Control limits for accumulation of plant metabolites: brute force is no substitute for understanding. (Q38072750)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23301840%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

review article

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title

Control limits for accumulation of plant metabolites: brute force is no substitute for understanding (English)

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21 February 2020

1

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21 February 2020

author name string

Piero Morandini

series ordinal

1

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28 August 2017

10 January 2013

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23301840%20AND%20SRC:MED&resulttype=core&format=json

Plant Biotechnology Journal

21 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23301840%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

volume

11

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21 February 2020

page(s)

253-267

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21 February 2020

issue

2

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Generation of transgenic maize with enhanced provitamin A content

21 February 2020

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High-lysine maize: the key discoveries that have made it possible

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Increase in ascorbate content of transgenic tobacco plants overexpressing the acerola (Malpighia glabra) phosphomannomutase gene

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A golden era—pro-vitamin A enhancement in diverse crops

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Field performance of transgenic sugarcane expressing isomaltulose synthase.

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Physiological and developmental regulation of seed oil production.

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Production of renewable polymers from crop plants

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Folate biofortification in food plants

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Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

21 January 2018

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Golden Rice and 'Golden' crops for human nutrition

21 January 2018

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Transgenic Arabidopsis plants can accumulate polyhydroxybutyrate to up to 4% of their fresh weight.

21 January 2018

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Expression in yeast and tobacco of plant cDNAs encoding acyl CoA:diacylglycerol acyltransferase

21 January 2018

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Enhancing ascorbate in fruits and tubers through over-expression of the L-galactose pathway gene GDP-L-galactose phosphorylase.

21 January 2018

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Metabolic engineering of hydroxy fatty acid production in plants: RcDGAT2 drives dramatic increases in ricinoleate levels in seed oil.

21 January 2018

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Fructan biosynthesis in transgenic plants

21 January 2018

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An in vivo data-driven framework for classification and quantification of enzyme kinetics and determination of apparent thermodynamic data

21 January 2018

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A comparative transcriptomic, fluxomic and metabolomic analysis of the response of Saccharomyces cerevisiae to increases in NADPH oxidation

21 January 2018

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Compartmentation of triacylglycerol accumulation in plants

21 January 2018

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Co-ordinated synthesis of gentiobiitol and sorbitol, evidence of sorbitol glycosylation in transgenic sugarcane

21 January 2018

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Homogentisate phytyltransferase activity is limiting for tocopherol biosynthesis in Arabidopsis

21 January 2018

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Manipulation of L-ascorbic acid biosynthesis pathways in Solanum lycopersicum: elevated GDP-mannose pyrophosphorylase activity enhances L-ascorbate levels in red fruit.

21 January 2018

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Understanding the regulation of aspartate metabolism using a model based on measured kinetic parameters

21 January 2018

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Altering trehalose-6-phosphate content in transgenic potato tubers affects tuber growth and alters responsiveness to hormones during sprouting.

21 January 2018

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Engineered sorbitol accumulation induces dwarfism in Japanese persimmon

21 January 2018

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An engineered sorbitol cycle alters sugar composition, not growth, in transformed tobacco.

21 January 2018

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Progress in the dissection and manipulation of vitamin E synthesis

21 January 2018

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Vitamin synthesis in plants: tocopherols and carotenoids

21 January 2018

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Folate biofortification in tomatoes by engineering the pteridine branch of folate synthesis

21 January 2018

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Folate biofortification of tomato fruit

21 January 2018

1 reference

Metabolic engineering of potato carotenoid content through tuber-specific overexpression of a bacterial mini-pathway

21 January 2018

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Integrated metabolomic and transcriptomic analyses of high-tryptophan rice expressing a mutant anthranilate synthase alpha subunit.

21 January 2018

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Response of Pseudomonas putida KT2440 to increased NADH and ATP demand.

21 January 2018

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Engineering vitamin E content: from Arabidopsis mutant to soy oil.

21 January 2018

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Elevation of seed alpha-tocopherol levels using plant-based transcription factors targeted to an endogenous locus

21 January 2018

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Nutritious crops producing multiple carotenoids--a metabolic balancing act.

21 January 2018

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Combinatorial genetic transformation of cereals and the creation of metabolic libraries for the carotenoid pathway

21 January 2018

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Transgenic rice grains expressing a heterologous ρ-hydroxyphenylpyruvate dioxygenase shift tocopherol synthesis from the γ to the α isoform without increasing absolute tocopherol levels

21 January 2018

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Physiological control of metabolic flux: the requirement for multisite modulation

21 January 2018

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Vitamin deficiencies in humans: can plant science help?

21 January 2018

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Genetic engineering of carotenoid formation in tomato fruit and the potential application of systems and synthetic biology approaches

21 January 2018

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Coexpression analysis identifies Rice Starch Regulator1, a rice AP2/EREBP family transcription factor, as a novel rice starch biosynthesis regulator

21 January 2018

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Pathway engineering of Brassica napus seeds using multiple key enzyme genes involved in ketocarotenoid formation

21 January 2018

1 reference

Removing allergens and reducing toxins from food crops

21 January 2018

1 reference

Repression of seed maturation genes by a trihelix transcriptional repressor in Arabidopsis seedlings

21 January 2018

1 reference

Regulation of starch biosynthesis in response to a fluctuating environment

21 January 2018

1 reference

Sucrose metabolism in plastids

21 January 2018

1 reference

Bacterial growth rate reflects a bottleneck in resource allocation

21 January 2018

1 reference

Field trials and tribulations--making sense of the regulations for experimental field trials of transgenic crops in Europe

21 January 2018

1 reference

Microbial sucrose isomerases: producing organisms, genes and enzymes

21 January 2018

1 reference

Use of TILLING and robotised enzyme assays to generate an allelic series of Arabidopsis thaliana mutants with altered ADP-glucose pyrophosphorylase activity

21 January 2018

1 reference

Folate biosynthesis, turnover, and transport in plants.

21 January 2018

1 reference

Natural genetic variation in lycopene epsilon cyclase tapped for maize biofortification

21 January 2018

1 reference

Biosynthesis of astaxanthin in tobacco leaves by transplastomic engineering

21 January 2018

1 reference

Transgenic potato tubers accumulate high levels of 1-kestose and nystose: functional identification of a sucrose sucrose 1-fructosyltransferase of artichoke (Cynara scolymus) blossom discs

21 January 2018

1 reference

Transgenic potato (Solanum tuberosum) tubers synthesize the full spectrum of inulin molecules naturally occurring in globe artichoke (Cynara scolymus) roots

21 January 2018

1 reference

Enhanced ascorbic acid accumulation in transgenic potato confers tolerance to various abiotic stresses

21 January 2018

1 reference

Metabolic engineering of omega3-very long chain polyunsaturated fatty acid production by an exclusively acyl-CoA-dependent pathway

21 January 2018

1 reference

Metabolic regulation: a control analytic perspective

21 January 2018

1 reference

Regulating the cellular economy of supply and demand

21 January 2018

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Supply-demand analysis a framework for exploring the regulatory design of metabolism

21 January 2018

1 reference

Enhancement of folates in plants through metabolic engineering

21 January 2018

1 reference

Improving nutritional quality of maize proteins by expressing sense and antisense zein genes

21 January 2018

1 reference

High lysine and high tryptophan transgenic maize resulting from the reduction of both 19- and 22-kD alpha-zeins.

21 January 2018

1 reference

The tryptophan pathway is involved in the defense responses of rice against pathogenic infection via serotonin production

21 January 2018

1 reference

Storage Protein Synthesis in Maize: II. Reduced Synthesis of a Major Zein Component by the Opaque-2 Mutant of Maize.

21 January 2018

1 reference

Alterations in tocopherol cyclase activity in transgenic and mutant plants of Arabidopsis affect tocopherol content, tocopherol composition, and oxidative stress.

21 January 2018

1 reference

Metabolically engineered oilseed crops with enhanced seed tocopherol

21 January 2018

1 reference

Endoplasmic reticulum-located PDAT1-2 from castor bean enhances hydroxy fatty acid accumulation in transgenic plants

21 January 2018

1 reference

Down-regulation of β-carotene hydroxylase increases β-carotene and total carotenoids enhancing salt stress tolerance in transgenic cultured cells of sweetpotato.

21 January 2018

1 reference

The multifaceted role of aspartate-family amino acids in plant metabolism

21 January 2018

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Application of functional genomics to pathway optimization for increased isoprenoid production.

21 January 2018

1 reference

Lysophosphatidic acid acyltransferase from coconut endosperm mediates the insertion of laurate at the sn-2 position of triacylglycerols in lauric rapeseed oil and can increase total laurate levels

21 January 2018

1 reference

The glycolytic flux in Escherichia coli is controlled by the demand for ATP.

21 January 2018

1 reference

The extent to which ATP demand controls the glycolytic flux depends strongly on the organism and conditions for growth

21 January 2018

1 reference

Chemically inducible expression of the PHB biosynthetic pathway in Arabidopsis.

21 January 2018

1 reference

Transport and sorting of the solanum tuberosum sucrose transporter SUT1 is affected by posttranslational modification

21 January 2018

1 reference

Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts.

21 January 2018

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The role of plastidial glucose-6-phosphate/phosphate translocators in vegetative tissues of Arabidopsis thaliana mutants impaired in starch biosynthesis

21 January 2018

1 reference

Phenology, growth and physiological adjustments of oil palm (Elaeis guineensis) to sink limitation induced by fruit pruning.

21 January 2018

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Vernonia DGATs increase accumulation of epoxy fatty acids in oil.

21 January 2018

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Post-translational redox modification of ADP-glucose pyrophosphorylase in response to light is not a major determinant of fine regulation of transitory starch accumulation in Arabidopsis leaves.

21 January 2018

1 reference

Nanometer propagation of millisecond motions in V-type allostery

21 January 2018

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The cauliflower Or gene encodes a DnaJ cysteine-rich domain-containing protein that mediates high levels of beta-carotene accumulation.

21 January 2018

1 reference

New frontiers in oilseed biotechnology: meeting the global demand for vegetable oils for food, feed, biofuel, and industrial applications

21 January 2018

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Carotenoid crystal formation in Arabidopsis and carrot roots caused by increased phytoene synthase protein levels

21 January 2018

1 reference

Expression of rapeseed microsomal lysophosphatidic acid acyltransferase isozymes enhances seed oil content in Arabidopsis.

21 January 2018

1 reference

The ethanolic fermentation pathway supports respiration and lipid biosynthesis in tobacco pollen

21 January 2018

1 reference

Biosynthesis, regulation and functions of tocochromanols in plants

21 January 2018

1 reference

NTRC links built-in thioredoxin to light and sucrose in regulating starch synthesis in chloroplasts and amyloplasts.

21 January 2018

1 reference

Seed-specific heterologous expression of a nasturtium FAE gene in Arabidopsis results in a dramatic increase in the proportion of erucic acid

21 January 2018

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The regulation of agricultural biotechnology: science shows a better way.

21 January 2018

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Impact of unusual fatty acid synthesis on futile cycling through beta-oxidation and on gene expression in transgenic plants

21 January 2018

1 reference

The second green revolution? Production of plant-based biodegradable plastics

21 January 2018

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Rethinking metabolic control.

21 January 2018

1 reference

Inactivation of allergens and toxins

21 January 2018

1 reference

Metabolic control analysis: a tool for designing strategies to manipulate metabolic pathways.

21 January 2018

1 reference

Metabolic profiling of tryptophan-overproducing rice calli that express a feedback-insensitive alpha subunit of anthranilate synthase

21 January 2018

1 reference

Efficient silencing of reporter transgenes coupled to known functional promoters in sugarcane, a highly polyploid crop species

21 January 2018

1 reference

Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways

21 January 2018

1 reference

When more is better: multigene engineering in plants

21 January 2018

1 reference

Synergistic metabolism in hybrid corn indicates bottlenecks in the carotenoid pathway and leads to the accumulation of extraordinary levels of the nutritionally important carotenoid zeaxanthin.

21 January 2018

1 reference

Targeting of the polyhydroxybutyrate biosynthetic pathway to the plastids of Arabidopsis thaliana results in high levels of polymer accumulation

21 January 2018

1 reference

Metabolic engineering of seeds can achieve levels of omega-7 fatty acids comparable with the highest levels found in natural plant sources

21 January 2018

1 reference

A strategy for increasing an in vivo flux by genetic manipulations. The tryptophan system of yeast

21 January 2018

1 reference

Arabidopsis 3-hydroxy-3-methylglutaryl-CoA reductase is regulated at the post-translational level in response to alterations of the sphingolipid and the sterol biosynthetic pathways

21 January 2018

1 reference

Folate biofortification of lettuce by expression of a codon optimized chicken GTP cyclohydrolase I gene

21 January 2018

1 reference

Expression of fungal diacylglycerol acyltransferase2 genes to increase kernel oil in maize

21 January 2018

1 reference

Decreased expression of plastidial adenylate kinase in potato tubers results in an enhanced rate of respiration and a stimulation of starch synthesis that is attributable to post-translational redox-activation of ADP-glucose pyrophosphorylase

21 January 2018

1 reference

Genetically modified myths and realities

21 January 2018

1 reference

Sink regulation of photosynthesis.

21 January 2018

1 reference

Recruiting a new substrate for triacylglycerol synthesis in plants: the monoacylglycerol acyltransferase pathway

21 January 2018

1 reference

Regulation must be revolutionized

21 January 2018

1 reference

Duplicate maize Wrinkled1 transcription factors activate target genes involved in seed oil biosynthesis.

21 January 2018

1 reference

Ascorbic acid contents in transgenic potato plants overexpressing two dehydroascorbate reductase genes.

21 January 2018

1 reference

Analysis of transgenic tobacco plants containing varying amounts of ribulose-1,5-bisphosphate carboxylase/oxygenase

21 January 2018

1 reference

Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome

21 January 2018

1 reference

Engineering plant shikimate pathway for production of tocotrienol and improving herbicide resistance

21 January 2018

1 reference

Engineering fructan metabolism in plants

21 January 2018

1 reference

Engineering plastid fatty acid biosynthesis to improve food quality and biofuel production in higher plants

21 January 2018

1 reference

Identifying and characterising regulatory metabolites with generalised supply-demand analysis.

21 January 2018

1 reference

Kinetic and thermodynamic aspects of enzyme control and regulation.

21 January 2018

1 reference

Sugar sensing and signaling in plants: conserved and novel mechanisms

21 January 2018

1 reference

Metabolic engineering of the omega-3 long chain polyunsaturated fatty acid biosynthetic pathway into transgenic plants.

21 January 2018

1 reference

The BioCassava plus program: biofortification of cassava for sub-Saharan Africa

21 January 2018

1 reference

Overproduction of glycolytic enzymes in yeast

21 January 2018

1 reference

Expression of ZmLEC1 and ZmWRI1 increases seed oil production in maize

21 January 2018

1 reference

Sorbitol-6-phosphate dehydrogenase expression in transgenic tobacco. High amounts of sorbitol lead to necrotic lesions

21 January 2018

1 reference

Disturbance in the allocation of carbohydrates to regenerative organs in transgenic Nicotiana tabacum L.

21 January 2018

1 reference

Oil accumulation in leaves directed by modification of fatty acid breakdown and lipid synthesis pathways

21 January 2018

1 reference

Production of polyhydroxybutyrate in switchgrass, a value-added co-product in an important lignocellulosic biomass crop

21 January 2018

1 reference

Folate fortification of rice by metabolic engineering.

21 January 2018

1 reference

Biotechnological approaches for the production of polyhydroxyalkanoates in microorganisms and plants - a review

21 January 2018

1 reference

Molecular cloning and characterization of a KCS gene from Cardamine graeca and its heterologous expression in Brassica oilseeds to engineer high nervonic acid oils for potential medical and industrial use.

21 January 2018

1 reference

Glyoxalase I--structure, function and a critical role in the enzymatic defence against glycation

21 January 2018

1 reference

Peroxisomal polyhydroxyalkanoate biosynthesis is a promising strategy for bioplastic production in high biomass crops

21 January 2018

1 reference

Evidence that the hexose-to-sucrose ratio does not control the switch to storage product accumulation in oilseeds: analysis of tobacco seed development and effects of overexpressing apoplastic invertase

21 January 2018

1 reference

Metabolic engineering of plants to produce very long-chain polyunsaturated fatty acids

21 January 2018

1 reference

Analysis of polyhydroxybutyrate flux limitations by systematic genetic and metabolic perturbations

21 January 2018

1 reference

Improving the content of essential amino acids in crop plants: goals and opportunities

21 January 2018

1 reference

Transgenic potato overproducing L-ascorbic acid resisted an increase in methylglyoxal under salinity stress via maintaining higher reduced glutathione level and glyoxalase enzyme activity.

21 January 2018

1 reference

Biotechnological production and application of vitamin E: current state and prospects

21 January 2018

1 reference

Nonsymbiotic hemoglobin-2 leads to an elevated energy state and to a combined increase in polyunsaturated fatty acids and total oil content when overexpressed in developing seeds of transgenic Arabidopsis plants

21 January 2018

1 reference

High-level tryptophan accumulation in seeds of transgenic rice and its limited effects on agronomic traits and seed metabolite profile.

21 January 2018

1 reference

Developmental and feedforward control of the expression of folate biosynthesis genes in tomato fruit.

21 January 2018

1 reference

Expression of a heterologous SnRK1 in tomato increases carbon assimilation, nitrogen uptake and modifies fruit development.

21 January 2018

1 reference

Increased vitamin C content accompanied by an enhanced recycling pathway confers oxidative stress tolerance in Arabidopsis

21 January 2018

1 reference

Engineering starch accumulation by manipulation of phosphate metabolism of starch.

21 January 2018

1 reference

Increasing the flow of carbon into seed oil.

21 January 2018

1 reference

Production of tailor-made fructans in sugar beet by expression of onion fructosyltransferase genes

21 January 2018

1 reference

Isomaltulose is actively metabolized in plant cells.

21 January 2018

1 reference

Stepwise engineering to produce high yields of very long-chain polyunsaturated fatty acids in plants

21 January 2018

1 reference

Maize provitamin a carotenoids, current resources, and future metabolic engineering challenges

21 January 2018

1 reference

An overview on the role of methylglyoxal and glyoxalases in plants

21 January 2018

1 reference

Rare genetic variation at Zea mays crtRB1 increases beta-carotene in maize grain

21 January 2018

1 reference

Metabolomics-driven quantitative analysis of ammonia assimilation in E. coli

21 January 2018

1 reference

Metabolic engineering of plant L-ascorbic acid biosynthesis: recent trends and applications.

21 January 2018

1 reference

Overriding the co-limiting import of carbon and energy into tuber amyloplasts increases the starch content and yield of transgenic potato plants

21 January 2018

1 reference

Overexpression of SlGMEs leads to ascorbate accumulation with enhanced oxidative stress, cold, and salt tolerance in tomato.

21 January 2018

1 reference

A phenylalanine in DGAT is a key determinant of oil content and composition in maize

21 January 2018

1 reference

Increased lysine synthesis coupled with a knockout of its catabolism synergistically boosts lysine content and also transregulates the metabolism of other amino acids in Arabidopsis seeds

21 January 2018

1 reference

Lysine metabolism is concurrently regulated by synthesis and catabolism in both reproductive and vegetative tissues

21 January 2018

1 reference

Combinatorial genetic transformation generates a library of metabolic phenotypes for the carotenoid pathway in maize

21 January 2018

1 reference

Simultaneous expression of Arabidopsis ρ-hydroxyphenylpyruvate dioxygenase and MPBQ methyltransferase in transgenic corn kernels triples the tocopherol content

21 January 2018

1 reference

21 January 2018

1 reference

Trade-offs between biomass growth and inducible biosynthesis of polyhydroxybutyrate in transgenic poplar

21 January 2018

1 reference

Synthesis of Short-Chain-Length/Medium-Chain Length Polyhydroxyalkanoate (PHA) Copolymers in Peroxisomes of Transgenic Sugarcane Plants

21 January 2018

1 reference

Enhanced polyhydroxybutyrate production in transgenic sugarcane

21 January 2018

1 reference

Retention during Processing and Bioaccessibility of β-Carotene in High β-Carotene Transgenic Cassava Root

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/PBI.12035

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23301840%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23301840%20AND%20SRC:MED&resulttype=core&format=json