Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones. (Q37934725)

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12 February 2020

review article

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title

Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones (English)

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12 February 2020

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2

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12 February 2020

author name string

Chenrui Li

series ordinal

1

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12 February 2020

Zhong Zuo

series ordinal

3

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publication date

19 September 2011

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Biopharmaceutics and Drug Disposition

12 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21928297%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

32

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issue

8

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12 February 2020

page(s)

427-445

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Natural and hemisynthetic neoclerodane diterpenoids from scutellaria and their antifeedant activity

12 February 2020

cites work

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Phase I study of the botanical formulation PHY906 with capecitabine in advanced pancreatic and other gastrointestinal malignancies

21 January 2018

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Isolation and purification of baicalein, wogonin and oroxylin A from the medicinal plant Scutellaria baicalensis by high-speed counter-current chromatography

21 January 2018

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Anti-inflammatory effects of Scutellaria baicalensis water extract on LPS-activated RAW 264.7 macrophages.

21 January 2018

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Effects of Scutellariae Radix on gene expression in HEK 293 cells using cDNA microarray.

21 January 2018

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Flavones from Scutellaria baicalensis Georgi attenuate apoptosis and protein oxidation in neuronal cell lines

21 January 2018

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Scutellariae radix extracts suppress ethanol-induced caspase-11 expression and cell death in N(2)a cells

21 January 2018

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Antioxidant activity of anti-inflammatory plant extracts

21 January 2018

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Extract from Scutellaria baicalensis Georgi attenuates oxidant stress in cardiomyocytes.

21 January 2018

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Effect of Scutellariae Radix extract on experimental dextran-sulfate sodium-induced colitis in rats.

21 January 2018

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Flavonoids from Radix Scutellariae as potential stroke therapeutic agents by targeting the second postsynaptic density 95 (PSD-95)/disc large/zonula occludens-1 (PDZ) domain of PSD-95.

21 January 2018

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Inhibitory effect of Coptidis Rhizoma and Scutellariae Radix on azoxymethane-induced aberrant crypt foci formation in rat colon.

21 January 2018

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Potential ex vivo immunomodulatory effects of San-Huang-Xie-Xin-Tang and its component herbs on mice and humans.

21 January 2018

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Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell

21 January 2018

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Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines

21 January 2018

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Differential protein expression of the inhibitory effects of a standardized extract from Scutellariae radix in liver cancer cell lines using liquid chromatography and tandem mass spectrometry.

21 January 2018

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Effect of Scutellariae radix extract on the high glucose-induced apoptosis in cultured vascular endothelial cells

21 January 2018

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The genus Scutellaria an ethnopharmacological and phytochemical review

21 January 2018

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Separation and purification of baicalin and wogonoside from the Chinese medicinal plant Scutellaria baicalensis Georgi by high-speed counter-current chromatography

21 January 2018

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On-line continuous flow ultrasonic extraction coupled with high performance liquid chromatographic separation for determination of the flavonoids from root of Scutellaria baicalensis Georgi

21 January 2018

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Contents of major bioactive flavones in proprietary traditional Chinese medicine products and reference herb of radix Scutellariae.

21 January 2018

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Upregulation of interferon-gamma and interleukin-4, Th cell-derived cytokines by So-Shi-Ho-Tang (Sho-Saiko-To) occurs at the level of antigen presenting cells, but not CD4 T cells.

21 January 2018

1 reference

Sho-saiko-to (Xiao-Chai-Hu-Tang) and crude saikosaponins inhibit hepatitis B virus in a stable HBV-producing cell line

21 January 2018

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Inhibitory effects of baicalein and wogonin on lipopolysaccharide-induced nitric oxide production in macrophages

21 January 2018

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Flavonoid baicalein attenuates activation-induced cell death of brain microglia

21 January 2018

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The flavonoid baicalin exhibits anti-inflammatory activity by binding to chemokines

21 January 2018

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Differential inhibitory effects of baicalein and baicalin on LPS-induced cyclooxygenase-2 expression through inhibition of C/EBPbeta DNA-binding activity

21 January 2018

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Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi

21 January 2018

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Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices

21 January 2018

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Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth-inhibitory activities toward prostate carcinoma

21 January 2018

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Baicalin, an inhibitor of HIV-1 production in vitro

21 January 2018

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Human cytomegalovirus-inhibitory flavonoids: studies on antiviral activity and mechanism of action

21 January 2018

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Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system.

21 January 2018

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Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes

21 January 2018

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Baicalin attenuates oxygen-glucose deprivation-induced injury via inhibiting NMDA receptor-mediated 5-lipoxygenase activation in rat cortical neurons.

21 January 2018

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The flavonoid baicalin protects against cerebrovascular dysfunction and brain inflammation in experimental heatstroke.

21 January 2018

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Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells

21 January 2018

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Inhibition of TPA-induced cyclooxygenase-2 expression and skin inflammation in mice by wogonin, a plant flavone from Scutellaria radix

21 January 2018

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In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production

21 January 2018

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Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships

21 January 2018

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Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and Ca(2+)-dependent endonuclease

21 January 2018

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Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells

21 January 2018

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Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation

21 January 2018

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Anticonvulsant effect of wogonin isolated from Scutellaria baicalensis

21 January 2018

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The herbal medicine Sho-saiko-to selectively inhibits CD8+ T-cell proliferation

21 January 2018

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Anti-hepatitis B virus activity of wogonin in vitro and in vivo

21 January 2018

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5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic properties

21 January 2018

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Effect of the flavonoid, oroxylin A, on transient cerebral hypoperfusion-induced memory impairment in mice.

21 January 2018

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The ameliorating effect of oroxylin A on scopolamine-induced memory impairment in mice.

21 January 2018

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Synthesis and in vitro study of novel 7-O-acyl derivatives of Oroxylin A as antibacterial agents

21 January 2018

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Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity

21 January 2018

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21 January 2018

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Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo

21 January 2018

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Antiviral Chinese medicinal herbs against respiratory syncytial virus

21 January 2018

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Flavonoids with prolyl oligopeptidase inhibitory activity isolated from Scutellaria racemosa Pers

21 January 2018

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Mechanistic study on the intestinal absorption and disposition of baicalein.

21 January 2018

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Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu- tang across human intestinal Caco-2 cell monolayers

21 January 2018

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Role of intestinal first-pass metabolism of baicalein in its absorption process.

21 January 2018

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Enteric excretion of baicalein, a flavone of Scutellariae Radix, via glucuronidation in rat: involvement of multidrug resistance-associated protein 2.

21 January 2018

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Involvement of UDP-glucuronosyltransferases in the extensive liver and intestinal first-pass metabolism of flavonoid baicalein.

21 January 2018

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Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes

21 January 2018

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A catenary model to study transport and conjugation of baicalein, a bioactive flavonoid, in the Caco-2 cell monolayer: demonstration of substrate inhibition.

21 January 2018

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Absorption and metabolism of flavonoids

21 January 2018

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Urinary pharmacokinetics of baicalein, wogonin and their glycosides after oral administration of Scutellariae Radix in humans

21 January 2018

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Absorption and enterohepatic circulation of baicalin in rats

21 January 2018

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Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporter

21 January 2018

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Kinetic difference of baicalin in rat blood and cerebral nuclei after intravenous administration of Scutellariae Radix extract

21 January 2018

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21 January 2018

Herb-drug interactions

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Significant decrease of cyclosporine bioavailability in rats caused by a decoction of the roots of Scutellaria baicalensis

21 January 2018

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Metabolism of dietary polyphenols and possible interactions with drugs

21 January 2018

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Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2.

21 January 2018

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Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats

21 January 2018

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Pharmacokinetics of baicalein, baicalin and wogonin after oral administration of a standardized extract of Scutellaria baicalensis, PF-2405 in rats.

21 January 2018

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Comparative study of Scutellaria planipes and Scutellaria baicalensis

21 January 2018

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Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties

21 January 2018

1 reference

Identification and quantification of eight flavones in root and shoot tissues of the medicinal plant huang-qin (Scutellaria baicalensis Georgi) using high-performance liquid chromatography with diode array and mass spectrometric detection

21 January 2018

1 reference

Combinative method using HPLC fingerprint and quantitative analyses for quality consistency evaluation of an herbal medicinal preparation produced by different manufacturers

21 January 2018

1 reference

Simultaneous determination of eight active components in Chinese medicine 'YIQING' capsule using high-performance liquid chromatography.

21 January 2018

1 reference

Analysis of fuzhisan and quantitation of baicalin and ginsenoside Rb(1) by HPLC-DAD-ELSD.

21 January 2018

1 reference

Development of the chromatographic fingerprint of herbal preparations Shuang-Huang-Lian oral liquid.

21 January 2018

1 reference

Determination of gentiopicroside, mangiferin, palmatine, berberine, baicalin, wogonin and glycyrrhizin in the traditional Chinese medicinal preparation sann-joong-kuey-jian-tang by high-performance liquid chromatography.

21 January 2018

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Comparison of metabolic pharmacokinetics of baicalin and baicalein in rats

21 January 2018

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High-performance liquid chromatographic method for simultaneous determination of baicalein and baicalein 7-glucuronide in rat plasma.

21 January 2018

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Quantitation of the flavonoid wogonin and its major metabolite wogonin-7 beta-D-glucuronide in rat plasma by liquid chromatography-tandem mass spectrometry

21 January 2018

1 reference

Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid, in Beagle dogs.

21 January 2018

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Comparison of the pharmacokinetics of hawthorn phenolics in extract versus individual pure compound.

21 January 2018

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Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract and kavalactones in vivo and in vitro

21 January 2018

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Comparative pharmacokinetic study of paeoniflorin after oral administration of pure paeoniflorin, extract of Cortex Moutan and Shuang-Dan prescription to rats.

21 January 2018

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Effects of the coexisting diterpenoid tanshinones on the pharmacokinetics of cryptotanshinone and tanshinone IIA in rat.

21 January 2018

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Pharmacokinetic interaction between tanshinones and polyphenolic extracts of salvia miltinorrhiza BUNGE after intravenous administration in rats

21 January 2018

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Pharmacokinetic comparisons of schizandrin after oral administration of schizandrin monomer, Fructus Schisandrae aqueous extract and Sheng-Mai-San to rats.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BDD.771

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21928297%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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