Aβ toxicity in Alzheimer's disease (Q37993451)

26 August 2017

Aβ toxicity in Alzheimer's disease (English)

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26 August 2017

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Virve Cavallucci

1

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Marcello D'Amelio

object named as

Marcello D'Amelio

series ordinal

2

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Francesco Cecconi

object named as

Francesco Cecconi

series ordinal

3

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publication date

14 March 2012

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26 August 2017

Molecular Neurobiology

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26 August 2017

45

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26 August 2017

366-378

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26 August 2017

2

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https://scigraph.springernature.com/pub.10.1007/s12035-012-8251-3

26 August 2017

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21 January 2018

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Presenile dementia and Alzheimer's disease in mongolism.

21 January 2018

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Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

21 January 2018

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

21 January 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

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Candidate gene for the chromosome 1 familial Alzheimer's disease locus

21 January 2018

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

21 January 2018

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Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

21 January 2018

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

21 January 2018

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How common are the "common" neurologic disorders?

21 January 2018

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Aging of the brain, entropy, and Alzheimer disease

21 January 2018

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Post-menopausal estrogen deprivation and Alzheimer's disease

21 January 2018

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Endogenous estrogen levels and Alzheimer's disease among postmenopausal women.

21 January 2018

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Estrogens, episodic memory, and Alzheimer's disease: a critical update

21 January 2018

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Head injury and the risk of AD in the MIRAGE study

21 January 2018

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Effects of closed traumatic brain injury and genetic factors on the development of Alzheimer's disease.

21 January 2018

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Vascular risk factors for Alzheimer's disease: an epidemiologic perspective.

21 January 2018

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Midlife blood pressure and dementia: the Honolulu-Asia aging study.

21 January 2018

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Midlife vascular risk factors and late-life mild cognitive impairment: A population-based study

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Physical activity, diet, and risk of Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Cognitive activities delay onset of memory decline in persons who develop dementia

21 January 2018

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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

21 January 2018

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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

21 January 2018

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Genome-wide analysis of genetic loci associated with Alzheimer disease

21 January 2018

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

21 January 2018

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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

21 January 2018

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Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

ADAMs family members as amyloid precursor protein alpha-secretases

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

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PS1 N- and C-terminal fragments form a complex that functions in APP processing and Notch signaling

21 January 2018

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PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

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The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

21 January 2018

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The role of A beta 42 in Alzheimer's disease

21 January 2018

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Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.

21 January 2018

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Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8.

21 January 2018

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Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

21 January 2018

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Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP).

21 January 2018

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Beta-amyloid catabolism: roles for neprilysin (NEP) and other metallopeptidases?

21 January 2018

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Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline

21 January 2018

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

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APP processing and synaptic function

21 January 2018

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NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production.

21 January 2018

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Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory

21 January 2018

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https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Endogenous amyloid-β is necessary for hippocampal synaptic plasticity and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Cleavage of Alzheimer's amyloid precursor protein by alpha-secretase occurs at the surface of neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Phenotype associated with APP duplication in five families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Deciphering the genetic basis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease--therapeutic aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

On the structural definition of amyloid fibrils and other polypeptide aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Alzheimer's disease: from pathology to therapeutic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Recent progress in understanding Alzheimer's β-amyloid structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Intracellular amyloid-beta in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Intraneuronal Abeta42 accumulation in human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Distinct pools of beta-amyloid in Alzheimer disease-affected brain: a clinicopathologic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Pharmacology of acetylcholinesterase inhibitors and N-methyl-D-aspartate receptors for combination therapy in the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

The cholinergic hypothesis of geriatric memory dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Expression of nicotinic acetylcholine receptor subunits in the cerebral cortex in Alzheimer's disease: histotopographical correlation with amyloid plaques and hyperphosphorylated-tau protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Fractional Ca2+ currents through somatic and dendritic glutamate receptor channels of rat hippocampal CA1 pyramidal neurones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Amyloid beta peptides and glutamatergic synaptic dysregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Electrophysiological effects of 25-35 amyloid-beta-protein on guinea-pig lateral septal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Regulation of NMDA receptor trafficking by amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Reduced levels of the tyrosine phosphatase STEP block β amyloid-mediated GluA1/GluA2 receptor internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Maturation of autophagic vacuoles in Mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Regulation mechanisms and signaling pathways of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Methods in mammalian autophagy research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Macroautophagy is not directly involved in the metabolism of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Rapamycin alleviates toxicity of different aggregate-prone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12035-012-8251-3

The production of amyloid beta peptide is a critical requirement for the viability of central neurons.

21 January 2018

1 reference

12 December 2020

Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

1 reference

12 December 2020

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

12 December 2020

Visual memory predicts Alzheimer's disease more than a decade before diagnosis

1 reference

12 December 2020

Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion

1 reference

12 December 2020

Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias

1 reference

12 December 2020

Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome.

1 reference

12 December 2020

Intraneuronal Abeta42 accumulation in Down syndrome brain.

1 reference

12 December 2020

Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS. Honolulu-Asia aging Study.

1 reference

12 December 2020

Intraneuronal Aβ accumulation, amyloid plaques, and synapse pathology in Alzheimer's disease.

1 reference

12 December 2020

Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease.

1 reference

12 December 2020

Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

1 reference

12 December 2020

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

1 reference

12 December 2020

Genetic variability of apolipoprotein E in a Polish population

1 reference

12 December 2020

Pathological correlates of cognitive decline in Alzheimer's disease

1 reference

12 December 2020

Functions of the APP gene family in the nervous system: insights from mouse models

1 reference

12 December 2020

Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area

1 reference

12 December 2020

Apolipoprotein E genotypes in sporadic early and late-onset Alzheimer's disease.

1 reference

12 December 2020

Proteolytic processing and cell biological functions of the amyloid precursor protein

1 reference

12 December 2020

10.1007/S12035-012-8251-3

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22415442