The role of iron as a mediator of oxidative stress in Alzheimer disease (Q37996961)

26 August 2017

The role of iron as a mediator of oxidative stress in Alzheimer disease (English)

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26 August 2017

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3

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26 August 2017

Paula I Moreira

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Xiongwei Zhu

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4

object named as

Xiongwei Zhu

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26 August 2017

Rudy J Castellani

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26 August 2017

23 March 2012

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26 August 2017

38

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133-138

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Therapeutic opportunities in Alzheimer disease: one for all or all for one?

26 August 2017

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Current approaches in the treatment of Alzheimer's disease

21 January 2018

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Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is 'too big to fail'.

21 January 2018

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Alzheimer disease pathology as a host response

21 January 2018

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Neuropathology of Alzheimer disease: pathognomonic but not pathogenic

21 January 2018

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The cell cycle hypothesis of Alzheimer's disease: suggestions for drug development

21 January 2018

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Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

21 January 2018

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Systemic iron metabolism: a review and implications for brain iron metabolism

21 January 2018

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21 January 2018

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Recent advances in disorders of iron metabolism: mutations, mechanisms and modifiers

21 January 2018

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Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system.

21 January 2018

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The iron-binding protein lactotransferrin is present in pathologic lesions in a variety of neurodegenerative disorders: a comparative immunohistochemical analysis.

21 January 2018

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Alternative RNA splicing generates a glycosylphosphatidylinositol-anchored form of ceruloplasmin in mammalian brain

21 January 2018

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Expression of the ceruloplasmin gene in the human retina and brain: implications for a pathogenic model in aceruloplasminemia

21 January 2018

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Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin?

21 January 2018

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Iron and transferrin uptake by brain and cerebrospinal fluid in the rat

21 January 2018

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Discovery of a brain promoter from the human transferrin gene and its utilization for development of transgenic mice that express human apolipoprotein E alleles

21 January 2018

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The roles of iron in health and disease

21 January 2018

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Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress

21 January 2018

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Iron and iron management proteins in neurobiology

21 January 2018

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Regional distribution of heme oxygenase, HSP70, and glutathione in brain: relevance for endogenous oxidant/antioxidant balance and stress tolerance

21 January 2018

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Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease.

21 January 2018

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Advanced Maillard reaction end products are associated with Alzheimer disease pathology

21 January 2018

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Oxidative damage in Alzheimer's.

21 January 2018

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Free radical formation in autopsy samples of Alzheimer and control cortex.

21 January 2018

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Increased cerebral glucose-6-phosphate dehydrogenase activity in Alzheimer's disease may reflect oxidative stress

21 January 2018

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Copper, iron and zinc in Alzheimer's disease senile plaques.

21 January 2018

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Vascular abnormalities: the insidious pathogenesis of Alzheimer's disease

21 January 2018

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Induction of amyloid precursor protein mRNA after heat shock in cultured human lymphoblastoid cells.

21 January 2018

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Ischemic stress induces deposition of amyloid beta immunoreactivity in human brain

21 January 2018

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Experimental brain injury induces expression of amyloid precursor protein, which may be related to neuronal loss in the hippocampus.

21 January 2018

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Hypoglycemia enhances the expression of mRNA encoding beta-amyloid precursor protein in rat primary cortical astroglial cells.

21 January 2018

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Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease

21 January 2018

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Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells.

21 January 2018

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Melatonin protects SHSY5Y neuroblastoma cells from cobalt-induced oxidative stress, neurotoxicity and increased beta-amyloid secretion

21 January 2018

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Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells.

21 January 2018

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Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

21 January 2018

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Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

21 January 2018

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Copernicus revisited: amyloid beta in Alzheimer's disease

21 January 2018

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Redox-active iron mediates amyloid-beta toxicity

21 January 2018

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The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease

21 January 2018

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Perivascular astrocytes within Alzheimer's disease plaques

21 January 2018

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Activated microglia cause iron-dependent lipid peroxidation in the presence of ferritin.

21 January 2018

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Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron

21 January 2018

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Sublethal RNA oxidation as a mechanism for neurodegenerative disease

21 January 2018

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RNA oxidation in Alzheimer disease and related neurodegenerative disorders

21 January 2018

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Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies

21 January 2018

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Cerebral amyloid angiopathy: major contributor or decorative response to Alzheimer's disease pathogenesis

21 January 2018

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Detection, identification and mapping of iron anomalies in brain tissue using X-ray absorption spectroscopy

21 January 2018

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TEM investigations of biogenic magnetite extracted from the human hippocampus.

21 January 2018

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Magnetite biomineralization in the human brain

21 January 2018

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Nanoscale biogenic iron oxides and neurodegenerative disease

21 January 2018

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Magnetic iron compounds in neurological disorders

21 January 2018

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Metal complexing agents as therapies for Alzheimer's disease

21 January 2018

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Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats

21 January 2018

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Brain ferritin iron may influence age- and gender-related risks of neurodegeneration.

21 January 2018

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In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice

21 January 2018

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Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

21 January 2018

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Nanoparticle and other metal chelation therapeutics in Alzheimer disease

21 January 2018

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Predicting the failure of amyloid-beta vaccine.

21 January 2018

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Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease

21 January 2018

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Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

21 January 2018

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

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Redox active iron accumulation in aceruloplasminemia

21 January 2018

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Characterization of Copper Interactions with Alzheimer Amyloid β Peptides

21 January 2018

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21 January 2018

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Arson. Tracking the culprit in Alzheimer's disease

21 January 2018

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In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

21 January 2018

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Oxidative stress induces increase in intracellular amyloid beta-protein production and selective activation of betaI and betaII PKCs in NT2 cells

21 January 2018

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High-resolution x-ray absorption spectroscopy studies of metal compounds in neurodegenerative brain tissue

21 January 2018

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction†

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIOF.1010

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26 August 2017

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PubMed ID

22447715