Using space-based investigations to inform cancer research on Earth (Q38098865)

28 August 2017

Using space-based investigations to inform cancer research on Earth (English)

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28 August 2017

Jeanne L Becker

1

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28 August 2017

Glauco R Souza

series ordinal

2

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28 August 2017

language of work or name

English

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publication date

12 April 2013

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28 August 2017

Nature Reviews Cancer

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28 August 2017

13

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28 August 2017

5

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28 August 2017

315-327

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https://scigraph.springernature.com/pub.10.1038/nrc3507

28 August 2017

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cites work

Growing tissues in microgravity

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Optimized suspension culture: the rotating-wall vessel

31 March 2020

1 reference

Tissue engineering of cartilage in space

31 March 2020

1 reference

The response of single human cells to zero gravity

31 March 2020

1 reference

Skylab experiment results: hematology studies

31 March 2020

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Space flight and the immune system

31 March 2020

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Bioreactors for tissue engineering: focus on mechanical constraints. A comparative review.

31 March 2020

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Three-dimensional tissue culture based on magnetic cell levitation.

31 March 2020

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Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes

31 March 2020

1 reference

Interaction of mouse mammary epithelial cells with collagen substrata: regulation of casein gene expression and secretion

31 March 2020

1 reference

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

31 March 2020

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Three-dimensional culture models of normal and malignant breast epithelial cells

31 March 2020

1 reference

Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer.

31 March 2020

1 reference

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

31 March 2020

1 reference

A Method to Measure the Radio and Chemosensitivity of Human Spheroids

31 March 2020

1 reference

Influence of glucose on metabolism and growth of rat glioma cells (C6) in multicellular spheroid culture

31 March 2020

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Multicellular spheroids: a three-dimensional in vitro culture system to study tumour biology

31 March 2020

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Cell culture for three-dimensional modeling in rotating-wall vessels: an application of simulated microgravity

31 March 2020

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Prospects for use of microgravity-based bioreactors to study three-dimensional host-tumor interactions in human neoplasia

31 March 2020

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Reduced shear stress: a major component in the ability of mammalian tissues to form three-dimensional assemblies in simulated microgravity

31 March 2020

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Modelling tissues in 3D: the next future of pharmaco-toxicology and food research?

31 March 2020

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Characterization of primary breast carcinomas grown in three-dimensional cultures.

31 March 2020

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Human breast cancer histoid: an in vitro 3-dimensional co-culture model that mimics breast cancer tissue

31 March 2020

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Heterogeneous breast tumoroids: An in vitro assay for investigating cellular heterogeneity and drug delivery

31 March 2020

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Three-dimensional endothelial-tumor epithelial cell interactions in human cervical cancers.

31 March 2020

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Morphologic differentiation of colon carcinoma cell lines HT-29 and HT-29KM in rotating-wall vessels

31 March 2020

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Induction of carcinoembryonic antigen expression in a three-dimensional culture system

31 March 2020

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Microgravity culture reduces apoptosis and increases the differentiation of a human colorectal carcinoma cell line

31 March 2020

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Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes.

31 March 2020

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A three-dimensional cell biology model of human hepatocellular carcinoma in vitro

31 March 2020

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Microgravity assay of neuroblastoma: in vitro aggregation kinetics and organoid morphology correlate with MYCN expression

31 March 2020

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Generation of a tumor spheroid in a microgravity environment as a 3D model of melanoma

31 March 2020

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A novel preclinical model of human malignant melanoma utilizing bioreactor rotating-wall vessels

31 March 2020

1 reference

Three-dimensional growth and differentiation of ovarian tumor cell line in high aspect rotating-wall vessel: morphologic and embryologic considerations

31 March 2020

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Three-dimensional culture of a mixed mullerian tumor of the ovary: expression of in vivo characteristics

31 March 2020

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Establishment of a three-dimensional human prostate organoid coculture under microgravity-simulated conditions: evaluation of androgen-induced growth and PSA expression

31 March 2020

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Three-dimensional growth patterns of various human tumor cell lines in simulated microgravity of a NASA bioreactor

31 March 2020

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Three-dimensional co-culture models to study prostate cancer growth, progression, and metastasis to bone

31 March 2020

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Coevolution of prostate cancer and bone stroma in three-dimensional coculture: implications for cancer growth and metastasis

31 March 2020

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Tri-dimensional prostate cell cultures in simulated microgravity and induced changes in lipid second messengers and signal transduction.

31 March 2020

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Identification of specific gravity sensitive signal transduction pathways in human A431 carcinoma cells

31 March 2020

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Simulated conditions of microgravity increases progesterone production in I-10 cells of Leydig tumor cell line

31 March 2020

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Protective effects of flavonoids against oxidative stress induced by simulated microgravity in SH-SY5Y cells

31 March 2020

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MAPK and SRC-Kinases Control EGR-1 and NF-κB Inductions by Changes in Mechanical Environment in Osteoblasts

31 March 2020

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TNF-alpha-dependent activation of NF-kappa B in human osteoblastic HOS-TE85 cells is repressed in vector-averaged gravity using clinostat rotation

31 March 2020

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Simulated microgravity alters differentiation and increases apoptosis in human follicular thyroid carcinoma cells.

31 March 2020

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Weightlessness induced apoptosis in normal thyroid cells and papillary thyroid carcinoma cells via extrinsic and intrinsic pathways

31 March 2020

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Simulated weightlessness changes the cytoskeleton and extracellular matrix proteins in papillary thyroid carcinoma cells

31 March 2020

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Gravity-sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids

31 March 2020

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Simulated microgravity using the Random Positioning Machine inhibits differentiation and alters gene expression profiles of 2T3 preosteoblasts

31 March 2020

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Effects of simulated microgravity on proliferation and chemosensitivity in malignant glioma cells

31 March 2020

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Modeled gravitational unloading triggers differentiation and apoptosis in preosteoclastic cells.

31 March 2020

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Differential behaviour of normal, transformed and Fanconi's anemia lymphoblastoid cells to modeled microgravity

31 March 2020

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Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture

31 March 2020

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Three-dimensional in vitro tissue culture models of breast cancer-- a review.

31 March 2020

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Capturing complex 3D tissue physiology in vitro

31 March 2020

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Forcing the third dimension

31 March 2020

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Three-dimensional cell culture matrices: state of the art.

31 March 2020

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Invasive glioblastoma cells acquire stemness and increased Akt activation.

31 March 2020

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Stable magnetic field gradient levitation of Xenopus laevis: toward low-gravity simulation

31 March 2020

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Diamagnetic levitation changes growth, cell cycle, and gene expression of Saccharomyces cerevisiae.

31 March 2020

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Magnetic levitation-based Martian and Lunar gravity simulator

31 March 2020

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Adipose tissue engineering in three-dimensional levitation tissue culture system based on magnetic nanoparticles

31 March 2020

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The resistance of intracellular mediators to doxorubicin and cisplatin are distinct in 3D and 2D endometrial cancer

31 March 2020

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Magnetic Levitation of MC3T3 Osteoblast Cells as a Ground-Based Simulation of Microgravity

31 March 2020

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Large gradient high magnetic field affects the association of MACF1 with actin and microtubule cytoskeleton

31 March 2020

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Mobility and invasiveness of metastatic esophageal cancer are potentiated by shear stress in a ROCK- and Ras-dependent manner

31 March 2020

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Shear stress induces internalization of E-cadherin and invasiveness in metastatic oesophageal cancer cells by a Src-dependent pathway.

31 March 2020

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Effects of the Tumor-Leukocyte Microenvironment on Melanoma-Neutrophil Adhesion to the Endothelium in a Shear Flow

31 March 2020

1 reference

What does physics have to do with cancer?

31 March 2020

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The physics of cancer: the role of physical interactions and mechanical forces in metastasis

31 March 2020

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Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1α.

31 March 2020

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Modulation of angiogenic and inflammatory response in glioblastoma by hypoxia

31 March 2020

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Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells.

31 March 2020

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Acquired multicellular-mediated resistance to alkylating agents in cancer

31 March 2020

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Rapid acquisition of multicellular drug resistance after a single exposure of mammary tumor cells to antitumor alkylating agents.

31 March 2020

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Multicellular resistance: a paradigm for clinical resistance?

31 March 2020

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Spaceflight alters immune cell function and distribution

31 March 2020

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Immune changes in test animals during spaceflight.

31 March 2020

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Spaceflight and development of immune responses

31 March 2020

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Spaceflight effects on T lymphocyte distribution, function and gene expression

31 March 2020

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Cytokine secretion by immune cells in space

31 March 2020

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Influence of spaceflight on the production of interleukin-3 and interleukin-6 by rat spleen and thymus cells

31 March 2020

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Mortality among U.S. astronauts: 1980-2009.

31 March 2020

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31 March 2020

Gene expression in space

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Mechanical culture conditions effect gene expression: gravity-induced changes on the space shuttle

31 March 2020

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cDNA microarray reveals altered cytoskeletal gene expression in space-flown leukemic T lymphocytes (Jurkat)

31 March 2020

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Spaceflight alters the gene expression profile of cervical cancer cells

31 March 2020

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Identification of genes associated with tumor development in CaSki cells in the cosmic space

31 March 2020

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Plectin-1 as a novel biomarker for pancreatic cancer

31 March 2020

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Plectin sidearms mediate interaction of intermediate filaments with microtubules and other components of the cytoskeleton

31 March 2020

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Plectin promotes migration and invasion of cancer cells and is a novel prognostic marker for head and neck squamous cell carcinoma.

31 March 2020

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Plectin regulates invasiveness of SW480 colon carcinoma cells and is targeted to podosome-like adhesions in an isoform-specific manner

31 March 2020

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The distribution of protein kinase C in human leukocytes is altered in microgravity

31 March 2020

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The kinetics of translocation and cellular quantity of protein kinase C in human leukocytes are modified during spaceflight

31 March 2020

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Microgravity modifies protein kinase C isoform translocation in the human monocytic cell line U937 and human peripheral blood T-cells

31 March 2020

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Microgravity reduces the differentiation of human osteoblastic MG-63 cells

31 March 2020

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Prolonged weightlessness affects promyelocytic multidrug resistance

31 March 2020

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The effect of weightlessness on cytoskeleton architecture and proliferation of human breast cancer cell line MCF-7.

31 March 2020

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Reciprocal regulation of 5alpha-dihydrotestosterone, interleukin-6 and interleukin-8 during proliferation of epithelial ovarian carcinoma

31 March 2020

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The nuclear factor-κB correlates with increased expression of interleukin-6 and promotes progression of gastric carcinoma

31 March 2020

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Prognostic or predictive plasma cytokines and angiogenic factors for patients treated with pazopanib for metastatic renal-cell cancer: a retrospective analysis of phase 2 and phase 3 trials

31 March 2020

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Enhanced chemosensitization in multidrug-resistant human breast cancer cells by inhibition of IL-6 and IL-8 production

31 March 2020

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Cytogenetic, morphologic and oncogene analysis of a cell line derived from a heterologous mixed mullerian tumor of the ovary

31 March 2020

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Prostate modeling experiment success becomes part of legacy of shuttle astronauts

31 March 2020

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Advances in tenascin-C biology

31 March 2020

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Microtubule self-organization is gravity-dependent

31 March 2020

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Integrity of actin fibers and microtubules influences metastatic tumor cell adhesion.

31 March 2020

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Biomechanics and biophysics of cancer cells

31 March 2020

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The role of the microenvironment in tumor growth and invasion

31 March 2020

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Control of cytoskeletal mechanics by extracellular matrix, cell shape, and mechanical tension

31 March 2020

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From cellular mechanotransduction to biologically inspired engineering: 2009 Pritzker Award Lecture, BMES Annual Meeting October 10, 2009.

31 March 2020

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Mechanical behavior in living cells consistent with the tensegrity model

31 March 2020

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Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure

31 March 2020

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Tensegrity I. Cell structure and hierarchical systems biology

31 March 2020

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Cell cycling determines integrin-mediated adhesion in osteoblastic ROS 17/2.8 cells exposed to space-related conditions

31 March 2020

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Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells

31 March 2020

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Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence

31 March 2020

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Does reduced gravity alter cellular response to ionizing radiation?

31 March 2020

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Biomarkers of space radiation risk

31 March 2020

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Thyroid cell growth: sphingomyelin metabolism as non-invasive marker for cell damage acquired during spaceflight.

31 March 2020

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Proteomics and genomics of microgravity

31 March 2020

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How and why does the proteome respond to microgravity?

31 March 2020

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Cancer research: past, present and future.

31 March 2020

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Ultrasound guided combined cryoablation and microencapsulated 5-Fluorouracil inhibits growth of human prostate tumors in xenogenic mouse model assessed by luminescence imaging

31 March 2020

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Percutaneous tumor ablation: microencapsulated echo-guided interstitial chemotherapy combined with cryosurgery increases necrosis in prostate cancer

31 March 2020

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Effect of NASA Light-Emitting Diode Irradiation on Molecular Changes for Wound Healing in Diabetic Mice

31 March 2020

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Amelioration of oral mucositis pain by NASA near-infrared light-emitting diodes in bone marrow transplant patients

31 March 2020

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Low-level laser therapy in acute pain: a systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials.

31 March 2020

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COX-2 mRNA expression decreases in the subplantar muscle of rat paw subjected to carrageenan-induced inflammation after low level laser therapy

31 March 2020

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Toward optimizing lighting as a countermeasure to sleep and circadian disruption in space flight

31 March 2020

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Sensitivity of the human circadian system to short-wavelength (420-nm) light

31 March 2020

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Blue light from light-emitting diodes elicits a dose-dependent suppression of melatonin in humans

31 March 2020

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Circadian stage-dependent inhibition of human breast cancer metabolism and growth by the nocturnal melatonin signal: consequences of its disruption by light at night in rats and women

31 March 2020

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Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats

31 March 2020

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Rotating night shifts and risk of breast cancer in women participating in the nurses' health study

31 March 2020

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Night-shift work and risk of colorectal cancer in the nurses' health study

31 March 2020

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Melanoma growth and tumorigenicity in models of microgravity

31 March 2020

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12 December 2020

Epithelial-mesenchymal transition, the tumor microenvironment, and metastatic behavior of epithelial malignancies.

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12 December 2020

Detection of hydroxyapatite in calcified cardiovascular tissues

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12 December 2020

Matricellular proteins: a sticky affair with cancers

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12 December 2020

Responses of gravity level variations on the NASA/JSC bioreactor system

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12 December 2020

Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer

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12 December 2020

Low gravity on earth by magnetic levitation of biological material

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12 December 2020

Regulatory effect of e2, IL-6 and IL-8 on the growth of epithelial ovarian cancer cells.

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12 December 2020

Culture in vector-averaged gravity environment in a clinostat results in detachment of osteoblastic ROS 17/2.8 cells.

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12 December 2020

Gravity-dependent phenomena at the scale of the single cell.

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12 December 2020

Ground-based methods reproduce space-flight experiments and show that weak vibrations trigger microtubule self-organisation

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12 December 2020

Altered gravity conditions affect early EGF-induced signal transduction in human epidermal A431 cells

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12 December 2020

Demonstration of an extracellular matrix in multicellular tumor spheroids.

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12 December 2020

Once we know all the radiobiology we need to know, how can we use it to predict space radiation risks and achieve fame and fortune?

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12 December 2020

Characterization of the tumorigenic and metastatic potential of a poorly differentiated human colon cancer cell line

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12 December 2020

Multiplexed profiling of secreted proteins for the detection of potential space biomarkers

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12 December 2020

Changes in the immune system during and after spaceflight

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12 December 2020

Spaceflight alters microtubules and increases apoptosis in human lymphocytes (Jurkat).

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12 December 2020

Assembly of a Three-Dimensional Multitype Bronchiole Coculture Model Using Magnetic Levitation

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12 December 2020

Some qualitative and quantitative aspects of the fast-rotating clinostat as a research tool

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12 December 2020

Induction and reversal of cell adhesion-dependent multicellular drug resistance in solid breast tumors

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12 December 2020

Overview of the spaceflight radiation environment and its impact on cell biology experiments.

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12 December 2020

The internal dynamics of slowly rotating biological systems.

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12 December 2020

Clinostats and bioreactors

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12 December 2020

Effects of vinblastine and 5-fluorouracil on human glioma and thyroid cancer cell monolayers and spheroids

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12 December 2020

Ground-based studies and space experiment with potato leaf explants

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12 December 2020

Potato tuber formation in the spaceflight environment

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12 December 2020

Hematological and immunological changes during space flight

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12 December 2020

Discovery of differentially expressed genes associated with paclitaxel resistance using cDNA array technology: analysis of interleukin (IL) 6, IL-8, and monocyte chemotactic protein 1 in the paclitaxel-resistant phenotype.

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12 December 2020

Implications for interrelationships between nuclear architecture and control of gene expression under microgravity conditions

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12 December 2020

Epidermal growth factor-induced cell rounding is sensitive to simulated microgravity

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12 December 2020

Antigenic protein in microgravity-grown human mixed Mullerian ovarian tumor (LN1) cells preserved in RNA stabilizing agent.

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12 December 2020

Longterm conditions of mimicked weightlessness influences the cytoskeleton in thyroid cells

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12 December 2020

How cells (might) sense microgravity.

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12 December 2020

Ocular input for human melatonin regulation: relevance to breast cancer.

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12 December 2020

Influence of glucose and buffer capacity in the culture medium on growth and pH in spheroids of human thyroid carcinoma and human glioma origin.

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12 December 2020

Effects of simulated microgravity on thyroid carcinoma cells.

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12 December 2020

Identifiers

DOI

10.1038/NRC3507

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Dimensions Publication ID

28 August 2017

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