Bioorthogonal labelling of biomolecules: new functional handles and ligation methods (Q38130840)

29 August 2017

Bioorthogonal labelling of biomolecules: new functional handles and ligation methods (English)

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29 August 2017

bioorthogonal chemistry

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Marjoke F Debets

1

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PubMed ID

23969529

29 August 2017

Jan C M van Hest

series ordinal

2

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PubMed ID

23969529

29 August 2017

Floris P J T Rutjes

series ordinal

3

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29 August 2017

23 August 2013

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Organic and Biomolecular Chemistry

29 August 2017

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29 August 2017

11

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29 August 2017

38

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29 August 2017

6439-6455

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Bioorthogonal chemistry: fishing for selectivity in a sea of functionality

29 August 2017

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Choosing an effective protein bioconjugation strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

In vivo imaging of membrane-associated glycans in developing zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

In vivo chemistry for pretargeted tumor imaging in live mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Copper-free click chemistry for dynamic in vivo imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Bioorthogonal chemistry: recent progress and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

From mechanism to mouse: a tale of two bioorthogonal reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Expanding the chemical biologist's tool kit: chemical labelling strategies and its applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Protein organic chemistry and applications for labeling and engineering in live-cell systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

A new strategy for the site-specific modification of proteins in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Dual-surface modification of the tobacco mosaic virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

A Pictet-Spengler ligation for protein chemical modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Azide: a unique dipole for metal-free bioorthogonal ligations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Single-step azide introduction in proteins via an aqueous diazo transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Nanobody-functionalized polymersomes for tumor-vessel targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Cell surface engineering by a modified Staudinger reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Mechanistic investigation of the staudinger ligation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Staudinger ligation: a peptide from a thioester and azide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Chemical remodelling of cell surfaces in living animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

A FRET-based fluorogenic phosphine for live-cell imaging with the Staudinger ligation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Probing mucin-type O-linked glycosylation in living animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Copper-free click chemistry in living animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Staudinger ligation as a method for bioconjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Iterative in situ click chemistry creates antibody-like protein-capture agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Cu-catalyzed azide-alkyne cycloaddition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Click chemistry: 1,2,3-triazoles as pharmacophores

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Click nucleic acid ligation: applications in biology and nanotechnology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Labeling live cells by copper-catalyzed alkyne--azide click chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Analysis and optimization of copper-catalyzed azide-alkyne cycloaddition for bioconjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Biocompatible copper(I) catalysts for in vivo imaging of glycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Cu-free click cycloaddition reactions in chemical biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Bioconjugation with strained alkenes and alkynes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Readily accessible bicyclononynes for bioorthogonal labeling and three-dimensional imaging of living cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

A Comparative Study of Bioorthogonal Reactions with Azides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Second-generation difluorinated cyclooctynes for copper-free click chemistry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Development and evaluation of new cyclooctynes for cell surface glycan imaging in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Benzyne click chemistry with in situ generated aromatic azides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Benzyne click chemistry: synthesis of benzotriazoles from benzynes and azides

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Thiacycloalkynes for copper-free click chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

A hydrophilic azacyclooctyne for Cu-free click chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast huisgen cycloadditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Selective labeling of living cells by a photo-triggered click reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Polar dibenzocyclooctynes for selective labeling of extracellular glycoconjugates of living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Reactivity of biarylazacyclooctynones in copper-free click chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Synthesis, X-ray structure, and properties of a tetrabenzannelated 1,2,4,5-cyclophane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Difluorobenzocyclooctyne: synthesis, reactivity, and stabilization by beta-cyclodextrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

A non-fluorinated monobenzocyclooctyne for rapid copper-free click reactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

A fluorogenic probe for the copper(I)-catalyzed azide-alkyne ligation reaction: modulation of the fluorescence emission via 3(n,pi)-1(pi,pi) inversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

A fluorogenic 1,3-dipolar cycloaddition reaction of 3-azidocoumarins and acetylenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Fluorogenic azidofluoresceins for biological imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Synthesis of a fluorogenic cyclooctyne activated by Cu-free click chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

A fluorogenic probe for the catalyst-free detection of azide-tagged molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Metal-free triazole formation as a tool for bioconjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Thiol-selective fluorogenic probes for labeling and release

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Application of metal-free triazole formation in the synthesis of cyclic RGD-DTPA conjugates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Visualizing enveloping layer glycans during zebrafish early embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Imaging cell surface glycosylation in vivo using "double click" chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Protein modification by strain-promoted alkyne-nitrone cycloaddition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Copper-free "click" modification of DNA via nitrile oxide-norbornene 1,3-dipolar cycloaddition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

High-density DNA functionalization by a combination of Cu-catalyzed and cu-free click chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Metal-free sequential [3 + 2]-dipolar cycloadditions using cyclooctynes and 1,3-dipoles of different reactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Strain-promoted cycloadditions of cyclic nitrones with cyclooctynes for labeling human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Kinetics studies of rapid strain-promoted [3 + 2]-cycloadditions of nitrones with biaryl-aza-cyclooctynone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Site-specific conjugation of ScFvs antibodies to nanoparticles by bioorthogonal strain-promoted alkyne-nitrone cycloaddition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Diazo Compounds as Highly Tunable Reactants in 1,3-Dipolar Cycloaddition Reactions with Cycloalkynes().

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Tetrazine-based cycloadditions: application to pretargeted live cell imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Design and synthesis of highly reactive dienophiles for the tetrazine-trans-cyclooctene ligation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Biomedical applications of tetrazine cycloadditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Genetic Encoding of bicyclononynes and trans-cyclooctenes for site-specific protein labeling in vitro and in live mammalian cells via rapid fluorogenic Diels-Alder reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Genetic encoding of a bicyclo[6.1.0]nonyne-charged amino acid enables fast cellular protein imaging by metal-free ligation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Live-cell imaging of cyclopropene tags with fluorogenic tetrazine cycloadditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Functionalized cyclopropenes as bioorthogonal chemical reporters

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Fluorescent live-cell imaging of metabolically incorporated unnatural cyclopropene-mannosamine derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Metabolic glycan imaging by isonitrile-tetrazine click chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Bioorthogonal turn-on probes for imaging small molecules inside living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

A photoinducible 1,3-dipolar cycloaddition reaction for rapid, selective modification of tetrazole-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Genetically encoded cyclopropene directs rapid, photoclick-chemistry-mediated protein labeling in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Fast alkene functionalization in vivo by Photoclick chemistry: HOMO lifting of nitrile imine dipoles

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Photoinducible bioorthogonal chemistry: a spatiotemporally controllable tool to visualize and perturb proteins in live cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

A bioorthogonal chemistry strategy for probing protein lipidation in live cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Olefin cross-metathesis on proteins: investigation of allylic chalcogen effects and guiding principles in metathesis partner selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Allyl sulfides are privileged substrates in aqueous cross-metathesis: application to site-selective protein modification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Copper-free Sonogashira cross-coupling for functionalization of alkyne-encoded proteins in aqueous medium and in bacterial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

A bioorthogonal quadricyclane ligation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Control and design of mutual orthogonality in bioorthogonal cycloadditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

Bioorthogonal reaction pairs enable simultaneous, selective, multi-target imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

BODIPY-tetrazine derivatives as superbright bioorthogonal turn-on probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

A Genetically Encoded Norbornene Amino Acid for the Mild and Selective Modification of Proteins in a Copper-Free Click Reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

General Method for Site-Specific Protein Immobilization by Staudinger Ligation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3OB41329B

21 January 2018

Identifiers

DOI

10.1039/C3OB41329B

1 reference

29 August 2017

1 reference

PubMed ID

23969529