Gamma histone 2AX (γ-H2AX)as a predictive tool in radiation oncology (Q38194616)

30 August 2017

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title

Gamma histone 2AX (γ-H2AX)as a predictive tool in radiation oncology (English)

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30 August 2017

Stamatia Pouliliou

1

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ORCID Public Data File 2021

author name string

Michael I Koukourakis

series ordinal

2

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30 August 2017

10 March 2014

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30 August 2017

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30 August 2017

19

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30 August 2017

3

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30 August 2017

167-180

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Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins

30 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

The synergistic effect of dimethylamino benzoylphenylurea (NSC #639829) and X-irradiation on human lung carcinoma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Are mouse lens epithelial cells more sensitive to γ-irradiation than lymphocytes?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

gammaH2AX expression in tumors exposed to cisplatin and fractionated irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Vorinostat enhances the radiosensitivity of a breast cancer brain metastatic cell line grown in vitro and as intracranial xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Radiosensitizing effect of epothilone B on human epithelial cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Elevated radiation-induced γH2AX foci in G2 phase heterozygous BRCA2 fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Suberoylanilide hydroxamic acid affects γH2AX expression in osteosarcoma, atypical teratoid rhabdoid tumor and normal tissue cell lines after irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

The loss of gammaH2AX signal is a marker of DNA double strand breaks repair only at low levels of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

TGFβ1 inhibition increases the radiosensitivity of breast cancer cells in vitro and promotes tumor control by radiation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Prolonged expression of the γ-H2AX DNA repair biomarker correlates with excess acute and chronic toxicity from radiotherapy treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

In vivo versus in vitro individual radiosensitivity analysed in healthy donors and in prostate cancer patients with and without severe side effects after radiotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Genomic instability in mice lacking histone H2AX

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

"Contextual" synthetic lethality and/or loss of heterozygosity: tumor hypoxia and modification of DNA repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Bystander effects induced by continuous low-dose-rate 125I seeds potentiate the killing action of irradiation on human lung cancer cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Targeting epidermal growth factor receptor-associated signaling pathways in non-small cell lung cancer cells: implication in radiation response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Activation of DNA damage response signaling in mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

ATR and ATRIP: partners in checkpoint signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Sensitization of breast carcinoma cells to ionizing radiation by small molecule inhibitors of DNA-dependent protein kinase and ataxia telangiectsia mutated

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Celastrol potentiates radiotherapy by impairment of DNA damage processing in human prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Radioprotective effect of hypothermia on cells - a multiparametric approach to delineate the mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Relative biological effectiveness of mammography X-rays at the level of DNA and chromosomes in lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Repeated exposure of human fibroblasts to ionizing radiation reveals an adaptive response that is not mediated by interleukin-6 or TGF-β.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Celecoxib induced tumor cell radiosensitization by inhibiting radiation induced nuclear EGFR transport and DNA-repair: a COX-2 independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Enhancement of in vitro and in vivo tumor cell radiosensitivity by the DNA methylation inhibitor zebularine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Detailed analysis of DNA repair and senescence marker kinetics over the life span of a human fibroblast cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Radiation-induced blood-brain barrier damages: an in vitro study.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

H2AX: the histone guardian of the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Dynamics of γH2AX formation and elimination in mammalian cells after X-irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Radiosensitization of cervical cancer cells via double-strand DNA break repair inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Human follicular stem cells: their presence in plucked hair and follicular cell culture

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

DNA double-strand break analysis by γ-H2AX foci: a useful method for determining the overreactors to radiation-induced acute reactions among head-and-neck cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

ID1 affects the efficacy of radiotherapy in glioblastoma through inhibition of DNA repair pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

In vitro and in vivo radiosensitization of colorectal cancer HT-29 cells by the smac mimetic JP-1201.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

DNA damage recognition via activated ATM and p53 pathway in nonproliferating human prostate tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Radiosensitization of tumour cell lines by the polyphenol Gossypol results from depressed double-strand break repair and not from enhanced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Flow cytometric analysis of phosphorylated histone H2AX following exposure to ionizing radiation in human microvascular endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Phosphorylated histone H2AX in relation to cell survival in tumor cells and xenografts exposed to single and fractionated doses of X-rays

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Residual γH2AX foci predict local tumour control after radiotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Tissue-specific DNA-PK-dependent H2AX phosphorylation and gamma-H2AX elimination after X-irradiation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

The defect of Ku70 affects sensitivity to x-ray and radiation-induced caspase-dependent apoptosis in lung cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Adamantanyl-histone deacetylase inhibitor H6CAHA exhibits favorable pharmacokinetics and augments prostate cancer radiation sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Phase 0 clinical trial of the poly (ADP-ribose) polymerase inhibitor ABT-888 in patients with advanced malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Mangiferin aglycone attenuates radiation-induced damage on human intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Damage to cellular DNA from particulate radiations, the efficacy of its processing and the radiosensitivity of mammalian cells. Emphasis on DNA double strand breaks and chromatin breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Correlation of dynamic changes in γ-H2AX expression in peripheral blood lymphocytes from head and neck cancer patients with radiation-induced oral mucositis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

DNA repair: the importance of phosphorylating histone H2AX.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Circulating tumor cells: a window into cancer biology and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3' processing signals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

DNA mismatch repair protein MSH2 dictates cellular survival in response to low dose radiation in endometrial carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Ferulic acid inhibits gamma radiation-induced DNA strand breaks and enhances the survival of mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Residual DNA double strand breaks in perfused but not in unperfused areas determine different radiosensitivity of tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Autocrine regulation of γ-irradiation-induced DNA damage response via extracellular nucleotides-mediated activation of P2Y6 and P2Y12 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Endogenous and radiation-induced expression of gammaH2AX in biopsies from patients treated for carcinoma of the uterine cervix

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

PX-478, an inhibitor of hypoxia-inducible factor-1alpha, enhances radiosensitivity of prostate carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

The presence of iodinated contrast agents amplifies DNA radiation damage in computed tomography.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Cellular machineries for chromosomal DNA repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

A rapid flow cytometry test based on histone H2AX phosphorylation for the sensitive and specific diagnosis of ataxia telangiectasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Impaired elimination of DNA double-strand break-containing lymphocytes in ataxia telangiectasia and Nijmegen breakage syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Radiosensitization of prostate cancer cells by the dual PI3K/mTOR inhibitor BEZ235 under normoxic and hypoxic conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Histone H2A variants H2AX and H2AZ

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Megabase chromatin domains involved in DNA double-strand breaks in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

DNA double-strand break rejoining in complex normal tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Accumulation of DNA double-strand breaks in normal tissues after fractionated irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

In vitro and in vivo radiosensitization of glioblastoma cells by the poly (ADP-ribose) polymerase inhibitor E7016.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Targeting radiation-induced G(2) checkpoint activation with the Wee-1 inhibitor MK-1775 in glioblastoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Relative biological efficiency of protons at low and therapeutic doses in induction of 53BP1/γH2AX foci in lymphocytes from umbilical cord blood

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

A buccal cell model comet assay: development and evaluation for human biomonitoring and nutritional studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

DNA damage response in resting and proliferating peripheral blood lymphocytes treated by camptothecin or X-ray

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Targeting epidermal growth factor receptor/human epidermal growth factor receptor 2 signalling pathway by a dual receptor tyrosine kinase inhibitor afatinib for radiosensitisation in murine bladder carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

A low-dose hypersensitive keratinocyte loss in response to fractionated radiotherapy is associated with growth arrest and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Depletion of the type 1 IGF receptor delays repair of radiation-induced DNA double strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Requirement of the MRN complex for ATM activation by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

γH2AX as a marker of DNA double strand breaks and genomic instability in human population studies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Early increase of radiation-induced γH2AX foci in a human Ku70/80 knockdown cell line characterized by an enhanced radiosensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

H2AX phosphorylation screen of cells from radiosensitive cancer patients reveals a novel DNA double-strand break repair cellular phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Compromised hematopoiesis and increased DNA damage following non-lethal ionizing radiation of a human hematopoietic system reconstituted in immunodeficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Melanoma cells express elevated levels of phosphorylated histone H2AX foci

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Lack of a correlation between γH2AX foci kinetics in lymphocytes and the severity of acute normal tissue reactions during IMRT treatment for head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

CD44 is a biomarker associated with human prostate cancer radiation sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Inhibiting UHRF1 expression enhances radiosensitivity in human esophageal squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

Expression of activated checkpoint kinase 2 and histone 2AX in exfoliative oral cells after exposure to ionizing radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

DNA Repair Alterations in Children With Pediatric Malignancies: Novel Opportunities to Identify Patients at Risk for High-Grade Toxicities

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1354750X.2014.898099

10.3109/1354750X.2014.898099

21 January 2018

Identifiers

DOI

1 reference

30 August 2017

1 reference

PubMed ID

24611829