Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents (Q38182522)

30 August 2017

Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents (English)

1 reference

30 August 2017

1 reference

Ola Engkvist

2

0 references

Qing-Dong Wang

object named as

Qing-Dong Wang

5

0 references

author name string

Alleyn T Plowright

1

1 reference

30 August 2017

Adrian Gill

3

1 reference

30 August 2017

Laurent Knerr

4

1 reference

30 August 2017

language of work or name

English

0 references

publication date

27 January 2014

1 reference

Angewandte Chemie International Edition

30 August 2017

0 references

volume

53

1 reference

30 August 2017

16

1 reference

30 August 2017

4056-4075

1 reference

Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

30 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Towards regenerative therapy for cardiac disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Myocyte renewal and ventricular remodelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Evidence for cardiomyocyte renewal in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Cardiomyogenesis in the adult human heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Functional screening identifies miRNAs inducing cardiac regeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Regenerating new heart with stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Reprogramming toward heart regeneration: stem cells and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Developmental and regenerative biology of multipotent cardiovascular progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Chemical control of stem cell fate and developmental potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Chemical approaches to studying stem cell biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Small molecule-based approaches to adult stem cell therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

microRNAs in cardiac development and regeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Protein therapeutics for cardiac regeneration after myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Proteins and small molecules for cellular regenerative medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Conformation of thymosin beta 9 in water/fluoroalcohol solution determined by NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Targeting native adult heart progenitors with cardiogenic small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Regenerative medicinal chemistry: the in situ control of stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

A chemical biology approach to myocardial regeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Target validation using chemical probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Biological spectra analysis: Linking biological activity profiles to molecular structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Systematic exploration of dual-acting modulators from a combined medicinal chemistry and biology perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

The why and how of phenotypic small-molecule screens

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Impedance-based detection of beating rhythm and proarrhythmic effects of compounds on stem cell-derived cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

How many drug targets are there?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Target identification for small bioactive molecules: finding the needle in the haystack

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

The importance of Wnt signaling in cardiovascular development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Wnt/beta-catenin signaling and small molecule inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell-derived mesoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Structure-activity relationship studies of small-molecule inhibitors of Wnt response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Wnt inhibition correlates with human embryonic stem cell cardiomyogenesis: a structure-activity relationship study based on inhibitors for the Wnt response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Stepwise chemically induced cardiomyocyte specification of human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

GSK-3-selective inhibitors derived from Tyrian purple indirubins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Discovery of novel potent and highly selective glycogen synthase kinase-3β (GSK3β) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

In vivo monitoring of cardiomyocyte proliferation to identify chemical modifiers of heart regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Visualizing spatiotemporal dynamics of multicellular cell-cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Identification of a nonpeptide ligand that releases bioactive insulin-like growth factor-I from its binding protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Peptidomimetic small-molecule compounds promoting cardiogenesis of stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Cardiogenic small molecules that enhance myocardial repair by stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Regulated expression of pH sensing G Protein-coupled receptor-68 identified through chemical biology defines a new drug target for ischemic heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Lipophilicity in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Hypothesis driven drug design: improving quality and effectiveness of the design-make-test-analyse cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

The influence of drug-like concepts on decision-making in medicinal chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Reawakening atlas: chemical approaches to repair or replace dysfunctional musculature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Inhibition of microRNA function by antimiR oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

The art of microRNA research

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Designing chemically modified oligonucleotides for targeted gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

An overview of sugar-modified oligonucleotides for antisense therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Improved targeting of miRNA with antisense oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

LNA: a versatile tool for therapeutics and genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Inhibition of miR-15 protects against cardiac ischemic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Morpholino antisense oligomers: design, preparation, and properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Specificity, duplex degradation and subcellular localization of antagomirs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Silencing of microRNAs in vivo with 'antagomirs'

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

MicroRNA-34a regulates cardiac ageing and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

MicroRNAs in the p53 network: micromanagement of tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Heart repair by reprogramming non-myocytes with cardiac transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

LNA-mediated microRNA silencing in non-human primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

The future of peptide-based drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Protein therapeutics: a summary and pharmacological classification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Delivery of therapeutic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Can we prevent immunogenicity of human protein drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Effects of glycosylation on the stability of protein pharmaceuticals

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

21 January 2018

Emerging PEGylated drugs

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Self-liganded Suzuki-Miyaura coupling for site-selective protein PEGylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Thymosin beta4 and Ac-SDKP: tools to mend a broken heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Cardioprotective effects of growth hormone-releasing hormone agonist after myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Cardioprotective growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Cardiac progenitor cells and biotinylated insulin-like growth factor-1 nanofibers improve endogenous and exogenous myocardial regeneration after infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Apoptosis and the cardiac action of insulin-like growth factor I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

IGF-1, inflammation and stem cells: interactions during muscle regeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Hepatocyte growth factor: a multifunctional cytokine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Hepatocyte growth factor prevents ventricular remodeling and dysfunction in mice via Akt pathway and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Local delivery of protease-resistant stromal cell derived factor-1 for stem cell recruitment after myocardial infarction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

The bispecific SDF1-GPVI fusion protein preserves myocardial function after transient ischemia in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Controlled release of stromal cell-derived factor-1 alpha in situ increases c-kit+ cell homing to the infarcted heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

An open-label dose escalation study to evaluate the safety of administration of nonviral stromal cell-derived factor-1 plasmid to treat symptomatic ischemic heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Therapeutic potential of neuregulin-1 in cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Role of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-talk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Cardiomyocyte cell cycle regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

De novo cardiomyocytes from within the activated adult heart after injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Synthesis and biological evaluation of superactive agonists of growth hormone-releasing hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

The translatability of animal models for clinical development: biomarkers and disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

p38 Mitogen-activated protein kinase controls a switch between cardiomyocyte and neuronal commitment of murine embryonic stem cells by activating myocyte enhancer factor 2C-dependent bone morphogenetic protein 2 transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Aiming for the heart: targeted delivery of drugs to diseased cardiac tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

Cardiac Stem Cells Possess Growth Factor-Receptor Systems That After Activation Regenerate the Infarcted Myocardium, Improving Ventricular Function and Long-Term Survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201307034

21 January 2018

Identifiers

DOI

10.1002/ANIE.201307034

1 reference

30 August 2017

1 reference