Is the mTOR-signalling cascade disrupted in Schizophrenia? (Q38165200)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24266366%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

Maarten van den Buuse

series ordinal

2

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Journal of Neurochemistry

8 June 2020

language of work or name

English

0 references

publication date

25 December 2013

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30 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24266366%20AND%20SRC:MED&resulttype=core&format=json

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24266366%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

129

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24266366%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

page(s)

377-387

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24266366%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

issue

3

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The role of serotonin in the pathophysiology and treatment of schizophrenia

8 June 2020

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mTOR signaling in the hippocampus is necessary for memory formation.

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Time-restricted role for dendritic activation of the mTOR-p70 S6K pathway in the induction of late-phase long-term potentiation in the CA1

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A recollection of mTOR signaling in learning and memory

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Extinction memory is impaired in schizophrenia

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Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth.

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Capture of a protein synthesis-dependent component of long-term depression

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GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR

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5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia

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Epigenetics: Stress makes its molecular mark

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The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif

21 January 2018

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An evaluation of a stress management program for individuals with schizophrenia.

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Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function

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Translational control via the mammalian target of rapamycin pathway is critical for the formation and stability of long-term fear memory in amygdala neurons.

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Identification of Protor as a novel Rictor-binding component of mTOR complex-2

21 January 2018

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Increased truncated TrkB receptor expression and decreased BDNF/TrkB signaling in the frontal cortex of reeler mouse model of schizophrenia

21 January 2018

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Signaling mechanisms underlying Slit2-induced collapse of Xenopus retinal growth cones

21 January 2018

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Glucocorticoids modulate the mTOR pathway in the hippocampus: differential effects depending on stress history.

21 January 2018

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mTORC1 signalling and mRNA translation

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21 January 2018

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Reelin supplementation recovers sensorimotor gating, synaptic plasticity and associative learning deficits in the heterozygous reeler mouse

21 January 2018

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5-HT6 receptor antagonists as potential therapeutics for cognitive impairment

21 January 2018

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

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Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

21 January 2018

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Identification of a conserved motif required for mTOR signaling

21 January 2018

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BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal development.

21 January 2018

1 reference

Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice

21 January 2018

1 reference

BDNF activates mTOR to regulate GluR1 expression required for memory formation

21 January 2018

1 reference

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

21 January 2018

1 reference

Glucocorticoid regulation of brain-derived neurotrophic factor: relevance to hippocampal structural and functional plasticity.

21 January 2018

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Role of mTOR in physiology and pathology of the nervous system

21 January 2018

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Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro

21 January 2018

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Epigenetic aberration of the human REELIN gene in psychiatric disorders.

21 January 2018

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A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

21 January 2018

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Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

21 January 2018

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Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

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Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology

21 January 2018

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Glutamatergic drugs for schizophrenia: a systematic review and meta-analysis

21 January 2018

1 reference

Mammalian target of rapamycin complex 1 (mTORC1) and 2 (mTORC2) control the dendritic arbor morphology of hippocampal neurons

21 January 2018

1 reference

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

21 January 2018

1 reference

Induction and maintenance of late-phase long-term potentiation in isolated dendrites of rat hippocampal CA1 pyramidal neurones

21 January 2018

1 reference

Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation

21 January 2018

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Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons

21 January 2018

1 reference

The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment

21 January 2018

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Multiple roles for mammalian target of rapamycin signaling in both glutamatergic and GABAergic synaptic transmission

21 January 2018

1 reference

Sex-specific and region-specific changes in BDNF-TrkB signalling in the hippocampus of 5-HT1A receptor and BDNF single and double mutant mice.

21 January 2018

1 reference

Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

21 January 2018

1 reference

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 January 2018

1 reference

Genetic variation in BDNF is associated with antipsychotic treatment resistance in patients with schizophrenia

21 January 2018

1 reference

mTOR Inhibition ameliorates cognitive and affective deficits caused by Disc1 knockdown in adult-born dentate granule neurons

21 January 2018

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