Looking back into the future: 30 years of metabolomics at TNO. (Q38102969)

28 August 2017

Looking back into the future: 30 years of metabolomics at TNO. (English)

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28 August 2017

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3

Ben van Ommen

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author name string

Jan van der Greef

1

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28 August 2017

Herman van Wietmarschen

2

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28 August 2017

Ben van Ommen

3

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28 August 2017

Elwin Verheij

4

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28 August 2017

29 April 2013

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Mass Spectrometry Reviews

28 August 2017

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28 August 2017

32

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28 August 2017

399-415

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28 August 2017

5

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Correlation network analysis for data integration and biomarker selection

28 August 2017

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Systems medicine: the future of medical genomics and healthcare

21 January 2018

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The NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Organisation

21 January 2018

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An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach.

21 January 2018

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Circadian integration of metabolism and energetics

21 January 2018

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NMR studies of body fluids

21 January 2018

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Large-scale human metabolomics studies: a strategy for data (pre-) processing and validation

21 January 2018

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Quantitative profiling of bile acids in biofluids and tissues based on accurate mass high resolution LC-FT-MS: compound class targeting in a metabolomics workflow

21 January 2018

1 reference

Evidence of the regulatory effect of Ginkgo biloba extract on skin blood flow and study of its effects on urinary metabolites in healthy humans

21 January 2018

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Visualization and identification of health space, based on personalized molecular phenotype and treatment response to relevant underlying biological processes

21 January 2018

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The effect of environmental conditions on extracellular protease activity in controlled fermentations of Aspergillus niger

21 January 2018

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The WHO Definition of 'Health'

21 January 2018

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New figures of merit for comprehensive functional genomics data: the metabolomics case

21 January 2018

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Filling gaps in PPAR-alpha signaling through comparative nutrigenomics analysis.

21 January 2018

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Traditional processing strongly affects metabolite composition by hydrolysis in Rehmannia glutinosa roots

21 January 2018

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Integrative biological analysis of the APOE*3-leiden transgenic mouse

21 January 2018

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Nutrigenomics: the impact of biomics technology on nutrition research

21 January 2018

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Simultaneous quantitative analysis of metabolites using ion-pair liquid chromatography-electrospray ionization mass spectrometry.

21 January 2018

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Chronobiology and the treatment of rheumatoid arthritis

21 January 2018

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The challenges for molecular nutrition research 3: comparative nutrigenomics research as a basis for entering the systems level

21 January 2018

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Advancing drug discovery through systems biology

21 January 2018

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Nutritional systems biology modeling: from molecular mechanisms to physiology

21 January 2018

1 reference

21 January 2018

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Equating, or correction for between-block effects with application to body fluid LC-MS and NMR metabolomics data sets

21 January 2018

1 reference

Coordination of the transcriptome and metabolome by the circadian clock

21 January 2018

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Establishing reporting standards for metabolomic and metabonomic studies: a call for participation

21 January 2018

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Metabolism and circadian rhythms--implications for obesity

21 January 2018

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Metabolic flexibility and insulin resistance

21 January 2018

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Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum

21 January 2018

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Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial

21 January 2018

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Simplivariate models: ideas and first examples

21 January 2018

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Owner controlled data exchange in nutrigenomic collaborations: the NuGO information network

21 January 2018

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Novel diagnostics of metabolic dysfunction detected in breath and plasma by selective isotope-assisted labeling

21 January 2018

1 reference

Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach

21 January 2018

1 reference

Bromobenzene-induced hepatotoxicity at the transcriptome level

21 January 2018

1 reference

Toxicogenomic analysis of gene expression changes in rat liver after a 28-day oral benzene exposure

21 January 2018

1 reference

Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology

21 January 2018

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Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis

21 January 2018

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How to distinguish healthy from diseased? Classification strategy for mass spectrometry-based clinical proteomics

21 January 2018

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RPLC-ion-trap-FTMS method for lipid profiling of plasma: method validation and application to p53 mutant mouse model.

21 January 2018

1 reference

Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats.

21 January 2018

1 reference

Plasma and liver lipidomics response to an intervention of rimonabant in ApoE*3Leiden.CETP transgenic mice

21 January 2018

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Effects of organically and conventionally produced feed on biomarkers of health in a chicken model

21 January 2018

1 reference

How should we define health?

21 January 2018

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A genome-wide perspective of genetic variation in human metabolism

21 January 2018

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Reciprocal regulation of the neural and innate immune systems

21 January 2018

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Perioperative exercise training in elderly subjects.

21 January 2018

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Analysis of longitudinal metabolomics data

21 January 2018

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Direct sequencing of neuropeptides in biological tissue by MALDI-PSD mass spectrometry

21 January 2018

1 reference

A strategy for identifying differences in large series of metabolomic samples analyzed by GC/MS.

21 January 2018

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Personalised nutrition: status and perspectives

21 January 2018

1 reference

Profiling of endogenous peptides in human synovial fluid by NanoLC-MS: method validation and peptide identification.

21 January 2018

1 reference

The case for strategic international alliances to harness nutritional genomics for public and personal health

21 January 2018

1 reference

Harnessing Nutrigenomics: Development of web-based communication, databases, resources, and tools

21 January 2018

1 reference

Metabolic footprinting and systems biology: the medium is the message

21 January 2018

1 reference

Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: a combined transcriptomics and metabolomics analysis

21 January 2018

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Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance

21 January 2018

1 reference

Microbial metabolomics with gas chromatography/mass spectrometry

21 January 2018

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Metabolic profiling of ultrasmall sample volumes with GC/MS: from microliter to nanoliter samples.

21 January 2018

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Semi-automated non-target processing in GC × GC-MS metabolomics analysis: applicability for biomedical studies

21 January 2018

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Bioconversion of red ginseng saponins in the gastro-intestinal tract in vitro model studied by high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry.

21 January 2018

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OMICS-driven biomarker discovery in nutrition and health

21 January 2018

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Medium chain acylcarnitines dominate the metabolite pattern in humans under moderate intensity exercise and support lipid oxidation

21 January 2018

1 reference

Health: a comprehensive concept.

21 January 2018

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Primer on medical genomics. Part XIV: Introduction to systems biology--a new approach to understanding disease and treatment

21 January 2018

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Fast atom bombardment: A new mass spectrometric method for peptide sequence analysis

21 January 2018

1 reference

Standard reporting requirements for biological samples in metabolomics experiments: environmental context

21 January 2018

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Why life oscillates--from a topographical towards a functional chronobiology.

21 January 2018

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Systems biology: Metabonomics.

21 January 2018

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Host-gut microbiota metabolic interactions

21 January 2018

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Closed-loop, multiobjective optimization of two-dimensional gas chromatography/mass spectrometry for serum metabolomics.

21 January 2018

1 reference

Systematic functional analysis of the yeast genome

21 January 2018

1 reference

Quantitative Analysis of Urine Vapor and Breath by Gas-Liquid Partition Chromatography

21 January 2018

1 reference

Plasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status

21 January 2018

1 reference

Activation and function of immediate-early genes in the nervous system

21 January 2018

1 reference

A principal component analysis based method to discover chemical differences in comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry (GCxGC-TOFMS) separations of metabolites in plant samples.

21 January 2018

1 reference

A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations

21 January 2018

1 reference

Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program

21 January 2018

1 reference

Effect of body fat distribution on the transcription response to dietary fat interventions

21 January 2018

1 reference

The effect of preanalytical factors on stability of the proteome and selected metabolites in cerebrospinal fluid (CSF).

21 January 2018

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Assessing the performance of statistical validation tools for megavariate metabolomics data

21 January 2018

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Analyzing longitudinal microbial metabolomics data

21 January 2018

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Microbial production host selection for converting second-generation feedstocks into bioproducts

21 January 2018

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Simplivariate models: uncovering the underlying biology in functional genomics data

21 January 2018

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Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research

21 January 2018

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Metabolic profiling technologies for biomarker discovery in biomedicine and drug development

21 January 2018

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Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity

21 January 2018

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ANOVA-simultaneous component analysis (ASCA): a new tool for analyzing designed metabolomics data

21 January 2018

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Fusion of mass spectrometry-based metabolomics data

21 January 2018

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Dynamic metabolomic data analysis: a tutorial review

21 January 2018

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Allostasis: a model of predictive regulation

21 January 2018

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Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting

21 January 2018

1 reference

Single-cell metabolomics comes of age: new developments in mass spectrometry profiling and imaging.

21 January 2018

1 reference

Non-invasive measurement of brain damage in a primate model of multiple sclerosis.

21 January 2018

1 reference

Characterization of virus infected cell cultures by pyrolysis/direct chemical ionization mass spectrometry

21 January 2018

1 reference

Improving the analysis of designed studies by combining statistical modelling with study design information

21 January 2018

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Centering, scaling, and transformations: improving the biological information content of metabolomics data

21 January 2018

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Metabolomics data exploration guided by prior knowledge

21 January 2018

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Systems biology, connectivity and the future of medicine

21 January 2018

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Perspective: All systems go.

21 January 2018

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Innovation: Rescuing drug discovery: in vivo systems pathology and systems pharmacology

21 January 2018

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The role of analytical sciences in medical systems biology

21 January 2018

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Metabolomics-based systems biology and personalized medicine: moving towards n = 1 clinical trials?

21 January 2018

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Systems biology-based diagnostic principles as pillars of the bridge between Chinese and Western medicine

21 January 2018

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Analytical error reduction using single point calibration for accurate and precise metabolomic phenotyping.

21 January 2018

1 reference

Discovery of early-stage biomarkers for diabetic kidney disease using ms-based metabolomics (FinnDiane study).

21 January 2018

1 reference

Towards replacing closed with open target selection strategies

21 January 2018

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Microbial metabolomics: replacing trial-and-error by the unbiased selection and ranking of targets.

21 January 2018

1 reference

Multivariate analysis of microarray data by principal component discriminant analysis: prioritizing relevant transcripts linked to the degradation of different carbohydrates in Pseudomonas putida S12.

21 January 2018

1 reference

Microbial metabolomics: toward a platform with full metabolome coverage.

21 January 2018

1 reference

Comprehensive analysis of the metabolome of Pseudomonas putida S12 grown on different carbon sources.

21 January 2018

1 reference

A structured overview of simultaneous component based data integration

21 January 2018

1 reference

Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers

21 January 2018

1 reference

Insight in modulation of inflammation in response to diclofenac intervention: a human intervention study

21 January 2018

1 reference

Metabolomics (liver and blood profiling) in a mouse model in response to fasting: a study of hepatic steatosis

21 January 2018

1 reference

Personalized nutrition from a health perspective: luxury or necessity?

21 January 2018

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Nutrigenomics: exploiting systems biology in the nutrition and health arena

21 January 2018

1 reference

The challenges for molecular nutrition research 4: the "nutritional systems biology level".

21 January 2018

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A network biology model of micronutrient related health

21 January 2018

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The challenges for molecular nutrition research 2: quantification of the nutritional phenotype

21 January 2018

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Challenging homeostasis to define biomarkers for nutrition related health

21 January 2018

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Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies

21 January 2018

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Identification of POMC processing products in single melanotrope cells by matrix-assisted laser desorption/ionization mass spectrometry

21 January 2018

1 reference

Systems biology guided by Chinese medicine reveals new markers for sub-typing rheumatoid arthritis patients.

21 January 2018

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Sub-typing of rheumatic diseases based on a systems diagnosis questionnaire

21 January 2018

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Statistical analysis of the spontaneously emitted photon signals from palm and dorsal sides of both hands in human subjects.

21 January 2018

1 reference

Using ultra-weak photon emission to determine the effect of oligomeric proanthocyanidins on oxidative stress of human skin.

21 January 2018

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Analysis by mass spectrometry of POMC-derived peptides in amphibian melanotrope subpopulations

21 January 2018

1 reference

A combination of proteomics, principal component analysis and transcriptomics is a powerful tool for the identification of biomarkers for macrophage maturation in the U937 cell line.

21 January 2018

1 reference

Characterization of anti-inflammatory compounds using transcriptomics, proteomics, and metabolomics in combination with multivariate data analysis.

21 January 2018

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Statistical validation of megavariate effects in ASCA

21 January 2018

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Endocrine pulse identification using penalized methods and a minimum set of assumptions

21 January 2018

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Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology

21 January 2018

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Systems toxicology study of doxorubicin on rats using ultra performance liquid chromatography coupled with mass spectrometry based metabolomics

21 January 2018

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Alkaloid profiling of the Chinese herbal medicine Fuzi by combination of matrix-assisted laser desorption ionization mass spectrometry with liquid chromatography-mass spectrometry

21 January 2018

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Lipidomics reveals multiple pathway effects of a multi-components preparation on lipid biochemistry in ApoE*3Leiden.CETP mice

21 January 2018

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Urine metabolomics combined with the personalized diagnosis guided by Chinese medicine reveals subtypes of pre-diabetes.

21 January 2018

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Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

21 January 2018

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HMDB: the Human Metabolome Database

21 January 2018

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Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes

21 January 2018

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Identification of prognostic and diagnostic biomarkers of glucose intolerance in ApoE3Leiden mice

21 January 2018

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Building a disease risk model of osteoporosis based on traditional Chinese medicine symptoms and western medicine risk factors

21 January 2018

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Applications of a new subspace clustering algorithm (COSA) in medical systems biology

21 January 2018

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Identification of an urinary metabolite profile associated with osteoarthritis

21 January 2018

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Summary recommendations for standardization and reporting of metabolic analyses

21 January 2018

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The Metabolomics Standards Initiative

21 January 2018

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Phenotype characterisation using integrated gene transcript, protein and metabolite profiling.

21 January 2018

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The Impact of Delayed Storage on the Measured Proteome and Metabolome of Human Cerebrospinal Fluid

21 January 2018

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High resolution proton magnetic resonance spectroscopy of biological fluids

21 January 2018

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A strategy for modelling dynamic responses in metabolic samples characterized by GC/MS

21 January 2018

1 reference

5 May 2024

https://opencitations.net/index/api/v1/citations/10.1007/S11306-006-0027-1

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DOI

10.1002/MAS.21370

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release_peaqm2jpizb23mnyofxuefgyfq

28 August 2017

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24 November 2022

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