Oxidative stress, Nox isoforms and complications of diabetes--potential targets for novel therapies (Q38019841)

27 August 2017

Oxidative stress, Nox isoforms and complications of diabetes--potential targets for novel therapies (English)

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27 August 2017

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Jennifer L Wilkinson-Berka

27 August 2017

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27 August 2017

Mona Sedeek

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27 August 2017

Richard L Hebert

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27 August 2017

Stephen P Gray

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27 August 2017

Elyse Di Marco

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27 August 2017

Jay C Jha

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27 August 2017

Mark E Cooper

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27 August 2017

Karin Jandeleit-Dahm

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27 August 2017

Ernesto L Schiffrin

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27 August 2017

language of work or name

English

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publication date

19 June 2012

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Journal of Cardiovascular Translational Research

27 August 2017

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27 August 2017

5

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27 August 2017

509-518

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https://scigraph.springernature.com/pub.10.1007/s12265-012-9387-2

27 August 2017

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Exacerbation of endothelial dysfunction during the progression of diabetes: role of oxidative stress

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Advanced glycation urinary protein-bound biomarkers and severity of diabetic nephropathy in man.

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Oxidative stress and diabetic cardiovascular complications

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The renin-angiotensin-aldosterone system and glucose homeostasis

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Oxidative stress and diabetic cardiovascular disorders: roles of mitochondria and NADPH oxidase

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Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling

21 January 2018

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NADPH oxidases in cardiovascular disease: insights from in vivo models and clinical studies.

21 January 2018

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The NOX-ROS connection: targeting Nox1 control of N-cadherin shedding in vascular smooth muscle cells

21 January 2018

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Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling

21 January 2018

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Activation of thromboxane receptor modulates interleukin-1β-induced monocyte adhesion--a novel role of Nox1.

21 January 2018

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Renal redox-sensitive signaling, but not blood pressure, is attenuated by Nox1 knockout in angiotensin II-dependent chronic hypertension

21 January 2018

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The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice

21 January 2018

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Role for Nox1 NADPH oxidase in atherosclerosis

21 January 2018

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The p47phox- and NADPH oxidase organiser 1 (NOXO1)-dependent activation of NADPH oxidase 1 (NOX1) mediates endothelial nitric oxide synthase (eNOS) uncoupling and endothelial dysfunction in a streptozotocin-induced murine model of diabetes

21 January 2018

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Gene transfer of NAD(P)H oxidase inhibitor to the vascular adventitia attenuates medial smooth muscle hypertrophy

21 January 2018

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Angiotensin II-dependent chronic hypertension and cardiac hypertrophy are unaffected by gp91phox-containing NADPH oxidase.

21 January 2018

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Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet

21 January 2018

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NOX3 NADPH oxidase couples transient receptor potential vanilloid 1 to signal transducer and activator of transcription 1-mediated inflammation and hearing loss

21 January 2018

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A genome-wide search for linkage to renal function phenotypes in West Africans with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Oxidative stress mediates the stimulation of sympathetic nerve activity in the phenol renal injury model of hypertension

21 January 2018

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Hyperglycemia enhances IGF-I-stimulated Src activation via increasing Nox4-derived reactive oxygen species in a PKCζ-dependent manner in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Nox5 and the regulation of cellular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Poldip2, a novel regulator of Nox4 and cytoskeletal integrity in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

NADPH oxidase 4 mediates TGF-β-induced smooth muscle α-actin via p38MAPK and serum response factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

The E-loop is involved in hydrogen peroxide formation by the NADPH oxidase Nox4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Upregulation of Nox4 by TGF{beta}1 oxidizes SERCA and inhibits NO in arterial smooth muscle of the prediabetic Zucker rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

NOX4 pathway as a source of selective insulin resistance and responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Molecular regulation of NADPH oxidase 5 via the MAPK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Positive regulation of NADPH oxidase 5 by proinflammatory-related mechanisms in human aortic smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

NOX5 expression is increased in intramyocardial blood vessels and cardiomyocytes after acute myocardial infarction in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Expression and functional significance of NADPH oxidase 5 (Nox5) and its splice variants in human blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Transient congenital hypothyroidism

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Pathogenesis, prevention, and treatment of diabetic nephropathy.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Oxidative stress as a major culprit in kidney disease in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Effects of NADPH oxidase inhibitor in diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Translocation of Glomerular p47phox and p67phox by Protein Kinase C-β Activation Is Required for Oxidative Stress in Diabetic Nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

AGER1 regulates endothelial cell NADPH oxidase-dependent oxidant stress via PKC-delta: implications for vascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Reactive oxygen species-regulated signaling pathways in diabetic nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Redox dependence of glomerular epithelial cell hypertrophy in response to glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Global prevalence and major risk factors of diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Role of NADPH oxidase and Stat3 in statin-mediated protection against diabetic retinopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Inhibition of reactive oxygen species by Lovastatin downregulates vascular endothelial growth factor expression and ameliorates blood-retinal barrier breakdown in db/db mice: role of NADPH oxidase 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Neuronal NAD(P)H oxidases contribute to ROS production and mediate RGC death after ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Neuroprotection from retinal ischemia/reperfusion injury by NOX2 NADPH oxidase deletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Inflammation in diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Cellular crosstalk between TNF-α, NADPH oxidase, PKCβ2, and C2GNT in human leukocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Reactive oxygen generated by Nox1 triggers the angiogenic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Role of NADPH oxidase in retinal vascular inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

NAD(P)H oxidase-dependent regulation of CCL2 production during retinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Suppression of retinal peroxisome proliferator-activated receptor gamma in experimental diabetes and oxygen-induced retinopathy: role of NADPH oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

RILLKKMPSV influences the vasculature, neurons and glia, and (pro)renin receptor expression in the retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

The renin-angiotensin system and the developing retinal vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Angiotensin and diabetic retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Involvement of angiotensin II-dependent vascular endothelial growth factor gene expression via NADPH oxidase in the retina in a type 2 diabetic rat model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Candesartan attenuates diabetic retinal vascular pathology by restoring glyoxalase-I function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

p47phox is required for atherosclerotic lesion progression in ApoE(-/-) mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Protein tyrosine phosphatase PTPepsilonM negatively regulates PDGF beta-receptor signaling induced by high glucose and PDGF in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Ultrastructural analysis and electron microscopic localization of Nox4 in healthy and atherosclerotic human aorta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

NADPH oxidases: functions and pathologies in the vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Nox1 is involved in angiotensin II-mediated hypertension: a study in Nox1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Effect of apocynin on the induction of ulcerative lesions in rat skin injected with tubercle bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

The effects of diphenyleneiodonium on mitochondrial reactions. Relation of binding of diphenylene[125I]iodonium to mitochondria to the extent of inhibition of oxygen uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Classical inhibitors of NOX NAD(P)H oxidases are not specific.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Comparative pharmacology of chemically distinct NADPH oxidase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

NADPH oxidase inhibitors: a patent review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Novel therapeutic approaches in limiting oxidative stress and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Targeting NADPH oxidases for the treatment of cancer and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12265-012-9387-2

Activation of nicotinamide adenine dinucleotide phosphate (reduced form) oxidase by advanced glycation end products links oxidative stress to altered retinal vascular endothelial growth factor expression

21 January 2018

1 reference

12 December 2020

Aldose reductase, oxidative stress, and diabetic mellitus

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12 December 2020

Acute and chronic fluctuations in blood glucose levels can increase oxidative stress in type 2 diabetes mellitus.

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12 December 2020

Opportunity nox: the future of NADPH oxidases as therapeutic targets in cardiovascular disease.

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12 December 2020

AP-1 proteins mediate hyperglycemia-induced activation of the human TGF-beta1 promoter in mesangial cells.

1 reference

12 December 2020

Potential role of the NADPH oxidase NOX1 in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice

1 reference

12 December 2020

High glucose concentration affects the oxidant-antioxidant balance in cultured mouse podocytes

1 reference

12 December 2020

Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells

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12 December 2020

Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity

1 reference

12 December 2020

Tyrphostin AG490 reduces NAPDH oxidase activity and expression in the aorta of hypercholesterolemic apolipoprotein E-deficient mice

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12 December 2020

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12 December 2020

Role of high glucose-induced nuclear factor-kappaB activation in monocyte chemoattractant protein-1 expression by mesangial cells.

1 reference

12 December 2020

Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes

1 reference

12 December 2020

Interaction of diabetes and ACE2 in the pathogenesis of cardiovascular disease in experimental diabetes

1 reference

12 December 2020

Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy

1 reference

12 December 2020

Pigment epithelium-derived factor inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor expression

1 reference

12 December 2020

Hypoxia and oxidative stress in the causation of diabetic retinopathy

1 reference

12 December 2020

Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system

1 reference

12 December 2020

Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis

1 reference

12 December 2020

NADPH oxidase-derived reactive oxygen species in the regulation of endothelial phenotype

1 reference

12 December 2020

10.1007/S12265-012-9387-2

Identifiers

DOI

1 reference

Dimensions Publication ID

27 August 2017

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