BRCA1--conductor of the breast stem cell orchestra: the role of BRCA1 in mammary gland development and identification of cell of origin of BRCA1 mutant breast cancer (Q37994602)

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scientific article published on September 2012

Language	Label	Description	Also known as
English	BRCA1--conductor of the breast stem cell orchestra: the role of BRCA1 in mammary gland development and identification of cell of origin of BRCA1 mutant breast cancer	scientific article published on September 2012

Statements

scholarly article

1 reference

Europe PubMed Central

26 August 2017

BRCA1--conductor of the breast stem cell orchestra: the role of BRCA1 in mammary gland development and identification of cell of origin of BRCA1 mutant breast cancer (English)

1 reference

Europe PubMed Central

26 August 2017

author name string

Niamh E Buckley

1

1 reference

Europe PubMed Central

26 August 2017

Paul B Mullan

2

1 reference

Europe PubMed Central

26 August 2017

publication date

1 September 2012

1 reference

Europe PubMed Central

26 August 2017

Stem Cell Reviews and Reports

1 reference

Europe PubMed Central

26 August 2017

8

1 reference

Europe PubMed Central

26 August 2017

3

1 reference

Europe PubMed Central

26 August 2017

982-993

1 reference

Europe PubMed Central

26 August 2017

https://scigraph.springernature.com/pub.10.1007/s12015-012-9354-y

0 references

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Hallmarks of 'BRCAness' in sporadic cancers

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

BRCA1 physically associates with p53 and stimulates its transcriptional activity.

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

BRCA1 regulates the interferon gamma-mediated apoptotic response

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

BRCA1 functions as a breast stem cell regulator

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

BRCA1 regulates human mammary stem/progenitor cell fate

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Will cancer stem cells provide new therapeutic targets?

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Breast cancer: origins and evolution

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Repeated observation of breast tumor subtypes in independent gene expression data sets

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Tamoxifen and risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study. Hereditary Breast Cancer Clinical Study Group

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

The BRCA1 C-terminal domain: structure and function.

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

The BRCT Domain Is a Phospho-Protein Binding Domain

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Evidence for a transcriptional activation function of BRCA1 C-terminal region

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Mutation and cancer: statistical study of retinoblastoma

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Cancer biology. A matter of dosage

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Germline TP53 mutations in breast cancer families with multiple primary cancers: is TP53 a modifier of BRCA1?

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair.

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia.

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Basal cytokeratins and their relationship to the cellular origin and functional classification of breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues.

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Brca1 regulates in vitro differentiation of mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer.

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible gene

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

The DeltaNp63 proteins are key allies of BRCA1 in the prevention of basal-like breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Antagonistic roles of Notch and p63 in controlling mammary epithelial cell fates

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Transcriptome analysis of the normal human mammary cell commitment and differentiation process

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancers

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

p63 regulates an adhesion programme and cell survival in epithelial cells

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

BRCA1 transcriptionally regulates genes involved in breast tumorigenesis

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Cells of origin in cancer

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Cancer stem cells: back to Darwin?

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes.

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Mammary development meets cancer genomics.

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Transcriptional activation by BRCA1

1 reference

https://api.crossref.org/works/10.1007%2FS12015-012-9354-Y

21 January 2018

Roles of BRCA1 and its interacting proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22426855

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of BRCA1 expression in Japanese sporadic breast carcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/22426855

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRCA1 transcriptionally regulates genes associated with the basal-like phenotype in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22426855

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155

1 reference

https://pubmed.ncbi.nlm.nih.gov/22426855

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: distinctive spectrum and structural distribution.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22426855

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 2,5 oligoadenylate synthetase/RNaseL pathway is a novel effector of BRCA1- and interferon-gamma-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22426855

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BRCA1: a scaffold for p53 response?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22426855

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic myelocytic leukemia. Origin of some lymphocytes from leukemic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22426855

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brca1 and Brca2 protein expression patterns in different tissues of murine origin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22426855

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S12015-012-9354-Y

1 reference

Europe PubMed Central

26 August 2017

1 reference

Europe PubMed Central

26 August 2017

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