Peroxisome proliferator-activated receptor-γ as a therapeutic target for hepatic fibrosis: from bench to bedside (Q38018841)

27 August 2017

Peroxisome proliferator-activated receptor-γ as a therapeutic target for hepatic fibrosis: from bench to bedside (English)

1 reference

27 August 2017

Feng Zhang

1

1 reference

27 August 2017

Desong Kong

series ordinal

2

1 reference

27 August 2017

Yin Lu

series ordinal

3

1 reference

27 August 2017

Shizhong Zheng

series ordinal

4

1 reference

27 August 2017

15 June 2012

1 reference

Cellular and Molecular Life Sciences

27 August 2017

1 reference

27 August 2017

70

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27 August 2017

2

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27 August 2017

259-276

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https://scigraph.springernature.com/pub.10.1007/s00018-012-1046-x

27 August 2017

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RNA-binding protein RBMS3 is expressed in activated hepatic stellate cells and liver fibrosis and increases expression of transcription factor Prx1.

21 January 2018

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Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation

21 January 2018

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21 January 2018

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21 January 2018

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PPARgamma is essential for protection against nonalcoholic steatohepatitis.

21 January 2018

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Peroxisome proliferator-activated receptors gamma reverses hepatic nutritional fibrosis in mice and suppresses activation of hepatic stellate cells in vitro.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice

21 January 2018

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Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis

21 January 2018

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Rosiglitazone prevents murine hepatic fibrosis induced by Schistosoma japonicum

21 January 2018

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Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice

21 January 2018

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Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice

21 January 2018

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21 January 2018

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Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice

21 January 2018

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Effects of rosiglitazone on the liver histology and mitochondrial function in ob/ob mice.

21 January 2018

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Pioglitazone prevents early-phase hepatic fibrogenesis caused by carbon tetrachloride.

21 January 2018

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Prevention of ethanol-induced liver injury in rats by an agonist of peroxisome proliferator-activated receptor-gamma, pioglitazone

21 January 2018

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Protective effect of pioglitazone against endotoxin-induced liver injury through prevention of Kupffer cell sensitization

21 January 2018

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Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met

21 January 2018

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Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet

21 January 2018

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Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation

21 January 2018

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Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats

21 January 2018

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Selective inhibition of activated stellate cells and protection from carbon tetrachloride-induced liver injury in rats by a new PPARgamma agonist KR62776.

21 January 2018

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Effectiveness of the PPARγ agonist, GW570, in liver fibrosis

21 January 2018

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Indenone derivatives: a novel template for peroxisome proliferator-activated receptor gamma (PPARgamma) agonists

21 January 2018

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Activation of PPARgamma is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro

21 January 2018

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Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-gamma in rat hepatic stellate cells

21 January 2018

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Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation

21 January 2018

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Epidemiology and natural history of non-alcoholic steatohepatitis

21 January 2018

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Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection

21 January 2018

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Human fatty liver disease: old questions and new insights

21 January 2018

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A pilot study of a thiazolidinedione, troglitazone, in nonalcoholic steatohepatitis

21 January 2018

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Thiazolidinediones for the treatment in NASH: sustained benefit after drug discontinuation?

21 January 2018

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Interim results of a pilot study demonstrating the early effects of the PPAR-gamma ligand rosiglitazone on insulin sensitivity, aminotransferases, hepatic steatosis and body weight in patients with non-alcoholic steatohepatitis

21 January 2018

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Clinical trial: insulin-sensitizing agents may reduce consequences of insulin resistance in individuals with non-alcoholic steatohepatitis

21 January 2018

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The effects of 48 weeks of rosiglitazone on hepatocyte mitochondria in human nonalcoholic steatohepatitis

21 January 2018

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Safety and effectiveness of rosiglitazone in type 2 diabetes patients with nonalcoholic Fatty liver disease.

21 January 2018

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Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial

21 January 2018

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Design and validation of a histological scoring system for nonalcoholic fatty liver disease

21 January 2018

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Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial

21 January 2018

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Efficacy of insulin-sensitizing agents in nonalcoholic fatty liver disease

21 January 2018

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Effect of pioglitazone on biochemical indices of non-alcoholic fatty liver disease in upper body obesity

21 January 2018

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A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis

21 January 2018

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A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis

21 January 2018

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Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis

21 January 2018

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Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis

21 January 2018

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Oxidative and nitrosative stress and fibrogenic response

21 January 2018

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A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis

21 January 2018

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Pioglitazone versus vitamin E versus placebo for the treatment of non-diabetic patients with non-alcoholic steatohepatitis: PIVENS trial design

21 January 2018

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Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis

21 January 2018

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Farglitazar lacks antifibrotic activity in patients with chronic hepatitis C infection

21 January 2018

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Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ

21 January 2018

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The role of thiazolidinediones in non-alcoholic steatohepatitis - a systematic review and meta analysis.

21 January 2018

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Meta-analysis: insulin sensitizers for the treatment of non-alcoholic steatohepatitis

21 January 2018

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Meta-analysis: pioglitazone improves liver histology and fibrosis in patients with non-alcoholic steatohepatitis

21 January 2018

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Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass.

21 January 2018

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Hepatology may have problems with putative surrogate outcome measures

21 January 2018

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Genomics and proteomics in liver fibrosis and cirrhosis.

21 January 2018

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Application of metabonomics on an experimental model of fibrosis and cirrhosis induced by thioacetamide in rats

21 January 2018

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Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice

21 January 2018

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Upregulation of peroxisome proliferator-activated receptor gamma coactivator gene (PGC1A) during weight loss is related to insulin sensitivity but not to energy expenditure

21 January 2018

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The safety of thiazolidinediones

21 January 2018

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Rosiglitazone: a European regulatory perspective.

21 January 2018

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Regulatory action on rosiglitazone by the U.S. Food and Drug Administration

21 January 2018

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Second-generation thiazolidinediones and hepatotoxicity

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Risk of bladder cancer among diabetic patients treated with pioglitazone: interim report of a longitudinal cohort study.

21 January 2018

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Assessing the association of pioglitazone use and bladder cancer through drug adverse event reporting

21 January 2018

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Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis

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PPARgamma2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes.

21 January 2018

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Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells

21 January 2018

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Peroxisome proliferator-activated receptor gamma activation modulates cyclin D1 transcription via beta-catenin-independent and cAMP-response element-binding protein-dependent pathways in mouse hepatocytes

21 January 2018

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Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.

21 January 2018

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21 January 2018

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Activated hepatic stellate cells express keratinocyte growth factor in chronic liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1046-X

Roles of PPARs in NAFLD: potential therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1046-X

Administration of the potent PPARalpha agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1046-X

Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, improves hepatic microcirculatory patency and oxygen availability in a high-fat-diet-induced fatty liver in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1046-X

PPARalpha expression protects male mice from high fat-induced nonalcoholic fatty liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1046-X

A pilot trial of fenofibrate for the treatment of non-alcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1046-X

PPARalpha regulates the hepatotoxic biomarker alanine aminotransferase (ALT1) gene expression in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1046-X

Pharmacokinetics, pharmacodynamics, and tolerability of aleglitazar in patients with type 2 diabetes: results from a randomized, placebo-controlled clinical study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1046-X

Effects of aleglitazar, a balanced dual peroxisome proliferator-activated receptor α/γ agonist on glycemic and lipid parameters in a primate model of the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1046-X

Tesaglitazar, a dual PPAR-α/γ agonist, hamster carcinogenicity, investigative animal and clinical studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1046-X

Peroxisome proliferated-activated receptor gamma ligand, Pioglitazone, does not prevent hepatic fibrosis in mice

21 January 2018

1 reference

12 December 2020

Peroxisome proliferator-activated receptor gamma inhibits hepatic fibrosis in rats

1 reference

12 December 2020

The peroxisome proliferator-activated receptor-gamma agonist, pioglitazone, inhibits fat accumulation and fibrosis in the livers of rats fed a choline-deficient, l-amino acid-defined diet

1 reference

12 December 2020

Chemokines in liver inflammation and fibrosis

1 reference

12 December 2020

Regulation of murine macrophage proinflammatory and anti-inflammatory cytokines by ligands for peroxisome proliferator-activated receptor-gamma: counter-regulatory activity by IFN-gamma.

1 reference

12 December 2020

A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease

1 reference

12 December 2020

Peroxisome proliferator-activated receptors--from active regulators of macrophage biology to pharmacological targets in the treatment of cardiovascular disease

1 reference

12 December 2020

Vitamin A storage in hepatic stellate cells in the regenerating rat liver: with special reference to zonal heterogeneity

1 reference

12 December 2020

Rosiglitazone attenuates liver inflammation in a rat model of nonalcoholic steatohepatitis

1 reference

12 December 2020

Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone

1 reference

12 December 2020

PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis

1 reference

12 December 2020

Targeted delivery of drugs for liver fibrosis

1 reference

12 December 2020

PPAR gamma inhibits growth of rat hepatic stellate cells and TGF beta-induced connective tissue growth factor expression

1 reference

12 December 2020

Rosiglitazone treatment in nondiabetic subjects with nonalcoholic fatty liver disease

1 reference

12 December 2020

Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans

1 reference

12 December 2020

Inhibition of PPARγ prevents type I diabetic bone marrow adiposity but not bone loss

1 reference

12 December 2020

Pioglitazone prevents acute liver injury induced by ethanol and lipopolysaccharide through the suppression of tumor necrosis factor-alpha

1 reference

12 December 2020

Effects of PPARg agonist pioglitazone on rat hepatic fibrosis

1 reference

12 December 2020

Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis

1 reference

12 December 2020

Peroxisome Proliferator-Activated Receptor α Protects against Obesity-Induced Hepatic Inflammation

1 reference

12 December 2020

The effects of discontinuing pioglitazone in patients with nonalcoholic steatohepatitis

1 reference

12 December 2020

Changes in serum adipokine levels during pioglitazone treatment for nonalcoholic steatohepatitis: relationship to histological improvement

1 reference

12 December 2020

Liver fibrogenesis and metabolic factors

1 reference

12 December 2020

Adenovirus-mediated peroxisome proliferator activated receptor gamma overexpression prevents nutritional fibrotic steatohepatitis in mice

1 reference

12 December 2020

Ligands of peroxisome proliferator-activated receptor γ modulate profibrogenic and proinflammatory actions in hepatic stellate cells

1 reference

12 December 2020

Rosiglitazone versus rosiglitazone and metformin versus rosiglitazone and losartan in the treatment of nonalcoholic steatohepatitis in humans: a 12-month randomized, prospective, open- label trial

1 reference

12 December 2020

10.1007/S00018-012-1046-X

Identifiers

DOI

1 reference

27 August 2017

1 reference