EPHA3 as a novel therapeutic target in the hematological malignancies (Q38025161)

27 August 2017

EPHA3 as a novel therapeutic target in the hematological malignancies (English)

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27 August 2017

Niamh Keane

1

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27 August 2017

Ciara Freeman

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2

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27 August 2017

Ronan Swords

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3

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27 August 2017

Francis J Giles

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4

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27 August 2017

1 June 2012

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Expert Review of Hematology

27 August 2017

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27 August 2017

5

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27 August 2017

325-340

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27 August 2017

3

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Unified Nomenclature for Eph Family Receptors and Their Ligands, the Ephrins

27 August 2017

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A novel putative tyrosine kinase receptor encoded by the eph gene

21 January 2018

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Cell signaling by receptor tyrosine kinases

21 January 2018

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An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly

21 January 2018

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Eph receptor signalling casts a wide net on cell behaviour

21 January 2018

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Eph-ephrin bidirectional signaling in physiology and disease

21 January 2018

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Architecture of Eph receptor clusters

21 January 2018

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Recruitment of Eph receptors into signaling clusters does not require ephrin contact

21 January 2018

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The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization

21 January 2018

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Phosphorylation of tyrosine residues in the kinase domain and juxtamembrane region regulates the biological and catalytic activities of Eph receptors

21 January 2018

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Cancer somatic mutations disrupt functions of the EphA3 receptor tyrosine kinase through multiple mechanisms

21 January 2018

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Eph/ephrin signaling: networks.

21 January 2018

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Dancing with the dead: Eph receptors and their kinase-null partners

21 January 2018

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Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell lines

21 January 2018

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Dissecting the EphA3/Ephrin-A5 interactions using a novel functional mutagenesis screen

21 January 2018

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Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation

21 January 2018

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Three distinct molecular surfaces in ephrin-A5 are essential for a functional interaction with EphA3.

21 January 2018

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Distinct subdomains of the EphA3 receptor mediate ligand binding and receptor dimerization

21 January 2018

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Autoregulation by the juxtamembrane region of the human ephrin receptor tyrosine kinase A3 (EphA3)

21 January 2018

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Concurrent binding of anti-EphA3 antibody and ephrin-A5 amplifies EphA3 signaling and downstream responses: potential as EphA3-specific tumor-targeting reagents

21 January 2018

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Regulation of process retraction and cell migration by EphA3 is mediated by the adaptor protein Nck1

21 January 2018

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Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse

21 January 2018

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Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling

21 January 2018

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Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases

21 January 2018

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Rac signalling: a radical view

21 January 2018

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Transformation mediated by RhoA requires activity of ROCK kinases

21 January 2018

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Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts.

21 January 2018

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Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

21 January 2018

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EphA3 is induced by CD28 and IGF-1 and regulates cell adhesion.

21 January 2018

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Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins

21 January 2018

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Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10

21 January 2018

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Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans

21 January 2018

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Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells.

21 January 2018

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PTP1B regulates Eph receptor function and trafficking

21 January 2018

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Eph-dependent cell-cell adhesion and segregation in development and cancer.

21 January 2018

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Expression of the Tyro4/Mek4/Cek4 gene specifically marks a subset of embryonic motor neurons and their muscle targets.

21 January 2018

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Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers

21 January 2018

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Loss-of-function analysis of EphA receptors in retinotectal mapping.

21 January 2018

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Graded expression of EphA3 in the retina and ephrin-A2 in the superior colliculus during initial development of coarse topography in the wallaby retinocollicular projection

21 January 2018

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Topographic mapping from the retina to the midbrain is controlled by relative but not absolute levels of EphA receptor signaling

21 January 2018

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High EphA3 expressing ophthalmic trigeminal sensory axons are sensitive to ephrin-A5-Fc: implications for lobe specific axon guidance

21 January 2018

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Expression profiles of EphA3 at both the RNA and protein level in the developing mammalian forebrain.

21 January 2018

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EphA3 Null Mutants Do Not Demonstrate Motor Axon Guidance Defects

21 January 2018

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Segregation and pathfinding of callosal axons through EphA3 signaling.

21 January 2018

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A critical role for the EphA3 receptor tyrosine kinase in heart development

21 January 2018

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Regulation of heart valve morphogenesis by Eph receptor ligand, ephrin-A1

21 January 2018

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Eph receptors and ephrin ligands: important players in angiogenesis and tumor angiogenesis

21 January 2018

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Eph receptors and ephrin ligands: embryogenesis to tumorigenesis

21 January 2018

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Eph receptors and ephrins in cancer: bidirectional signalling and beyond

21 January 2018

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The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway

21 January 2018

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EphB receptor activity suppresses colorectal cancer progression

21 January 2018

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EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt

21 January 2018

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Cancer stem cells in nervous system tumors

21 January 2018

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Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.

21 January 2018

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Molecular requirements for epithelial-mesenchymal transition during tumor progression

21 January 2018

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EphA receptor signaling--complexity and emerging themes

21 January 2018

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Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway

21 January 2018

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Activation of ephrin A proteins influences hematopoietic stem cell adhesion and trafficking patterns

21 January 2018

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Ephrins and Eph receptors in stem cells and cancer

21 January 2018

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Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone.

21 January 2018

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EphB signaling controls lineage plasticity of adult neural stem cell niche cells

21 January 2018

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EphB receptors regulate stem/progenitor cell proliferation, migration, and polarity during hippocampal neurogenesis

21 January 2018

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Identification of stem cells in small intestine and colon by marker gene Lgr5

21 January 2018

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The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse

21 January 2018

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Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

21 January 2018

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The developing cancer stem-cell model: clinical challenges and opportunities

21 January 2018

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Leukaemia stem cells and the evolution of cancer-stem-cell research.

21 January 2018

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A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

21 January 2018

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Prospective identification of tumorigenic breast cancer cells

21 January 2018

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Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma

21 January 2018

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The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells

21 January 2018

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CD28 expressed on malignant plasma cells induces a prosurvival and immunosuppressive microenvironment

21 January 2018

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Epithelial-mesenchymal transition, cancer stem cells and treatment resistance

21 January 2018

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Cancer stem cells and EMT in carcinoma.

21 January 2018

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Transcriptional profiling of human cord blood CD133+ and cultured bone marrow mesenchymal stem cells in response to hypoxia

21 January 2018

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Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches.

21 January 2018

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Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104

21 January 2018

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Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/EHM.12.19

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27 August 2017

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