Peptide nucleic acids: a review on recent patents and technology transfer (Q38176989)

30 August 2017

title

Peptide nucleic acids: a review on recent patents and technology transfer (English)

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30 August 2017

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Roberto Gambari

1

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language of work or name

English

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publication date

3 January 2014

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Expert Opinion on Therapeutic Patents

30 August 2017

published in

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30 August 2017

volume

24

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30 August 2017

issue

3

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30 August 2017

page(s)

267-294

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Multiplexed nucleic acid-based assays for molecular diagnostics of human disease.

30 August 2017

cites work

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Conjugates of PNA with naphthalene diimide derivatives having a broad range of DNA affinities.

21 January 2018

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Aptamers: from bench side research towards patented molecules with therapeutic applications.

21 January 2018

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Peptide-based delivery of steric-block PNA oligonucleotides.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Incorporation of 3-aminobenzanthrone into 2'-deoxyoligonucleotides and its impact on duplex stability

21 January 2018

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Use of fully modified 2'-O-methyl antisense oligos for loss-of-function studies in vertebrate embryos

21 January 2018

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Effective incorporation of 2'-O-methyl-oligoribonucleotides into liposomes and enhanced cell association through modification with thiocholesterol

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2014.863874

miR-122 targeting with LNA/2'-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Tuning of conformational preorganization in model 2',5'- and 3',5'-linked oligonucleotides by 3'- and 2'-O-methoxyethyl modification

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Nano RNA aptamer wire for analysis of vitamin B₁₂.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2014.863874

The analysis of major impurities of lipophilic-conjugated phosphorothioate oligonucleotides by ion-pair reversed-phase HPLC combined with MALDI-TOF-MS.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Phosphorothioate nucleotides and oligonucleotides - recent progress in synthesis and application

21 January 2018

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Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Sequence-specific targeting of duplex DNA by peptide nucleic acids via triplex strand invasion

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2014.863874

PNA-assembled graphene oxide for sensitive and selective detection of DNA.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2014.863874

PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Recent advances in the development of peptide nucleic acid as a gene-targeted drug

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Sensitive detection of nucleic acids by PNA hybridization directed co-localization of fluorescent beads

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Cationic liposomes as delivery systems for double-stranded PNA-DNA chimeras exhibiting decoy activity against NF-kappaB transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Antisense mediated exon skipping therapy for duchenne muscular dystrophy (DMD)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Inhibition of 5'-UTR RNA conformational switching in HIV-1 using antisense PNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Antitumor activity of sustained N-myc reduction in rhabdomyosarcomas and transcriptional block by antigene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Targeting of antisense PNA oligomers to human galanin receptor type 1 mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Down-regulation of MDM2 and activation of p53 in human cancer cells by antisense 9-aminoacridine-PNA (peptide nucleic acid) conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Cell-permeable peptide nucleic acid designed to bind to the 5'-untranslated region of E-cadherin transcript induces potent and sequence-specific antisense effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Prospects for antisense peptide nucleic acid (PNA) therapies for HIV

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Synthesis and Splice-Redirecting Activity of Branched, Arginine-Rich Peptide Dendrimer Conjugates of Peptide Nucleic Acid Oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Optimization of peptide nucleic acid antisense oligonucleotides for local and systemic dystrophin splice correction in the mdx mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Overview of alternative oligonucleotide chemistries for exon skipping

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

MicroRNA regulation of the synaptic plasticity-related gene Arc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Potent and sustained cellular inhibition of miR-122 by lysine-derivatized peptide nucleic acids (PNA) and phosphorothioate locked nucleic acid (LNA)/2'-O-methyl (OMe) mixmer anti-miRs in the absence of transfection agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Modulation of the biological activity of microRNA-210 with peptide nucleic acids (PNAs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Cellular uptakes, biostabilities and anti-miR-210 activities of chiral arginine-PNAs in leukaemic K562 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

PNA-based microRNA inhibitors elicit anti-inflammatory effects in microglia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Synthesis and evaluation of a conformationally constrained pyridazinone PNA-monomer for recognition of thymine in triple-helix structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

A Novel PNA-Monomer for Recognition of Thymine in Triple-Helix Structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Site-directed inhibition of DNA replication by triple helix formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Cooperative strand invasion of double-stranded DNA by peptide nucleic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Strand invasion of mixed-sequence B-DNA by acridine-linked, gamma-peptide nucleic acid (gamma-PNA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Strand invasion of conventional PNA to arbitrary sequence in DNA assisted by single-stranded DNA binding protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Introduction of disulfide bond to the main chain of PNA to switch its hybridization and invasion activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Clear-cut observation of PNA invasion using nanomechanical DNA origami devices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Peptide nucleic acid.DNA strand displacement loops as artificial transcription promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Site-directed recombination via bifunctional PNA-DNA conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Artificial restriction DNA cutters to promote homologous recombination in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Development of artificial restriction DNA cutter composed of Ce(Iv)/EDTA and PNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Origin of high fidelity in target-sequence recognition by PNA-Ce(IV)/EDTA combinations as site-selective DNA cutters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Effects of decoy molecules targeting NF-kappaB transcription factors in Cystic fibrosis IB3-1 cells: recruitment of NF-kappaB to the IL-8 gene promoter and transcription of the IL-8 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Decoy oligodeoxyribonucleotides and peptide nucleic acids-DNA chimeras targeting nuclear factor kappa-B: inhibition of IL-8 gene expression in cystic fibrosis cells infected with Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Sequence-specific nucleic acid detection from binary pore conductance measurement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Real time RNA transcription monitoring by Thiazole Orange (TO)-conjugated Peptide Nucleic Acid (PNA) probes: norovirus detection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Detection and identification of specific bacteria in wound biofilms using peptide nucleic acid fluorescent in situ hybridization (PNA FISH).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

PNA FIT-probes for the dual color imaging of two viral mRNA targets in influenza H1N1 infected live cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Reliable detection of rare mutations in EGFR gene codon L858 by PNA-LNA PCR clamp in non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Label-free DNA electrochemical sensor based on a PNA-functionalized conductive polymer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Comparison of a PNA clamp PCR and an ARMS/Scorpion PCR assay for the detection of K-ras mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Evaluation of peptide nucleic acid probe-based real-time PCR for detection of Mycobacterium tuberculosis complex and nontuberculous mycobacteria in respiratory specimens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Femtomol SPR detection of DNA-PNA hybridization with the assistance of DNA-guided polyaniline deposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

SPR study of DNA hybridization with DNA and PNA probes under stringent conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Thiolated pyrrolidinyl peptide nucleic acids for the detection of DNA hybridization using surface plasmon resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Comparison of DNA, aminoethylglycyl PNA and pyrrolidinyl PNA as probes for detection of DNA hybridization using surface plasmon resonance technique

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Surface plasmon resonance sensing of nucleic acids: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Hybridisation based DNA screening on peptide nucleic acid (PNA) oligomer arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Direct detection of point mutations in nonamplified human genomic DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Progress in developing PNA as a gene-targeted drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Advantages of peptide nucleic acids as diagnostic platforms for detection of nucleic acids in resource-limited settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Heterogeneity in telomere length of human chromosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Quantitative and multiplexed microRNA sensing in living cells based on peptide nucleic acid and nano graphene oxide (PANGO).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Improved synthesis strategy for peptide nucleic acids (PNA) appropriate for cell-specific fluorescence imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Visualizing nucleic acids in living cells by fluorescence in vivo hybridization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Detection of endogenous K-ras mRNA in living cells at a single base resolution by a PNA molecular beacon.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Fluorescence imaging of influenza H1N1 mRNA in living infected cells using single-chromophore FIT-PNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Monitoring gene therapy by external imaging of mRNA: pilot study on murine erythropoietin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Fluorescence imaging of single-copy DNA sequences within the human genome using PNA-directed padlock probe assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Imaging mRNA expression levels in living cells with PNA·DNA binary FRET probes delivered by cationic shell-crosslinked nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Imaging of mRNA in live cells using nucleic acid-templated reduction of azidorhodamine probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Fluorescence-based detection of single nucleotide permutation in DNA via catalytically templated reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Imaging human pancreatic cancer xenografts by targeting mutant KRAS2 mRNA with [(111)In]DOTA(n)-poly(diamidopropanoyl)(m)-KRAS2 PNA-D(Cys-Ser-Lys-Cys) nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

PET imaging of CCND1 mRNA in human MCF7 estrogen receptor positive breast cancer xenografts with oncogene-specific [64Cu]chelator-peptide nucleic acid-IGF1 analog radiohybridization probes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Induction of apoptosis of human primary osteoclasts treated with a transcription factor decoy mimicking a promoter region of estrogen receptor alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Induction of estrogen receptor alpha expression with decoy oligonucleotide targeted to NFATc1 binding sites in osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Molecular interactions with nuclear factor kappaB (NF-kappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Antisense properties of peptide nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Inhibition of gene expression inside cells by peptide nucleic acids: effect of mRNA target sequence, mismatched bases, and PNA length

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

MicroRNAs: small RNAs with a big role in gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Silence from within: endogenous siRNAs and miRNAs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

MicroRNA functions in animal development and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Advances in the techniques for the prediction of microRNA targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

MicroRNAs as therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Cancer therapy via modulation of micro RNA levels: a promising future

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Silencing of microRNAs in vivo with 'antagomirs'

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Efficient inhibition of miR-155 function in vivo by peptide nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Expression of miR-210 during erythroid differentiation and induction of gamma-globin gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Liposomes as carriers for DNA-PNA hybrids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

A highly effective and long-lasting inhibition of miRNAs with PNA-based antisense oligonucleotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Potent and selective inhibition of A-to-I RNA editing with 2'-O-methyl/locked nucleic acid-containing antisense oligoribonucleotides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Optimizing anti-gene oligonucleotide 'Zorro-LNA' for improved strand invasion into duplex DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Antisense gapmers selectively suppress individual oncogenic p73 splice isoforms and inhibit tumor growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Radiohybridization PET imaging of KRAS G12D mRNA expression in human pancreas cancer xenografts with [(64)Cu]DO3A-peptide nucleic acid-peptide nanoparticles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Alternative options for DNA-based experimental therapy of β-thalassemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Sequence-specific modification of a beta-thalassemia locus by small DNA fragments in human erythroid progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Triplex-forming peptide nucleic acids induce heritable elevations in gamma-globin expression in hematopoietic progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Simple and sensitive detection of mutations in the ras proto-oncogenes using PNA-mediated PCR clamping

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

EGFR mutation testing in lung cancer: a review of available methods and their use for analysis of tumour tissue and cytology samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp-based detection test for gefitinib-refractory T790M epidermal growth factor receptor mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Intracellular Uptake and Inhibition of Gene Expression by PNAs and PNA−Peptide Conjugates†

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

Ionic Effects on the Stability and Conformation of Peptide Nucleic Acid Complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2014.863874

10.1517/13543776.2014.863874

21 January 2018

Identifiers

DOI

1 reference

30 August 2017

1 reference