The centrosome as potential target for cancer therapy and prevention (Q38051759)

27 August 2017

The centrosome as potential target for cancer therapy and prevention (English)

1 reference

27 August 2017

2

Markus Hohenfellner

1 reference

27 August 2017

Nina Korzeniewski

1

1 reference

PubMed ID

23062185

27 August 2017

Stefan Duensing

series ordinal

3

1 reference

PubMed ID

23062185

27 August 2017

language of work or name

English

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publication date

15 October 2012

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Expert Opinion on Therapeutic Targets

27 August 2017

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27 August 2017

17

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27 August 2017

43-52

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27 August 2017

1

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Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris

27 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

A mechanism linking extra centrosomes to chromosomal instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Merotelic attachments and non-homologous end joining are the basis of chromosomal instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Centrosome amplification drives chromosomal instability in breast tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Structure and duplication of the centrosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Control of daughter centriole formation by the pericentriolar material

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Centrosome aberrations: cause or consequence of cancer progression?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Centrosome abnormalities and genomic instability by episomal expression of human papillomavirus type 16 in raft cultures of human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Human papillomaviruses and centrosome duplication errors: modeling the origins of genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

The HPV-16 E7 oncoprotein induces centriole multiplication through deregulation of Polo-like kinase 4 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Analysis of centrosome overduplication in correlation to cell division errors in high-risk human papillomavirus (HPV)-associated anal neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Cyclin-dependent kinase inhibitor indirubin-3'-oxime selectively inhibits human papillomavirus type 16 E7-induced numerical centrosome anomalies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Anaphase catastrophe is a target for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Excessive centrosome abnormalities without ongoing numerical chromosome instability in a Burkitt's lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Centrosome-independent mitotic spindle formation in vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Self-organisation and forces in the microtubule cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

A clinical overview of centrosome amplification in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Single-cell analysis of ploidy and centrosomes underscores the peculiarity of normal hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

The Polo kinase Plk4 functions in centriole duplication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Plk4-induced centriole biogenesis in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Mechanism limiting centrosome duplication to once per cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Segregating sister genomes: the molecular biology of chromosome separation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Centrosomal Aki1 and cohesin function in separase-regulated centriole disengagement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Normal cells, but not cancer cells, survive severe Plk1 depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Small interfering RNA-mediated Polo-like kinase 1 depletion preferentially reduces the survival of p53-defective, oncogenic transformed cells and inhibits tumor growth in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Cell cycle kinases as therapeutic targets for cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Plk4 trans-autophosphorylation regulates centriole number by controlling betaTrCP-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Daughter centriole elongation is controlled by proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Proliferation of cancer cells despite CDK2 inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

The conversion of centrioles to centrosomes: essential coupling of duplication with segregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Mitotic regulation by NIMA-related kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Breaking the ties that bind: new advances in centrosome biology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Plk1 controls the Nek2A-PP1γ antagonism in centrosome disjunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Spindle assembly in Xenopus egg extracts: respective roles of centrosomes and microtubule self-organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Polo and Aurora kinases: lessons derived from chemical biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Mitosis in a cell with multiple centrioles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Managing the centrosome numbers game: from chaos to stability in cancer cell division

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Let's huddle to prevent a muddle: centrosome declustering as an attractive anticancer strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Proteins required for centrosome clustering in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Spindle multipolarity is prevented by centrosomal clustering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Centrosome clustering and chromosomal (in)stability: a matter of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Phase I study of GSK461364, a specific and competitive Polo-like kinase 1 inhibitor, in patients with advanced solid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

A phase I pharmacokinetic study of HMN-214, a novel oral stilbene derivative with polo-like kinase-1-interacting properties, in patients with advanced solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Activity of the multitargeted kinase inhibitor, AT9283, in imatinib-resistant BCR-ABL-positive leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Update on Aurora Kinase Targeted Therapeutics in Oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Characterization of Alisertib (MLN8237), an investigational small-molecule inhibitor of aurora A kinase using novel in vivo pharmacodynamic assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Phase I assessment of new mechanism-based pharmacodynamic biomarkers for MLN8054, a small-molecule inhibitor of Aurora A kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

P276-00, a novel cyclin-dependent inhibitor induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Toxicity and toxicokinetics of the cyclin-dependent kinase inhibitor AG-024322 in cynomolgus monkeys following intravenous infusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

A phase I pharmacokinetic and pharmacodynamic study of AT7519, a cyclin-dependent kinase inhibitor in patients with refractory solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Monastrol inhibition of the mitotic kinesin Eg5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2013.731396

10.1517/14728222.2013.731396

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference

PubMed ID

23062185