Alpha-1 antitrypsin: a potent anti-inflammatory and potential novel therapeutic agent (Q37986292)

26 August 2017

Alpha-1 antitrypsin: a potent anti-inflammatory and potential novel therapeutic agent (English)

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26 August 2017

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David A Bergin

1

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26 August 2017

Killian Hurley

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2

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26 August 2017

Noel G McElvaney

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3

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26 August 2017

Emer P Reeves

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4

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26 August 2017

15 February 2012

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Archivum Immunologiae et Therapiae Experimentalis

26 August 2017

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26 August 2017

60

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26 August 2017

2

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26 August 2017

81-97

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https://scigraph.springernature.com/pub.10.1007/s00005-012-0162-5

26 August 2017

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cites work

Alpha1-antitrypsin deficiency: a position statement of the Canadian Thoracic Society.

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Effects of Proteinase Inhibitors on Polymorphonuclear Neutrophil Polarization

21 January 2018

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Induction of inflammatory cytokine release from cultured human monocytes by C-reactive protein

21 January 2018

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Measurements of proteinase 3 and its complexes with alpha 1-proteinase inhibitor and anti-neutrophil cytoplasm antibodies (ANCA) in plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Complement receptor expression on neutrophils at an inflammatory site, the Pseudomonas-infected lung in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

α-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Abnormal overexpression of mastocytes in skin biopsies of fibromyalgia patients

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Efficacy of alpha1-antitrypsin augmentation therapy in conditions other than pulmonary emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Expression and secretion of alpha1-proteinase inhibitor are regulated by proinflammatory cytokines in human pancreatic islet cells

21 January 2018

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Modulation of inflammation and immunity by cyclic AMP.

21 January 2018

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Alpha 1-acid glycoprotein potentiates lipopolysaccharide-induced secretion of interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha by human monocytes and alveolar and peritoneal macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Oncostatin M is a potent stimulator of alpha1-antitrypsin secretion in lung epithelial cells: modulation by transforming growth factor-beta and interferon-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Lung deposition of inhaled alpha1-proteinase inhibitor in cystic fibrosis and alpha1-antitrypsin deficiency.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Exacerbations in subjects with alpha-1 antitrypsin deficiency receiving augmentation therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Evidence for unfolded protein response activation in monocytes from individuals with alpha-1 antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Plasma markers of endothelial dysfunction in pulmonary hypertension

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Probing serpin reactive-loop conformations by proteolytic cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

α-1-Antitrypsin Ameliorates Cigarette Smoke–induced Emphysema in the Mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Alpha1-antitrypsin suppresses TNF-alpha and MMP-12 production by cigarette smoke-stimulated macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Biosynthesis of alpha1-proteinase inhibitor by human lung-derived epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Alpha 1-antitrypsin deficiency, emphysema, and liver disease. Genetic basis and strategies for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

A randomized clinical trial of alpha(1)-antitrypsin augmentation therapy

21 January 2018

1 reference

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Exploring the role of CT densitometry: a randomised study of augmentation therapy in alpha1-antitrypsin deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Inhibition of proteinase 3 by [alpha]1-antitrypsin in vitro predicts very fast inhibition in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Asthma and allergy in alpha-1 antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Serum Inhibitors of Fibrinolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Delivery of rSLPI in a liposomal carrier for inhalation provides protection against cathepsin L degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Neutrophil elastase inhibitors, SC-37698 and SC-39026, reduce endotoxin-induced lung dysfunction in awake sheep.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Alpha-1 antitrypsin deficiency: a conformational disease associated with lung and liver manifestations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Combination of alpha-1 antitrypsin and doxycycline suppresses collagen-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

New Findings in PiZZ alpha1-antitrypsin deficiency-related panniculitis. Demonstration of skin polymers and high dosing requirements of intravenous augmentation therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Recombinant DNA-produced alpha 1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha 1-antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Pretreatment of sivelestat sodium hydrate improves the lung microcirculation and alveolar damage in lipopolysaccharide-induced acute lung inflammation in hamsters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Inhibition of lipopolysaccharide-mediated human monocyte activation, in vitro, by alpha1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Alpha1-antitrypsin inhibits the activity of the matriptase catalytic domain in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Alpha-1-antitrypsin is present in the specific granules of human eosinophilic granulocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

α 1-antitrypsin enhances insulin secretion and prevents cytokine-mediated apoptosis in pancreatic β-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Gene regulation of the serine proteinase inhibitors α 1 -antitrypsin and α 1 -antichymotrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Alpha 1-antitrypsin binds to and interferes with functionality of EspB from atypical and typical enteropathogenic Escherichia coli strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Biochemical, molecular characterization, and glycoproteomic analyses of alpha(1)-proteinase inhibitor products used for replacement therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Comprehensive glyco-proteomic analysis of human alpha1-antitrypsin and its charge isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Augmentation therapy reduces frequency of lung infections in antitrypsin deficiency: a new hypothesis with supporting data

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Site-specific enzymatic polysialylation of therapeutic proteins using bacterial enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Recombinant AAV serotype and capsid mutant comparison for pulmonary gene transfer of alpha-1-antitrypsin using invasive and noninvasive delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

The mechanism of Z alpha 1-antitrypsin accumulation in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Inhibition profiles of human tissue kallikreins by serine protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Neutrophilic inflammation and IL-8 levels in induced sputum of alpha-1-antitrypsin PiMZ subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Safety and efficacy of recombinant alpha(1)-antitrypsin therapy in cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Modulation of airway inflammation in cystic fibrosis. In vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Cytokines in the pathogenesis of rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Novel functions of human alpha(1)-protease inhibitor after S-nitrosylation: inhibition of cysteine protease and antibacterial activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

S-nitrosylated human alpha(1)-protease inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Prolonged islet allograft survival by alpha-1 antitrypsin: the role of humoral immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Cell-specific expression of alpha 1-antitrypsin in human intestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Z alpha1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Discovery and optimization of a natural HIV-1 entry inhibitor targeting the gp41 fusion peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Exacerbations in {alpha}1-antitrypsin deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Hashimoto's thyroiditis and homozygous alpha 1-antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Elevated cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytic cells and endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

The novel phosphodiesterase 4 inhibitor, CI-1044, inhibits LPS-induced TNF-alpha production in whole blood from COPD patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Human neutrophil defensin and serpins form complexes and inactivate each other

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Polymers of alpha(1)-antitrypsin are chemotactic for human neutrophils: a new paradigm for the pathogenesis of emphysema

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Alpha-1-antitrypsin deficiency: diagnosis and treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Synthesis of stress proteins is increased in individuals with homozygous PiZZ alpha 1-antitrypsin deficiency and liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Elastase regulates the synthesis of its inhibitor, alpha 1-proteinase inhibitor, and exaggerates the defect in homozygous PiZZ alpha 1 PI deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Alpha-1 antitrypsin treatment of spontaneously diabetic nonobese diabetic mice receiving islet allografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Anti-proteinase 3 antibody activation of neutrophils can be inhibited by alpha1-antitrypsin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

alpha1-Antitrypsin augmentation therapy for PI*MZ heterozygotes: a cautionary note.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Does alpha1-antitrypsin augmentation therapy slow the annual decline in FEV1 in patients with severe hereditary alpha1-antitrypsin deficiency? Wissenschaftliche Arbeitsgemeinschaft zur Therapie von Lungenerkrankungen (WATL) alpha1-AT study group.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Mechanism of alpha-1 antitrypsin endocytosis by lung endothelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Role of human neutrophil peptides in lung inflammation associated with α1-antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Effects of alpha 1-antitrypsin on endotoxin-induced lung inflammation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Alpha-1-antitrypsin augmentation therapy in deficient individuals enrolled in the Alpha-1 Foundation DNA and Tissue Bank

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Lung disease associated with alpha1-antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Serpina1 is a potent inhibitor of IL-8-induced hematopoietic stem cell mobilization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Secretion of alpha 1-antitrypsin by alveolar epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Deficiency of the Chemotactic Factor Inactivator in Human Sera with α1-Antitrypsin Deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Alpha1-antitrypsin protects beta-cells from apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

HIV replication in CD4+ T lymphocytes in the presence and absence of follicular dendritic cells: inhibition of replication mediated by α-1-antitrypsin through altered IκBα ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Regulation of Adenovirus-Mediated Elafin Transgene Expression by Bacterial Lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Inhibition of neutrophil superoxide production by human plasma α1 -antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

Processing of tumour necrosis factor-α precursor by metalloproteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-012-0162-5

10.1007/S00005-012-0162-5

21 January 2018

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DOI

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26 August 2017

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