Plasmodium cell biology should inform strategies used in the development of antimalarial transmission-blocking drugs (Q38066991)

28 August 2017

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title

Plasmodium cell biology should inform strategies used in the development of antimalarial transmission-blocking drugs (English)

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28 August 2017

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Michael J Delves

1

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publication date

1 December 2012

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Future Medicinal Chemistry

28 August 2017

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28 August 2017

4

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28 August 2017

18

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28 August 2017

2251-2263

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A Research Agenda to Underpin Malaria Eradication

28 August 2017

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https://api.crossref.org/works/10.4155%2FFMC.12.182

The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Thousands of chemical starting points for antimalarial lead identification

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Chemical genetics of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence "transmission blocking" assay

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

A malaria gametocytocidal assay using oxidoreduction indicator, alamarBlue

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Plasmodium falciparum gametocytes: the effect of chloroquine on their development

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparum

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Antimalarial drugs and the mosquito transmission of Plasmodium

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Transmission-blocking activities of quinine, primaquine, and artesunate

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

24- and 48-hour cycles of malaria parasites in the blood; their purpose, production and control

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Proteome analysis of separated male and female gametocytes reveals novel sex-specific Plasmodium biology

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Sex ratio of Plasmodium falciparum gametocytes in inhabitants of Dielmo, Senegal

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Plasmodium falciparum gametocyte carriage, sex ratios and asexual parasite rates in Nigerian children before and after a treatment protocol policy change instituting the use of artemisinin-based combination therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Identification of xanthurenic acid as the putative inducer of malaria development in the mosquito

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

The action of metabolic inhibitors on microgametogenesis in Plasmodium yoelii nigeriensis

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Quantitative assessment of DNA replication to monitor microgametogenesis in Plasmodium berghei

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Malaria gametocytogenesis

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Regulation of sexual development of Plasmodium by translational repression

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Reverse genetics screen identifies six proteins important for malaria development in the mosquito

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Female inheritance of malarial lap genes is essential for mosquito transmission

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

A central role for P48/45 in malaria parasite male gamete fertility

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

The design and interpretation of laboratory assays measuring mosquito transmission of Plasmodium

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Early diagnosis and treatment of uncomplicated malaria and patterns of health seeking in Vietnam

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Gametocyte clearance in uncomplicated and severe Plasmodium falciparum malaria after artesunate-mefloquine treatment in Thailand

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Novel 4-aminoquinoline analogs highly active against the blood and sexual stages of Plasmodium in vivo and in vitro

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

A high-throughput screen targeting malaria transmission stages opens new avenues for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

A biologist's perspective on malaria vaccine development

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Artemisinins and the biological basis for the PfATP6/SERCA hypothesis

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

The Plasmodium falciparum Ca 2+ -ATPase PfATP6: insensitive to artemisinin, but a potential drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparum

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Effects of artemisinin derivatives on malaria transmissibility.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Appropriate time for primaquine treatment to reduce Plasmodium falciparum transmission in hypoendemic areas

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Primaquine revisited six decades after its discovery

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Sulfadoxine-pyrimethamine impairs Plasmodium falciparum gametocyte infectivity and Anopheles mosquito survival

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Identification of pyrimethamine- and chloroquine-resistant Plasmodium falciparum in Africa between 1984 and 1998: genotyping of archive blood samples

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

A semi-automated method for counting fluorescent malaria oocysts increases the throughput of transmission blocking studies

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

A randomized trial to monitor the efficacy and effectiveness by QT-NASBA of artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment and transmission control of uncomplicated Plasmodium falciparum malaria in western Kenya

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Therapeutic efficacy and effect on gametocyte carriage of an artemisinin and a non-based combination treatment in children with uncomplicated P. falciparum malaria, living in an area with high-level chloroquine resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Interactions of methylene blue with human disulfide reductases and their orthologues from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: a randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Inhibiting Plasmodium cytochrome bc1: a complex issue

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Inhibitory action of the anti-malarial compound atovaquone (566C80) against Plasmodium berghei ANKA in the mosquito, Anopheles stephensi

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

The pharmacokinetics and pharmacodynamics of atovaquone and proguanil for the treatment of uncomplicated falciparum malaria in third-trimester pregnant women

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Spiroindolones, a potent compound class for the treatment of malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Mitochondria in malaria and related parasites: ancient, diverse and streamlined.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Retracted: Branched tricarboxylic acid metabolism in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Metabolic fate of fumarate, a side product of the purine salvage pathway in the intraerythrocytic stages of Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Diversity in mitochondrial metabolic pathways in parasitic protists Plasmodium and Cryptosporidium

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.12.182

The multiple roles of the mitochondrion of the malarial parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Arrested oocyst maturation in Plasmodium parasites lacking type II NADH:ubiquinone dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Suppressive effect of azithromycin on Plasmodium berghei mosquito stage development and apicoplast replication

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

GFP-targeting allows visualization of the apicoplast throughout the life cycle of live malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

The systematic functional analysis of Plasmodium protein kinases identifies essential regulators of mosquito transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

A Plasmodium calcium-dependent protein kinase controls zygote development and transmission by translationally activating repressed mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Universal features of post-transcriptional gene regulation are critical for Plasmodium zygote development

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

The roles of temperature, pH and mosquito factors as triggers of male and female gametogenesis of Plasmodium berghei in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

PbGEST mediates malaria transmission to both mosquito and vertebrate host

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

Calcium and a calcium-dependent protein kinase regulate gamete formation and mosquito transmission in a malaria parasite

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.12.182

21 January 2018

Identifiers

DOI

10.4155/FMC.12.182

1 reference

28 August 2017

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PubMed ID

23234549