Peroxisome proliferator-activated receptors and Alzheimer's disease: hitting the blood-brain barrier (Q38089668)

28 August 2017

Peroxisome proliferator-activated receptors and Alzheimer's disease: hitting the blood-brain barrier (English)

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28 August 2017

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Juan M Zolezzi

1

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PubMed ID

23494748

28 August 2017

Nibaldo C Inestrosa

series ordinal

2

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28 August 2017

14 March 2013

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28 August 2017

Molecular Neurobiology

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28 August 2017

48

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28 August 2017

438-451

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28 August 2017

3

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https://scigraph.springernature.com/pub.10.1007/s12035-013-8435-5

28 August 2017

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Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1.

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Molecular biology of the blood-brain and the blood-cerebrospinal fluid barriers: similarities and differences

21 January 2018

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Molecular biology of the blood-brain barrier

21 January 2018

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The CNS as a target for peptides and peptide-based drugs

21 January 2018

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Estradiol reduces activity of the blood-brain barrier Na-K-Cl cotransporter and decreases edema formation in permanent middle cerebral artery occlusion

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Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications

21 January 2018

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Lipid rafts and caveolae as portals for endocytosis: new insights and common mechanisms

21 January 2018

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Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells

21 January 2018

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Tissue plasminogen activator inhibits P-glycoprotein activity in brain endothelial cells

21 January 2018

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21 January 2018

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Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood-brain barrier model for drug uptake and transport studies

21 January 2018

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Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease

21 January 2018

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Blood-brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy

21 January 2018

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Blood-brain barrier dysfunction and epilepsy: pathophysiologic role and therapeutic approaches

21 January 2018

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Inflammation and dephosphorylation of the tight junction protein occludin in an experimental model of multiple sclerosis.

21 January 2018

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Neuropsychological assessment of dementia

21 January 2018

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Neuropathology of Alzheimer's disease

21 January 2018

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The nature and effects of cortical microvascular pathology in aging and Alzheimer's disease

21 January 2018

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ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

21 January 2018

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Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease

21 January 2018

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LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.

21 January 2018

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Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

21 January 2018

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Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model

21 January 2018

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Association of ApoE and LRP mRNA levels with dementia and AD neuropathology

21 January 2018

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Association of CLU and PICALM variants with Alzheimer's disease.

21 January 2018

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Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

21 January 2018

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Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease

21 January 2018

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Apolipoprotein E3 (ApoE3) but not ApoE4 protects against synaptic loss through increased expression of protein kinase C epsilon

21 January 2018

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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

21 January 2018

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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

21 January 2018

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Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease

21 January 2018

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Blood-brain barrier P-glycoprotein function in healthy subjects and Alzheimer's disease patients: effect of polymorphisms in the ABCB1 gene

21 January 2018

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Inflammation-induced dysfunction of the low-density lipoprotein receptor-related protein-1 at the blood-brain barrier: protection by the antioxidant N-acetylcysteine

21 January 2018

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Lipopolysaccharide impairs amyloid β efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood-brain barrier

21 January 2018

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No evidence for additional blood-brain barrier P-glycoprotein dysfunction in Alzheimer's disease patients with microbleeds

21 January 2018

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1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells

21 January 2018

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Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice

21 January 2018

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Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Peripheral reduction of β-amyloid is sufficient to reduce brain β-amyloid: implications for Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Aβ₁₋₄₂-RAGE interaction disrupts tight junctions of the blood-brain barrier via Ca²⁺-calcineurin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

The dioxin and peroxisome proliferator-activated receptors: nuclear receptors in search of endogenous ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Peroxisomal proliferation protects from beta-amyloid neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Nuclear receptors as therapeutic targets for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Metabolic health and nuclear-receptor sensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

New insights into the role of peroxisome proliferator-activated receptors in regulating the inflammatory response after tissue injury

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Peroxisome proliferator-activated receptor gamma (PPAR-γ) and neurodegenerative disorders

21 January 2018

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21 January 2018

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The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment

21 January 2018

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PPARγ and Oxidative Stress: Con(β) Catenating NRF2 and FOXO

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Peroxisome proliferator-activated receptor-γ activation reduces cyclooxygenase-2 expression in vascular smooth muscle cells from hypertensive rats by interfering with oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Preclinical success against Alzheimer's disease with an old drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

ApoE promotes the proteolytic degradation of Abeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Mechanisms underlying the rapid peroxisome proliferator-activated receptor-γ-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

In vivo imaging reveals selective peroxisome proliferator activated receptor modulator activity of the synthetic ligand 3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid (MK-886).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Regulation of breast cancer resistant protein by peroxisome proliferator-activated receptor α in human brain microvessel endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Peroxisome-proliferator-activated receptor-alpha activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Peroxisome proliferator-activated receptor delta regulation of miR-15a in ischemia-induced cerebral vascular endothelial injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

PPARalpha and PPARgamma attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

PPARα and PPARγ protect against HIV-1-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

PPAR gamma activation protects the brain against microvascular dysfunction in sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Peroxisome proliferator-activated receptor-γ activation with angiotensin II type 1 receptor blockade is pivotal for the prevention of blood-brain barrier impairment and cognitive decline in type 2 diabetic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Oxidative damage in Alzheimer's.

21 January 2018

1 reference

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Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Pioglitazone treatment increases COX-2-derived prostacyclin production and reduces oxidative stress in hypertensive rats: role in vascular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

The ethics of early evidence--preparing for a possible breakthrough in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Brain drug targeting: a computational approach for overcoming blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Preliminary biocompatibility investigation of magnetic albumin nanosphere designed as a potential versatile drug delivery system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-013-8435-5

Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease

21 January 2018

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12 December 2020

Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease

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12 December 2020

Impaired mitochondrial function in psychiatric disorders

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12 December 2020

Astrocytic A beta 1-42 uptake is determined by A beta-aggregation state and the presence of amyloid-associated proteins

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12 December 2020

Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis

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12 December 2020

Na(+)-dependent glutamate transporters (EAAT1, EAAT2, and EAAT3) of the blood-brain barrier. A mechanism for glutamate removal

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12 December 2020

Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease.

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12 December 2020

In vitro models of the blood-brain barrier

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12 December 2020

Immunohistochemical localization of adherens junction components in blood-brain barrier microvessels of the rat.

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12 December 2020

Mrp1 multidrug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells.

1 reference

12 December 2020

Peroxisome proliferators reduce spatial memory impairment, synaptic failure, and neurodegeneration in brains of a double transgenic mice model of Alzheimer's disease

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12 December 2020

From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-β levels

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12 December 2020

Enhanced brain amyloid-β clearance by rifampicin and caffeine as a possible protective mechanism against Alzheimer's disease

1 reference

12 December 2020

ABCG2- and ABCG4-mediated efflux of amyloid-β peptide 1-40 at the mouse blood-brain barrier

1 reference

12 December 2020

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

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12 December 2020

Carbon nanotube-mediated wireless cell permeabilization: drug and gene uptake

1 reference

12 December 2020

Prediction of blood-brain barrier permeation in drug discovery from in vivo, in vitro and in silico models

1 reference

12 December 2020

The active and passive exchanges of inorganic ions through the surfaces of living cells and through living membranes generally

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12 December 2020

Peripheral administration of antisense oligonucleotides targeting the amyloid-β protein precursor reverses AβPP and LRP-1 overexpression in the aged SAMP8 mouse brain

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12 December 2020

Blood-brain barrier-specific properties of a human adult brain endothelial cell line

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12 December 2020

Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein

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12 December 2020

Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition

1 reference

12 December 2020

Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system.

1 reference

12 December 2020

10.1007/S12035-013-8435-5

Identifiers

DOI

1 reference

PubMed ID

23494748

Dimensions Publication ID

28 August 2017

0 references

1 reference

PubMed ID

23494748