Systemic mastocytosis in adults: 2012 Update on diagnosis, risk stratification, and management (Q37992835)

26 August 2017

title

Systemic mastocytosis in adults: 2012 Update on diagnosis, risk stratification, and management (English)

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26 August 2017

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systemic mastocytosis

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Animesh Pardanani

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26 August 2017

publication date

1 April 2012

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American Journal of Hematology

26 August 2017

published in

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26 August 2017

volume

87

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26 August 2017

issue

4

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26 August 2017

page(s)

401-411

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Bone marrow findings in systemic mastocytosis

26 August 2017

cites work

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Bone marrow mast cell morphologic features and hematopoietic dyspoiesis in systemic mast cell disease

21 January 2018

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Pediatric-onset mastocytosis: a long term clinical follow-up and correlation with bone marrow histopathology

21 January 2018

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Urticaria pigmentosa: a review of 67 pediatric cases

21 January 2018

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Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors

21 January 2018

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A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome

21 January 2018

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Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness

21 January 2018

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Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome

21 January 2018

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FIP1L1-PDGFRA fusion: prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia

21 January 2018

1 reference

Imatinib for systemic mast-cell disease

21 January 2018

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CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy

21 January 2018

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Characterization of three new imatinib-responsive fusion genes in chronic myeloproliferative disorders generated by disruption of the platelet-derived growth factor receptor beta gene.

21 January 2018

1 reference

Systemic mastocytosis with associated clonal haematological non-mast cell lineage diseases: a histopathological challenge

21 January 2018

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Detection of c-kit point mutation Asp-816 --> Val in microdissected pooled single mast cells and leukemic cells in a patient with systemic mastocytosis and concomitant chronic myelomonocytic leukemia.

21 January 2018

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Significance of systemic mast cell disease with associated hematologic disorders

21 January 2018

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Prognostically relevant breakdown of 123 patients with systemic mastocytosis associated with other myeloid malignancies

21 January 2018

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Demonstration that mast cells, T cells, and B cells bearing the activating kit mutation D816V occur in clusters within the marrow of patients with mastocytosis

21 January 2018

1 reference

KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation

21 January 2018

1 reference

Identification of activating c-kit mutations in adult-, but not in childhood-onset indolent mastocytosis: a possible explanation for divergent clinical behavior

21 January 2018

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Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product

21 January 2018

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One-step detection of c-kit point mutations using peptide nucleic acid-mediated polymerase chain reaction clamping and hybridization probes

21 January 2018

1 reference

Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis

21 January 2018

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Mast cell disease associated with acute myeloid leukemia: detection of a new c-kit mutation Asp816His

21 January 2018

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Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations.

21 January 2018

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c-kit Mutations in patients with childhood-onset mastocytosis and genotype-phenotype correlation

21 January 2018

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KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors

21 January 2018

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Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia

21 January 2018

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Novel germline mutation of KIT associated with familial gastrointestinal stromal tumors and mastocytosis

21 January 2018

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A novel K509I mutation of KIT identified in familial mastocytosis-in vitro and in vivo responsiveness to imatinib therapy

21 January 2018

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A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib

21 January 2018

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A germline mutation in KIT in familial diffuse cutaneous mastocytosis

21 January 2018

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Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation

21 January 2018

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Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit.

21 January 2018

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Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates

21 January 2018

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Clonal analysis of NRAS activating mutations in KIT-D816V systemic mastocytosis

21 January 2018

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Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras.

21 January 2018

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Histopathological and immunohistochemical aspects of mastocytosis.

21 January 2018

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CD25 indicates the neoplastic phenotype of mast cells: a novel immunohistochemical marker for the diagnosis of systemic mastocytosis (SM) in routinely processed bone marrow biopsy specimens.

21 January 2018

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Immunohistochemical properties of bone marrow mast cells in systemic mastocytosis: evidence for expression of CD2, CD117/Kit, and bcl-x(L).

21 January 2018

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Aberrant expression of CD30 in neoplastic mast cells in high-grade mastocytosis

21 January 2018

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Flow cytometric analysis of normal and neoplastic mast cells: role in diagnosis and follow-up of mast cell disease

21 January 2018

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Bone marrow mast cell immunophenotyping in adults with mast cell disease: a prospective study of 33 patients

21 January 2018

1 reference

Mast cells as "tunable" effector and immunoregulatory cells: recent advances.

21 January 2018

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Molecular diagnosis of mast cell disorders: a paper from the 2005 William Beaumont Hospital Symposium on Molecular Pathology

21 January 2018

1 reference

Variable presence of KITD816V in clonal haematological non-mast cell lineage diseases associated with systemic mastocytosis (SM-AHNMD).

21 January 2018

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Prognosis in adult indolent systemic mastocytosis: a long-term study of the Spanish Network on Mastocytosis in a series of 145 patients.

21 January 2018

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Mast cells from different molecular and prognostic subtypes of systemic mastocytosis display distinct immunophenotypes.

21 January 2018

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Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria

21 January 2018

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Proposal for a revised classification of systemic mastocytosis.

21 January 2018

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Response of severe systemic mastocytosis to interferon alpha

21 January 2018

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Successful treatment of systemic mastocytosis with high-dose interferon-alfa: long-term follow-up of a case

21 January 2018

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Response to therapy with interferon alpha-2b and prednisolone in aggressive systemic mastocytosis: report of five cases and review of the literature.

21 January 2018

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Management of patients with systemic mastocytosis: review of M. D. Anderson Cancer Center experience

21 January 2018

1 reference

Cytoreductive therapy in 108 adults with systemic mastocytosis: Outcome analysis and response prediction during treatment with interferon-alpha, hydroxyurea, imatinib mesylate or 2-chlorodeoxyadenosine

21 January 2018

1 reference

Interest of interferon alpha in systemic mastocytosis. The French experience and review of the literature

21 January 2018

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In vitro and in vivo growth-inhibitory effects of cladribine on neoplastic mast cells exhibiting the imatinib-resistant KIT mutation D816V.

21 January 2018

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PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects

21 January 2018

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Cladribine therapy in a patient with an aleukemic subvariant of mast cell leukemia

21 January 2018

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Treatment of systemic mast-cell disease with cladribine

21 January 2018

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Cladribine therapy for systemic mastocytosis.

21 January 2018

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Treatment of systemic mast cell disease with 2-chlorodeoxyadenosine

21 January 2018

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Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit receptors found in mast cell neoplasms

21 January 2018

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Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit

21 January 2018

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The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations

21 January 2018

1 reference

Imatinib mesylate in the treatment of systemic mastocytosis: a phase II trial

21 January 2018

1 reference

Phase II study of imatinib mesylate as therapy for patients with systemic mastocytosis

21 January 2018

1 reference

Advanced mast cell disease: an Italian Hematological Multicenter experience

21 January 2018

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Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies

21 January 2018

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Dasatinib (BMS-354825) inhibits KITD816V, an imatinib-resistant activating mutation that triggers neoplastic growth in most patients with systemic mastocytosis

21 January 2018

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Synergistic growth-inhibitory effects of two tyrosine kinase inhibitors, dasatinib and PKC412, on neoplastic mast cells expressing the D816V-mutated oncogenic variant of KIT.

21 January 2018

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Treatment responses to cladribine and dasatinib in rapidly progressing aggressive mastocytosis.

21 January 2018

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Chemotherapy and dasatinib induce long-term hematologic and molecular remission in systemic mastocytosis with acute myeloid leukemia with KIT D816V.

21 January 2018

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Phase II study of dasatinib in Philadelphia chromosome-negative acute and chronic myeloid diseases, including systemic mastocytosis

21 January 2018

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Dasatinib therapy for systemic mastocytosis: four cases

21 January 2018

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Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412.

21 January 2018

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Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation.

21 January 2018

1 reference

Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT

21 January 2018

1 reference

Masitinib for the treatment of systemic and cutaneous mastocytosis with handicap: a phase 2a study

21 January 2018

1 reference

Depression in patients with mastocytosis: prevalence, features and effects of masitinib therapy

21 January 2018

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Blood CD34-c-Kit+ cell rate correlates with aggressive forms of systemic mastocytosis and behaves like a mast cell precursor

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/AJH.23134

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26 August 2017

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