Natural product synthesis in the age of scalability (Q38171270)

30 August 2017

title

Natural product synthesis in the age of scalability (English)

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30 August 2017

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Christian A Kuttruff

1

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30 August 2017

Martin D Eastgate

series ordinal

2

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30 August 2017

Phil S Baran

series ordinal

3

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30 August 2017

language of work or name

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16 December 2013

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30 August 2017

published in

Natural Product Reports

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30 August 2017

volume

31

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30 August 2017

issue

4

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30 August 2017

page(s)

419-432

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The economies of synthesis

30 August 2017

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Synthesis at the molecular frontier

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Aiming for the ideal synthesis

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Protecting-group-free synthesis as an opportunity for invention

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If C-H bonds could talk: selective C-H bond oxidation

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From micrograms to grams: scale-up synthesis of eribulin mesylate

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A convergent enantioselective route to structurally diverse 6-deoxytetracycline antibiotics

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8-Azatetracyclines: synthesis and evaluation of a novel class of tetracycline antibacterial agents

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Synthesis and antibacterial activity of pentacyclines: a novel class of tetracycline analogs

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Two-step synthesis of carbohydrates by selective aldol reactions

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Enantioselective organocatalytic direct aldol reactions of alpha-oxyaldehydes: step one in a two-step synthesis of carbohydrates

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Development of a Large-Scale Synthetic Route to Manufacture (−)-Huperzine A

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Nature-inspired total synthesis of (-)-fusarisetin A.

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Total synthesis of (-)-fusarisetin A and reassignment of the absolute configuration of its natural counterpart

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Scalable total syntheses of N-linked tryptamine dimers by direct indole-aniline coupling: psychotrimine and kapakahines B and F.

21 January 2018

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The psychotrimine natural products have antibacterial activity against Gram-positive bacteria and act via membrane disruption

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Enantiospecific Total Syntheses of Kapakahines B and F

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Cortistatins A, B, C, and D, anti-angiogenic steroidal alkaloids, from the marine sponge Corticium simplex

21 January 2018

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Synthesis of (+)-cortistatin A.

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Strategic redox relay enables a scalable synthesis of ouabagenin, a bioactive cardenolide.

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3EZ,20Ac-ingenol, a catalytic inhibitor of topoisomerases, downregulates p-Akt and induces DSBs and apoptosis of DT40 cells

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Ingenol mebutate gel for actinic keratosis

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Tobacco smoking and dermatologic surgery

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Effective treatment of squamous cell carcinomas with ingenol mebutate gel in immunologically intact SKH1 mice

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Clinical findings using ingenol mebutate gel to treat actinic keratoses

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An Enantioselective Synthesis of FR182877 Provides a Chemical Rationalization of Its Structure and Affords Multigram Quantities of Its Direct Precursor

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The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity

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Identifiers

DOI

10.1039/C3NP70090A

1 reference

30 August 2017

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