Role of serotonin in Alzheimer's disease: a new therapeutic target? (Q37922766)

25 August 2017

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title

Role of serotonin in Alzheimer's disease: a new therapeutic target? (English)

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25 August 2017

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Werner J Geldenhuys

1

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25 August 2017

Cornelis J Van der Schyf

series ordinal

2

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25 August 2017

1 September 2011

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25 August 2017

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25 August 2017

25

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25 August 2017

9

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25 August 2017

765-781

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https://scigraph.springernature.com/pub.10.2165/11590190-000000000-00000

25 August 2017

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21 January 2018

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21 January 2018

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A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease

21 January 2018

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

21 January 2018

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Tau in Alzheimer disease and related tauopathies

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The serotonin1A receptor partial agonist S15535 [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine] enhances cholinergic transmission and cognitive function in rodents: a combined neurochemical and behavioral analysis

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Dimebon improves learning in animals with experimental Alzheimer's disease

21 January 2018

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Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

21 January 2018

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A novel rat serotonin (5-HT6) receptor: molecular cloning, localization and stimulation of cAMP accumulation

21 January 2018

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21 January 2018

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21 January 2018

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Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus

21 January 2018

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Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling

21 January 2018

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A null mutation of the serotonin 6 receptor alters acute responses to ethanol

21 January 2018

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Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation

21 January 2018

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Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790.

21 January 2018

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A role for 5-ht6 receptors in retention of spatial learning in the Morris water maze.

21 January 2018

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SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models.

21 January 2018

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Oral administration of the 5-HT6 receptor antagonists SB-357134 and SB-399885 improves memory formation in an autoshaping learning task

21 January 2018

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The 5-HT6 Receptor Antagonist SB-271046 Reverses Scopolamine-Disrupted Consolidation of a Passive Avoidance Task and Ameliorates Spatial Task Deficits in Aged Rats

21 January 2018

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Influence of the 5-HT6 receptor on acetylcholine release in the cortex: pharmacological characterization of 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine, a potent and selective 5-HT6 receptor antagonist

21 January 2018

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Immuno-localization of serotonin 5-HT6 receptor-like material in the rat central nervous system

21 January 2018

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5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease

21 January 2018

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5-HT6 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing consolidation--an effect sensitive to NMDA receptor antagonism

21 January 2018

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Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466

21 January 2018

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The selective 5-HT6 receptor antagonists SB-271046 and SB-399885 potentiate NCAM PSA immunolabeling of dentate granule cells, but not neurogenesis, in the hippocampal formation of mature Wistar rats

21 January 2018

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New 5-HT(1A) receptor ligands containing a N'-cyanoisonicotinamidine nucleus: synthesis and in vitro pharmacological evaluation

21 January 2018

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The serotonin 5-HT4 receptor. 1. Design of a new class of agonists and receptor map of the agonist recognition site.

21 January 2018

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The serotonin 5-HT4 receptor. 2. Structure-activity studies of the indole carbazimidamide class of agonists

21 January 2018

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Optimization of a pharmacophore model for 5-HT4 agonists using CoMFA and receptor based alignment

21 January 2018

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Synthesis of specific bivalent probes that functionally interact with 5-HT(4) receptor dimers

21 January 2018

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Design, synthesis, and biological evaluation of new 5-HT4 receptor agonists: application as amyloid cascade modulators and potential therapeutic utility in Alzheimer's disease

21 January 2018

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Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).

21 January 2018

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Synthesis and SAR of tolylamine 5-HT6 antagonists

21 January 2018

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Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles

21 January 2018

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Discovery of a proneurogenic, neuroprotective chemical

21 January 2018

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[(11)C]Dimebon, radiosynthesis and lipophilicity of a new potential PET agent for imaging of Alzheimer's disease and Huntington's disease

21 January 2018

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Novel and Potent 5-Piperazinyl Methyl-N 1-aryl Sulfonyl Indole Derivatives as 5-HT6 Receptor Ligands

21 January 2018

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1-Sulfonylindazoles as potent and selective 5-HT6 ligands

21 January 2018

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Possible differences in modes of agonist and antagonist binding at human 5-HT6 receptors

21 January 2018

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Benzimidazole derivatives as new serotonin 5-HT6 receptor antagonists. Molecular mechanisms of receptor inactivation.

21 January 2018

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A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.

21 January 2018

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Action of dimebon on histamine receptors

21 January 2018

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12 December 2020

Dimebon and tacrine inhibit neurotoxic action of beta-amyloid in culture and block L-type Ca(2+) channels

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12 December 2020

SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype

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12 December 2020

5-HT4 receptor stimulation facilitates acetylcholine release in rat frontal cortex.

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12 December 2020

Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs

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12 December 2020

Sub-types of serotonin receptors: biochemical changes and pharmacological consequences.

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12 December 2020

Antihistamine agent Dimebon as a novel neuroprotector and a cognition enhancer

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12 December 2020

Involvement of an altered 5-HT -{6} receptor function in behavioral symptoms of Alzheimer's disease.

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12 December 2020

Role of 5-HT4 receptors in the mouse passive avoidance test

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12 December 2020

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12 December 2020

A racial difference in apolipoprotein E allele frequencies between the Japanese and Caucasian populations.

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12 December 2020

Guidelines for managing Alzheimer's disease: part I. Assessment

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12 December 2020

Guidelines for managing Alzheimer's disease: Part II. Treatment.

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12 December 2020

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12 December 2020

New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors

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Beyond the cholinergic hypothesis: do current drugs work in Alzheimer's disease?

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12 December 2020

The rise and fall of Dimebon

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Identifiers

DOI

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Dimensions Publication ID

25 August 2017

1002443630

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Fatcat ID

release_4437rgboxfa33pah6oswnvibyu

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Fatcat

https://api.fatcat.wiki/v0/release/4437rgboxfa33pah6oswnvibyu

24 November 2022

mapped directly with Wikidata item

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