mTORC1 regulates CD8+ T-cell glucose metabolism and function independently of PI3K and PKB. (Q38091510)

28 August 2017

mTORC1 regulates CD8+ T-cell glucose metabolism and function independently of PI3K and PKB. (English)

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28 August 2017

David K Finlay

1

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28 August 2017

1 April 2013

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Biochemical Society Transactions

28 August 2017

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28 August 2017

41

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28 August 2017

2

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28 August 2017

681-686

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mTOR signaling in growth control and disease

28 August 2017

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

Notch-induced T cell development requires phosphoinositide-dependent kinase 1.

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120359

Fuel feeds function: energy metabolism and the T-cell response

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

Induction of glucose metabolism in stimulated T lymphocytes is regulated by mitogen-activated protein kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

The CD28 signaling pathway regulates glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120359

c-Myc mediates pre-TCR-induced proliferation but not developmental progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

c-Myc regulates mammalian body size by controlling cell number but not cell size

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120359

Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

The selectivity of protein kinase inhibitors: a further update

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

Specificity and mechanism of action of some commonly used protein kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

The nuts and bolts of AGC protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

FOXO1 regulates L-Selectin and a network of human T cell homing molecules downstream of phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

Novel Foxo1-dependent transcriptional programs control T(reg) cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120359

21 January 2018

Identifiers

DOI

10.1042/BST20120359

1 reference

28 August 2017

1 reference

PubMed ID

23514176