Microglial dynamics and role in the healthy and diseased brain: a paradigm of functional plasticity (Q38203788)

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Microglial dynamics and role in the healthy and diseased brain: a paradigm of functional plasticity (English)

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TREM2 Variants in Alzheimer's Disease

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Variant of TREM2 Associated with the Risk of Alzheimer's Disease

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Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

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6 September 2017

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CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson's disease

6 September 2017

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Synaptic pruning by microglia is necessary for normal brain development

6 September 2017

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6 September 2017

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Adult neurogenesis in the mammalian brain: significant answers and significant questions

6 September 2017

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Physiology of microglia

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Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons

6 September 2017

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Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death

6 September 2017

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Microglial morphology and dynamic behavior is regulated by ionotropic glutamatergic and GABAergic neurotransmission

6 September 2017

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Microglia in the CNS: immigrants from another world

6 September 2017

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Microglial interactions with synapses are modulated by visual experience

6 September 2017

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The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective

6 September 2017

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Fate mapping analysis reveals that adult microglia derive from primitive macrophages

6 September 2017

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Pericytes are required for blood-brain barrier integrity during embryogenesis

6 September 2017

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Regulation of tau pathology by the microglial fractalkine receptor

6 September 2017

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Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis

6 September 2017

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Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation.

6 September 2017

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6 September 2017

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Neuroinflammation in Huntington's disease

6 September 2017

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Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

6 September 2017

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Degenerating synaptic boutons in prion disease: microglia activation without synaptic stripping

6 September 2017

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Systemic inflammation and disease progression in Alzheimer disease

6 September 2017

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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

6 September 2017

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Regulation of dynamic behavior of retinal microglia by CX3CR1 signaling

6 September 2017

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Microglia processes block the spread of damage in the brain and require functional chloride channels

6 September 2017

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Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals

6 September 2017

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Microglial physiology: unique stimuli, specialized responses

6 September 2017

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Microglia: gatekeepers of central nervous system immunology.

6 September 2017

1 reference

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TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

6 September 2017

1 reference

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Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease

6 September 2017

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Can the immune system be harnessed to repair the CNS?

6 September 2017

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Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance

6 September 2017

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The classical complement cascade mediates CNS synapse elimination

6 September 2017

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Debate: "is increasing neuroinflammation beneficial for neural repair?".

6 September 2017

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Microglia: active sensor and versatile effector cells in the normal and pathologic brain

6 September 2017

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Neurotransmitter receptors on microglia.

6 September 2017

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Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology

6 September 2017

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Systemic infections and inflammation affect chronic neurodegeneration

6 September 2017

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The origin and cell lineage of microglia: new concepts

6 September 2017

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Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

6 September 2017

1 reference

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Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD

6 September 2017

1 reference

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Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease

6 September 2017

1 reference

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Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: role of tumor necrosis factor- alpha

6 September 2017

1 reference

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ATP mediates rapid microglial response to local brain injury in vivo

6 September 2017

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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

6 September 2017

1 reference

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Alzheimer's disease: Abeta, tau and synaptic dysfunction

6 September 2017

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Milestones of neuronal development in the adult hippocampus

6 September 2017

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Neural activity and the dynamics of central nervous system development

6 September 2017

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Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses

6 September 2017

1 reference

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Preliminary studies on Alzheimer's disease using cDNA microarrays

6 September 2017

1 reference

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Alternative activation of macrophages

6 September 2017

1 reference

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The possible role of complement activation in Alzheimer disease

6 September 2017

1 reference

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ITAMs versus ITIMs: striking a balance during cell regulation

6 September 2017

1 reference

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Inflammation and Alzheimer's disease

6 September 2017

1 reference

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Microglial activation in the developing rat olfactory bulb

6 September 2017

1 reference

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Colonisation of the developing human brain and spinal cord by microglia: a review

6 September 2017

1 reference

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Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor

6 September 2017

1 reference

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Microglial response to amyloid plaques in APPsw transgenic mice.

6 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Immunohistochemical study of amoeboid microglial cells in fetal rat brain.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Synaptic activity and the construction of cortical circuits

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Microglia: a sensor for pathological events in the CNS

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Turnover of resident microglia in the normal adult mouse brain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Macrophages, microglial cells, and HLA-DR antigens in fetal and infant brain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Synuclein activates microglia in a model of Parkinson's disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Microglia derive from progenitors, originating from the yolk sac, and which proliferate in the brain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Regulation of microglial proliferation during chronic neurodegeneration

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Activation of the classical complement pathway in brain tissue of Alzheimer patients

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Localization of morphologically distinct microglial populations in the developing human fetal brain: implications for ontogeny.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Proliferation of parenchymal microglia is the main source of microgliosis after ischaemic stroke

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Rare contacts between synapses and microglial processes containing high levels of Iba1 and actin--a postembedding immunogold study in the healthy rat brain.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Differential cell proliferation in the cortex of the APPswePS1dE9 Alzheimer's disease mouse model.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: a multimodal imaging study

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Soothing the inflamed brain: effect of non-steroidal anti-inflammatory drugs on Alzheimer's disease pathology.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Enhanced microglial clearance of myelin debris in T cell-infiltrated central nervous system.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Microglial activation in presymptomatic Huntington's disease gene carriers

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Microglial activation correlates with severity in Huntington disease: a clinical and PET study.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Presence of reactive microglia in monkey substantia nigra years after 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine administration

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Microglial phagocytosis of apoptotic inflammatory T cells leads to down-regulation of microglial immune activation.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Early and progressive accumulation of reactive microglia in the Huntington disease brain

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Increased complement biosynthesis by microglia and complement activation on neurons in Huntington's disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Development of microglia in the postnatal rat hippocampus.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Expression of the receptor for macrophage colony stimulating factor by brain microglia and its upregulation in brains of patients with Alzheimer's disease and amyotrophic lateral sclerosis.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Use of carbon labeling to demonstrate the role of blood monocytes as precursors of the 'ameboid cells' present in the corpus callosum of postnatal rats

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4412879

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1177%2F1073858414530512

Phagocytosis of apoptotic inflammatory cells downregulates microglial chemoattractive function and migration of encephalitogenic T cells

21 January 2018

1 reference

12 December 2020

Macrophages in haemopoietic and other tissues of the developing mouse detected by the monoclonal antibody F4/80

1 reference

12 December 2020

Nitric oxide synthase and neuronal vulnerability in Parkinson's disease.

1 reference

12 December 2020

The benefits and limitations of animal models for translational research in neurodegenerative diseases

1 reference

12 December 2020

Differential involvement of perineuronal astrocytes and microglia in synaptic stripping after hypoglossal axotomy

1 reference

12 December 2020

Time-course of nigrostriatal neurodegeneration and neuroinflammation in the 6-hydroxydopamine-induced axonal and terminal lesion models of Parkinson's disease in the rat

1 reference

12 December 2020

Inflammatory processes in Alzheimer's disease

1 reference

12 December 2020

Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients

1 reference

12 December 2020

Displacement of synaptic terminals from regenerating motoneurons by microglial cells

1 reference

12 December 2020

Neurotrophins and the anti-inflammatory agents interleukin-4 (IL-4), IL-10, IL-11 and transforming growth factor-beta1 (TGF-beta1) down-regulate T cell costimulatory molecules B7 and CD40 on cultured rat microglia

1 reference

12 December 2020

Identifiers

DOI

10.1177/1073858414530512

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24722525%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24722525%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24722525%20AND%20SRC:MED&resulttype=core&format=json