DSP4, a selective neurotoxin for the locus coeruleus noradrenergic system. A review of its mode of action (Q38223203)

31 August 2017

DSP4, a selective neurotoxin for the locus coeruleus noradrenergic system. A review of its mode of action (English)

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31 August 2017

Svante B Ross

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31 August 2017

Carina Stenfors

series ordinal

2

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31 August 2017

language of work or name

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26 June 2014

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31 August 2017

Neurotoxicity Research

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31 August 2017

27

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31 August 2017

1

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31 August 2017

15-30

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https://scigraph.springernature.com/pub.10.1007/s12640-014-9482-z

31 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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On the long-lasting inhibitory effect of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP 4) on the active uptake of noradrenaline

21 January 2018

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Changes in postnatal norepinephrine alter alpha-2 adrenergic receptor development

21 January 2018

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N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) has differential efficacy for causing central noradrenergic lesions in two different rat strains: comparison between Long-Evans and Sprague-Dawley rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-014-9482-Z

Protective effect of 7-nitroindazole against DSP-4 induced noradrenaline depletion in mouse hippocampus

21 January 2018

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A comprehensive analysis of the effect of DSP4 on the locus coeruleus noradrenergic system in the rat

21 January 2018

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Effects of DSP4 on the noradrenergic phenotypes and its potential molecular mechanisms in SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-014-9482-Z

Neurotoxic effects of DSP-4 on the central noradrenergic system in male zebra finches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-014-9482-Z

Neuroprotective profile of the multitarget drug rasagiline in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12640-014-9482-Z

Interference of the noradrenergic neurotoxin DSP4 with neuronal and nonneuronal monoamine transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-014-9482-Z

Differential effects of DSP-4 on noradrenaline axons in cerebral cortex and hypothalamus may reflect heterogeneity of noradrenaline uptake sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-014-9482-Z

Immunohistochemical evidence of neuroprotection by R(-)-deprenyl and N-(2-hexyl)-N-methylpropargylamine on DSP-4-induced degeneration of rat brain noradrenergic axons and terminals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-014-9482-Z

Intracerebroventricular infusion of CRF increases extracellular concentrations of norepinephrine in the hippocampus and cortex as determined by in vivo voltammetry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12640-014-9482-Z

Dose-dependent effects of noradrenergic denervation by DSP-4 treatment on forced swimming and beta-adrenoceptor binding in the rat

21 January 2018

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12 December 2020

DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine)—A useful denervation tool for central and peripheral noradrenaline neurons

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12 December 2020

The aziridinium derivative of DSP4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine) accelerates the beating rate of isolated rat atria by enhancing the spontaneous release of noradrenaline

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12 December 2020

DSP-4, a noradrenergic neurotoxin, produces sex-specific effects on pairing and courtship behavior in zebra finches

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12 December 2020

Chemical transformations of xylamine (N-2'-chloroethyl-N-ethyl-2-methylbenzylamine) in solution. Pharmacological activity of the species derived from this irreversible norepinephrine uptake inhibitor

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12 December 2020

The effect of DSP-4 (N-[2-chloroethyl]-N-ethyl-2-bromobenzylamine) on monoamine oxidase activities in tissues of the rat.

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12 December 2020

The role of cysteines and histidins of the norepinephrine transporter

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12 December 2020

[3H]nisoxetine--a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments

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12 December 2020

Neurotoxic effects of DSP-4 on the noradrenergic system of the goldfish brain

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12 December 2020

The noradrenergic neurotoxin DSP-4 eliminates the coeruleospinal projection but spares projections of the A5 and A7 groups to the ventral horn of the rat spinal cord.

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12 December 2020

Noradrenaline and learning: effects of the noradrenergic neurotoxin DSP4 on imprinting in the domestic chick.

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12 December 2020

Altered hindlimb extension in the rat after DSP-4: a useful marker of central noradrenergic depletion

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12 December 2020

3Hnisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding

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12 December 2020

Central DSP-4 treatment decreases norepinephrine levels and courtship behavior in male zebra finches

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12 December 2020

Neuroprotective effects of some monoamine oxidase-B inhibitors against DSP-4-induced noradrenaline depletion in the mouse hippocampus

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12 December 2020

DSP-4 treatment produces abnormal tyrosine hydroxylase immunoreactive fibers in rat hippocampus

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12 December 2020

On the mechanism of the accumulation of 3H-bretylium in peripheral sympathetic nerves

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12 December 2020

Experimentally-induced neuron loss in the locus coeruleus of adult rats

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12 December 2020

Neurochemical, neuroprotective and neurorescue effects of aliphatic N-methylpropargylamines; new MAO-B inhibitors without amphetamine-like properties

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12 December 2020

The actions of xylamine on central noradrenergic neurons

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12 December 2020

Synthesis and adrenergic neuron blocking properties of some alkylating analogues of bretylium

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12 December 2020

Characterization of [3H]desipramine binding associated with neuronal norepinephrine uptake sites in rat brain membranes.

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12 December 2020

Quantification of presynaptic alpha 2-adrenoceptors in rat brain after short-term DSP-4 lesioning

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12 December 2020

Recovery of central noradrenergic neurons one year after the administration of the neurotoxin DSP4

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12 December 2020

Aliphatic N-methylpropargylamines as potential neurorescue agents

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12 December 2020

Depletion of NOS activity in the rat dentate gyrus neurons by DSP-4 and protection by deprenyl

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12 December 2020

Neurotoxicity of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP 4) on noradrenergic neurons is mimicked by its cyclic aziridinium derivative

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12 December 2020

Selective effects of DSP-4 on locus coeruleus axons: are there pharmacologically different types of noradrenergic axons in the central nervous system?

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12 December 2020

[3H]Xylamine accumulation by two sympathetically innervated tissues

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12 December 2020

Interactions of bretylium and other drugs on guinea-pig atria: evidence for inhibition of neuronal monoamine oxidase by bretylium.

1 reference

12 December 2020

The response of noradrenergic axons to systemically administered DSP-4 in the rat: an immunohistochemical study using antibodies to noradrenaline and dopamine-beta-hydroxylase.

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12 December 2020

Cyclizing compounds. I. Tertiary N-(2-bromobenzyl)-N-haloalkylamines with adrenergic blocking action.

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12 December 2020

Overflow of noradrenaline and dopamine in frontal cortex after [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine] (DSP-4) treatment: in vivo microdialysis study in anaesthetized rats

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12 December 2020

Neuroprotection by R(-)-deprenyl and N-2-hexyl-N-methylpropargylamine on DSP-4, a neurotoxin, induced degeneration of noradrenergic neurons in the rat locus coeruleus

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12 December 2020

PC12 variants deficient in catecholamine transport

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12 December 2020

Xylamine, an irreversible inhibitor of norepinephrine uptake, is transported by this same uptake mechanism in cultured rat superior cervical ganglia.

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12 December 2020

Characterization of xylamine binding to proteins of PC12 pheochromocytoma cells.

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12 December 2020

Effects of the noradrenaline neurotoxin DSP 4 on monoamine neurons and their transmitter turnover in rat CNS

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12 December 2020

The effects of xylamine, a nitrogen mustard on [3H]norepinephrine accumulation in rabbit aorta

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12 December 2020

Hippocampal norepinephrine-like voltammetric responses following infusion of corticotropin-releasing factor into the locus coeruleus

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12 December 2020

10.1007/S12640-014-9482-Z

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31 August 2017

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