Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation (Q38012151)

27 August 2017

Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation (English)

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27 August 2017

Darius Ghaderi

1

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27 August 2017

Mai Zhang

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2

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27 August 2017

Nancy Hurtado-Ziola

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3

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27 August 2017

Ajit Varki

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4

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27 August 2017

1 January 2012

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Biotechnology and Genetic Engineering Reviews

27 August 2017

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27 August 2017

28

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27 August 2017

147-175

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N-glycan patterns of human transferrin produced in Trichoplusia ni insect cells: effects of mammalian galactosyltransferase.

27 August 2017

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Chemical diversity in the sialic acids and related alpha-keto acids: an evolutionary perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

The impact of glycosylation on the biological function and structure of human immunoglobulins.

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Mechanism of uptake and incorporation of the non-human sialic acid N-glycolylneuraminic acid into human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

The influence of natural antibody specificity on antigen immunogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Nucleotide sugar transporters of the Golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Seed-based expression systems for plant molecular farming

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Loss of N-glycolylneuraminic acid in human evolution. Implications for sialic acid recognition by siglecs

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Appropriate glycosylation of recombinant proteins for human use: implications of choice of expression system

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Sialic acids: carbohydrate moieties that influence the biological and physical properties of biopharmaceutical proteins and living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation?

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

In planta protein sialylation through overexpression of the respective mammalian pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

N-glycosylation engineering of plants for the biosynthesis of glycoproteins with bisected and branched complex N-glycans

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Advances in the biology and chemistry of sialic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Reduction of CMP-N-acetylneuraminic acid hydroxylase activity in engineered Chinese hamster ovary cells using an antisense-RNA strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Glycan engineering and production of 'humanized' glycoprotein in yeast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Inactivation of CMP-N-acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3-galactose

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Siglecs and their roles in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Immunogenicity of protein therapeutics

21 January 2018

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https://api.crossref.org/works/10.5661%2FBGER-28-147

Engineering of glycosylation in yeast and other fungi: current state and perspectives

21 January 2018

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https://api.crossref.org/works/10.5661%2FBGER-28-147

GlycoPEGylation of recombinant therapeutic proteins produced in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Regulation of macropinocytosis by p21-activated kinase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Expression systems for therapeutic glycoprotein production.

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Process economics of industrial monoclonal antibody manufacture

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

N-glycosylation site mapping of human serotransferrin by serial lectin affinity chromatography, fast atom bombardment-mass spectrometry, and 1H nuclear magnetic resonance spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Validation of immunoassays used to assess immunogenicity to therapeutic monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Plant-specific glycosylation patterns in the context of therapeutic protein production.

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Genetic engineering of recombinant glycoproteins and the glycosylation pathway in mammalian host cells

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Human natural anti-Gal IgG regulates alternative complement pathway activation on bacterial surfaces

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Glycosylation engineering in yeast: the advent of fully humanized yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Human embryonic stem cells contaminated

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach.

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Alu-mediated inactivation of the human CMP- N-acetylneuraminic acid hydroxylase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

N-glycolylneuraminic acid deficiency in mice: implications for human biology and evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Evidence for a human-specific mechanism for diet and antibody-mediated inflammation in carcinoma progression

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

N-glycolylneuraminic acid xenoantigen contamination of human embryonic and mesenchymal stem cells is substantially reversible.

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Antigen of “serum sickness” type of heterophile antibodies in human sera: Identification as gangliosides with N-glycolylneuraminic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Re-visiting the endogenous capacity for recombinant glycoprotein sialylation by baculovirus-infected Tn-4h and DpN1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

A phase I trial of adoptive transfer of allogeneic natural killer cells in patients with advanced non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

The molecular basis for the absence of N-glycolylneuraminic acid in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

N-glycosylation engineering of biopharmaceutical expression systems

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Xenotransplantation: the importance of the Galalpha1,3Gal epitope in hyperacute vascular rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Modifications of cell surface sialic acids modulate cell adhesion mediated by sialoadhesin and CD22.

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Production and N-glycan analysis of secreted human erythropoietin glycoprotein in stably transfected Drosophila S2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Expression of β-1,4-galactosyltransferase and suppression of β-N-acetylglucosaminidase to aid synthesis of complex N-glycans in insect Drosophila S2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Fat, meat, and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products

21 January 2018

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https://api.crossref.org/works/10.5661%2FBGER-28-147

Baculovirus as versatile vectors for protein expression in insect and mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

N-Glycolylneuraminic acid in human tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Human embryonic stem cells express an immunogenic nonhuman sialic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Insect cell technology is a versatile and robust vaccine manufacturing platform

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Production of complex multiantennary N-glycans in Nicotiana benthamiana plants.

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Effects of natural human antibodies against a nonhuman sialic acid that metabolically incorporates into activated and malignant immune cells

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Meat consumption and colorectal cancer risk: dose-response meta-analysis of epidemiological studies

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Protein glycosylation in bacteria: sweeter than ever

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Evidence for efficient uptake and incorporation of sialic acid by eukaryotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: potential implications for disease

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Human xeno-autoantibodies against a non-human sialic acid serve as novel serum biomarkers and immunotherapeutics in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

The perspectives for porcine-to-human xenografts

21 January 2018

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https://api.crossref.org/works/10.5661%2FBGER-28-147

Production of alpha 1,3-galactosyltransferase-deficient pigs

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Structural characterization of N-linked oligosaccharides on monoclonal antibody cetuximab by the combination of orthogonal matrix-assisted laser desorption/ionization hybrid quadrupole-quadrupole time-of-flight tandem mass spectrometry and sequentia

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

International comparisons of mortality rates for cancer of the breast, ovary, prostate, and colon, and per capita food consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Panitumumab: a fully human monoclonal antibody with activity in metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Achievements and challenges of sialic acid research

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

A comprehensive phylogenetic analysis of Rieske and Rieske-type iron-sulfur proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

A combined method for producing homogeneous glycoproteins with eukaryotic N-glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

A risk-based bioanalytical strategy for the assessment of antibody immune responses against biological drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

The Biosynthesis of N-Glycoloylneuraminic Acid Occurs by Hydroxylation of the CMP-Glycoside of N-Acetylneuraminic Acid

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Fucose in N-glycans: from plant to man.

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Immunological property of antibodies against N-glycolylneuraminic acid epitopes in cytidine monophospho-N-acetylneuraminic acid hydroxylase-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Characterization of mouse sialyltransferase genes: their evolution and diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Multiple changes in sialic acid biology during human evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Diversity in cell surface sialic acid presentations: implications for biology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Biomedical differences between human and nonhuman hominids: potential roles for uniquely human aspects of sialic acid biology

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

N-linked glycosylation in Campylobacter jejuni and its functional transfer into E. coli

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Genetically modified animals and pharmacological research

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Manufacturing of biopharmaceuticals and implications for biosimilars

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Relationships between the N‐glycan structures and biological activities of recombinant human erythropoietins produced using different culture conditions and purification procedures

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Milk consumption in relation to incidence of prostate, breast, colon, and rectal cancers: is there an independent effect?

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

Anti-N-glycolylneuraminic acid antibodies identified in healthy human serum

21 January 2018

1 reference

https://api.crossref.org/works/10.5661%2FBGER-28-147

21 January 2018

Identifiers

DOI

10.5661/BGER-28-147

1 reference

27 August 2017

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