Hitting a complex target: an update on interleukin-6 trans-signalling (Q37983123)

26 August 2017

title

Hitting a complex target: an update on interleukin-6 trans-signalling (English)

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26 August 2017

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Stefan Rose-John

2

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author name string

Georg H Waetzig

series ordinal

1

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26 August 2017

language of work or name

English

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publication date

1 February 2012

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Expert Opinion on Therapeutic Targets

26 August 2017

published in

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26 August 2017

volume

16

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26 August 2017

issue

2

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26 August 2017

page(s)

225-236

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Tocilizumab for rheumatoid arthritis: a Cochrane systematic review

26 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

The value of blocking IL-6 outside of rheumatoid arthritis: current perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

The pro- and anti-inflammatory properties of the cytokine interleukin-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

ADAM17: a molecular switch to control inflammation and tissue regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

No inhibition of IL-27 signaling by soluble gp130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Conservation of IL-6 trans-signaling mechanisms controlling L-selectin adhesion by fever-range thermal stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Although IL-6 Trans-Signaling Is Sufficient To Drive Local Immune Responses, Classical IL-6 Signaling Is Obligate for the Induction of T Cell-Mediated Autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

The IL-6/sIL-6R complex as a novel target for therapeutic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Transgenic blockade of interleukin 6 transsignaling abrogates inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Interleukin-6-deficient mice develop mature-onset obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Interleukin-6 regulates pancreatic alpha-cell mass expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Role of IL-6 trans-signaling in CCl₄induced liver damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Early hepatocyte DNA synthetic response posthepatectomy is modulated by IL-6 trans-signaling and PI3K/AKT activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Central role of IL-6 receptor signal-transducing chain gp130 in activation of L-selectin adhesion by fever-range thermal stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Fever-range thermal stress promotes lymphocyte trafficking across high endothelial venules via an interleukin 6 trans-signaling mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

IL-6 trans-signaling licenses mouse and human tumor microvascular gateways for trafficking of cytotoxic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Soluble gp130 promotes intestinal epithelial hyperplasia during reovirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Increased inflammation and impaired resistance to Chlamydophila pneumoniae infection in Dusp1(-/-) mice: critical role of IL-6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Cytokines and atherosclerosis: a comprehensive review of studies in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model*

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

IL-6-dependent mucosal protection prevents establishment of a microbial niche for attaching/effacing lesion-forming enteric bacterial pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Impaired immune and acute-phase responses in interleukin-6-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Protective role of interleukin-6 during Yersinia enterocolitica infection is mediated through the modulation of inflammatory cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2012.660307

10.1517/14728222.2012.660307

21 January 2018

Identifiers

DOI

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26 August 2017

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