Polymeric nanotherapeutics: clinical development and advances in stealth functionalization strategies (Q38166550)

30 August 2017

Polymeric nanotherapeutics: clinical development and advances in stealth functionalization strategies (English)

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30 August 2017

Che-Ming J Hu

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30 August 2017

Ronnie H Fang

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2

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30 August 2017

Brian T Luk

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3

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30 August 2017

Liangfang Zhang

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4

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30 August 2017

language of work or name

English

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publication date

26 November 2013

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30 August 2017

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30 August 2017

6

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30 August 2017

1

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30 August 2017

65-75

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Nanomedicine: developing smarter therapeutic and diagnostic modalities

30 August 2017

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PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect

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Nanoparticle-based combination therapy toward overcoming drug resistance in cancer

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Polymeric nanoparticles with precise ratiometric control over drug loading for combination therapy

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Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy

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Synthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannels

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Biodegradable long-circulating polymeric nanospheres

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PEGylation, successful approach to drug delivery

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Nanoparticle therapeutics: an emerging treatment modality for cancer

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Nanocarriers as an emerging platform for cancer therapy

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Half-antibody functionalized lipid-polymer hybrid nanoparticles for targeted drug delivery to carcinoembryonic antigen presenting pancreatic cancer cells.

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Therapeutic nanoparticles to combat cancer drug resistance

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Nanoparticles in medicine: therapeutic applications and developments

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In vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and efficacy

21 January 2018

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Preclinical evaluation of Genexol-PM, a nanoparticle formulation of paclitaxel, as a novel radiosensitizer for the treatment of non-small cell lung cancer

21 January 2018

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Multicenter phase II trial of Genexol-PM, a Cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer.

21 January 2018

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Multicenter phase II trial of Genexol-PM, a novel Cremophor-free, polymeric micelle formulation of paclitaxel, with cisplatin in patients with advanced non-small-cell lung cancer.

21 January 2018

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Synthesis of linear, beta-cyclodextrin-based polymers and their camptothecin conjugates

21 January 2018

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Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor-bearing mice

21 January 2018

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Preclinical results of camptothecin-polymer conjugate (IT-101) in multiple human lymphoma xenograft models

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Correlating preclinical animal studies and human clinical trials of a multifunctional, polymeric nanoparticle

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Development of a nonviral gene delivery vehicle for systemic application

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Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles

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Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

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A phase 2 study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction

21 January 2018

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Preclinical to clinical development of the novel camptothecin nanopharmaceutical CRLX101.

21 January 2018

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A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours.

21 January 2018

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NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel

21 January 2018

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Preclinical and clinical studies of anticancer agent-incorporating polymer micelles

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Phase I clinical trial and pharmacokinetic evaluation of NK911, a micelle-encapsulated doxorubicin

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Phase I study of NK012, a novel SN-38-incorporating micellar nanoparticle, in adult patients with solid tumors

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Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies

21 January 2018

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PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics

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Biodistribution of long-circulating PEG-grafted nanocapsules in mice: effects of PEG chain length and density.

21 January 2018

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Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere-serum interface: implications for stealth nanoparticle engineering

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Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives

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Effects of cleavable PEG-cholesterol derivatives on the accelerated blood clearance of PEGylated liposomes

21 January 2018

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Antibody against poly(ethylene glycol) adversely affects PEG-asparaginase therapy in acute lymphoblastic leukemia patients

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Relationship between complement activation, cellular uptake and surface physicochemical aspects of novel PEG-modified nanocapsules.

21 January 2018

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Poly(ethylene glycol)s generate complement activation products in human serum through increased alternative pathway turnover and a MASP-2-dependent process.

21 January 2018

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Role of complement activation in hypersensitivity reactions to doxil and hynic PEG liposomes: experimental and clinical studies

21 January 2018

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Combination therapy: opportunities and challenges for polymer-drug conjugates as anticancer nanomedicines

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Using small-angle neutron scattering to study the solution conformation of N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates

21 January 2018

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HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action

21 January 2018

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Properties of HPMA copolymer-doxorubicin conjugates with pH-controlled activation: effect of polymer chain modification

21 January 2018

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New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting

21 January 2018

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Development of HPMA copolymer-anticancer conjugates: clinical experience and lessons learnt

21 January 2018

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Polymer conjugates as anticancer nanomedicines

21 January 2018

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Coating of vesicles with hydrophilic reactive polymers

21 January 2018

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Ultralow-fouling, functionalizable, and hydrolyzable zwitterionic materials and their derivatives for biological applications

21 January 2018

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Difference in hydration between carboxybetaine and sulfobetaine

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Nonfouling behavior of polycarboxybetaine-grafted surfaces: structural and environmental effects

21 January 2018

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Zwitterionic polymer-modified silicon microring resonators for label-free biosensing in undiluted human plasma

21 January 2018

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Zwitterionic carboxybetaine polymer surfaces and their resistance to long-term biofilm formation

21 January 2018

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Ultra low fouling zwitterionic polymers with a biomimetic adhesive group

21 January 2018

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Zwitterionic hydrogels implanted in mice resist the foreign-body reaction.

21 January 2018

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Imaging and cell targeting characteristics of magnetic nanoparticles modified by a functionalizable zwitterionic polymer with adhesive 3,4-dihydroxyphenyl-l-alanine linkages

21 January 2018

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Superhydrophilic zwitterionic polymers stabilize liposomes

21 January 2018

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Functionalizable and ultrastable zwitterionic nanogels

21 January 2018

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Multifunctional and degradable zwitterionic nanogels for targeted delivery, enhanced MR imaging, reduction-sensitive drug release, and renal clearance

21 January 2018

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Nanoparticles for drug delivery prepared from amphiphilic PLGA zwitterionic block copolymers with sharp contrast in polarity between two blocks

21 January 2018

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Evaluation of circulation profiles of liposomes coated with hydrophilic polymers having different molecular weights in rats

21 January 2018

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Effects of surfactants on the properties of PLGA nanoparticles

21 January 2018

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Evasion of the accelerated blood clearance phenomenon by coating of nanoparticles with various hydrophilic polymers

21 January 2018

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The use of PVP as a polymeric carrier to improve the plasma half-life of drugs.

21 January 2018

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Effect of liposome characteristics and dose on the pharmacokinetics of liposomes coated with poly(amino acid)s

21 January 2018

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Formation of core-shell type biodegradable polymeric micelles from amphiphilic poly(aspartic acid)-block-polylactide diblock copolymer.

21 January 2018

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Synthesis and characterization of RGD peptide grafted poly(ethylene glycol)-b-poly(L-lactide)-b-poly(L-glutamic acid) triblock copolymer

21 January 2018

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Paclitaxel-loaded poly(gamma-glutamic acid)-poly(lactide) nanoparticles as a targeted drug delivery system against cultured HepG2 cells.

21 January 2018

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Formation of reversible shell cross-linked micelles from the biodegradable amphiphilic diblock copolymer poly(L-cysteine)-block-poly(L-lactide).

21 January 2018

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Biodegradation, biodistribution and toxicity of chitosan

21 January 2018

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Polysaccharide-decorated nanoparticles

21 January 2018

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Improving the therapeutic efficacy of peptides and proteins: a role for polysialic acids

21 January 2018

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Metastatic Potential Is Positively Correlated with Cell Surface Sialylation of Cultured Murine Tumor Cell Lines

21 January 2018

1 reference

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Polysialic acid at the cell surface: biophysics in service of cell interactions and tissue plasticity.

21 January 2018

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Polysialylated insulin: synthesis, characterization and biological activity in vivo

21 January 2018

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Importance of sialic acid residues illuminated by live animal imaging using phosphorylcholine self-assembled monolayer-coated quantum dots

21 January 2018

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PLGA nanoparticles surface decorated with the sialic acid, N-acetylneuraminic acid.

21 January 2018

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Sialic acid and glycopeptides conjugated PLGA nanoparticles for central nervous system targeting: In vivo pharmacological evidence and biodistribution.

21 January 2018

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Monosialoganglioside liposome-entrapped enzyme uptake by hepatic cells

21 January 2018

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Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors

21 January 2018

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Effect of chemically modified GM1 and neoglycolipid analogs of GM1 on liposome circulation time: evidence supporting the dysopsonin hypothesis

21 January 2018

1 reference

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New amphipatic polymer-lipid conjugates forming long-circulating reticuloendothelial system-evading liposomes

21 January 2018

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Role of CD47 as a marker of self on red blood cells

21 January 2018

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Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3NR05444F

Self inhibition of phagocytosis: the affinity of 'marker of self' CD47 for SIRPalpha dictates potency of inhibition but only at low expression levels.

21 January 2018

1 reference

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The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation

21 January 2018

1 reference

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Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles

21 January 2018

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Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

21 January 2018

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A pathogenic picornavirus acquires an envelope by hijacking cellular membranes

21 January 2018

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Exosome-mediated transmission of hepatitis C virus between human hepatoma Huh7.5 cells.

21 January 2018

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'Marker-of-self' functionalization of nanoscale particles through a top-down cellular membrane coating approach

21 January 2018

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Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles

21 January 2018

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Erythrocyte-inspired delivery systems

21 January 2018

1 reference

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Surface functionalization of gold nanoparticles with red blood cell membranes

21 January 2018

1 reference

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Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions

21 January 2018

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Erythrocyte membrane-cloaked polymeric nanoparticles for controlled drug loading and release.

21 January 2018

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Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles

21 January 2018

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A biomimetic nanosponge that absorbs pore-forming toxins

21 January 2018

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Exosome nanotechnology: an emerging paradigm shift in drug delivery: exploitation of exosome nanovesicles for systemic in vivo delivery of RNAi heralds new horizons for drug delivery across biological barriers

21 January 2018

1 reference

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Biological functions and biogenesis of secreted bacterial outer membrane vesicles

21 January 2018

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Reconstructed stem cell nanoghosts: a natural tumor targeting platform.

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3NR05444F

Delivery of chemotherapeutic drugs in tumour cell-derived microparticles.

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1039/C3NR05444F

1 reference

30 August 2017

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