Promiscuity as a functional trait: intrinsically disordered regions as central players of interactomes (Q38132466)

29 August 2017

Promiscuity as a functional trait: intrinsically disordered regions as central players of interactomes (English)

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29 August 2017

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3

M Madan Babu

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29 August 2017

Guillaume Lamour

2

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ORCID Public Data File 2021

author name string

Alexander Cumberworth

series ordinal

1

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PubMed ID

23988124

29 August 2017

Jörg Gsponer

series ordinal

4

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PubMed ID

23988124

29 August 2017

language of work or name

English

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publication date

1 September 2013

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29 August 2017

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29 August 2017

454

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29 August 2017

3

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29 August 2017

361-369

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Interactome: gateway into systems biology

29 August 2017

1 reference

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The human disease network

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Toward a functional analysis of the yeast genome through exhaustive two-hybrid screens

21 January 2018

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A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

21 January 2018

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A comprehensive two-hybrid analysis to explore the yeast protein interactome

21 January 2018

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Proteome survey reveals modularity of the yeast cell machinery

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A protein complex network of Drosophila melanogaster

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A map of the interactome network of the metazoan C. elegans

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Towards a proteome-scale map of the human protein–protein interaction network

21 January 2018

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Network biology: understanding the cell's functional organization

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Specificity and stability in topology of protein networks

21 January 2018

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Evidence for dynamically organized modularity in the yeast protein-protein interaction network

21 January 2018

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Dynamic Complex Formation During the Yeast Cell Cycle

21 January 2018

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Relating three-dimensional structures to protein networks provides evolutionary insights

21 January 2018

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Flexible nets. The roles of intrinsic disorder in protein interaction networks.

21 January 2018

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Intrinsically unstructured proteins and their functions

21 January 2018

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D²P²: database of disordered protein predictions

21 January 2018

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Mechanism of coupled folding and binding of an intrinsically disordered protein

21 January 2018

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Molecular mechanism of the nuclear protein import cycle

21 January 2018

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Prediction and Functional Analysis of Native Disorder in Proteins from the Three Kingdoms of Life

21 January 2018

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Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions.

21 January 2018

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Protein binding specificity versus promiscuity.

21 January 2018

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Limitations of induced folding in molecular recognition by intrinsically disordered proteins

21 January 2018

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Hub promiscuity in protein-protein interaction networks

21 January 2018

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Network medicine: a network-based approach to human disease

21 January 2018

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Experimental and computational approaches for the study of calmodulin interactions.

21 January 2018

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What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae?

21 January 2018

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Intrinsic disorder is a common feature of hub proteins from four eukaryotic interactomes

21 January 2018

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Identification of transient hub proteins and the possible structural basis for their multiple interactions

21 January 2018

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Interaction between intrinsically disordered proteins frequently occurs in a human protein-protein interaction network

21 January 2018

1 reference

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Domain distribution and intrinsic disorder in hubs in the human protein-protein interaction network

21 January 2018

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Assessing the utility of gene co-expression stability in combination with correlation in the analysis of protein-protein interaction networks

21 January 2018

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Coupled folding and binding with alpha-helix-forming molecular recognition elements.

21 January 2018

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Analysis of molecular recognition features (MoRFs)

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20130545

MoRFpred, a computational tool for sequence-based prediction and characterization of short disorder-to-order transitioning binding regions in proteins

21 January 2018

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Intrinsic disorder and protein multibinding in domain, terminal, and linker regions

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20130545

Characterization of molecular recognition features, MoRFs, and their binding partners

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20130545

Intrinsic disorder and protein function

21 January 2018

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Intrinsic disorder: signaling via highly specific but short-lived association

21 January 2018

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Fuzzy complexes: polymorphism and structural disorder in protein-protein interactions

21 January 2018

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Fuzziness: linking regulation to protein dynamics

21 January 2018

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Fuzzy complexes: a more stochastic view of protein function

21 January 2018

1 reference

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Recognition pliability is coupled to structural heterogeneity: a calmodulin intrinsically disordered binding region complex

21 January 2018

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Describing sequence-ensemble relationships for intrinsically disordered proteins

21 January 2018

1 reference

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Net charge per residue modulates conformational ensembles of intrinsically disordered proteins

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20130545

The unfoldomics decade: an update on intrinsically disordered proteins.

21 January 2018

1 reference

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Linking folding and binding

21 January 2018

1 reference

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Direct observations of conformational distributions of intrinsically disordered p53 peptides using UV Raman and explicit solvent simulations

21 January 2018

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Conformational selection in the molten globule state of the nuclear coactivator binding domain of CBP

21 January 2018

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Intrinsic disorder mediates the diverse regulatory functions of the Cdk inhibitor p21

21 January 2018

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Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

21 January 2018

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Attributes of short linear motifs.

21 January 2018

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ELM--the database of eukaryotic linear motifs

21 January 2018

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The identification of short linear motif-mediated interfaces within the human interactome

21 January 2018

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The switches.ELM resource: a compendium of conditional regulatory interaction interfaces

21 January 2018

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Protein-protein interaction through beta-strand addition

21 January 2018

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A quantitative protein interaction network for the ErbB receptors using protein microarrays

21 January 2018

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PDZ domain binding selectivity is optimized across the mouse proteome

21 January 2018

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Evidence for the concerted evolution between short linear protein motifs and their flanking regions

21 January 2018

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Contextual specificity in peptide-mediated protein interactions

21 January 2018

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The RNA degradosome of Escherichia coli: an mRNA-degrading machine assembled on RNase E.

21 January 2018

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Low-complexity regions within protein sequences have position-dependent roles

21 January 2018

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Simple sequences are rare in the Protein Data Bank

21 January 2018

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Non-globular domains in protein sequences: automated segmentation using complexity measures

21 January 2018

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Glutamine repeats and neurodegeneration

21 January 2018

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Physical chemistry of polyglutamine: intriguing tales of a monotonous sequence

21 January 2018

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Location of disorder in coiled coil proteins is influenced by its biological role and subcellular localization: a GO-based study on human proteome

21 January 2018

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Studies of the RNA degradosome-organizing domain of the Escherichia coli ribonuclease RNase E.

21 January 2018

1 reference

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Multi-scale sequence correlations increase proteome structural disorder and promiscuity

21 January 2018

1 reference

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Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation

21 January 2018

1 reference

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The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

21 January 2018

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The molecular regulation of programmed necrotic cell injury

21 January 2018

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21 January 2018

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RNA granules: post-transcriptional and epigenetic modulators of gene expression

21 January 2018

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A role for Q/N-rich aggregation-prone regions in P-body localization.

21 January 2018

1 reference

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Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels

21 January 2018

1 reference

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Cell-free formation of RNA granules: bound RNAs identify features and components of cellular assemblies.

21 January 2018

1 reference

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Getting RNA and protein in phase

21 January 2018

1 reference

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Phase transitions in the assembly of multivalent signalling proteins

21 January 2018

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Motif switches: decision-making in cell regulation

21 January 2018

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Cell regulation: determined to signal discrete cooperation

21 January 2018

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

21 January 2018

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Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure

21 January 2018

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Structure and intrinsic disorder in protein autoinhibition.

21 January 2018

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Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism

21 January 2018

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Tissue-specific splicing of disordered segments that embed binding motifs rewires protein interaction networks

21 January 2018

1 reference

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Tissue-specific alternative splicing remodels protein-protein interaction networks.

21 January 2018

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Linear motifs confer functional diversity onto splice variants

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20130545

Rewiring the dynamic interactome

21 January 2018

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The role of structural disorder in the rewiring of protein interactions through evolution.

21 January 2018

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Diverse functional manifestations of intrinsic structural disorder in molecular chaperones.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20130545

Conditional disorder in chaperone action

21 January 2018

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Structural plasticity of an acid-activated chaperone allows promiscuous substrate binding

21 January 2018

1 reference

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Bleach activates a redox-regulated chaperone by oxidative protein unfolding

21 January 2018

1 reference

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Intrinsically disordered proteins as molecular shields

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130545

Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130545

System-wide analysis reveals intrinsically disordered proteins are prone to ubiquitylation after misfolding stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130545

Functional diversity and structural disorder in the human ubiquitination pathway

21 January 2018

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Cell signaling in space and time: where proteins come together and when they're apart

21 January 2018

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Tight regulation of unstructured proteins: from transcript synthesis to protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130545

Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130545

Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130545

Intrinsically disordered proteins: regulation and disease

21 January 2018

1 reference

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Cellular strategies for regulating functional and nonfunctional protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130545

Intrinsically Disordered Proteins in Human Diseases: Introducing the D 2 Concept

21 January 2018

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p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion

21 January 2018

1 reference

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Protein misfolding, functional amyloid, and human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130545

An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130545

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130545

Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130545

Effect of sampling on topology predictions of protein-protein interaction networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130545

A Folded Excited State of Ligand-Free Nuclear Coactivator Binding Domain (NCBD) Underlies Plasticity in Ligand Recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20130545

21 January 2018

Identifiers

DOI

10.1042/BJ20130545

1 reference

29 August 2017

1 reference

PubMed ID

23988124