HuR's role in gemcitabine efficacy: an exception or opportunity? (Q37940426)

25 August 2017

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title

HuR's role in gemcitabine efficacy: an exception or opportunity? (English)

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25 August 2017

Jonathan R Brody

1

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PubMed ID

21957028

25 August 2017

Gregory E Gonye

series ordinal

2

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25 August 2017

30 November 2010

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Wiley interdisciplinary reviews. RNA

25 August 2017

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25 August 2017

2

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25 August 2017

3

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25 August 2017

435-444

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Cancer genes and the pathways they control

25 August 2017

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Global analysis of stress-regulated mRNA turnover by using cDNA arrays

21 January 2018

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Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

21 January 2018

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The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase.

21 January 2018

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Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells.

21 January 2018

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Diverse molecular functions of Hu proteins

21 January 2018

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ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR.

21 January 2018

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The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation

21 January 2018

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Wnt-5a mRNA translation is suppressed by the Elav-like protein HuR in human breast epithelial cells.

21 January 2018

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HuR recruits let-7/RISC to repress c-Myc expression

21 January 2018

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Overexpression of ELAV-like protein HuR is associated with increased COX-2 expression in atrophy, high-grade prostatic intraepithelial neoplasia, and incidental prostate cancer in cystoprostatectomies

21 January 2018

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Increased expression of cytoplasmic HuR in familial adenomatous polyposis.

21 January 2018

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Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression

21 January 2018

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Cytoplasmic HuR expression is a prognostic factor in invasive ductal breast carcinoma.

21 January 2018

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Cytoplasmic expression of HuR is related to cyclooxygenase-2 expression in colon cancer.

21 January 2018

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Tissue microarray analysis of 560 patients with colorectal adenocarcinoma: high expression of HuR predicts poor survival

21 January 2018

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The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis

21 January 2018

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Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype

21 January 2018

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The RNA binding protein HuR differentially regulates unique subsets of mRNAs in estrogen receptor negative and estrogen receptor positive breast cancer

21 January 2018

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Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis

21 January 2018

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HuR regulates p21 mRNA stabilization by UV light

21 January 2018

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Identification of a target RNA motif for RNA-binding protein HuR.

21 January 2018

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Surgical treatment of pancreatic cancer: the role of adjuvant and multimodal therapies

21 January 2018

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Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine.

21 January 2018

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Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: relationship to molecular mechanisms of gemcitabine resistance and survival

21 January 2018

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Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer.

21 January 2018

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In vivo induction of resistance to gemcitabine results in increased expression of ribonucleotide reductase subunit M1 as the major determinant

21 January 2018

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In situ protein expression of RRM1, ERCC1, and BRCA1 in metastatic breast cancer patients treated with gemcitabine-based chemotherapy

21 January 2018

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RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation

21 January 2018

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Ribonucleoprotein infrastructure regulating the flow of genetic information between the genome and the proteome

21 January 2018

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The fuzzy math of solid tumor stem cells: a perspective.

21 January 2018

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Tandem phosphorylation of serines 221 and 318 by protein kinase Cdelta coordinates mRNA binding and nucleocytoplasmic shuttling of HuR.

21 January 2018

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Phosphorylation of HuR by Chk2 regulates SIRT1 expression

21 January 2018

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Nuclear HuR accumulation through phosphorylation by Cdk1

21 January 2018

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Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylation

21 January 2018

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Regulation of HuR by DNA Damage Response Kinases

21 January 2018

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Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair.

21 January 2018

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AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

21 January 2018

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Protein ligands to HuR modulate its interaction with target mRNAs in vivo

21 January 2018

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Identification of sequences required for inhibition of oncogene-mediated transformation by pp32.

21 January 2018

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Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression

21 January 2018

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Tumor suppression and potentiation by manipulation of pp32 expression

21 January 2018

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pp32 reduction induces differentiation of TSU-Pr1 cells

21 January 2018

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Correction to "Modulation of oncogenic potential by alternative gene use in human prostate cancer"

21 January 2018

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Expression of pp32 gene family members in breast cancer

21 January 2018

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Role of the RNA-binding protein HuR in colon carcinogenesis

21 January 2018

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miR-519 suppresses tumor growth by reducing HuR levels

21 January 2018

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Posttranscriptional orchestration of an anti-apoptotic program by HuR.

21 January 2018

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A new approach to decoding life: systems biology

21 January 2018

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Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays

21 January 2018

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Ribonomics: identifying mRNA subsets in mRNP complexes using antibodies to RNA-binding proteins and genomic arrays

21 January 2018

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A systems view of mRNP biology

21 January 2018

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Coordinated posttranscriptional mRNA population dynamics during T-cell activation

21 January 2018

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Reduced nuclear export of HuR mRNA by HuR is linked to the loss of HuR in replicative senescence

21 January 2018

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HITS-CLIP yields genome-wide insights into brain alternative RNA processing

21 January 2018

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An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/WRNA.62

1 reference

25 August 2017

1 reference

PubMed ID

21957028