The amyloid precursor protein: a biochemical enigma in brain development, function and disease (Q38107684)

29 August 2017

The amyloid precursor protein: a biochemical enigma in brain development, function and disease (English)

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29 August 2017

Natalia N Nalivaeva

1

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PubMed ID

23684647

29 August 2017

Anthony J Turner

series ordinal

2

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PubMed ID

23684647

29 August 2017

language of work or name

English

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publication date

16 May 2013

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29 August 2017

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29 August 2017

587

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29 August 2017

2046-2054

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29 August 2017

13

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Alzheimer's disease: the amyloid cascade hypothesis

29 August 2017

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Amyloid-independent mechanisms in Alzheimer's disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Soluble Aβ oligomer production and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Current status of vaccination therapies in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Amyloid precursor protein is a primary androgen target gene that promotes prostate cancer growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

The production of the Alzheimer amyloid precursor protein (APP) in extraneuronal tissue does not increase in old age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

What the evolution of the amyloid protein precursor supergene family tells us about its function

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Amyloid precursor protein trafficking, processing, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Tissue-specific expression of three types of beta-protein precursor mRNA: enhancement of protease inhibitor-harboring types in Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Expression of amyloid precursor protein mRNA isoforms in rat brain is differentially regulated during postnatal maturation and by cholinergic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Regulation of promoter activity of the APP gene by cytokines and growth factors: implications in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Estradiol regulates APP mRNA alternative splicing in the mice brain cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Non-coding RNAs with essential roles in neurodegenerative disorders

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

MicroRNA-101 downregulates Alzheimer's amyloid-β precursor protein levels in human cell cultures and is differentially expressed.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

MicroRNA-153 physiologically inhibits expression of amyloid-β precursor protein in cultured human fetal brain cells and is dysregulated in a subset of Alzheimer disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Development of transgenic rats producing human beta-amyloid precursor protein as a model for Alzheimer's disease: transgene and endogenous APP genes are regulated tissue-specifically

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Alzheimer's disease and diabetes: new insights and unifying therapies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Quantification of the binding properties of Cu2+ to the amyloid beta peptide: coordination spheres for human and rat peptides and implication on Cu2+-induced aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Altered amyloid protein processing in platelets of patients with Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Reduced platelet amyloid precursor protein ratio (APP ratio) predicts conversion from mild cognitive impairment to Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Proteolytic processing of Alzheimer's β-amyloid precursor protein

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Amyloid precursor protein processing and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Nuclear signalling by membrane protein intracellular domains: the AICD enigma

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Homo- and heterodimerization of APP family members promotes intercellular adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Pancortins interact with amyloid precursor protein and modulate cortical cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Amyloid precursor protein binding protein-1 modulates cell cycle progression in fetal neural stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Ontogenetic changes in protein level of amyloid precursor protein (APP) in growth cones and synaptosomes from rat brain and prenatal expression pattern of APP mRNA isoforms in developing rat embryo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Developmental regulation of amyloid precursor protein at the neuromuscular junction in mouse skeletal muscle

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Functions of the APP gene family in the nervous system: insights from mouse models

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Interactome of the amyloid precursor protein APP in brain reveals a protein network involved in synaptic vesicle turnover and a close association with Synaptotagmin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Expression of human amyloid precursor protein in rat cortical neurons inhibits calcium oscillations.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Role of APP for dendritic spine formation and stability

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Amyloid precursor protein (APP) regulates synaptic structure and function

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

APP overexpression prevents neuropathic pain and motoneuron death after peripheral nerve injury in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Ligand-dependent G protein coupling function of amyloid transmembrane precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Amyloid-beta precursor protein mediates neuronal toxicity of amyloid beta through Go protein activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Mitochondrial β-amyloid in Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

The "LEARn" (Latent Early-life Associated Regulation) model integrates environmental risk factors and the developmental basis of Alzheimer's disease, and proposes remedial steps

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Expression of amyloid precursor protein (beta-APP) in the neonatal brain following hypoxic ischaemic injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Differential expression of ADAM15 and ADAM17 metalloproteases in the rat brain after severe hypobaric hypoxia and hypoxic preconditioning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Effect of hypoxia/ischemia and hypoxic preconditioning/reperfusion on expression of some amyloid-degrading enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

APP knockout mice experience acute mortality as the result of ischemia

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Effect of sodium valproate administration on brain neprilysin expression and memory in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Hypoxia-induced down-regulation of neprilysin by histone modification in mouse primary cortical and hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Effects of hypoxia and oxidative stress on expression of neprilysin in human neuroblastoma cells and rat cortical neurones and astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Restraint stress induces beta-amyloid precursor protein mRNA expression in the rat basolateral amygdala

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

The physiology of the β-amyloid precursor protein intracellular domain AICD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Inhibitors of γ-secretase stabilize the complex and differentially affect processing of amyloid precursor protein and other substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Secretory form of Alzheimer amyloid precursor protein 695 in human brain lacks beta/A4 amyloid immunoreactivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Contribution of Kunitz Protease Inhibitor and Transmembrane Domains to Amyloid Precursor Protein Homodimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Structural features of the KPI domain control APP dimerization, trafficking, and processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Mediator: the missing link in amyloid precursor protein nuclear signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Epigenetic control of aquaporin 1 expression by the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Characterization of amyloid-β precursor protein intracellular domain-associated transcriptional complexes in SH-SY5Y neurocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Swedish mutation within amyloid precursor protein modulates global gene expression towards the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Gamma-secretase: proteasome of the membrane?

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Recovery of learning and memory is associated with chromatin remodelling

21 January 2018

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https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Altered histone acetylation is associated with age-dependent memory impairment in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-beta degrading enzyme neprilysin

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

The impact of amyloid precursor protein signalling and histone deacetylase inhibition on neprilysin expression in human prostate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Epidermal growth factor receptor is a preferred target for treating amyloid-β-induced memory loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

A ternary complex consisting of AICD, FE65, and TIP60 down-regulates Stathmin1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

The APP intracellular domain (AICD) inhibits Wnt signalling and promotes neurite outgrowth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

Amyloid precursor protein controls cholesterol turnover needed for neuronal activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

The amyloid precursor protein (APP) family members are key players in S-adenosylmethionine formation by MAT2A and modify BACE1 and PSEN1 gene expression-relevance for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2013.05.010

10.1016/J.FEBSLET.2013.05.010

21 January 2018

Identifiers

DOI

1 reference

29 August 2017

1 reference

PubMed ID

23684647