Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond (Q37998314)

26 August 2017

Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond (English)

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26 August 2017

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P Mark Hogarth

1

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PubMed ID

22460124

26 August 2017

Geoffrey A Pietersz

series ordinal

2

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26 August 2017

30 March 2012

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Nature Reviews Drug Discovery

26 August 2017

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26 August 2017

11

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26 August 2017

4

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26 August 2017

311-331

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https://scigraph.springernature.com/pub.10.1038/nrd2909

26 August 2017

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cites work

Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer

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Fc receptors and their role in immune regulation and autoimmunity

21 January 2018

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IgG antibodies produced during subcutaneous allergen immunotherapy mediate inhibition of basophil activation via a mechanism involving both FcgammaRIIA and FcgammaRIIB.

21 January 2018

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Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12.

21 January 2018

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CD16 promotes Escherichia coli sepsis through an FcR gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation

21 January 2018

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Divergent immunoglobulin g subclass activity through selective Fc receptor binding

21 January 2018

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Structural Basis for Fc RIIa Recognition of Human IgG and Formation of Inflammatory Signaling Complexes

21 January 2018

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Alteration of the Fc gamma RIIa dimer interface affects receptor signaling but not ligand binding.

21 January 2018

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Crystal structure of the human leukocyte Fc receptor, Fc gammaRIIa

21 January 2018

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CD23/FcεRII: molecular multi-tasking

21 January 2018

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Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells

21 January 2018

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Recent advances using FcRn overexpression in transgenic animals to overcome impediments of standard antibody technologies to improve the generation of specific antibodies.

21 January 2018

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Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.

21 January 2018

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Cytokine-induced immune complex binding to the high-affinity IgG receptor, FcγRI, in the presence of monomeric IgG.

21 January 2018

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Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses.

21 January 2018

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The Human Low Affinity Fcγ Receptors IIa, IIb, and III Bind IgG with Fast Kinetics and Distinct Thermodynamic Properties

21 January 2018

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Biochemical analysis and crystallisation of Fc gamma RIIa, the low affinity receptor for IgG.

21 January 2018

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Impact of Fc{gamma}RIIa-Fc{gamma}RIIIa polymorphisms and KRAS mutations on the clinical outcome of patients with metastatic colorectal cancer treated with cetuximab plus irinotecan.

21 January 2018

1 reference

Insights into the role of Fc gamma receptors (FcgammaRs) genetic variations in monoclonal antibody-based anti-cancer therapy.

21 January 2018

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Fcγ receptor polymorphisms and clinical efficacy of rituximab in non-Hodgkin lymphoma and chronic lymphocytic leukemia

21 January 2018

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Regulation of hematopoietic cell function by inhibitory immunoglobulin G receptors and their inositol lipid phosphatase effectors.

21 January 2018

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Structural comparison of fucosylated and nonfucosylated Fc fragments of human immunoglobulin G1

21 January 2018

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The structure of a human type III Fcgamma receptor in complex with Fc

21 January 2018

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Recognition of IgG by Fcgamma receptor. The role of Fc glycosylation and the binding of peptide inhibitors

21 January 2018

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The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex

21 January 2018

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X-ray crystallographic studies of IgG-Fc gamma receptor interactions

21 January 2018

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Crystal Structure of Fc Receptor I and Its Implication in High Affinity -Immunoglobulin Binding

21 January 2018

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Structure of the Fc fragment of human IgE bound to its high-affinity receptor Fc epsilonRI alpha

21 January 2018

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Insights into IgA-mediated immune responses from the crystal structures of human FcalphaRI and its complex with IgA1-Fc

21 January 2018

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FcR gamma chain deletion results in pleiotrophic effector cell defects

21 January 2018

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Recombinant soluble human Fc gamma RII: production, characterization, and inhibition of the Arthus reaction

21 January 2018

1 reference

Deletion of fcgamma receptor IIB renders H-2(b) mice susceptible to collagen-induced arthritis

21 January 2018

1 reference

Role of activatory Fc gamma RI and Fc gamma RIII and inhibitory Fc gamma RII in inflammation and cartilage destruction during experimental antigen-induced arthritis

21 January 2018

1 reference

Fc receptors: rubor redux

21 January 2018

1 reference

Human neutrophil Fcgamma receptors initiate and play specialized nonredundant roles in antibody-mediated inflammatory diseases

21 January 2018

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The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease

21 January 2018

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Expression of FcgammaRIII is required for development of collagen-induced arthritis.

21 January 2018

1 reference

FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses

21 January 2018

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Differential Contribution of Three Activating IgG Fc Receptors (Fc RI, Fc RIII, and Fc RIV) to IgG2a- and IgG2b-Induced Autoimmune Hemolytic Anemia in Mice

21 January 2018

1 reference

FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection

21 January 2018

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Humanized mouse models of FcR clearance in immune platelet disorders

21 January 2018

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Fcgamma receptors as regulators of immune responses

21 January 2018

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Antibody-mediated modulation of immune responses.

21 January 2018

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FcgammaRIIb inhibits allergic lung inflammation in a murine model of allergic asthma

21 January 2018

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Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria.

21 January 2018

1 reference

Regulation of human neutrophil Fcγ receptor IIa by C5a receptor promotes inflammatory arthritis in mice

21 January 2018

1 reference

Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9.

21 January 2018

1 reference

A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population

21 January 2018

1 reference

Fc receptors are major mediators of antibody based inflammation in autoimmunity

21 January 2018

1 reference

Recombinant soluble human FcgammaR1A (CD64A) reduces inflammation in murine collagen-induced arthritis

21 January 2018

1 reference

Generation of a high-affinity Fcgamma receptor by Ig-domain swapping between human CD64A and CD16A.

21 January 2018

1 reference

Extravasations and emigration of neutrophils to the inflammatory site depend on the interaction of immune-complex with Fcgamma receptors and can be effectively blocked by decoy Fcgamma receptors

21 January 2018

1 reference

Treatment of lupus-prone NZB/NZW F1 mice with recombinant soluble Fc gamma receptor II (CD32).

21 January 2018

1 reference

Human neutrophil Fc gamma receptor distribution and structure

21 January 2018

1 reference

CD32B, the human inhibitory Fc-gamma receptor IIB, as a target for monoclonal antibody therapy of B-cell lymphoma

21 January 2018

1 reference

Expression profile of FcgammaRIIb on leukocytes and its dysregulation in systemic lupus erythematosus

21 January 2018

1 reference

In vivo handling of soluble complement fixing Ab/dsDNA immune complexes in chimpanzees

21 January 2018

1 reference

Treatment of refractory immune thrombocytopenic purpura with an anti-Fc gamma-receptor antibody

21 January 2018

1 reference

Blockade of clearance of immune complexes by an anti-Fc gamma receptor monoclonal antibody

21 January 2018

1 reference

Monoclonal antibody 197 (anti-Fc gamma RI) infusion in a patient with immune thrombocytopenia purpura (ITP) results in down-modulation of Fc gamma RI on circulating monocytes

21 January 2018

1 reference

FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications.

21 January 2018

1 reference

A novel polymorphism in the Fcgamma receptor IIB (CD32B) transmembrane region alters receptor signaling

21 January 2018

1 reference

Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis.

21 January 2018

1 reference

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

21 January 2018

1 reference

Association of FcgR2a, but not FcgR3a, with inflammatory bowel diseases across three Caucasian populations†

21 January 2018

1 reference

FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity

21 January 2018

1 reference

Copy number, linkage disequilibrium and disease association in the FCGR locus

21 January 2018

1 reference

Stable "zeta" peptides that act as potent antagonists of the high-affinity IgE receptor

21 January 2018

1 reference

A novel family of hairpin peptides that inhibit IgE activity by binding to the high-affinity IgE receptor

21 January 2018

1 reference

Monoclonal antibodies and synthetic peptides define the active site of FcεRI and a potential receptor antagonist

21 January 2018

1 reference

Localization of the IgG effector site for monocyte receptors

21 January 2018

1 reference

A new ligand for immunoglobulin g subdomains by screening of a synthetic peptide library

21 January 2018

1 reference

Characterization of an FcgammaRI-binding peptide selected by phage display

21 January 2018

1 reference

Convergent solutions to binding at a protein-protein interface

21 January 2018

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A synthetic mimic of human Fc receptors: defined chemical modification of cell surfaces enables efficient endocytic uptake of human immunoglobulin-G.

21 January 2018

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Identification of cyclic peptides able to mimic the functional epitope of IgG1-Fc for human Fc gammaRI.

21 January 2018

1 reference

Identification of a high affinity FcgammaRIIA-binding peptide that distinguishes FcgammaRIIA from FcgammaRIIB and exploits FcgammaRIIA-mediated phagocytosis and degradation

21 January 2018

1 reference

An FcgammaRIIa-binding peptide that mimics the interaction between FcgammaRIIa and IgG.

21 January 2018

1 reference

Inhibition of destructive autoimmune arthritis in FcgammaRIIa transgenic mice by small chemical entities

21 January 2018

1 reference

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis

21 January 2018

1 reference

R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation

21 January 2018

1 reference

Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk.

21 January 2018

1 reference

Clinical uses of intravenous immunoglobulin.

21 January 2018

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Mechanisms of action of intravenous immunoglobulins

21 January 2018

1 reference

The IgG molecule as a biological immune response modifier: mechanisms of action of intravenous immune serum globulin in autoimmune and inflammatory disorders

21 January 2018

1 reference

Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin.

21 January 2018

1 reference

Intravenous immunoglobulin in autoimmune disorders: an insight into the immunoregulatory mechanisms.

21 January 2018

1 reference

Mechanisms of action of intravenous immunoglobulin in the treatment of immune thrombocytopenia

21 January 2018

1 reference

Infusion of Fc gamma fragments for treatment of children with acute immune thrombocytopenic purpura.

21 January 2018

1 reference

Intravenous immunoglobulin ameliorates ITP via activating Fc gamma receptors on dendritic cells

21 January 2018

1 reference

Anti-Inflammatory Activity of Immunoglobulin G Resulting from Fc Sialylation

21 January 2018

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Intravenous gammaglobulin suppresses inflammation through a novel T(H)2 pathway.

21 January 2018

1 reference

Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action

21 January 2018

1 reference

Glycosylation as a strategy to improve antibody-based therapeutics

21 January 2018

1 reference

Quantitation of the oligosaccharides of human serum IgG from patients with rheumatoid arthritis: a critical evaluation of different methods.

21 January 2018

1 reference

Evolution of anti-CD20 monoclonal antibody therapeutics in oncology

21 January 2018

1 reference

Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma

21 January 2018

1 reference

FCGR2APolymorphism Is Correlated With Clinical Outcome After Immunotherapy of Neuroblastoma With Anti-GD2 Antibody and Granulocyte Macrophage Colony-Stimulating Factor

21 January 2018

1 reference

Clinical outcome of lymphoma patients after idiotype vaccination is correlated with humoral immune response and immunoglobulin G Fc receptor genotype

21 January 2018

1 reference

FcγRIIIa and FcγRIIa polymorphisms do not predict response to rituximab in B-cell chronic lymphocytic leukemia

21 January 2018

1 reference

FCGR3A and FCGR2A polymorphisms may not correlate with response to alemtuzumab in chronic lymphocytic leukemia

21 January 2018

1 reference

In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling.

21 January 2018

1 reference

Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy.

21 January 2018

1 reference

Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy.

21 January 2018

1 reference

Engineered antibody Fc variants with enhanced effector function

21 January 2018

1 reference

Enhancing the potency of therapeutic monoclonal antibodies via Fc optimization.

21 January 2018

1 reference

High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.

21 January 2018

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In vivo enzymatic modulation of IgG glycosylation inhibits autoimmune disease in an IgG subclass-dependent manner

21 January 2018

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Glycosylation and biological activity of CAMPATH-1H expressed in different cell lines and grown under different culture conditions

21 January 2018

1 reference

Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity

21 January 2018

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Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity

21 January 2018

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The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity

21 January 2018

1 reference

Establishment of FUT8 knockout Chinese hamster ovary cells: an ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity

21 January 2018

1 reference

Modulation of therapeutic antibody effector functions by glycosylation engineering: influence of Golgi enzyme localization domain and co-expression of heterologous beta1, 4-N-acetylglucosaminyltransferase III and Golgi alpha-mannosidase II.

21 January 2018

1 reference

The carbohydrate at FcgammaRIIIa Asn-162. An element required for high affinity binding to non-fucosylated IgG glycoforms

21 January 2018

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Control of recombinant monoclonal antibody effector functions by Fc N-glycan remodeling in vitro

21 January 2018

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Rapid production of recombinant human IgG With improved ADCC effector function in a transient expression system

21 January 2018

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Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors

21 January 2018

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Chapter 4: Multitasking by exploitation of intracellular transport functions the many faces of FcRn.

21 January 2018

1 reference

X-ray Crystal Structures of Monomeric and Dimeric Peptide Inhibitors in Complex with the Human Neonatal Fc Receptor, FcRn

21 January 2018

1 reference

Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,)

21 January 2018

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Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential

21 January 2018

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Engineered human IgG antibodies with longer serum half-lives in primates

21 January 2018

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Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).

21 January 2018

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Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies

21 January 2018

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Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy

21 January 2018

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Inhibition of immune responses by ITAM-bearing receptors

21 January 2018

1 reference

Pivotal involvement of Fcgamma receptor IIA in the neutralization of lipopolysaccharide signaling via a potent novel anti-TLR4 monoclonal antibody 15C1.

21 January 2018

1 reference

Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy

21 January 2018

1 reference

Modulation of antibody effector function

21 January 2018

1 reference

Targeting FcαRI on polymorphonuclear cells induces tumor cell killing through autophagy

21 January 2018

1 reference

Immunoglobulin A: A next generation of therapeutic antibodies?

21 January 2018

1 reference

Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution

21 January 2018

1 reference

Fc gamma RIIa, not Fc gamma RIIb, is constitutively and functionally expressed on skin-derived human mast cells

21 January 2018

1 reference

Co-aggregation of FcgammaRII with FcepsilonRI on human mast cells inhibits antigen-induced secretion and involves SHIP-Grb2-Dok complexes

21 January 2018

1 reference

Interaction with FcγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody.

21 January 2018

1 reference

An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells

21 January 2018

1 reference

Inhibitory ITAM Signaling Traps Activating Receptors with the Phosphatase SHP-1 to Form Polarized "Inhibisome" Clusters

21 January 2018

1 reference

The C1q receptor site on immunoglobulin G

21 January 2018

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In vivo veritas: the surprising roles of Fc receptors in immunity

21 January 2018

1 reference

The IgG Fc contains distinct Fc receptor (FcR) binding sites: the leukocyte receptors Fc gamma RI and Fc gamma RIIa bind to a region in the Fc distinct from that recognized by neonatal FcR and protein A

31 March 2020

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The interaction of Fc alpha RI with IgA and its implications for ligand binding by immunoreceptors of the leukocyte receptor cluster

31 March 2020

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Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcgammaRII

31 March 2020

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Development of spontaneous multisystem autoimmune disease and hypersensitivity to antibody-induced inflammation in Fcgamma receptor IIa-transgenic mice

31 March 2020

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Role of Fc receptor gamma chain in inflammation and cartilage damage during experimental antigen-induced arthritis

31 March 2020

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Surface-bound anti-type II collagen-containing immune complexes induce production of tumor necrosis factor alpha, interleukin-1beta, and interleukin-8 from peripheral blood monocytes via Fc gamma receptor IIA: a potential pathophysiologic mechanism

31 March 2020

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FcR-bearing myeloid cells are responsible for triggering murine lupus nephritis

31 March 2020

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FcgammaRIIB deficiency leads to autoimmunity and a defective response to apoptosis in Mrl-MpJ mice

31 March 2020

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Transgenic mice expressing human FcgammaRIIa have enhanced sensitivity to induced autoimmune arthritis as well as elevated Th17 cells

31 March 2020

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Targeting immune complex-mediated hypersensitivity with recombinant soluble human FcgammaRIA (CD64A)

31 March 2020

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Amelioration of collagen-induced arthritis by human recombinant soluble FcgammaRIIb

31 March 2020

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The human mononuclear phagocyte high-affinity Fc receptor, FcRI, defined by a monoclonal antibody, 10.1.

31 March 2020

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Humanized mAb H22 binds the human high affinity Fc receptor for IgG (FcgammaRI), blocks phagocytosis, and modulates receptor expression

31 March 2020

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Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility

31 March 2020

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The use of synthetic γ-chain peptides in the localization of the binding site(s) on human IgG1 for the Fc receptors of homologous monocytes and heterologous mouse macrophages

31 March 2020

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The structure of Fc receptor/Ig complexes: considerations on stoichiometry and potential inhibitors

31 March 2020

1 reference

Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene

31 March 2020

1 reference

Fc optimization of therapeutic antibodies enhances their ability to kill tumor cells in vitro and controls tumor expansion in vivo via low-affinity activating Fcgamma receptors

31 March 2020

1 reference

Improved effector functions of a therapeutic monoclonal Lewis Y-specific antibody by glycoform engineering

31 March 2020

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Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma

31 March 2020

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Transmembrane signaling: the joy of aggregation

31 March 2020

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12 December 2020

Human antibody effector function

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12 December 2020

Human monocytes and U937 cells bear two distinct Fc receptors for IgG.

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12 December 2020

[Allergy and autoimmunity mediated by IgG and Fcgamma receptors]

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12 December 2020

Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments.

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12 December 2020

Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype

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12 December 2020

Refined structure of an intact IgG2a monoclonal antibody

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12 December 2020

Blockade of Fc receptor-mediated binding to U-937 cells by murine monoclonal antibodies directed against a variety of surface antigens

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12 December 2020

Molecular basis of Fc receptor function

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12 December 2020

Identifiers

DOI

10.1038/NRD2909

1 reference

26 August 2017

1 reference

PubMed ID

22460124