Nuclease-mediated genome editing: At the front-line of functional genomics technology (Q38175498)

30 August 2017

Nuclease-mediated genome editing: At the front-line of functional genomics technology (English)

1 reference

30 August 2017

0 references

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24387662%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Knut Woltjen

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24387662%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

author name string

Tetsushi Sakuma

series ordinal

1

1 reference

30 August 2017

Knut Woltjen

series ordinal

2

1 reference

30 August 2017

language of work or name

1 reference

5 January 2014

1 reference

Development, Growth and Differentiation

30 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24387662%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

56

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24387662%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

2-13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24387662%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24387662%20AND%20SRC:MED&resulttype=core&format=json

ENU mutagenesis, a way forward to understand gene function

13 June 2020

cites work

1 reference

Targeted disruption of exogenous EGFP gene in medaka using zinc-finger nucleases.

21 January 2018

1 reference

Efficient targeted mutagenesis in medaka using custom-designed transcription activator-like effector nucleases

21 January 2018

1 reference

TALEN-based gene disruption in the dengue vector Aedes aegypti

21 January 2018

1 reference

In vivo genome editing using a high-efficiency TALEN system

21 January 2018

1 reference

Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases.

21 January 2018

1 reference

Compact designer TALENs for efficient genome engineering

21 January 2018

1 reference

Breaking the code of DNA binding specificity of TAL-type III effectors

21 January 2018

1 reference

TAL effectors: finding plant genes for disease and defense

21 January 2018

1 reference

Whole-rat conditional gene knockout via genome editing

21 January 2018

1 reference

Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs

21 January 2018

1 reference

Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century

21 January 2018

1 reference

Targeted genome modification in mice using zinc-finger nucleases

21 January 2018

1 reference

Efficient TALEN-mediated gene knockout in livestock

21 January 2018

1 reference

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

21 January 2018

1 reference

High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases

21 January 2018

1 reference

Efficient genome editing in Caenorhabditis elegans by CRISPR-targeted homologous recombination.

21 January 2018

1 reference

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

21 January 2018

1 reference

Multiplex genome engineering using CRISPR/Cas systems

21 January 2018

1 reference

ZFN-site searches genomes for zinc finger nuclease target sites and off-target sites.

21 January 2018

1 reference

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

21 January 2018

1 reference

TALE-mediated modulation of transcriptional enhancers in vivo

21 January 2018

1 reference

Targeted integration in rat and mouse embryos with zinc-finger nucleases

21 January 2018

1 reference

Targeted gene addition in human epithelial stem cells by zinc-finger nuclease-mediated homologous recombination

21 January 2018

1 reference

Simple methods for generating and detecting locus-specific mutations induced with TALENs in the zebrafish genome

21 January 2018

1 reference

Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination

21 January 2018

1 reference

TAL Effector-Nucleotide Targeter (TALE-NT) 2.0: tools for TAL effector design and target prediction

21 January 2018

1 reference

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

21 January 2018

1 reference

Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus

21 January 2018

1 reference

Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

21 January 2018

1 reference

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

21 January 2018

1 reference

Efficient generation of large-scale genome-modified mice using gRNA and CAS9 endonuclease

21 January 2018

1 reference

Targeted gene knockout by direct delivery of zinc-finger nuclease proteins

21 January 2018

1 reference

A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells

21 January 2018

1 reference

Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase

21 January 2018

1 reference

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes

21 January 2018

1 reference

Evolution of programmable zinc finger-recombinases with activity in human cells.

21 January 2018

1 reference

Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease.

21 January 2018

1 reference

Efficient targeting of a SCID gene by an engineered single-chain homing endonuclease

21 January 2018

1 reference

Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nucleases

21 January 2018

1 reference

Targeted chromosomal deletions and inversions in zebrafish

21 January 2018

1 reference

A rapid and general assay for monitoring endogenous gene modification

21 January 2018

1 reference

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases

21 January 2018

1 reference

Transcription activator-like effector nucleases efficiently disrupt the target gene in Iberian ribbed newts (Pleurodeles waltl), an experimental model animal for regeneration.

21 January 2018

1 reference

E-TALEN: a web tool to design TALENs for genome engineering.

21 January 2018

1 reference

Quantitative assay for TALEN activity at endogenous genomic loci

21 January 2018

1 reference

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

21 January 2018

1 reference

Genetic engineering of human pluripotent cells using TALE nucleases

21 January 2018

1 reference

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

21 January 2018

1 reference

Targeted mutagenesis in sea urchin embryos using TALENs.

21 January 2018

1 reference

Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis

21 January 2018

1 reference

DNA targeting specificity of RNA-guided Cas9 nucleases

21 January 2018

1 reference

Heritable and precise zebrafish genome editing using a CRISPR-Cas system

21 January 2018

1 reference

Efficient multiplex biallelic zebrafish genome editing using a CRISPR nuclease system

21 January 2018

1 reference

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

21 January 2018

1 reference

Modeling human epilepsy by TALEN targeting of mouse sodium channel Scn8a

21 January 2018

1 reference

TALENs: a widely applicable technology for targeted genome editing

21 January 2018

1 reference

Efficient targeted mutagenesis of the chordate Ciona intestinalis genome with zinc-finger nucleases.

21 January 2018

1 reference

Surrogate reporters for enrichment of cells with nuclease-induced mutations

21 January 2018

1 reference

Precision genome engineering with programmable DNA-nicking enzymes

21 January 2018

1 reference

Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain

21 January 2018

1 reference

Monomeric site-specific nucleases for genome editing

21 January 2018

1 reference

Cut-and-Paste of DNA Using an Artificial Restriction DNA Cutter

21 January 2018

1 reference

Cerebral organoids model human brain development and microcephaly

21 January 2018

1 reference

Targeted chromosomal deletions in human cells using zinc finger nucleases

21 January 2018

1 reference

Targeted chromosomal duplications and inversions in the human genome using zinc finger nucleases

21 January 2018

1 reference

Rapid and highly efficient construction of TALE-based transcriptional regulators and nucleases for genome modification

21 January 2018

1 reference

Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems.

21 January 2018

1 reference

piggyBac transposase tools for genome engineering

21 January 2018

1 reference

Isogenic human cell lines for drug discovery: regulation of target gene expression by engineered zinc-finger protein transcription factors.

21 January 2018

1 reference

Efficient and specific modifications of the Drosophila genome by means of an easy TALEN strategy.

21 January 2018

1 reference

Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions

21 January 2018

1 reference

Highly efficient and specific genome editing in silkworm using custom TALENs

21 January 2018

1 reference

Oligomerized pool engineering (OPEN): an 'open-source' protocol for making customized zinc-finger arrays

21 January 2018

1 reference

Robust, synergistic regulation of human gene expression using TALE activators

21 January 2018

1 reference

RNA-guided human genome engineering via Cas9

21 January 2018

1 reference

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

21 January 2018

1 reference

Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases

21 January 2018

1 reference

Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes

21 January 2018

1 reference

Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases

21 January 2018

1 reference

Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases

21 January 2018

1 reference

Chimeric TALE recombinases with programmable DNA sequence specificity

21 January 2018

1 reference

Efficient targeted mutagenesis in the monarch butterfly using zinc-finger nucleases

21 January 2018

1 reference

Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases

21 January 2018

1 reference

Modeling disease mutations by gene targeting in one-cell mouse embryos

21 January 2018

1 reference

An improved zinc-finger nuclease architecture for highly specific genome editing

21 January 2018

1 reference

Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA.

21 January 2018

1 reference

Efficient double-stranded DNA cleavage by artificial zinc-finger nucleases composed of one zinc-finger protein and a single-chain FokI dimer.

21 January 2018

1 reference

A simple cipher governs DNA recognition by TAL effectors

21 January 2018

1 reference

Molecular basis of engineered meganuclease targeting of the endogenous human RAG1 locus

21 January 2018

1 reference

TALE nucleases: tailored genome engineering made easy

21 January 2018

1 reference

Screening methods to identify TALEN-mediated knockout mice

21 January 2018

1 reference

Mojo Hand, a TALEN design tool for genome editing applications.

21 January 2018

1 reference

Zinc-finger nuclease-mediated targeted insertion of reporter genes for quantitative imaging of gene expression in sea urchin embryos.

21 January 2018

1 reference

Reading frame correction by targeted genome editing restores dystrophin expression in cells from Duchenne muscular dystrophy patients.

21 January 2018

1 reference

Efficient identification of TALEN-mediated genome modifications using heteroduplex mobility assays.

21 January 2018

1 reference

Transcription activator like effector (TALE)-directed piggyBac transposition in human cells

21 January 2018

1 reference

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

21 January 2018

1 reference

Engineering nucleases for gene targeting: safety and regulatory considerations.

21 January 2018

1 reference

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

21 January 2018

1 reference

Synergistic and tunable human gene activation by combinations of synthetic transcription factors

21 January 2018

1 reference

Cancer translocations in human cells induced by zinc finger and TALE nucleases

21 January 2018

1 reference

Site-directed nucleases: a paradigm shift in predictable, knowledge-based plant breeding.

21 January 2018

1 reference

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression

21 January 2018

1 reference

Creating designed zinc-finger nucleases with minimal cytotoxicity

21 January 2018

1 reference

Unexpected failure rates for modular assembly of engineered zinc fingers

21 January 2018

1 reference

Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

21 January 2018

1 reference

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

21 January 2018

1 reference

Genome engineering using the CRISPR-Cas9 system

21 January 2018

1 reference

A protocol describing the genetic correction of somatic human cells and subsequent generation of iPS cells.

21 January 2018

1 reference

FLASH assembly of TALENs for high-throughput genome editing

21 January 2018

1 reference

Targeted mutagenesis of multiple and paralogous genes in Xenopus laevis using two pairs of transcription activator-like effector nucleases.

21 January 2018

1 reference

Efficient TALEN construction and evaluation methods for human cell and animal applications.

21 January 2018

1 reference

Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity.

21 January 2018

1 reference

Regulation of gene expression in Arabidopsis thaliana by artificial zinc finger chimeras

21 January 2018

1 reference

ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool

21 January 2018

1 reference

Targeted mutagenesis in the malaria mosquito using TALE nucleases

21 January 2018

1 reference

Gene-trap mutagenesis: past, present and beyond

21 January 2018

1 reference

Versatile strategy for isolating transcription activator-like effector nuclease-mediated knockout mutants in Caenorhabditis elegans

21 January 2018

1 reference

High efficiency TALENs enable F0 functional analysis by targeted gene disruption in Xenopus laevis embryos

21 January 2018

1 reference

Efficient nonmeiotic allele introgression in livestock using custom endonucleases

21 January 2018

1 reference

Knockout rats generated by embryo microinjection of TALENs.

21 January 2018

1 reference

Diseases in a dish: modeling human genetic disorders using induced pluripotent cells

21 January 2018

1 reference

Use of zinc-finger nucleases to knock out the WAS gene in K562 cells: a human cellular model for Wiskott-Aldrich syndrome

21 January 2018

1 reference

Transcription activator-like effector proteins induce the expression of the frataxin gene

21 January 2018

1 reference

Genome editing with engineered zinc finger nucleases

21 January 2018

1 reference

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

21 January 2018

1 reference

Plant genome engineering with sequence-specific nucleases

21 January 2018

1 reference

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

21 January 2018

1 reference

Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme

21 January 2018

1 reference

Non-transgenic genome modifications in a hemimetabolous insect using zinc-finger and TAL effector nucleases

21 January 2018

1 reference

Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides

21 January 2018

1 reference

Targeted genome editing across species using ZFNs and TALENs

21 January 2018

1 reference

Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly.

21 January 2018

1 reference

EENdb: a database and knowledge base of ZFNs and TALENs for endonuclease engineering

21 January 2018

1 reference

Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish.

21 January 2018

1 reference

Optimized regulation of gene expression using artificial transcription factors

21 January 2018

1 reference

One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering

21 January 2018

1 reference

Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases.

21 January 2018

1 reference

Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon

21 January 2018

1 reference

TALEN-mediated precise genome modification by homologous recombination in zebrafish.

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/DGD.12111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24387662%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference