Activated protein C in the treatment of acute lung injury and acute respiratory distress syndrome (Q38089190)

28 August 2017

Activated protein C in the treatment of acute lung injury and acute respiratory distress syndrome (English)

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acute respiratory distress syndrome

28 August 2017

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4

Marcus J Schultz

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28 August 2017

Alexander D Cornet

1

1 reference

28 August 2017

Geerten P van Nieuw Amerongen

2

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28 August 2017

Albertus Beishuizen

3

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28 August 2017

Armand Rj Girbes

5

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28 August 2017

Ab Johan Groeneveld

6

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28 August 2017

language of work or name

English

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publication date

1 March 2009

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Expert Opinion on Drug Discovery

28 August 2017

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28 August 2017

4

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28 August 2017

3

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28 August 2017

219-227

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Incidence and outcomes of acute lung injury

28 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Epidemiology of acute lung injury and acute respiratory distress syndrome in The Netherlands: a survey.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440902721204

Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440902721204

Vascular pharmacology of acute lung injury and acute respiratory distress syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

The acute respiratory distress syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Cytokine balance in the lungs of patients with acute respiratory distress syndrome

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440902721204

The alveolar-epithelial barrier: a target for potential therapy

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440902721204

The endothelium in acute lung injury/acute respiratory distress syndrome

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440902721204

Bidirectional relation between inflammation and coagulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Bench-to-bedside review: functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

From evidence to clinical practice: effective implementation of therapeutic hypothermia to improve patient outcome after cardiac arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Randomized clinical trial of activated protein C for the treatment of acute lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Recombinant human activated protein C attenuates endotoxin-induced lung injury in awake sheep.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Protein C and thrombomodulin in human acute lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Thrombin-induced endothelial barrier disruption in intact microvessels: role of RhoA/Rho kinase-myosin phosphatase axis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Efficacy and safety of recombinant human activated protein C for severe sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

The cytoprotective protein C pathway

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440902721204

Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460440902721204

Activated protein C up-regulates IL-10 and inhibits tissue factor in blood monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Gene expression profiling of inflamed human endothelial cells and influence of activated protein C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

The effects of activated protein C and prostacyclin on arterial oxygenation and protein leakage in the lung and the gut under endotoxaemia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Effect of human recombinant interleukin-6 and interleukin-8 on monocyte procoagulant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Inhalation of activated protein C inhibits endotoxin-induced pulmonary inflammation in mice independent of neutrophil recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Expression and function of the endothelial protein C receptor in human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Effect of activated protein C on pulmonary blood flow and cytokine production in experimental acute lung injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Activated protein C attenuates intestinal reperfusion-induced acute lung injury: an experimental study in a rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Activated protein C inhibits the release of macrophage inflammatory protein-1-alpha from THP-1 cells and from human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Wnt5A/CaMKII signaling contributes to the inflammatory response of macrophages and is a target for the antiinflammatory action of activated protein C and interleukin-10

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Activated protein C attenuates acid-aspiration lung injury in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Drotrecogin alfa (activated) prevents smoke-induced increases in pulmonary microvascular permeability and proinflammatory cytokine IL-1beta in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Mechanisms of bacterial lipopolysaccharide-induced endothelial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Influence of drotrecogin alpha (activated) infusion on the variation of Bax/Bcl-2 and Bax/Bcl-xl ratios in circulating mononuclear cells: a cohort study in septic shock patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Activated protein C decreases tumor necrosis factor related apoptosis-inducing ligand by an EPCR- independent mechanism involving Egr-1/Erk-1/2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Protective signaling by activated protein C is mechanistically linked to protein C activation on endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actinin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

PAR1 cleavage and signaling in response to activated protein C and thrombin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Beneficial effects of recombinant human activated protein C in a ewe model of septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Intravenous administration of activated protein C in Pseudomonas-induced lung injury: impact on lung fluid balance and the inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Severe community-acquired pneumonia as a cause of severe sepsis: data from the PROWESS study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Use of an integrated clinical trial database to evaluate the effect of timing of drotrecogin alfa (activated) treatment in severe sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

The acute respiratory distress syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Is APC activation of endothelial cell PAR1 important in severe sepsis?: No.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

Activated Protein C Protection from Lung Inflammation in Endotoxin-Induced Injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460440902721204

10.1517/17460440902721204

21 January 2018

Identifiers

DOI

1 reference

release_rku5hrucvba2rlqqlt5fxqeczq

28 August 2017

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https://api.fatcat.wiki/v0/release/rku5hrucvba2rlqqlt5fxqeczq

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24 November 2022

based on heuristic

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