The risks of targeting co-inhibitory pathways to modulate pathogen-directed T cell responses (Q38075327)

28 August 2017

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title

The risks of targeting co-inhibitory pathways to modulate pathogen-directed T cell responses (English)

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28 August 2017

2

Annette Oxenius

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28 August 2017

Helge Frebel

1

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28 August 2017

16 January 2013

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28 August 2017

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28 August 2017

34

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28 August 2017

5

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28 August 2017

193-199

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Restoring function in exhausted CD8 T cells during chronic viral infection

28 August 2017

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12 December 2020

Cell intrinsic mechanisms of T-cell inhibition and application to cancer therapy

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12 December 2020

The role of TNF superfamily members in T-cell function and diseases

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12 December 2020

Safety, activity, and immune correlates of anti-PD-1 antibody in cancer

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12 December 2020

PD-1 inhibits antiviral immunity at the effector phase in the liver

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12 December 2020

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

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12 December 2020

The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology

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12 December 2020

IFN-gamma-receptor signaling ameliorates transplant vasculopathy through attenuation of CD8+ T-cell-mediated injury of vascular endothelial cells

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12 December 2020

Inhibitory receptors on lymphocytes: insights from infections

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12 December 2020

Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice.

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12 December 2020

PD-1 blockade in rhesus macaques: impact on chronic infection and prophylactic vaccination

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12 December 2020

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

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12 December 2020

The CD160, BTLA, LIGHT/HVEM pathway: a bidirectional switch regulating T-cell activation

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12 December 2020

B7-h1 expressed by activated CD8 T cells is essential for their survival.

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12 December 2020

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

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12 December 2020

How chronic viral infections impact on antigen-specific T-cell responses

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12 December 2020

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8+ T cell activation and cytolysis

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12 December 2020

Immunoregulation by tumor necrosis factor superfamily member LIGHT

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12 December 2020

Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo

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12 December 2020

PD-1 and its ligands in tolerance and immunity

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12 December 2020

CD160 and PD-1 co-expression on HIV-specific CD8 T cells defines a subset with advanced dysfunction

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12 December 2020

Innate IFN-γ is essential for programmed death ligand-1-mediated T cell stimulation following Listeria monocytogenes infection

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12 December 2020

PD-L1-expressing dendritic cells contribute to viral resistance during acute HSV-1 infection

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12 December 2020

Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection

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12 December 2020

PD-1: an inhibitory immunoreceptor involved in peripheral tolerance

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12 December 2020

Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection

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12 December 2020

A PD-1 polymorphism is associated with disease progression in multiple sclerosis.

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12 December 2020

Programmed death (PD)-1:PD-ligand 1/PD-ligand 2 pathway inhibits T cell effector functions during human tuberculosis

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12 December 2020

B7-H1 (programmed cell death ligand 1) is required for the development of multifunctional Th1 cells and immunity to primary, but not secondary, Salmonella infection

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12 December 2020

B7-H1 (CD274) inhibits the development of herpetic stromal keratitis (HSK).

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12 December 2020

PD-1/PD-L1 pathway and T-cell exhaustion in chronic hepatitis virus infection

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12 December 2020

Programmed death (PD)-1-deficient mice are extremely sensitive to murine hepatitis virus strain-3 (MHV-3) infection

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12 December 2020

Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis

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12 December 2020

Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor

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12 December 2020

Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis.

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12 December 2020

Murine malaria is exacerbated by CTLA-4 blockade

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12 December 2020

Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade

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12 December 2020

Exhaustion of tumor-specific CD8⁺ T cells in metastases from melanoma patients

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12 December 2020

HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria

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12 December 2020

The emerging toxicity profiles of anti-CTLA-4 antibodies across clinical indications

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12 December 2020

Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis.

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12 December 2020

The B7-CD28 superfamily

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12 December 2020

Immune modulation through 4-1BB enhances SIV vaccine protection in non-human primates against SIVmac251 challenge

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12 December 2020

Blockade of cytotoxic T-lymphocyte antigen-4 by ipilimumab results in dysregulation of gastrointestinal immunity in patients with advanced melanoma.

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12 December 2020

Interleukin-10 determines viral clearance or persistence in vivo

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12 December 2020

Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators

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12 December 2020

Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis

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12 December 2020

Programmed death ligand 2 regulates arginase induction and modifies Trypanosoma cruzi survival in macrophages during murine experimental infection

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12 December 2020

Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production

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12 December 2020

Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis

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12 December 2020

Combined blockade of programmed death-1 and activation of CD137 increase responses of human liver T cells against HBV, but not HCV.

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12 December 2020

Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice.

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12 December 2020

Cutting edge: T cell Ig mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity

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12 December 2020

CTLA-4 is important in maintaining long-term survival of cardiac allografts

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12 December 2020

The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut

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12 December 2020

Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection

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12 December 2020

Critical roles for LIGHT and its receptors in generating T cell-mediated immunity during Leishmania donovani infection

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12 December 2020

B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation

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12 December 2020

Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load

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12 December 2020

The PD-1 pathway in tolerance and autoimmunity

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12 December 2020

Coinhibitory molecules in hematologic malignancies: targets for therapeutic intervention

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12 December 2020

B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis.

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12 December 2020

Fatal pancreatitis in simian immunodeficiency virus SIV(mac251)-infected macaques treated with 2',3'-dideoxyinosine and stavudine following cytotoxic-T-lymphocyte-associated antigen 4 and indoleamine 2,3-dioxygenase blockade

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12 December 2020

Enhanced upper genital tract pathologies by blocking Tim-3 and PD-L1 signaling pathways in mice intravaginally infected with Chlamydia muridarum

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12 December 2020

Control of Toxoplasma reactivation by rescue of dysfunctional CD8+ T-cell response via PD-1-PDL-1 blockade

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12 December 2020

Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation

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12 December 2020

Role of PD-1 in HIV pathogenesis and as target for therapy

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12 December 2020

Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points

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12 December 2020

CTLA-4 blockade differentially influences the outcome of non-lethal and lethal Plasmodium yoelii infections

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12 December 2020

CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition

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12 December 2020

PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice.

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12 December 2020

The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo

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12 December 2020

Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells.

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12 December 2020

Blocking of PDL-1 interaction enhances primary and secondary CD8 T cell response to herpes simplex virus-1 infection

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12 December 2020

PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells

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12 December 2020

The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum

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12 December 2020

CNS expression of B7-H1 regulates pro-inflammatory cytokine production and alters severity of Theiler's virus-induced demyelinating disease

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12 December 2020

4-1BB signaling synergizes with programmed death ligand 1 blockade to augment CD8 T cell responses during chronic viral infection

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12 December 2020

PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis

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12 December 2020

Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates

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12 December 2020

Enhancement of antitumor immunity by CTLA-4 blockade

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12 December 2020

Identifiers

DOI

10.1016/J.IT.2012.12.002

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release_3qbj2ra3efc7tmyr6ucdpn4tva

28 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/3qbj2ra3efc7tmyr6ucdpn4tva

24 November 2022

mapped directly with Wikidata item

1 reference

https://api.fatcat.wiki/v0/release/3qbj2ra3efc7tmyr6ucdpn4tva

24 November 2022

mapped directly with Wikidata item

PubMed ID

23333205

1 reference

PubMed ID

23333205