Sodium-calcium exchangers (NCX): molecular hallmarks underlying the tissue-specific and systemic functions. (Q38166672)

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1 March 2020

title

Sodium-calcium exchangers (NCX): molecular hallmarks underlying the tissue-specific and systemic functions (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24281864%20AND%20SRC:MED&resulttype=core&format=json

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1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24281864%20AND%20SRC:MED&resulttype=core&format=json

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author name string

Daniel Khananshvili

series ordinal

1

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30 August 2017

27 November 2013

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24281864%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24281864%20AND%20SRC:MED&resulttype=core&format=json

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volume

466

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24281864%20AND%20SRC:MED&resulttype=core&format=json

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issue

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24281864%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

page(s)

43-60

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https://scigraph.springernature.com/pub.10.1007/s00424-013-1405-y

1 March 2020

exact match

0 references

cites work

Role of Na+-Ca2+ exchanger in myocardial ischemia/reperfusion injury: evaluation using a heterozygous Na+-Ca2+ exchanger knockout mouse model

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12 December 2020

Permanent focal brain ischemia induces isoform-dependent changes in the pattern of Na+/Ca2+ exchanger gene expression in the ischemic core, periinfarct area, and intact brain regions.

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12 December 2020

Positively charged cyclic hexapeptides, novel blockers for the cardiac sarcolemma Na(+)-Ca2+ exchanger.

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12 December 2020

Roles of two Ca2+-binding domains in regulation of the cardiac Na+-Ca2+ exchanger

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12 December 2020

Structure and Functional Analysis of a Ca2+ Sensor Mutant of the Na+/Ca2+ Exchanger

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12 December 2020

ERK1/2, p38, and JNK regulate the expression and the activity of the three isoforms of the Na+ /Ca2+ exchanger, NCX1, NCX2, and NCX3, in neuronal PC12 cells.

1 reference

12 December 2020

NCX3 knockout mice exhibit increased hippocampal CA1 and CA2 neuronal damage compared to wild-type mice following global cerebral ischemia

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12 December 2020

Molecular determinants of allosteric regulation in NCX proteins

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12 December 2020

Na/Ca exchange and contraction of the heart.

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12 December 2020

Two sides of the same coin: sodium homeostasis and signaling in astrocytes under physiological and pathophysiological conditions

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12 December 2020

Solubilization, purification, and reconstitution of the sodium-calcium exchanger from bovine retinal rod outer segments.

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12 December 2020

Nanoscale organization of junctophilin-2 and ryanodine receptors within peripheral couplings of rat ventricular cardiomyocytes

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12 December 2020

Rate-limiting mechanisms of exchange reactions in the cardiac sarcolemma Na(+)-Ca2+ exchanger

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12 December 2020

Cardiac sodium-calcium exchanger is regulated by allosteric calcium and exchanger inhibitory peptide at distinct sites

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12 December 2020

A novel isothiourea derivative selectively inhibits the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1

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12 December 2020

The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif

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12 December 2020

Na+/Ca2+ exchangers regulate the migration and proliferation of human gastric myofibroblasts.

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12 December 2020

Calcium influx through reversed NCX controls migration of microglia

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12 December 2020

Cardiac-specific ablation of the Na+-Ca2+ exchanger confers protection against ischemia/reperfusion injury

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12 December 2020

Enhanced learning and memory in mice lacking Na+/Ca2+ exchanger 2

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12 December 2020

Excitation-contraction coupling in Na+-Ca2+ exchanger knockout mice: reduced transsarcolemmal Ca2+ flux.

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12 December 2020

The cardiac Na+-Ca2+ exchanger has two cytoplasmic ion permeation pathways

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12 December 2020

The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis

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12 December 2020

Upregulation of Na+/Ca2+ exchanger and TRPC6 contributes to abnormal Ca2+ homeostasis in arterial smooth muscle cells from Milan hypertensive rats

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12 December 2020

Coordinated regulation of cardiac Na(+)/Ca (2+) exchanger and Na (+)-K (+)-ATPase by phospholemman (FXYD1)

1 reference

12 December 2020

Structural basis for alternating access of a eukaryotic calcium/proton exchanger

1 reference

12 December 2020

The topology of the cardiac Na⁺/Ca²⁺ exchanger, NCX1.

1 reference

12 December 2020

The glial sodium-calcium exchanger: a new target for nitric oxide-mediated cellular toxicity.

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12 December 2020

Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange

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12 December 2020

Mitochondrial exchanger NCLX plays a major role in the intracellular Ca2+ signaling, gliotransmission, and proliferation of astrocytes.

1 reference

12 December 2020

Residues contributing to the Na(+)-binding pocket of the SLC24 Na(+)/Ca(2+)-K(+) Exchanger NCKX2.

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12 December 2020

Ionic regulation of the cardiac sodium-calcium exchanger

1 reference

12 December 2020

Effect of overexpression of the brain-specific Na(+)/Ca(2+) exchanger splice variant NCX1.5 on NO cytotoxicity in HEK293 cells.

1 reference

12 December 2020

Characterization of zebrafish (Danio rerio) NCX4: a novel NCX with distinct electrophysiological properties.

1 reference

12 December 2020

Crystal structure of Ca2+/H+ antiporter protein YfkE reveals the mechanisms of Ca2+ efflux and its pH regulation

1 reference

12 December 2020

Alterations of atrial Ca(2+) handling as cause and consequence of atrial fibrillation

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12 December 2020

Pharmacology of brain Na+/Ca2+ exchanger: from molecular biology to therapeutic perspectives.

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12 December 2020

Key role of a PtdIns-4,5P2 micro domain in ionic regulation of the mammalian heart Na+/Ca2+ exchanger

1 reference

12 December 2020

Sodium/calcium exchanger: influence of metabolic regulation on ion carrier interactions

1 reference

12 December 2020

Allostery: absence of a change in shape does not imply that allostery is not at play

1 reference

12 December 2020

Upregulation of Na+/Ca2+ exchanger contributes to the enhanced Ca2+ entry in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension

1 reference

12 December 2020

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange

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12 December 2020

Cardiac excitation-contraction coupling

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12 December 2020

Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchanger

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12 December 2020

Termination of cardiac Ca(2+) sparks: an investigative mathematical model of calcium-induced calcium release

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12 December 2020

Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism

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12 December 2020

Kinetic and equilibrium properties of regulatory calcium sensors of NCX1 protein

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12 December 2020

The peptide "FRCRCFa", dialysed intracellularly, inhibits the Na/Ca exchange in rabbit ventricular myocytes with high affinity

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12 December 2020

Phospholemman: a novel cardiac stress protein

1 reference

12 December 2020

Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation

1 reference

12 December 2020

Essential role of the CBD1-CBD2 linker in slow dissociation of Ca2+ from the regulatory two-domain tandem of NCX1.

1 reference

12 December 2020

Na(+)/Ca (2+) exchange and the plasma membrane Ca(2+)-ATPase in β-cell function and diabetes.

1 reference

12 December 2020

How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension

1 reference

12 December 2020

NCLX: the mitochondrial sodium calcium exchanger.

1 reference

12 December 2020

Amino acid substitutions in the FXYD motif enhance phospholemman-induced modulation of cardiac L-type calcium channels

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12 December 2020

Transport of K+ by Na(+)-Ca2+, K+ exchanger in isolated rods of lizard retina

1 reference

12 December 2020

Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density

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12 December 2020

Molecular operations of the sodium-calcium exchanger revealed by conformation currents.

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12 December 2020

The structural basis of secondary active transport mechanisms.

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12 December 2020

Cardiac Na-Ca exchange and pH.

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12 December 2020

Cardiac sodium-calcium exchange and efficient excitation-contraction coupling: implications for heart disease

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12 December 2020

Mechanism of Partial Reactions in the Cardiac Na+-Ca2+Exchange Systema

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12 December 2020

Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+ exchanger type-1 in vascular smooth muscle

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12 December 2020

Triple threat: the Na+/Ca2+ exchanger in the pathophysiology of cardiac arrhythmia, ischemia and heart failure

1 reference

12 December 2020

The cation/Ca(2+) exchanger superfamily: phylogenetic analysis and structural implications

1 reference

12 December 2020

β-Cell preservation and regeneration in diabetes by modulation of β-cell Ca²⁺ homeostasis

1 reference

12 December 2020

Time-resolved monitoring of electrogenic Na+-Ca2+ exchange in the isolated cardiac sarcolemma vesicles by using a rapid-response fluorescent probe.

1 reference

12 December 2020

Voltage dependence of sodium-calcium exchange: predictions from kinetic models

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12 December 2020

Characterization and purification of a Na+/Ca2+ exchanger from an archaebacterium

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12 December 2020

The SLC8 gene family of sodium-calcium exchangers (NCX) - structure, function, and regulation in health and disease.

1 reference

12 December 2020

What keeps us ticking: a funny current, a calcium clock, or both?

1 reference

12 December 2020

Regulation of cardiac Na+,Ca2+ exchange and KATP potassium channels by PIP2.

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12 December 2020

Dynamic allostery: linkers are not merely flexible

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12 December 2020

Silencing or knocking out the Na(+)/Ca(2+) exchanger-3 (NCX3) impairs oligodendrocyte differentiation.

1 reference

12 December 2020

New insights into the contribution of arterial NCX to the regulation of myogenic tone and blood pressure

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12 December 2020

Regulation of cardiac Na(+)-Ca2+ exchanger by the endogenous XIP region

1 reference

12 December 2020

The SLC24 gene family of Na⁺/Ca²⁺-K⁺ exchangers: from sight and smell to memory consolidation and skin pigmentation

1 reference

12 December 2020

Gene structure evolution of the Na+-Ca2+ exchanger (NCX) family.

1 reference

12 December 2020

Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells.

1 reference

12 December 2020

The second Ca(2+)-binding domain of NCX1 binds Mg2+ with high affinity

1 reference

12 December 2020

Voltage-dependent modulation of ion binding and translocation in the cardiac Na(+)-Ca2+ exchange system

1 reference

12 December 2020

What regulates Na+/Ca2+ exchange? Focus on "Sodium-dependent inactivation of sodium/calcium exchange in transfected Chinese hamster ovary cells".

1 reference

12 December 2020

Na+/Ca2+ exchange inhibitors: a new class of calcium regulators

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12 December 2020

Cardiac Na+-Ca2+ exchanger: dynamics of Ca2+-dependent activation and deactivation in intact myocytes

1 reference

12 December 2020

The molecular determinants of ionic regulatory differences between brain and kidney Na+/Ca2+ exchanger (NCX1) isoforms

1 reference

12 December 2020

Sodium-calcium exchange: a molecular perspective

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12 December 2020

Distinction between the two basic mechanisms of cation transport in the cardiac Na(+)-Ca2+ exchange system

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12 December 2020

Sodium-calcium exchange is essential for effective triggering of calcium release in mouse heart

1 reference

12 December 2020

Alternative strategies in arrhythmia therapy: evaluation of Na/Ca exchange as an anti-arrhythmic target

1 reference

12 December 2020

Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate

1 reference

12 December 2020

Purification of the bovine rod outer segment Na+/Ca2+ exchanger

1 reference

12 December 2020

Steady-state and dynamic properties of cardiac sodium-calcium exchange. Sodium-dependent inactivation

1 reference

12 December 2020

Knockout mice for pharmacological screening: testing the specificity of Na+-Ca2+ exchange inhibitors

1 reference

12 December 2020

Acute inhibition of the Na(+)/Ca(2+) exchanger reduces proarrhythmia in an experimental model of chronic heart failure.

1 reference

12 December 2020

The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion

1 reference

12 December 2020

Ca2+ influx through reverse mode Na+/Ca2+ exchange is critical for vascular endothelial growth factor-mediated extracellular signal-regulated kinase (ERK) 1/2 activation and angiogenic functions of human endothelial cells

1 reference

12 December 2020

Plasmalemmal Na+/Ca2+ exchanger modulates Ca2+-dependent exocytotic release of glutamate from rat cortical astrocytes

1 reference

12 December 2020

Calcium cycling and signaling in cardiac myocytes.

1 reference

12 December 2020

Functional properties of transgenic mouse hearts overexpressing both calsequestrin and the Na(+)-Ca(2+) exchanger

1 reference

12 December 2020

The force-frequency relationship: insights from mathematical modeling.

1 reference

12 December 2020

NCX1 expression and functional activity increase in microglia invading the infarct core

1 reference

12 December 2020

The cardiac sodium-calcium exchanger NCX1 is a key player in the initiation and maintenance of a stable heart rhythm

1 reference

12 December 2020

Comparison of the organization of T-tubules, sarcoplasmic reticulum and ryanodine receptors in rat and human ventricular myocardium

1 reference

12 December 2020

Mutually exclusive and cassette exons underlie alternatively spliced isoforms of the Na/Ca exchanger

1 reference

12 December 2020

Functional comparison of the three isoforms of the Na+/Ca2+ exchanger (NCX1, NCX2, NCX3)

1 reference

12 December 2020

Sodium calcium exchange in the heart: necessity or luxury?

1 reference

12 December 2020

Novel regulation of cardiac Na pump via phospholemman.

1 reference

12 December 2020

Modes of Neuronal Calcium Entry and Homeostasis following Cerebral Ischemia

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12 December 2020

A common Ca2+-driven interdomain module governs eukaryotic NCX regulation

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12 December 2020

Kinetics and mechanism: modulation of ion transport in the cardiac sarcolemma sodium-calcium exchanger by protons, monovalent, ions, and temperature

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12 December 2020

Dynamics of calcium clearance in mouse pancreatic beta-cells.

1 reference

12 December 2020

Proton-sensing Ca2+ binding domains regulate the cardiac Na+/Ca2+ exchanger

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12 December 2020

Regulation and deregulation of cardiac Na(+)-Ca2+ exchange in giant excised sarcolemmal membrane patches

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12 December 2020

Tissue-specific expression of Na(+)-Ca2+ exchanger isoforms.

1 reference

12 December 2020

Functional differences in ionic regulation between alternatively spliced isoforms of the Na+-Ca2+ exchanger from Drosophila melanogaster

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12 December 2020

Molecular identity and functional properties of the mitochondrial Na+/Ca2+ exchanger

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12 December 2020

NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning.

1 reference

12 December 2020

Structural basis for the counter-transport mechanism of a H+/Ca2+ exchanger

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12 December 2020

Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure

1 reference

12 December 2020

Ionic regulatory properties of brain and kidney splice variants of the NCX1 Na(+)-Ca(2+) exchanger

1 reference

12 December 2020

The action of Na+ as a cofactor in the inhibition by cytoplasmic protons of the cardiac Na(+)-Ca2+ exchanger in the guinea-pig

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12 December 2020

Direct Loading of the purified endogenous inhibitor into the cytoplasm of patched cardiomyocytes blocks the ion currents and calcium transport through the NCX1 protein

1 reference

12 December 2020

Role of Na/Ca exchange and the plasma membrane Ca2+-ATPase in beta cell function and death

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12 December 2020

Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimers

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12 December 2020

Ca2+ binding alters the interdomain flexibility between the two cytoplasmic calcium-binding domains in the Na+/Ca2+ exchanger

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12 December 2020

Selective inhibition of sodium-calcium exchanger by SEA-0400 decreases early and delayed after depolarization in canine heart

1 reference

12 December 2020

Regulation of the cardiac Na(+)-Ca2+ exchanger by Ca2+. Mutational analysis of the Ca(2+)-binding domain

1 reference

12 December 2020

Dynamic features of allosteric Ca2+ sensor in tissue-specific NCX variants.

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12 December 2020

Potential therapeutic effects of Na+/Ca2+ exchanger inhibition in cardiac diseases

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12 December 2020

Interactions between Ca2+ binding domains of the Na+-Ca2+ exchanger and secondary regulation

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12 December 2020

Mechanisms underlying delayed afterdepolarizations in hypertrophied left ventricular myocytes of rats

1 reference

12 December 2020

Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger

1 reference

12 December 2020

Human atrial fibrillation: insights from computational electrophysiological models

1 reference

12 December 2020

How does regulatory Ca2+ regulate the Na+-Ca2+ exchanger?

1 reference

12 December 2020

SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells.

1 reference

12 December 2020

Regulation of cardiac Na+/Ca2+ exchanger by phospholemman

1 reference

12 December 2020

The stoichiometry of the cardiac sodium-calcium exchange system.

1 reference

12 December 2020

Combined Na(+)/Ca(2+) exchanger and L-type calcium channel block as a potential strategy to suppress arrhythmias and maintain ventricular function.

1 reference

12 December 2020

Steady-state and dynamic properties of cardiac sodium-calcium exchange. Secondary modulation by cytoplasmic calcium and ATP

1 reference

12 December 2020

Charge movement during Na+ translocation by native and cloned cardiac Na+/Ca2+ exchanger.

1 reference

12 December 2020

Structural Basis of the Ca2+ Inhibitory Mechanism of Drosophila Na+/Ca2+ Exchanger CALX and Its Modification by Alternative Splicing

1 reference

12 December 2020

Neuronal nitric oxide synthase inhibition attenuates the development of L-DOPA-induced dyskinesia in hemi-Parkinsonian rats.

1 reference

12 December 2020

SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models.

1 reference

12 December 2020

Identification of a peptide inhibitor of the cardiac sarcolemmal Na(+)-Ca2+ exchanger

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12 December 2020

Anomalous regulation of the Drosophila Na(+)-Ca2+ exchanger by Ca2+

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12 December 2020

Sodium/calcium exchange: its physiological implications

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12 December 2020

Ca2+ signaling in smooth muscle: TRPC6, NCX and LNats in nanodomains

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12 December 2020

G503 is obligatory for coupling of regulatory domains in NCX proteins.

1 reference

12 December 2020

Initial localization of regulatory regions of the cardiac sarcolemmal Na(+)-Ca2+ exchanger

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12 December 2020

SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease.

1 reference

12 December 2020

Transient reversal of the sodium/calcium exchanger boosts presynaptic calcium and synaptic transmission at a cerebellar synapse.

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12 December 2020

Ca2+ regulation in the Na+/Ca2+ exchanger involves two markedly different Ca2+ sensors

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12 December 2020

Population shift underlies Ca2+-induced regulatory transitions in the sodium-calcium exchanger (NCX).

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12 December 2020

Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport.

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12 December 2020

Genesis and regulation of the heart automaticity.

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12 December 2020

10.1007/S00424-013-1405-Y

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