Therapeutic role and ligands of medium- to long-chain Fatty Acid receptors. (Q38219404)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24917851%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

Therapeutic role and ligands of medium- to long-chain Fatty Acid receptors (English)

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20 March 2020

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2

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20 March 2020

author name string

Takafumi Hara

series ordinal

1

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20 March 2020

Akira Hirasawa

series ordinal

3

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20 March 2020

publication date

2 June 2014

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Frontiers in Endocrinology

20 March 2020

published in

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20 March 2020

volume

5

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20 March 2020

page(s)

83

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The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism

20 March 2020

cites work

1 reference

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The fatty acid receptor FFA1/GPR40 a decade later: how much do we know?

6 September 2017

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Free fatty acid receptors and their role in regulation of energy metabolism

6 September 2017

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FFA1-selective agonistic activity based on docking simulation using FFA1 and GPR120 homology models

6 September 2017

1 reference

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Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

6 September 2017

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The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin

6 September 2017

1 reference

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GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

6 September 2017

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Taste Preference for Fatty Acids Is Mediated by GPR40 and GPR120

6 September 2017

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Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice

6 September 2017

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GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

6 September 2017

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The regulation of adipogenesis through GPR120.

6 September 2017

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Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

6 September 2017

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Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation

6 September 2017

1 reference

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Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

6 September 2017

1 reference

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The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids

6 September 2017

1 reference

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Pleiotropic effects of fatty acids on pancreatic beta-cells

6 September 2017

1 reference

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Dimerization: an emerging concept for G protein-coupled receptor ontogeny and function

6 September 2017

1 reference

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Structure-activity relationships of GPR120 agonists based on a docking simulation.

6 September 2017

1 reference

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Novel selective ligands for free fatty acid receptors GPR120 and GPR40.

14 September 2017

1 reference

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Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules

14 September 2017

1 reference

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Free fatty acid receptor 1 (FFA(1)R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion.

14 September 2017

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G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1.

14 September 2017

1 reference

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Discovery of a potent and selective GPR120 agonist.

23 June 2018

1 reference

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TAK-875, an orally available G protein-coupled receptor 40/free fatty acid receptor 1 agonist, enhances glucose-dependent insulin secretion and improves both postprandial and fasting hyperglycemia in type 2 diabetic rats

23 June 2018

1 reference

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Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion

23 June 2018

1 reference

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Biological complexity is under the 'strange attraction' of non-esterified fatty acids

23 June 2018

1 reference

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GPR40 protein levels are crucial to the regulation of stimulated hormone secretion in pancreatic islets. Lessons from spontaneous obesity-prone and non-obese type 2 diabetes in rats.

23 June 2018

1 reference

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How reliable are G-protein-coupled receptor antibodies?

31 August 2018

1 reference

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Colocalization of GPR120 with phospholipase-Cbeta2 and alpha-gustducin in the taste bud cells in mice.

31 August 2018

1 reference

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Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists.

31 August 2018

1 reference

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GPR40 is expressed in glucagon producing cells and affects glucagon secretion.

31 August 2018

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31 August 2018

Identifiers

DOI

10.3389/FENDO.2014.00083

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24917851%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24917851%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24917851%20AND%20SRC:MED&resulttype=core&format=json