Progress and hurdles in the development of vaccines against enterotoxigenic Escherichia coli in humans (Q38032878)

27 August 2017

Progress and hurdles in the development of vaccines against enterotoxigenic Escherichia coli in humans (English)

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enterotoxigenic Escherichia coli

27 August 2017

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2

David A Sack

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27 August 2017

Weiping Zhang

1

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27 August 2017

1 June 2012

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Expert Review of Vaccines

27 August 2017

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27 August 2017

11

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27 August 2017

6

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27 August 2017

677-694

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Global, regional, and national causes of child mortality in 2008: a systematic analysis

27 August 2017

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Diarrhoea associated with heat-stable enterotoxin-producing strains of Escherichia coli

21 January 2018

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Prophylactic doxycycline for travelers' diarrhea. Results of a prospective double-blind study of Peace Corps volunteers in Kenya

21 January 2018

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Prevalence of enteric pathogens among international travelers with diarrhea acquired in Kenya (Mombasa), India (Goa), or Jamaica (Montego Bay).

21 January 2018

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Vaccines in travel health: from risk assessment to priorities

21 January 2018

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Randomised, double-blind, safety and efficacy of a killed oral vaccine for enterotoxigenic E. Coli diarrhoea of travellers to Guatemala and Mexico.

21 January 2018

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Enterotoxigenic Escherichia coli in developing countries: epidemiology, microbiology, clinical features, treatment, and prevention

21 January 2018

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Comparison of virulence gene profiles of Escherichia coli strains isolated from healthy and diarrheic swine.

21 January 2018

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Colonization factors of human enterotoxigenic Escherichia coli (ETEC).

21 January 2018

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Site-directed mutagenic alteration of potential active-site residues of the A subunit of Escherichia coli heat-labile enterotoxin. Evidence for a catalytic role for glutamic acid 112.

21 January 2018

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The heat-stable enterotoxins

21 January 2018

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Acute undifferentiated human diarrhea in the tropics. I. Alterations in intestinal micrflora

21 January 2018

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Enterotoxigenic Escherichia coli: identification and characterization

21 January 2018

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Disease Due to Enterotoxigenic Escherichia coli in Bangladeshi Adults: Clinical Aspects and a Controlled Trial of Tetracycline

21 January 2018

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Refinement of a human challenge model for evaluation of enterotoxigenic Escherichia coli vaccines

21 January 2018

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Prevention of travellers' diarrhoea by oral B-subunit/whole-cell cholera vaccine.

21 January 2018

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Evolutionary and functional relationships of colonization factor antigen i and other class 5 adhesive fimbriae of enterotoxigenic Escherichia coli

21 January 2018

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Development of oral vaccines against enterotoxinogenic Escherichia coli diarrhoea

21 January 2018

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Safety and immunogenicity of an oral inactivated enterotoxigenic Escherichia coli vaccine.

21 January 2018

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Safety and immunogenicity of an oral, killed enterotoxigenic Escherichia coli-cholera toxin B subunit vaccine in Egyptian adults

21 January 2018

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Safety and immunogenicity of two different lots of the oral, killed enterotoxigenic escherichia coli-cholera toxin B subunit vaccine in Israeli young adults

21 January 2018

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Oral, inactivated, whole cell enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine: results of the initial evaluation in children. PRIDE Study Group

21 January 2018

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Introductory evaluation of an oral, killed whole cell enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine in Egyptian infants

21 January 2018

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Induction of systemic antifimbria and antitoxin antibody responses in Egyptian children and adults by an oral, killed enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine

21 January 2018

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Safety and immunogenicity of an oral, inactivated enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine in Bangladeshi children 18–36 months of age

21 January 2018

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Characterization of a mutant Escherichia coli heat-labile toxin, LT(R192G/L211A), as a safe and effective oral adjuvant.

21 January 2018

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Construction of a non-toxigenic Escherichia coli oral vaccine strain expressing large amounts of CS6 and inducing strong intestinal and serum anti-CS6 antibody responses in mice

21 January 2018

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Construction and expression of immunogenic hybrid enterotoxigenic Escherichia coli CFA/I and CS2 colonization fimbriae for use in vaccines.

21 January 2018

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Construction and characterization of genetically defined aro omp mutants of enterotoxigenic Escherichia coli and preliminary studies of safety and immunogenicity in humans

21 January 2018

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Comparative safety and immunogenicity of two attenuated enterotoxigenic Escherichia coli vaccine strains in healthy adults

21 January 2018

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A double-blind, placebo-controlled trial to evaluate the efficacy of PTL-003, an attenuated enterotoxigenic E. coli (ETEC) vaccine strain, in protecting against challenge with virulent ETEC.

21 January 2018

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A combination vaccine consisting of three live attenuated enterotoxigenic Escherichia coli strains expressing a range of colonization factors and heat-labile toxin subunit B is well tolerated and immunogenic in a placebo-controlled double-blind phas

21 January 2018

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Generation and characterization of a live attenuated enterotoxigenic Escherichia coli combination vaccine expressing six colonization factors and heat-labile toxin subunit B.

21 January 2018

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Construction and phase I clinical evaluation of the safety and immunogenicity of a candidate enterotoxigenic Escherichia coli vaccine strain expressing colonization factor antigen CFA/I

21 January 2018

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Adjuvant activity of a nontoxic mutant of Escherichia coli heat-labile enterotoxin on systemic and mucosal immune responses elicited against a heterologous antigen carried by a live Salmonella enterica serovar Typhimurium vaccine strain

21 January 2018

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Combined vaccine regimen based on parenteral priming with a DNA vaccine and administration of an oral booster consisting of a recombinant Salmonella enterica serovar Typhimurium vaccine strain for immunization against infection with human-derived en

21 January 2018

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Ability of SPI2 mutant of S. typhi to effectively induce antibody responses to the mucosal antigen enterotoxigenic E. coli heat labile toxin B subunit after oral delivery to humans

21 January 2018

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Attenuated Shigella flexneri 2a vaccine strain CVD 1204 expressing colonization factor antigen I and mutant heat-labile enterotoxin of enterotoxigenic Escherichia coli

21 January 2018

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Attenuated Shigella flexneri 2a Delta guaBA strain CVD 1204 expressing enterotoxigenic Escherichia coli (ETEC) CS2 and CS3 fimbriae as a live mucosal vaccine against Shigella and ETEC infection

21 January 2018

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Genetic characterization and immunogenicity of coli surface antigen 4 from enterotoxigenic Escherichia coli when it is expressed in a Shigella live-vector strain

21 January 2018

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Immunogenicity of multivalent Shigella-ETEC candidate vaccine strains in a guinea pig model

21 January 2018

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Analysis of strategies to successfully vaccinate infants in developing countries against enterotoxigenic E. coli (ETEC) disease

21 January 2018

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Construction and preclinical evaluation of recombinant Peru-15 expressing high levels of the cholera toxin B subunit as a vaccine against enterotoxigenic Escherichia coli.

21 January 2018

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Construction of non-toxic Escherichia coli and Vibrio cholerae strains expressing high and immunogenic levels of enterotoxigenic E. coli colonization factor I fimbriae

21 January 2018

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Transcutaneous immunization using colonization factor and heat-labile enterotoxin induces correlates of protective immunity for enterotoxigenic Escherichia coli

21 January 2018

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Safety and immunogenicity of a prototype enterotoxigenic Escherichia coli vaccine administered transcutaneously

21 January 2018

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Safety and immunogenicity of an enterotoxigenic Escherichia coli vaccine patch containing heat-labile toxin: use of skin pretreatment to disrupt the stratum corneum

21 January 2018

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Transcutaneous immunization with the heat-labile toxin (LT) of enterotoxigenic Escherichia coli (ETEC): protective efficacy in a double-blind, placebo-controlled challenge study.

21 January 2018

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Use of a patch containing heat-labile toxin from Escherichia coli against travellers' diarrhoea: a phase II, randomised, double-blind, placebo-controlled field trial.

21 January 2018

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Genetic fusion of a non-toxic heat-stable enterotoxin-related decapeptide antigen to cholera toxin B-subunit

21 January 2018

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Genetic fusions of heat-labile (LT) and heat-stable (ST) toxoids of porcine enterotoxigenic Escherichia coli elicit neutralizing anti-LT and anti-STa antibodies

21 January 2018

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Heat-stable enterotoxin of enterotoxigenic Escherichia coli as a vaccine target

21 January 2018

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Heat-labile- and heat-stable-toxoid fusions (LTR₁₉₂G-STaP₁₃F) of human enterotoxigenic Escherichia coli elicit neutralizing antitoxin antibodies

21 January 2018

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Immunoactive chimeric ST-LT enterotoxins of Escherichia coli generated by in vitro gene fusion.

21 January 2018

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Full capacity of recombinant Escherichia coli heat-stable enterotoxin fusion proteins for extracellular secretion, antigenicity, disulfide bond formation, and activity

21 January 2018

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Genetic fusions of heat-labile toxoid (LT) and heat-stable toxin b (STb) of porcine enterotoxigenic Escherichia coli elicit protective anti-LT and anti-STb antibodies

21 January 2018

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Microbial-gut interactions in health and disease. Progress in enteric vaccine development

21 January 2018

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The EtpA exoprotein of enterotoxigenic Escherichia coli promotes intestinal colonization and is a protective antigen in an experimental model of murine infection

21 January 2018

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Vaccination with EtpA glycoprotein or flagellin protects against colonization with enterotoxigenic Escherichia coli in a murine model.

21 January 2018

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Outer membrane vesicles induce immune responses to virulence proteins and protect against colonization by enterotoxigenic Escherichia coli.

21 January 2018

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Preclinical evaluation of microencapsulated CFA/II oral vaccine against enterotoxigenic E. coli

21 January 2018

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Immunization of rabbits with enterotoxigenic E. coli colonization factor antigen (CFA/I) encapsulated in biodegradable microspheres of poly (lactide-co-glycolide).

21 January 2018

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Enteral immunization and challenge of volunteers given enterotoxigenic E. coli CFA/II encapsulated in biodegradable microspheres

21 January 2018

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Oral immunization of adult volunteers with microencapsulated enterotoxigenic Escherichia coli (ETEC) CS6 antigen

21 January 2018

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Intranasal immunization of BALB/c mice with enterotoxigenic Escherichia coli colonization factor CS6 encapsulated in biodegradable poly(DL-lactide-co-glycolide) microspheres.

21 January 2018

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The encapsulation of enterotoxigenic Escherichia coli colonization factor CS3 in biodegradable microspheres enhances the murine antibody response following intranasal administration.

21 January 2018

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Randomized clinical trial assessing the safety and immunogenicity of oral microencapsulated enterotoxigenic Escherichia coli surface antigen 6 with or without heat-labile enterotoxin with mutation R192G.

21 January 2018

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Oral immunization with a recombinant bacterial antigen produced in transgenic plants.

21 January 2018

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Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine.

21 January 2018

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Expression of the cholera toxin B subunit (CT-B) in maize seeds and a combined mucosal treatment against cholera and traveler's diarrhea.

21 January 2018

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Expression and immunogenicity of enterotoxigenic Escherichia coli heat-labile toxin B subunit in transgenic rice callus.

21 January 2018

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Edible vaccine protects mice against Escherichia coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene

21 January 2018

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Ingestion of transgenic carrots expressing the Escherichia coli heat-labile enterotoxin B subunit protects mice against cholera toxin challenge.

21 January 2018

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Expression of an Escherichia coli antigenic fusion protein comprising the heat labile toxin B subunit and the heat stable toxin, and its assembly as a functional oligomer in transplastomic tobacco plants

21 January 2018

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Immunogenicity of nuclear-encoded LTB:ST fusion protein from Escherichia coli expressed in tobacco plants.

21 January 2018

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In planta production of plant-derived and non-plant-derived adjuvants

21 January 2018

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Significance of heat-stable and heat-labile enterotoxins in porcine colibacillosis in an additive model for pathogenicity studies

21 January 2018

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Relative importance of heat-labile enterotoxin in the causation of severe diarrheal disease in the gnotobiotic piglet model by a strain of enterotoxigenic Escherichia coli that produces multiple enterotoxins

21 January 2018

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Observations on the pathogenic properties of the K88, Hly and Ent plasmids of Escherichia coli with particular reference to porcine diarrhoea

21 January 2018

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Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model

21 January 2018

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The New World primate, Aotus nancymae, as a model for examining the immunogenicity of a prototype enterotoxigenic Escherichia coli subunit vaccine.

21 January 2018

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A systematic review of experimental infections with enterotoxigenic Escherichia coli (ETEC).

21 January 2018

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Little heterogeneity among genes encoding heat-labile and heat-stable toxins of enterotoxigenic Escherichia coli strains isolated from diarrheal pigs

21 January 2018

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Genetic diversity of heat-labile toxin expressed by enterotoxigenic Escherichia coli strains isolated from humans

21 January 2018

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A systematic review of ETEC epidemiology focusing on colonization factor and toxin expression

21 January 2018

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Calibrated serological techniques demonstrate significant different serum response rates to an oral killed cholera vaccine between Swedish and Nicaraguan children.

21 January 2018

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Immunogenicity and efficacy of oral vaccines in developing countries: lessons from a live cholera vaccine

21 January 2018

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Vaccination against enterotoxigenic Escherichia coli, a cause of travelers' diarrhea

21 January 2018

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Serologic correlates of protection against enterotoxigenic Escherichia coli diarrhea

21 January 2018

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Preexisting antibodies to homologous colonization factors and heat-labile toxin in serum, and the risk to develop enterotoxigenic Escherichia coli-associated diarrhea.

21 January 2018

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Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in Asia: a randomised, double-blind, placebo-controlled trial

21 January 2018

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Effect of Human Rotavirus Vaccine on Severe Diarrhea in African Infants

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/ERV.12.37

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27 August 2017

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PubMed ID

22873126