregation. (Q38223690)

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21 March 2020

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Heavy metals and metalloids as a cause for protein misfolding and aggregation (English)

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Markus J Tamás

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Therese Jacobson

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Philipp Christen

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Sebastian Ibstedt

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25 February 2014

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Creative Commons Attribution

21 March 2020

copyright license

5 references

4 November 2019

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Global analysis of protein aggregation in yeast during physiological conditions and arsenite stress.

1 reference

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Arsenic binding to proteins

6 September 2017

1 reference

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Antimicrobial activity of metals: mechanisms, molecular targets and applications

6 September 2017

1 reference

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Untangling amyloid-β, tau, and metals in Alzheimer's disease

6 September 2017

1 reference

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The role of metal ions in amyloid formation: general principles from model peptides.

6 September 2017

1 reference

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Cellular strategies for regulating functional and nonfunctional protein aggregation

6 September 2017

1 reference

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6 September 2017

Glutathione synthesis

1 reference

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Metal dyshomeostasis and oxidative stress in Alzheimer's disease

6 September 2017

1 reference

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Metal imaging in neurodegenerative diseases

6 September 2017

1 reference

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Industrial toxicants and Parkinson's disease

6 September 2017

1 reference

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Mechanisms pertaining to arsenic toxicity

6 September 2017

1 reference

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Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases

6 September 2017

1 reference

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Molecular chaperones in protein folding and proteostasis

6 September 2017

1 reference

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Metalloregulatory proteins: metal selectivity and allosteric switching

6 September 2017

1 reference

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Transition metal homeostasis: from yeast to human disease.

6 September 2017

1 reference

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Molecular chaperones and associated cellular clearance mechanisms against toxic protein conformers in Parkinson's disease

6 September 2017

1 reference

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Protein quality control in the cytosol and the endoplasmic reticulum: brothers in arms.

6 September 2017

1 reference

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Cellular strategies for controlling protein aggregation

6 September 2017

1 reference

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Trivalent arsenic inhibits the functions of chaperonin complex

6 September 2017

1 reference

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The arsenic exposure hypothesis for Alzheimer disease

6 September 2017

1 reference

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Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML.

6 September 2017

1 reference

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How Saccharomyces cerevisiae copes with toxic metals and metalloids.

6 September 2017

1 reference

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Ribosome and transcript copy numbers, polysome occupancy and enzyme dynamics in Arabidopsis.

6 September 2017

1 reference

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Metalloproteins and metal sensing

6 September 2017

1 reference

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Biological and chemical approaches to diseases of proteostasis deficiency

6 September 2017

1 reference

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Genetic basis of arsenite and cadmium tolerance in Saccharomyces cerevisiae

6 September 2017

1 reference

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The native 3D organization of bacterial polysomes

6 September 2017

1 reference

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Arsenic(III) species inhibit oxidative protein folding in vitro

6 September 2017

1 reference

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Misfolded proteins partition between two distinct quality control compartments

6 September 2017

1 reference

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Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins

6 September 2017

1 reference

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Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms

6 September 2017

1 reference

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Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans

6 September 2017

1 reference

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Global transcriptome and deletome profiles of yeast exposed to transition metals

6 September 2017

1 reference

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Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide

6 September 2017

1 reference

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Identification of arsenic-binding proteins in human breast cancer cells

6 September 2017

1 reference

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An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity

6 September 2017

1 reference

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Intracellular signaling by the unfolded protein response

6 September 2017

1 reference

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Cadmium induces the expression of Grp78, an endoplasmic reticulum molecular chaperone, in LLC-PK1 renal epithelial cells

6 September 2017

1 reference

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Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia

6 September 2017

1 reference

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Cadmium inhibits mismatch repair by blocking the ATPase activity of the MSH2-MSH6 complex

6 September 2017

1 reference

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Integrating phenotypic and expression profiles to map arsenic-response networks

6 September 2017

1 reference

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Thermotolerance requires refolding of aggregated proteins by substrate translocation through the central pore of ClpB.

6 September 2017

1 reference

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Protein degradation and protection against misfolded or damaged proteins

6 September 2017

1 reference

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Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution

6 September 2017

1 reference

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Cadmium is a mutagen that acts by inhibiting mismatch repair.

6 September 2017

1 reference

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Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors

6 September 2017

1 reference

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Essential role of calcineurin in response to endoplasmic reticulum stress

6 September 2017

1 reference

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Protein Structure and the Energetics of Protein Stability.

6 September 2017

1 reference

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Zinc finger proteins as potential targets for toxic metal ions: differential effects on structure and function

6 September 2017

1 reference

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GFAT as a target molecule of methylmercury toxicity in Saccharomyces cerevisiae

6 September 2017

1 reference

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Principles that govern the folding of protein chains

6 September 2017

1 reference

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HSP104 required for induced thermotolerance

6 September 2017

1 reference

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Hsp104 is required for tolerance to many forms of stress

6 September 2017

1 reference

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Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030994

Rapid, transient induction of ER stress in the liver and kidney after acute exposure to heavy metal: evidence from transgenic sensor mice

14 September 2017

1 reference

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Reactive oxygen species are involved in arsenic trioxide inhibition of pyruvate dehydrogenase activity

14 September 2017

1 reference

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Biochemical effects of mercury, cadmium, and lead

14 September 2017

1 reference

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Induction of stress proteins in human endothelial cells by heavy metal ions and heat shock

14 September 2017

1 reference

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The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase

28 September 2017

1 reference

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Characterization of surface-exposed reactive cysteine residues in Saccharomyces cerevisiae

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030994

Application of the comprehensive set of heterozygous yeast deletion mutants to elucidate the molecular basis of cellular chromium toxicity

23 June 2018

1 reference

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Endoplasmic reticulum stress and alteration in calcium homeostasis are involved in cadmium-induced apoptosis

23 June 2018

1 reference

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Differential rate of ribosomal protein synthesis in Escherichia coli B/r

23 June 2018

1 reference

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Mathematical modelling of arsenic transport, distribution and detoxification processes in yeast.

23 June 2018

1 reference

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Glutathione serves an extracellular defence function to decrease arsenite accumulation and toxicity in yeast

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030994

Endoplasmic reticulum is a major target of cadmium toxicity in yeast.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030994

Heavy metal ions are potent inhibitors of protein folding

31 August 2018

1 reference

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Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response.

31 August 2018

1 reference

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Oxidative protein damage causes chromium toxicity in yeast

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030994

Low-level arsenite causes accumulation of ubiquitinated proteins in rabbit renal cortical slices and HEK293 cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030994

Proline cis-trans isomerization and protein folding

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030994

Sulfur sparing in the yeast proteome in response to sulfur demand.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030994

Bioassay of cadmium using a DNA microarray: genome-wide expression patterns of Saccharomyces cerevisiae response to cadmium

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030994

A proteome analysis of the cadmium response in Saccharomyces cerevisiae

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030994

Acute cadmium exposure inactivates thioltransferase (Glutaredoxin), inhibits intracellular reduction of protein-glutathionyl-mixed disulfides, and initiates apoptosis.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4030994

Life on the edge: a link between gene expression levels and aggregation rates of human proteins

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.3390%2FBIOM4010252

Arsenite interferes with protein folding and triggers formation of protein aggregates in yeast

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.3390%2FBIOM4010252

Induction of four proteins in chick embryo cells by sodium arsenite

21 January 2018

1 reference

12 December 2020

Transition series metals and sulfhydryl reagents induce the synthesis of four proteins in eukaryotic cells

1 reference

12 December 2020

Effect of zinc(II) on the refolding and reactivation of liver alcohol dehydrogenase

1 reference

12 December 2020

Changes of heavy metal, metallothionein and heat shock proteins in Sertoli cells induced by cadmium exposure

1 reference

12 December 2020

Regulation of the arsenic-responsive transcription factor Yap8p involves the ubiquitin-proteasome pathway

1 reference

12 December 2020

Mechanism of Cd2+ toxicity: Cd2+ inhibits photoactivation of Photosystem II by competitive binding to the essential Ca2+ site

1 reference

12 December 2020

Quantitative transcriptome, proteome, and sulfur metabolite profiling of the Saccharomyces cerevisiae response to arsenite

1 reference

12 December 2020

Complex formation between metallic cations and proteins, peptides and amino acids

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12 December 2020

Identifiers

DOI

10.3390/BIOM4010252

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24970215%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24970215%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24970215%20AND%20SRC:MED&resulttype=core&format=json