Identification of MFG-E8 as a novel therapeutic target for diseases (Q38131077)

29 August 2017

Identification of MFG-E8 as a novel therapeutic target for diseases (English)

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29 August 2017

3

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29 August 2017

Bao-Zhu Li

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29 August 2017

Hai-Yan Zhang

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2

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29 August 2017

Dong-Qing Ye

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4

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29 August 2017

language of work or name

English

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publication date

23 August 2013

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Expert Opinion on Therapeutic Targets

29 August 2017

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29 August 2017

17

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29 August 2017

1275-1285

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29 August 2017

11

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Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles

29 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Identification of a factor that links apoptotic cells to phagocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

SED1/MFG-E8: a bi-motif protein that orchestrates diverse cellular interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Review: milk fat globule-EGF factor 8 expression, function and plausible signal transduction in resolving inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Expression of milk fat globule epidermal growth factor 8 in immature dendritic cells for engulfment of apoptotic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

MFG-E8 regulates microglial phagocytosis of apoptotic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloid β toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Masking of phosphatidylserine inhibits apoptotic cell engulfment and induces autoantibody production in mice

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Phagocyte recognition of cells undergoing apoptosis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Constitutive exposure of phosphatidylserine on viable cells

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Recognition and phagocytosis of cells undergoing apoptosis

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.829455

The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Follicular dendritic cells control engulfment of apoptotic bodies by secreting Mfge8

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Milk fat globule-EGF factor VIII in sepsis and ischemia-reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Roles of milk fat globule-epidermal growth factor 8 in intestinal inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Novel therapeutic targets for sepsis: regulation of exaggerated inflammatory responses

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2013.829455

MFG-E8 released by apoptotic endothelial cells triggers anti-inflammatory macrophage reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Pyroptotic cells externalize eat-me and release find-me signals and are efficiently engulfed by macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

MFG-E8-mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

MFG-E8 attenuates intestinal inflammation in murine experimental colitis by modulating osteopontin-dependent alphavbeta3 integrin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Pre-treatment of recombinant mouse MFG-E8 downregulates LPS-induced TNF-α production in macrophages via STAT3-mediated SOCS3 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

MFG-E8 activates proliferation of vascular smooth muscle cells via integrin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Milk fat globule protein epidermal growth factor-8: a pivotal relay element within the angiotensin II and monocyte chemoattractant protein-1 signaling cascade mediating vascular smooth muscle cells invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Lactadherin promotes VEGF-dependent neovascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Pericyte-derived MFG-E8 regulates pathologic angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

NF-kappaB: linking inflammation and immunity to cancer development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

The inflammatory response to cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Capitalizing on the immunogenicity of dying tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

MFG-E8 regulates the immunogenic potential of dendritic cells primed with necrotic cell-mediated inflammatory signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Meta-analysis of TNF-alpha promoter - 238A/G polymorphism and SLE susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Autoimmunity in MFG-E8-deficient mice is associated with altered trafficking and enhanced cross-presentation of apoptotic cell antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Synergistic effect of Tim4 and MFG-E8 null mutations on the development of autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Aberrant splicing of the milk fat globule-EGF factor 8 (MFG-E8) gene in human systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Genetic polymorphism in milk fat globule-EGF factor 8 (MFG-E8) is associated with systemic lupus erythematosus in human.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Unravelling the pathogenesis of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Inflammatory bowel disease: past, present, and future

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Milk fat globule-EGF factor 8 is a critical protein for healing of dextran sodium sulfate-induced acute colitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Butyric acid attenuates intestinal inflammation in murine DSS-induced colitis model via milk fat globule-EGF factor 8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Dendritic cell-derived exosomes containing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Fractalkine-induced MFG-E8 leads to enhanced apoptotic cell clearance by macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor-factor VIII [corrected].

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Milk fat globule epidermal growth factor-factor VIII is down-regulated in sepsis via the lipopolysaccharide-CD14 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Recombinant human milk fat globule-EGF factor 8 produces dose-dependent benefits in sepsis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Milk fat globule EGF factor 8 attenuates sepsis-induced apoptosis and organ injury in alcohol-intoxicated rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Proteomic analysis of aorta and protective effects of grape seed procyanidin B2 in db/db mice reveal a critical role of milk fat globule epidermal growth factor-8 in diabetic arterial damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Evidence of a role for lactadherin in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Angiogenic endothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Milk fat globule epidermal growth factor-8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Milk fat globule-epidermal growth factor-factor 8 attenuates neutrophil infiltration in acute lung injury via modulation of CXCR2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Milk fat globule--EGF factor VIII ameliorates liver injury after hepatic ischemia-reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

Milk fat globule epidermal growth factor-factor 8 mitigates inflammation and tissue injury after hemorrhagic shock in experimental animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

The impact of MFG-E8 in chronic pancreatitis: potential for future immunotherapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

MFG-E8/Lactadherin Promotes Tumor Growth in an Angiogenesis-Dependent Transgenic Mouse Model of Multistage Carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.829455

10.1517/14728222.2013.829455

21 January 2018

Identifiers

DOI

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29 August 2017

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