Poly(ADP-ribose) polymerase-2: emerging transcriptional roles of a DNA-repair protein (Q38009733)

26 August 2017

Poly(ADP-ribose) polymerase-2: emerging transcriptional roles of a DNA-repair protein (English)

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26 August 2017

Magdolna Szántó

1

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26 August 2017

Attila Brunyánszki

2

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26 August 2017

Borbála Kiss

3

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26 August 2017

Lilla Nagy

4

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26 August 2017

Pál Gergely

5

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26 August 2017

László Virág

6

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26 August 2017

Péter Bai

7

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26 August 2017

13 May 2012

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Cellular and Molecular Life Sciences

26 August 2017

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26 August 2017

69

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26 August 2017

24

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26 August 2017

4079-4092

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https://scigraph.springernature.com/pub.10.1007/s00018-012-1003-8

26 August 2017

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https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Toward a unified nomenclature for mammalian ADP-ribosyltransferases.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Poly(ADP-ribose): novel functions for an old molecule

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

PARP-3 and APLF function together to accelerate nonhomologous end-joining

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

A bidirectional promoter connects the poly(ADP-ribose) polymerase 2 (PARP-2) gene to the gene for RNase P RNA. structure and expression of the mouse PARP-2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Ionising radiation induces the expression of PARP-1 and PARP-2 genes in Arabidopsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Toward specific functions of poly(ADP-ribose) polymerase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Active caspase-8 translocates into the nucleus of apoptotic cells to inactivate poly(ADP-ribose) polymerase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Identification of candidate substrates for poly(ADP-ribose) polymerase-2 (PARP2) in the absence of DNA damage using high-density protein microarrays

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

PARP-1, PARP-2, and the cellular response to low doses of ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Loss of poly(ADP-ribose) polymerase-2 leads to rapid development of spontaneous T-cell lymphomas in p53-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Parp1 facilitates alternative NHEJ, whereas Parp2 suppresses IgH/c-myc translocations during immunoglobulin class switch recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Poly(ADP-ribose) reactivates stalled DNA topoisomerase I and Induces DNA strand break resealing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Mitomycin C modulates DNA-double strand break repair genes in cervical carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Functional interaction between poly(ADP-Ribose) polymerase 2 (PARP-2) and TRF2: PARP activity negatively regulates TRF2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

The therapeutic potential of poly(ADP-ribose) polymerase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

PolyADP-ribosylation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

PARP-2 deficiency affects the survival of CD4+CD8+ double-positive thymocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Integrated genomics of susceptibility to alkylator-induced leukemia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Co-localization of poly(ADPR)polymerase 1 (PARP-1) poly(ADPR)polymerase 2 (PARP-2) and related proteins in rat testis nuclear matrix defined by chemical cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

LMTK2 and PARP-2 gene polymorphism and azoospermia secondary to meiotic arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Differential contribution of poly(ADP-ribose)polymerase-1 and -2 (PARP-1 and -2) to the poly(ADP-ribosyl)ation reaction in rat primary spermatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Determination of Poly (ADP-ribose) polymerase (PARP) homologues in human ejaculated sperm and its correlation with sperm maturation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Parp2 is required for the differentiation of post-meiotic germ cells: identification of a spermatid-specific complex containing Parp1, Parp2, TP2 and HSPA2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

PARP inhibitors: new partners in the therapy of cancer and inflammatory diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Poly (ADP-ribose) polymerases (PARPs) 1-3 regulate astrocyte activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Genetic ablation of PARP-1 protects against oxazolone-induced contact hypersensitivity by modulating oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

PARP-2 regulates SIRT1 expression and whole-body energy expenditure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Poly(ADP-ribose) polymerase-2 [corrected] controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/peroxisome proliferator-activated receptor-gamma [corrected] heterodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

PARP-2 interacts with TTF-1 and regulates expression of surfactant protein-B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

The histone subcode: poly(ADP-ribose) polymerase-1 (Parp-1) and Parp-2 control cell differentiation by regulating the transcriptional intermediary factor TIF1beta and the heterochromatin protein HP1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

The role of poly(ADP-ribosyl)ation in epigenetic events.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Epigenetics: poly(ADP-ribosyl)ation of PARP-1 regulates genomic methylation patterns

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Reciprocal binding of PARP-1 and histone H1 at promoters specifies transcriptional outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

The peroxisome proliferator-activated receptors: ligands and activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

The organization, promoter analysis, and expression of the human PPARgamma gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

PPARs and the complex journey to obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Combinatorial control of gene expression by nuclear receptors and coregulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

The Sir2 family of protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Sirtuins in mammals: insights into their biological function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Roles of SIRT1 in the acute and restorative phases following induction of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Differential effect of PARP-2 deletion on brain injury after focal and global cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Contributions of poly(ADP-ribose) polymerase-1 and -2 to nuclear translocation of apoptosis-inducing factor and injury from focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Mitochondria, oxidative metabolism and cell death in stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Alternative mitochondrial electron transfer as a novel strategy for neuroprotection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Dexrazoxane (ICRF-187) Protects Cardiac Myocytes Against Doxorubicin by Preventing Damage to Mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Melatonin protection against lethal myocyte injury induced by doxorubicin as reflected by effects on mitochondrial membrane potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Effect of polyphenols on oxidative stress and mitochondrial dysfunction in neuronal death and brain edema in cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Pathways for ischemic cytoprotection: role of sirtuins in caloric restriction, resveratrol, and ischemic preconditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1003-8

Antisense oligonucleotides to poly(ADP-ribose) polymerase-2 ameliorate colitis in interleukin-10-deficient mice

21 January 2018

1 reference

12 December 2020

Poly(ADP-ribose) in the cellular response to DNA damage

1 reference

12 December 2020

Ginsenoside Rd attenuates mitochondrial dysfunction and sequential apoptosis after transient focal ischemia

1 reference

12 December 2020

Structure of poly(ADP-ribose)

1 reference

12 December 2020

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

1 reference

12 December 2020

PARP-1 and PARP-2: New players in tumour development.

1 reference

12 December 2020

Quantification of in vivo levels of poly(ADP-ribose): tritium labeling method and radioimmunoassay

1 reference

12 December 2020

10.1007/S00018-012-1003-8

Identifiers

DOI

1 reference

26 August 2017

1 reference