Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson's disease-related dementia (Q38051969)

27 August 2017

Dysfunction of the locus coeruleus-norepinephrine system and related circuitry in Parkinson's disease-related dementia (English)

1 reference

27 August 2017

0 references

1 reference

Kelly Del Tredici

1

1 reference

PubMed ID

23064099

27 August 2017

Heiko Braak

series ordinal

2

1 reference

PubMed ID

23064099

27 August 2017

language of work or name

English

0 references

publication date

13 October 2012

1 reference

Journal of Neurology, Neurosurgery and Psychiatry

27 August 2017

1 reference

27 August 2017

84

1 reference

27 August 2017

774-783

1 reference

27 August 2017

7

1 reference

The distribution of Lewy bodies in the central and autonomic nervous systems in idiopathic paralysis agitans

27 August 2017

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The intermediolateral nucleus and Clarke's column in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Sensory deficit in Parkinson's disease: evidence of a cutaneous denervation

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Alpha-synuclein in Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Parkinson's disease and related neurodegenerative synucleinopathies linked to progressive accumulations of synuclein aggregates in brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Amygdala pathology in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Pale neurites, premature α-synuclein aggregates with centripetal extension from axon collaterals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Relationships between Lewy bodies and pale bodies in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Concentric hyalin intraneuronal inclusions of Lewy type in the brains of elderly persons (50 incidental cases): relationship to parkinsonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Ultrastructure of Lewy bodies in the stellate ganglion

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Neuropathology of immunohistochemically identified brainstem neurons in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Disease-specific patterns of locus coeruleus cell loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Differential response of the central noradrenergic nervous system to the loss of locus coeruleus neurons in Parkinson's disease and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Lewy pathology and neurodegeneration in premotor Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Neuropathological analysis of brainstem cholinergic and catecholaminergic nuclei in relation to rapid eye movement (REM) sleep behaviour disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Alpha-synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Lewy body pathology in normal elderly subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Evidence in favor of Braak staging of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Patterns of α-synuclein pathology in incidental cases and clinical subtypes of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Pathology of the sympathetic nervous system corresponding to the decreased cardiac uptake in 123I-metaiodobenzylguanidine (MIBG) scintigraphy in a patient with Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Evidence that incidental Lewy body disease is pre-symptomatic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Cell type specific sequestration of choline acetyltransferase and tyrosine hydroxylase within Lewy bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Noradrenergic mechanisms in stress and anxiety: I. Preclinical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Adaptive gain and the role of the locus coeruleus-norepinephrine system in optimal performance

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The locus ceruleus norepinephrine system: functional organization and potential clinical significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Descending control of pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part I: principles of functional organisation

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Central noradrenergic regulation of cerebral blood flow and vascular permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Autonomic nerves, mast cells, and amine receptors in human brain vessels. A histochemical and pharmacological study

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The locus coeruleus: neurobiology of a central noradrenergic nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Neurochemical coupled actions of transmitters in the microvasculature of the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Brain microvessels are innervated by locus ceruleus noradrenergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Perivascular nerves and the regulation of cerebrovascular tone

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The neuropsychology and neuropharmacology of the dorsal ascending noradrenergic bundle--a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The effect of lesions in the locus coeruleus on the physiological responses of the cerebral blood vessels in cats

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The locus coeruleus and noradrenergic modulation of cognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Hypocretin (orexin) cell loss in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The pedunculopontine nucleus in Parkinson's disease, progressive supranuclear palsy and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The pedunculopontine nucleus and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Anatomy, physiology, and pathophysiology of the pedunculopontine nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The pedunculopontine nucleus in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Loss of cholinergic neurons in the pedunculopontine nucleus in Parkinson's disease is related to disability of the patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Prevalence and characteristics of dementia in Parkinson disease: an 8-year prospective study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Clinical phenotype of Parkinson disease dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Clinical diagnostic criteria for dementia associated with Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Diagnostic procedures for Parkinson's disease dementia: recommendations from the movement disorder society task force

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Dementia and survival in Parkinson disease: a 12-year population study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Dementia in Parkinson's disease: a 20-year neuropsychological study (Sydney Multicentre Study).

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Lewy body cortical involvement may not always predict dementia in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Non-motor symptoms in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Cognitive status correlates with neuropathologic stage in Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Parkinson's disease: before the motor symptoms and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Alpha-synuclein-immunoreactive cortical Lewy bodies are associated with cognitive impairment in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Parkinson disease neuropathology: later-developing dementia and loss of the levodopa response

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Cortical Lewy bodies and Alzheimer-type changes in patients with Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Lewy Body Pathology in Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Impact of coexistent Alzheimer pathology on the natural history of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Aβ deposition is associated with enhanced cortical α-synuclein lesions in Lewy body diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The progression of pathology in longitudinally followed patients with Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The impact of argyrophilic grain disease on the development of dementia and its relationship to concurrent Alzheimer's disease-related pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Correlation of clinical features with argyrophilic grains at autopsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Colocalization of Tau and Alpha-Synuclein Epitopes in Lewy Bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

CSF amyloid-beta and tau proteins, and cognitive performance, in early and untreated Parkinson's disease: the Norwegian ParkWest study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

CSF Aβ(42) and tau in Parkinson's disease with cognitive impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Vascular cognitive impairment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Mixed brain pathologies in dementia: the BrainNet Europe consortium experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Impulsive and compulsive behaviors in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

On the role of dopamine replacement therapy in decision-making, working memory, and reward in Parkinson's disease: does the therapy-dose matter?

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Early-stage cognitive impairment in Parkinson's disease and the influence of dopamine replacement therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Diagnostic criteria for Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Phases of A beta-deposition in the human brain and its relevance for the development of AD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The sleep switch: hypothalamic control of sleep and wakefulness

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Sleepiness in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Abnormal sleep and sleepiness in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The pontine REM switch: past and present

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Delayed emergence of a parkinsonian disorder in 38% of 29 older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Rapid eye movement sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The REM sleep behavior disorder screening questionnaire--a new diagnostic instrument

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Neurodegeneration across stages of cognitive decline in Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Alzheimer's disease pattern of brain atrophy predicts cognitive decline in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Daytime sleepiness and other sleep disorders in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Disruptive nocturnal behavior in Parkinson's disease and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Further observations on the sympathetic pathways to the pupil

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Regulation of salivary gland function by autonomic nerves.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Quantitative study of salivary secretion in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The larynx for neurologists

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Dysphagia in Parkinson's disease: a therapeutic challenge?

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Cardiac autonomic dysfunction in idiopathic REM sleep behavior disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Cardiac autonomic denervation in Parkinson's disease is linked to REM sleep behavior disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

The prevalence and patterns of pharyngoesophageal dysmotility in patients with early stage Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Reduced sympathetically driven heart rate variability during sleep in Parkinson's disease: a case-control polysomnography-based study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Neurovascular regulation in the normal brain and in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Cortical hypoperfusion in Parkinson's disease assessed using arterial spin labeled perfusion MRI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Cognitive status correlates with white matter alteration in Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Morphological and pathological evolution of the brain microcirculation in aging and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Cognitive deficits in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Noradrenergic mechanisms in neurodegenerative diseases: a theory

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Norepinephrine: The redheaded stepchild of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Neuropathology of non-motor features of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Pathologic correlates of dementia in individuals with Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Autonomic Innervations in the Middle Ear and Pharynx

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

Sympathetic fiber origin of the superior laryngeal nerve and its branches: An anatomic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1136%2FJNNP-2011-301817

21 January 2018

Identifiers

DOI

10.1136/JNNP-2011-301817

1 reference

27 August 2017

1 reference

PubMed ID

23064099