Harnessing regulatory T cells for clinical use in transplantation: the end of the beginning (Q38193165)

30 August 2017

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title

Harnessing regulatory T cells for clinical use in transplantation: the end of the beginning (English)

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30 August 2017

S C Juvet

1

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30 August 2017

A G Whatcott

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2

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30 August 2017

A R Bushell

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3

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30 August 2017

K J Wood

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4

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30 August 2017

language of work or name

English

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publication date

4 March 2014

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American Journal of Transplantation

30 August 2017

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30 August 2017

14

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30 August 2017

4

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30 August 2017

750-763

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"Infectious" transplantation tolerance.

30 August 2017

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Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo.

21 January 2018

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In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells

21 January 2018

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Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes

21 January 2018

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Actively acquired tolerance of foreign cells

21 January 2018

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Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. Mediation of specific suppression by T helper/inducer cells

21 January 2018

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Specific unresponsiveness in rats with prolonged cardiac allograft survival after treatment with cyclosporine. III. Further characterization of the CD4+ suppressor cell and its mechanisms of action

21 January 2018

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Transplantation tolerance induced by antigen pretreatment and depleting anti-CD4 antibody depends on CD4+ T cell regulation during the induction phase of the response

21 January 2018

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

21 January 2018

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Control of regulatory T cell development by the transcription factor Foxp3

21 January 2018

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An essential role for Scurfin in CD4+CD25+ T regulatory cells

21 January 2018

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

21 January 2018

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Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation

21 January 2018

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CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation

21 January 2018

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Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood

21 January 2018

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Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood

21 January 2018

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Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

21 January 2018

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Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

21 January 2018

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Clinical application of regulatory T cells in type 1 diabetes.

21 January 2018

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The ONE Study compares cell therapy products in organ transplantation: introduction to a review series on suppressive monocyte-derived cells

21 January 2018

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Regulatory immune cells in transplantation

21 January 2018

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How regulatory T cells work

21 January 2018

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CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production

21 January 2018

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An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation

21 January 2018

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Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces

21 January 2018

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Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

21 January 2018

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Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

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CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

21 January 2018

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Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression.

21 January 2018

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CD39+Foxp3+ regulatory T Cells suppress pathogenic Th17 cells and are impaired in multiple sclerosis

21 January 2018

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CD4+CD25+ regulatory T cells suppress contact hypersensitivity reactions through a CD39, adenosine-dependent mechanism.

21 January 2018

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Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

21 January 2018

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CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor

21 January 2018

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Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance

21 January 2018

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GITR Blockade Facilitates Treg Mediated Allograft Survival

21 January 2018

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Infectious tolerance via the consumption of essential amino acids and mTOR signaling

21 January 2018

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IDO and regulatory T cell support are critical for cytotoxic T lymphocyte-associated Ag-4 Ig-mediated long-term solid organ allograft survival.

21 January 2018

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IFN-γ production by allogeneic Foxp3+ regulatory T cells is essential for preventing experimental graft-versus-host disease

21 January 2018

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IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo

21 January 2018

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IFN-gamma triggered STAT1-PKB/AKT signalling pathway influences the function of alloantigen reactive regulatory T cells

21 January 2018

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Interferon Gamma: Friend or Foe?

21 January 2018

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IFN-gamma acts directly on activated CD4+ T cells during mycobacterial infection to promote apoptosis by inducing components of the intracellular apoptosis machinery and by inducing extracellular proapoptotic signals

21 January 2018

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Interferon gamma is required for activation-induced death of T lymphocytes

21 January 2018

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Mast cells are essential intermediaries in regulatory T-cell tolerance

21 January 2018

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Regulation generation: the suppressive functions of human regulatory T cells

21 January 2018

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Cutting edge: Human regulatory T cells require IL-35 to mediate suppression and infectious tolerance

21 January 2018

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Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells

21 January 2018

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Human T regulatory cells can use the perforin pathway to cause autologous target cell death

21 January 2018

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Rapid suppression of cytokine transcription in human CD4+CD25 T cells by CD4+Foxp3+ regulatory T cells: independence of IL-2 consumption, TGF-beta, and various inhibitors of TCR signaling

21 January 2018

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Contribution of naïve and memory T-cell populations to the human alloimmune response.

21 January 2018

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Allograft rejection mediated by memory T cells is resistant to regulation

21 January 2018

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Relative resistance of human CD4(+) memory T cells to suppression by CD4(+) CD25(+) regulatory T cells

21 January 2018

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Non-human primate regulatory T cells: current biology and implications for transplantation

21 January 2018

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Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

21 January 2018

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Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo

21 January 2018

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Location and time-dependent control of rejection by regulatory T cells culminates in a failure to generate memory T cells

21 January 2018

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Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo

21 January 2018

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Promotion of allograft survival by CD4+CD25+ regulatory T cells: evidence for in vivo inhibition of effector cell proliferation.

21 January 2018

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L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection.

21 January 2018

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Transplantation in miniature swine: analysis of graft-infiltrating lymphocytes provides evidence for local suppression

21 January 2018

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Identification of regulatory T cells in tolerated allografts

21 January 2018

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Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response.

21 January 2018

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Regulatory T-cell therapy for transplantation: how many cells do we need?

21 January 2018

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Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity

21 January 2018

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Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient.

21 January 2018

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Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells.

21 January 2018

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Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease

21 January 2018

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Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells

21 January 2018

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Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly

21 January 2018

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Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation.

21 January 2018

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CD28 costimulation is essential for human T regulatory expansion and function

21 January 2018

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De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid

21 January 2018

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Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells

21 January 2018

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Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

21 January 2018

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Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function.

21 January 2018

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L-selectin is dispensable for T regulatory cell function postallogeneic bone marrow transplantation

21 January 2018

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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

21 January 2018

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Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model.

21 January 2018

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Ex vivo expanded human regulatory T cells can prolong survival of a human islet allograft in a humanized mouse model

21 January 2018

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Epigenetic control of the foxp3 locus in regulatory T cells

21 January 2018

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Human regulatory T cells against minor histocompatibility antigens: ex vivo expansion for prevention of graft-versus-host disease

21 January 2018

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Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy

21 January 2018

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Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors

21 January 2018

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High purity and yield of natural Tregs from cord blood using a single step selection method.

21 January 2018

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Multiple unit pooled umbilical cord blood is a viable source of therapeutic regulatory T cells.

21 January 2018

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Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.

21 January 2018

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Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.

21 January 2018

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Selective expression of latency-associated peptide (LAP) and IL-1 receptor type I/II (CD121a/CD121b) on activated human FOXP3+ regulatory T cells allows for their purification from expansion cultures

21 January 2018

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Reduced exposure to calcineurin inhibitors in renal transplantation

21 January 2018

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Natural Treg cells spontaneously differentiate into pathogenic helper cells in lymphopenic conditions.

21 January 2018

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Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

21 January 2018

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Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

21 January 2018

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TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursors

21 January 2018

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Induced regulatory T cells promote tolerance when stabilized by rapamycin and IL-2 in vivo.

21 January 2018

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Instability of Foxp3 expression limits the ability of induced regulatory T cells to mitigate graft versus host disease

21 January 2018

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In vivo SPECT reporter gene imaging of regulatory T cells.

21 January 2018

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Single cell tracking of gadolinium labeled CD4+ T cells by laser ablation inductively coupled plasma mass spectrometry

21 January 2018

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Rapamycin: clinical results and future opportunities

21 January 2018

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Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 production

21 January 2018

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Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4(+)CD25(+)FOXP3(+) T regulatory cell subpopulations

21 January 2018

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Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo

21 January 2018

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Increased frequency of regulatory T cells and selection of highly potent CD62L+ cells during treatment of human lung transplant recipients with rapamycin

21 January 2018

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Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients

21 January 2018

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Permanent CNI treatment for prevention of renal allograft rejection in sensitized hosts can be replaced by regulatory T cells.

21 January 2018

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Influence of combined treatment of low dose rapamycin and cyclosporin A on corneal allograft survival

21 January 2018

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Corticosteroids do not reverse the inhibitory effect of cyclosporine on regulatory T-cell activity in contrast to mycophenolate mofetil

21 January 2018

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Calcineurin inhibitor withdrawal after renal transplantation with alemtuzumab: clinical outcomes and effect on T-regulatory cells.

21 January 2018

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Once-daily extended-release versus twice-daily standard-release tacrolimus in kidney transplant recipients: a systematic review.

21 January 2018

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Immunologic monitoring in transplantation revisited

21 January 2018

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Regulatory T Cells and T Cell Depletion: Role of Immunosuppressive Drugs

21 January 2018

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Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/AJT.12647

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30 August 2017

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