Biomarkers and clinical tools in critically ill children: are we heading toward tailored drug therapy? (Q38021511)

27 August 2017

Biomarkers and clinical tools in critically ill children: are we heading toward tailored drug therapy? (English)

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27 August 2017

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3

Erwin Ista

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Dick Tibboel

4

object named as

Dick Tibboel

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27 August 2017

Erik A B Buijs

1

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27 August 2017

Alexandra J M Zwiers

2

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27 August 2017

Erwin Ista

3

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27 August 2017

Saskia N de Wildt

5

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27 August 2017

language of work or name

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1 June 2012

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27 August 2017

Biomarkers in Medicine

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27 August 2017

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27 August 2017

3

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27 August 2017

239-257

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Biomarkers in pediatrics: children as biomarker orphans

27 August 2017

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The Biomarkers Consortium: on the critical path of drug discovery.

21 January 2018

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Biomarkers and surrogate endpoints: preferred definitions and conceptual framework

21 January 2018

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Biomarker discovery and development in pediatric critical care medicine

21 January 2018

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Serum troponins as biomarkers of drug-induced cardiac toxicity

21 January 2018

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Biomarker qualification pilot process at the US Food and Drug Administration

21 January 2018

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The microcirculation of the critically ill pediatric patient

21 January 2018

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The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients

21 January 2018

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Clinical review: Update on hemodynamic monitoring--a consensus of 16

21 January 2018

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Cardiac output monitoring in pediatric patients

21 January 2018

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Impact of the pulmonary artery catheter in critically ill patients: meta-analysis of randomized clinical trials

21 January 2018

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Pulmonary artery catheters

21 January 2018

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Objective assessment of cardiac output in infants after cardiac surgery

21 January 2018

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Theory and in vitro validation of a new extracorporeal arteriovenous loop approach for hemodynamic assessment in pediatric and neonatal intensive care unit patients

21 January 2018

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Ultrasound dilution: an accurate means of determining cardiac output in children

21 January 2018

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Lactate and acid base as a hemodynamic monitor and markers of cellular perfusion

21 January 2018

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The first demonstration of lactic acid in human blood in shock by Johann Joseph Scherer (1814-1869) in January 1843.

21 January 2018

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Goal-directed medical therapy and point-of-care testing improve outcomes after congenital heart surgery

21 January 2018

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Levosimendan in congenital cardiac surgery: a randomized, double-blind clinical trial.

21 January 2018

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Children with single-ventricle physiology do not benefit from higher hemoglobin levels post cavopulmonary connection: results of a prospective, randomized, controlled trial of a restrictive versus liberal red-cell transfusion strategy.

21 January 2018

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Cardiopulmonary bypass flow rate: a risk factor for hyperlactatemia after surgical repair of secundum atrial septal defect in children

21 January 2018

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Blood lactate levels differ significantly between surviving and nonsurviving patients within the same risk-adjusted Classification for Congenital Heart Surgery (RACHS-1) group after pediatric cardiac surgery

21 January 2018

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Anaemia and its treatment in neurologically critically ill patients: being reasonable is easy without prospective trials

21 January 2018

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Hyperlactatemia in neonates admitted to the cardiac intensive care unit with critical heart disease

21 January 2018

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Late-onset hyperlactataemia following paediatric cardiac surgery

21 January 2018

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Serial blood lactate levels as a predictor of mortality in children after cardiopulmonary bypass surgery

21 January 2018

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The lactate:pyruvate ratio following open cardiac surgery in children

21 January 2018

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Serum lactate level has prognostic significance after pediatric cardiac surgery.

21 January 2018

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Postoperative lactate concentrations predict the outcome of infants aged 6 weeks or less after intracardiac surgery: a cohort follow-up to 18 months

21 January 2018

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Patterns of lactate values after congenital heart surgery and timing of cardiopulmonary support

21 January 2018

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Effects of fresh versus old stored blood in the priming solution on whole blood lactate levels during paediatric cardiac surgery

21 January 2018

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Point of care testing: improving pediatric outcomes

21 January 2018

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Changes in whole blood lactate levels during cardiopulmonary bypass for surgery for congenital cardiac disease: an early indicator of morbidity and mortality.

21 January 2018

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Serum lactate as a predictor of mortality after paediatric cardiac surgery

21 January 2018

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Serum lactates correlate with mortality after operations for complex congenital heart disease

21 January 2018

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Serum lactate levels as the predictor of outcome in pediatric septic shock

21 January 2018

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Transport of critically ill children in a resource-limited setting.

21 January 2018

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Jugular venous oxygen saturation or arteriovenous difference of lactate content and outcome in children with severe traumatic brain injury

21 January 2018

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Use of plasma lactate to predict early mortality and adverse outcome after neonatal extracorporeal membrane oxygenation: a prospective cohort in early childhood

21 January 2018

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Mechanism of lactic acidosis in children with acute severe asthma.

21 January 2018

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In vivo functional investigations of lactic acid in patients with respiratory chain disorders

21 January 2018

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Monitoring the microcirculation in the critically ill patient: current methods and future approaches.

21 January 2018

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Cerebral oximetry for pediatric anesthesia: why do intelligent clinicians disagree?

21 January 2018

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Orthogonal polarization spectral imaging: a new method for study of the microcirculation.

21 January 2018

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Sidestream Dark Field (SDF) imaging: a novel stroboscopic LED ring-based imaging modality for clinical assessment of the microcirculation.

21 January 2018

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Measurement of functional microcirculatory geometry and velocity distributions using automated image analysis

21 January 2018

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How to evaluate the microcirculation: report of a round table conference

21 January 2018

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Inhaled nitric oxide improves systemic microcirculation in infants with hypoxemic respiratory failure.

21 January 2018

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Changes in buccal microcirculation following extracorporeal membrane oxygenation in term neonates with severe respiratory failure

21 January 2018

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Persistent low microcirculatory vessel density in nonsurvivors of sepsis in pediatric intensive care.

21 January 2018

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Orthogonal polarization spectral imaging (OPS): a novel method to measure the microcirculation in term and preterm infants transcutaneously

21 January 2018

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Low birth weight infants do not have capillary rarefaction at birth: implications for early life influence on microcirculation

21 January 2018

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Functional vessel density in the first month of life in preterm neonates

21 January 2018

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Changes in microcirculation as early markers for infection in preterm infants--an observational prospective study.

21 January 2018

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Blood transfusion increases functional capillary density in the skin of anemic preterm infants

21 January 2018

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Evaluation of sublingual microcirculatory blood flow in the critically ill.

21 January 2018

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Point-of-care assessment of microvascular blood flow in critically ill patients

21 January 2018

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Comparison of 6% hydroxyethyl starch 130/0.4 and saline solution for resuscitation of the microcirculation during the early goal-directed therapy of septic patients.

21 January 2018

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Effects of vasopressinergic receptor agonists on sublingual microcirculation in norepinephrine-dependent septic shock

21 January 2018

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Levosimendan for resuscitating the microcirculation in patients with septic shock: a randomized controlled study

21 January 2018

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Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial

21 January 2018

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Risk factors of acute renal failure in critically ill children: A prospective descriptive epidemiological study

21 January 2018

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Modified RIFLE criteria in critically ill children with acute kidney injury

21 January 2018

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Acute kidney injury is an independent risk factor for pediatric intensive care unit mortality, longer length of stay and prolonged mechanical ventilation in critically ill children: a two-center retrospective cohort study

21 January 2018

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Serum creatinine as stratified in the RIFLE score for acute kidney injury is associated with mortality and length of stay for children in the pediatric intensive care unit

21 January 2018

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Glomerular filtration rate measurement and estimation in chronic kidney disease

21 January 2018

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Acute kidney injury in critically ill newborns: what do we know? What do we need to learn?

21 January 2018

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The future of pediatric acute kidney injury management--biomarkers

21 January 2018

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Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans.

21 January 2018

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Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage.

21 January 2018

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Human neutrophil gelatinase-associated lipocalin and homologous proteins in rat and mouse.

21 January 2018

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Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study

21 January 2018

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Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study

21 January 2018

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Neutrophil gelatinase-associated lipocalin concentrations predict development of acute kidney injury in neonates and children after cardiopulmonary bypass

21 January 2018

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Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock

21 January 2018

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Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study

21 January 2018

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Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery

21 January 2018

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Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure

21 January 2018

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The role of interleukin-18 in renal injury

21 January 2018

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Urinary interleukin-18 is a marker of human acute tubular necrosis

21 January 2018

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Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit

21 January 2018

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Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study

21 January 2018

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Urinary interleukin-18 is an acute kidney injury biomarker in critically ill children

21 January 2018

1 reference

Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration

21 January 2018

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Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury.

21 January 2018

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Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury

21 January 2018

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Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass

21 January 2018

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Urinary biomarkers in the early diagnosis of acute kidney injury

21 January 2018

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A rapid urine test for early detection of kidney injury.

21 January 2018

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Temporal relationship and predictive value of urinary acute kidney injury biomarkers after pediatric cardiopulmonary bypass

21 January 2018

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Earlier recognition of nephrotoxicity using novel biomarkers of acute kidney injury

21 January 2018

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High-dose fenoldopam reduces postoperative neutrophil gelatinase-associated lipocaline and cystatin C levels in pediatric cardiac surgery.

21 January 2018

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Consensus guidelines on sedation and analgesia in critically ill children

21 January 2018

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Sedation, analgesia, and neuromuscular blockade in the pediatric intensive care unit: survey of fellowship training programs

21 January 2018

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Current United Kingdom sedation practice in pediatric intensive care.

21 January 2018

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Tolerance, withdrawal, and physical dependency after long-term sedation and analgesia of children in the pediatric intensive care unit

21 January 2018

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Tolerance and withdrawal from prolonged opioid use in critically ill children

21 January 2018

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Withdrawal symptoms in children after long-term administration of sedatives and/or analgesics: a literature review. "Assessment remains troublesome"

21 January 2018

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Sedation and analgesia in children submitted to mechanical ventilation could be overestimated?

21 January 2018

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Occurrence of withdrawal in critically ill sedated children.

21 January 2018

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A prospective study of the adverse effects of midazolam on withdrawal in critically ill children

21 January 2018

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Practical approach to analgesia and sedation in the neonatal intensive care unit.

21 January 2018

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Recollection of children following intensive care

21 January 2018

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Paradoxical reaction following intravenous midazolam premedication in pediatric patients - a randomized placebo controlled trial of ketamine for rapid tranquilization.

21 January 2018

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Midazolam as premedication: is the emperor naked or just half-dressed?

21 January 2018

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Delirium in severely ill young children in the pediatric intensive care unit (PICU).

21 January 2018

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Children's factual and delusional memories of intensive care.

21 January 2018

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Agmatine and imidazoline receptors: their role in opioid analgesia, tolerance and dependence

21 January 2018

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The pharmacological importance of agmatine in the brain

21 January 2018

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Managing sedation withdrawal in children who undergo prolonged PICU admission after discharge to the ward

21 January 2018

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Opioid and benzodiazepine withdrawal symptoms in paediatric intensive care patients

21 January 2018

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The Withdrawal Assessment Tool-1 (WAT-1): an assessment instrument for monitoring opioid and benzodiazepine withdrawal symptoms in pediatric patients.

21 January 2018

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Construction of the Sophia Observation withdrawal Symptoms-scale (SOS) for critically ill children

21 January 2018

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Withdrawal symptoms in critically ill children after long-term administration of sedatives and/or analgesics: a first evaluation

21 January 2018

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Preventable harm occurring to critically ill children

21 January 2018

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Pediatric delirium in critical illness: phenomenology, clinical correlates and treatment response in 40 cases in the pediatric intensive care unit

21 January 2018

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Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit

21 January 2018

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On the utility of diagnostic instruments for pediatric delirium in critical illness: an evaluation of the Pediatric Anesthesia Emergence Delirium Scale, the Delirium Rating Scale 88, and the Delirium Rating Scale-Revised R-98.

21 January 2018

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The impact of delirium in the intensive care unit on hospital length of stay

21 January 2018

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Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit

21 January 2018

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Prolonged stay at the paediatric intensive care unit associated with paediatric delirium

21 January 2018

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Procalcitonin and C-reactive protein levels at admission as predictors of duration of acute brain dysfunction in critically ill patients

21 January 2018

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Early postoperative delirium after open-heart cardiac surgery is associated with decreased bispectral EEG and increased cortisol and interleukin-6.

21 January 2018

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Consciousness monitoring in ventilated patients: bispectral EEG monitors arousal not delirium.

21 January 2018

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EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit.

21 January 2018

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Serum levels of cytokines and EEG findings in children with influenza associated with mild neurological complications.

21 January 2018

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Screening pediatric delirium with an adapted version of the Sophia Observation withdrawal Symptoms scale (SOS).

21 January 2018

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Pharmacokinetics and analgesic effects of intravenous propacetamol vs rectal paracetamol in children after major craniofacial surgery.

21 January 2018

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Routine morphine infusion in preterm newborns who received ventilatory support: a randomized controlled trial

21 January 2018

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Morphine glucuronidation in preterm neonates, infants and children younger than 3 years

21 January 2018

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Prevention of Low Cardiac Output Syndrome in children: where is the evidence?

21 January 2018

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Cardiac output monitoring in newborns

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/BMM.12.28

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27 August 2017

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