Regulation and therapeutic strategies of 4-hydroxy-2-nonenal metabolism in heart disease (Q38163001)

30 August 2017

title

Regulation and therapeutic strategies of 4-hydroxy-2-nonenal metabolism in heart disease (English)

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30 August 2017

V R Mali

1

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30 August 2017

S S Palaniyandi

series ordinal

2

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30 August 2017

publication date

10 December 2013

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30 August 2017

published in

Free Radical Research

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30 August 2017

volume

48

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30 August 2017

issue

3

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30 August 2017

page(s)

251-263

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4-Hydroxy-2-nonenal: a product and mediator of oxidative stress

30 August 2017

cites work

1 reference

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Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

21 January 2018

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Modification of Cytochrome c by 4-hydroxy- 2-nonenal: evidence for histidine, lysine, and arginine-aldehyde adducts

21 January 2018

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Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion

21 January 2018

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Catalytic site-specific inhibition of the 20S proteasome by 4-hydroxynonenal

21 January 2018

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Inactivation of the proteasome by 4-hydroxy-2-nonenal is site specific and dependant on 20S proteasome subtypes

21 January 2018

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4-Hydroxy-2-nonenal induces mitochondrial dysfunction and aberrant axonal outgrowth in adult sensory neurons that mimics features of diabetic neuropathy

21 January 2018

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Oxidative modifications of cardiac mitochondria and inhibition of cytochrome c oxidase activity by 4-hydroxynonenal.

21 January 2018

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4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes

21 January 2018

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Aldose reductase decreases endoplasmic reticulum stress in ischemic hearts

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Oxidative stress and covalent modification of protein with bioactive aldehydes

21 January 2018

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4-hydroxynonenal: a membrane lipid oxidation product of medicinal interest.

21 January 2018

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In vitro and in silico characterization of peroxiredoxin 6 modified by 4-hydroxynonenal and 4-oxononenal

21 January 2018

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Role of reactive aldehyde in cardiovascular diseases

21 January 2018

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Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders

21 January 2018

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Carvedilol decreases elevated oxidative stress in human failing myocardium

21 January 2018

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Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target?

21 January 2018

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Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1.

21 January 2018

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Short-term exercise training protects against doxorubicin-induced cardiac mitochondrial damage independent of HSP72

21 January 2018

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Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase

21 January 2018

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Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition

21 January 2018

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Role of 4-hydroxy-trans-2-nonenal in cell functions

21 January 2018

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Role of aldehyde dehydrogenases in endogenous and xenobiotic metabolism.

21 January 2018

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Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily

21 January 2018

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Metabolism of 4-hydroxynonenal by rat Kupffer cells

21 January 2018

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https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Update on the aldehyde dehydrogenase gene (ALDH) superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Alterations in the diabetic myocardial proteome coupled with increased myocardial oxidative stress underlies diabetic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Interactions of glutathione transferases with 4-hydroxynonenal

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Metabolism of the lipid peroxidation product, 4-hydroxy-trans-2-nonenal, in isolated perfused rat heart

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Oligomeric behavior of Bordetella pertussis adenylate cyclase toxin in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Structural and kinetic determinants of aldehyde reduction by aldose reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Aldose reductase is an obligatory mediator of the late phase of ischemic preconditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Aldose reductase functions as a detoxification system for lipid peroxidation products in vasculitis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Role of nitric oxide in regulating aldose reductase activation in the ischemic heart

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Identification of cardiac oxidoreductase(s) involved in the metabolism of the lipid peroxidation-derived aldehyde-4-hydroxynonenal

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Redox activation of aldose reductase in the ischemic heart

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Formation of 4-hydroxy-2-nonenal protein adducts in the ischemic rat heart after transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Role of 4-hydroxynonenal in modification of cytochrome c oxidase in ischemia/reperfused rat heart

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Oxidative stress and cellular stress response in diabetic nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Mass spectrometry for detection of 4-hydroxy-trans-2-nonenal (HNE) adducts with peptides and proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

4-Hydroxynonenal and cholesterol oxidation products in atherosclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Increased 4-hydroxynonenal formation contributes to obesity-related lipolytic activation in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

ALDH2 protects against stroke by clearing 4-HNE.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Lipid peroxidation dysregulation in ischemic stroke: plasma 4-HNE as a potential biomarker?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Oxidative damage and myofiber degeneration in the gastrocnemius of patients with peripheral arterial disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Amelioration of angiotensin II-induced salt-sensitive hypertension by liver-type fatty acid-binding protein in proximal tubules

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Effects of 4-hydroxynonenal on vascular endothelial and smooth muscle cell redox signaling and function in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

4-hydroxynonenal induces apoptosis, NF-kappaB-activation and formation of 8-isoprostane in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Iron in human atheroma and LDL oxidation by macrophages following erythrophagocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

4-Hydroxynonenal enhances MMP-2 production in vascular smooth muscle cells via mitochondrial ROS-mediated activation of the Akt/NF-kappaB signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Mechanism of 4-HNE mediated inhibition of hDDAH-1: implications in no regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Oxidative stress regulates left ventricular PDE5 expression in the failing heart

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Ethanol and acetaldehyde in alcoholic cardiomyopathy: from bad to ugly en route to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Mechanisms of alcoholic heart disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

AMP-dependent kinase and autophagic flux are involved in aldehyde dehydrogenase-2-induced protection against cardiac toxicity of ethanol

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Diabetes impairs the enzymatic disposal of 4-hydroxynonenal in rat liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Cardiac reperfusion injury: aging, lipid peroxidation, and mitochondrial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Myocardial ischaemia inhibits mitochondrial metabolism of 4-hydroxy-trans-2-nonenal.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Electrophysiological effects of 4-hydroxynonenal, an aldehydic product of lipid peroxidation, on isolated rat ventricular myocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

4-hydroxynonenal (4-HNE) has been widely accepted as an inducer of oxidative stress. Is this the whole truth about it or can 4-HNE also exert protective effects?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

TRPA1: the central molecule for chemical sensing in pain pathway?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Role of 4-hydroxynonenal and its metabolites in signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

4-hydroxynonenal from pathology to physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: a possible mechanism for lipid peroxidation-induced carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Importance of the bioenergetic reserve capacity in response to cardiomyocyte stress induced by 4-hydroxynonenal

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Effects of 4-hydroxynonenal on mitochondrial 3-hydroxy-3-methylglutaryl (HMG-CoA) synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Cardiac mitochondrial NADP+-isocitrate dehydrogenase is inactivated through 4-hydroxynonenal adduct formation: an event that precedes hypertrophy development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Mitochondria, oxidative stress and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

4-hydroxynonenal induces apoptosis via caspase-3 activation and cytochrome c release.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Role of the electrophilic lipid peroxidation product 4-hydroxynonenal in the development and maintenance of obesity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Apoptosis of PC12 cells by 4-hydroxy-2-nonenal is mediated through selective activation of the c-Jun N-terminal protein kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

HNE interacts directly with JNK isoforms in human hepatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Redox regulation of 4-hydroxy-2-nonenal-mediated endothelial barrier dysfunction by focal adhesion, adherens, and tight junction proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Inhibition of cardiac myocyte contraction by 4-hydroxy-trans-2-nonenal

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

4-Hydroxy-2-nonenal induces calcium overload via the generation of reactive oxygen species in isolated rat cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Autophagy in ALDH2-elicited cardioprotection against ischemic heart disease: Slayer or savior?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Cytoskeletal alterations in cultured cardiomyocytes following exposure to the lipid peroxidation product, 4-hydroxynonenal.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

The antihypertensive hydralazine is an efficient scavenger of acrolein.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Carbonyl scavenger and antiatherogenic effects of hydrazine derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Angiotensin II receptor antagonists and angiotensin-converting enzyme inhibitors lower in vitro the formation of advanced glycation end products: biochemical mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

The antioxidant effects of statins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Exercise training restores cardiac protein quality control in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Exercise-induced attenuation of obesity, hyperinsulinemia, and skeletal muscle lipid peroxidation in the OLETF rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

Oxidative stress of myosin contributes to skeletal muscle dysfunction in rats with chronic heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2013.864761

10.3109/10715762.2013.864761

21 January 2018

Identifiers

DOI

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release_ssoz4vaf5zg6dhml3u5ez7ftdm

30 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/ssoz4vaf5zg6dhml3u5ez7ftdm

mapped directly with Wikidata item

24 November 2022

based on heuristic

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