Bruton tyrosine kinase (BTK) and its role in B-cell malignancy (Q37997075)

26 August 2017

Bruton tyrosine kinase (BTK) and its role in B-cell malignancy (English)

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26 August 2017

Joseph J Buggy

1

1 reference

PubMed ID

22449073

26 August 2017

Laurence Elias

series ordinal

2

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26 August 2017

1 April 2012

1 reference

International Reviews of Immunology

26 August 2017

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26 August 2017

31

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26 August 2017

2

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26 August 2017

119-132

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The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

26 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Expression of Bruton's tyrosine kinase protein within the B cell lineage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

The Bruton's tyrosine kinase gene is expressed throughout B cell differentiation, from early precursor B cell stages preceding immunoglobulin gene rearrangement up to mature B cell stages

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Primary B cell immunodeficiencies: comparisons and contrasts

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Role of Bruton's tyrosine kinase in immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Btk dosage determines sensitivity to B cell antigen receptor cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Impaired expansion of mouse B cell progenitors lacking Btk.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Signalling of Bruton's tyrosine kinase, Btk.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Characteristic sequence motifs at the breakpoints of the hybrid genes FUS/CHOP, EWS/CHOP and FUS/ERG in myxoid liposarcoma and acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Tec kinases mediate sustained calcium influx via site-specific tyrosine phosphorylation of the phospholipase Cgamma Src homology 2-Src homology 3 linker

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Btk/Tec kinases regulate sustained increases in intracellular Ca2+ following B-cell receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Different protein tyrosine kinases are required for B cell antigen receptor-mediated activation of extracellular signal-regulated kinase, c-Jun NH2-terminal kinase 1, and p38 mitogen-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Genetic analysis of B cell antigen receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Regulation of B-cell fate by antigen-receptor signals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

B cell antigen receptor signaling: roles in cell development and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Regulation of Btk by Src family tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

PI3 kinase signals BCR-dependent mature B cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Bruton's tyrosine kinase is required for activation of IkappaB kinase and nuclear factor kappaB in response to B cell receptor engagement

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Regulation of B lymphocyte development and activation by Bruton's tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Proteasome-dependent autoregulation of Bruton tyrosine kinase (Btk) promoter via NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Dual functions of Bruton's tyrosine kinase and Tec kinase during Fcgamma receptor-induced signaling and phagocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Roles for phosphoinositide 3-kinases, Bruton's tyrosine kinase, and Jun kinases in B lymphocyte chemotaxis and homing.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Intracellular signalling controlling integrin activation in lymphocytes

21 January 2018

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https://api.crossref.org/works/10.3109%2F08830185.2012.664797

G Protein beta gamma subunits act on the catalytic domain to stimulate Bruton's agammaglobulinemia tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

The B cell antigen receptor controls integrin activity through Btk and PLCgamma2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Bruton's tyrosine kinase regulates apoptosis and JNK/SAPK kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Neutrophil development and function critically depend on Bruton tyrosine kinase in a mouse model of X-linked agammaglobulinemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Bruton's tyrosine kinase (BTK) is a binding partner for hypoxia induced mitogenic factor (HIMF/FIZZ1) and mediates myeloid cell chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

The tec family tyrosine kinase Btk Regulates RANKL-induced osteoclast maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Elevated cytokine production restores bone resorption by human Btk-deficient osteoclasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Integrated signalling pathways for mast-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Mast cells are novel independent prognostic markers in prostate cancer and represent a target for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Modeling pharmacological inhibition of mast cell degranulation as a therapy for insulinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Tumor suppressor function of Bruton tyrosine kinase is independent of its catalytic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Mechanisms of B-cell lymphoma pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Cutting edge: constitutive B cell receptor signaling is critical for basal growth of B lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Lymphoma dissemination: the other face of lymphocyte homing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

CXCL12 (SDF-1)/CXCR4 pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Mantle cell lymphoma cells express high levels of CXCR4, CXCR5, and VLA-4 (CD49d): importance for interactions with the stromal microenvironment and specific targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Homeostatic chemokines drive migration of malignant B cells in patients with non-Hodgkin lymphomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Stromal gene signatures in large-B-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Chemosensitizing anti-cancer activity of LFM-A13, a leflunomide metabolite analog targeting polo-like kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Inhibition of IgE-mediated secretion from human basophils with a highly selective Bruton's tyrosine kinase, Btk, inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

B-cell receptors and heavy chain diseases: guilty by association?

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Phosphatidylinositol 3'-kinase catalytic subunit alpha gene amplification contributes to the pathogenesis of mantle cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Identification of genes regulated by dexamethasone in multiple myeloma cells using oligonucleotide arrays

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Characterization of clonogenic multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Mimicry of a constitutively active pre-B cell receptor in acute lymphoblastic leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Fcgamma receptors as regulators of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

Bruton's Tyrosine Kinase and Phospholipase Cγ2 Mediate Chemokine-Controlled B Cell Migration and Homing

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F08830185.2012.664797

10.3109/08830185.2012.664797

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22449073