Road to clinical efficacy: challenges and novel strategies for antimicrobial peptide development (Q37894693)

24 August 2017

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title

Road to clinical efficacy: challenges and novel strategies for antimicrobial peptide development (English)

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24 August 2017

antimicrobial peptide

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Randal Eckert

1

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24 August 2017

1 June 2011

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24 August 2017

17

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based on heuristic

inferred from page(s)

published in

Future Microbiology

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24 August 2017

6

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24 August 2017

635-651

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24 August 2017

6

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Cathelicidin LL-37: a multitask antimicrobial peptide

24 August 2017

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Defensins and other antimicrobial peptides: a historical perspective and an update

21 January 2018

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Antimicrobial peptides: general overview and clinical implications in human health and disease.

21 January 2018

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Antimicrobial peptides from marine invertebrates as a new frontier for microbial infection control.

21 January 2018

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Antimicrobial peptides of multicellular organisms

21 January 2018

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Binding of amphipathic alpha-helical antimicrobial peptides to lipid membranes: lessons from temporins B and L.

21 January 2018

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Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations.

21 January 2018

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Lantibiotics: diverse activities and unique modes of action

21 January 2018

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Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?

21 January 2018

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Can antimicrobial peptides scavenge around a cell in less than a second?

21 January 2018

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Multifunctional host defense peptides: intracellular-targeting antimicrobial peptides

21 January 2018

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Defensins as anti-inflammatory compounds and mucosal adjuvants

21 January 2018

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The roles of cathelicidin LL-37 in immune defences and novel clinical applications

21 January 2018

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The chemistry and biology of LL-37

21 January 2018

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Anionic antimicrobial peptides from eukaryotic organisms.

21 January 2018

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Theta-defensins: cyclic antimicrobial peptides produced by binary ligation of truncated alpha-defensins

21 January 2018

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Defensins: antimicrobial peptides for therapeutic development

21 January 2018

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Susceptibility of periodontopathogenic and cariogenic bacteria to defensins and potential therapeutic use of defensins in oral diseases

21 January 2018

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Cathelicidins and functional analogues as antisepsis molecules.

21 January 2018

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Dermaseptins and magainins: antimicrobial peptides from frogs' skin-new sources for a promising spermicides microbicides-a mini review

21 January 2018

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Novel antifungal agents, targets or therapeutic strategies for the treatment of invasive fungal diseases: a review of the literature (2005-2009).

21 January 2018

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Antimicrobial peptides as model molecules for the development of novel antiviral agents in aquaculture.

21 January 2018

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Antimicrobial peptides: natural templates for synthetic membrane-active compounds.

21 January 2018

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Novel therapies based on cationic antimicrobial peptides

21 January 2018

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New antimicrobial hexapeptides: synthesis, antimicrobial activities, cytotoxicity, and mechanistic studies

21 January 2018

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In vitro system for high-throughput screening of random peptide libraries for antimicrobial peptides that recognize bacterial membranes

21 January 2018

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APD2: the updated antimicrobial peptide database and its application in peptide design

21 January 2018

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CAMP: a useful resource for research on antimicrobial peptides

21 January 2018

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Role of peptide hydrophobicity in the mechanism of action of alpha-helical antimicrobial peptides

21 January 2018

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Pandrug-resistant Gram-negative bacteria: the dawn of the post-antibiotic era?

21 January 2018

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Therapeutic challenges in the era of antibiotic resistance

21 January 2018

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Strategic paradigm shifts in the antimicrobial drug discovery process of the 21st century

21 January 2018

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Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies

21 January 2018

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New approaches in peptide antibiotics

21 January 2018

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Omiganan pentahydrochloride in the front line of clinical applications of antimicrobial peptides

21 January 2018

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Structure, membrane orientation, mechanism, and function of pexiganan--a highly potent antimicrobial peptide designed from magainin.

21 January 2018

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The role of toll-like receptors in the pathogenesis and treatment of dermatological disease

21 January 2018

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Are cationic antimicrobial peptides also 'double-edged swords'?

21 January 2018

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Antibacterial peptides for therapeutic use: obstacles and realistic outlook

21 January 2018

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Antimicrobial peptides: premises and promises

21 January 2018

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Novispirin G10-induced lung toxicity in a Klebsiella pneumoniae infection model

21 January 2018

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Investigation of the cytotoxicity of eukaryotic and prokaryotic antimicrobial peptides in intestinal epithelial cells in vitro.

21 January 2018

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Investigation of the cytotoxicity of antimicrobial peptide P40 on eukaryotic cells

21 January 2018

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Plectasin, a fungal defensin, targets the bacterial cell wall precursor Lipid II.

21 January 2018

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Control of cell selectivity of antimicrobial peptides

21 January 2018

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End-tagging of ultra-short antimicrobial peptides by W/F stretches to facilitate bacterial killing

21 January 2018

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The effects of tryptophan and hydrophobicity on the structure and bioactivity of novel indolicidin derivatives with promising pharmaceutical potential

21 January 2018

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Origin of low mammalian cell toxicity in a class of highly active antimicrobial amphipathic helical peptides

21 January 2018

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Antimicrobial and chemoattractant activity, lipopolysaccharide neutralization, cytotoxicity, and inhibition by serum of analogs of human cathelicidin LL-37.

21 January 2018

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Activity of the de novo engineered antimicrobial peptide WLBU2 against Pseudomonas aeruginosa in human serum and whole blood: implications for systemic applications

21 January 2018

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De novo generation of cationic antimicrobial peptides: influence of length and tryptophan substitution on antimicrobial activity

21 January 2018

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Cell-penetrating peptides and antimicrobial peptides: how different are they?

21 January 2018

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Selective cytotoxicity following Arg-to-Lys substitution in tritrpticin adopting a unique amphipathic turn structure

21 January 2018

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De novo design of potent antimicrobial peptides

21 January 2018

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A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic efficacy against cancer and diminished toxicity in mice

21 January 2018

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Design of nontoxic analogues of cathelicidin-derived bovine antimicrobial peptide BMAP-27: the role of leucine as well as phenylalanine zipper sequences in determining its toxicity

21 January 2018

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N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: a case study in latarcins

21 January 2018

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Divorcing folding from function: how acylation affects the membrane-perturbing properties of an antimicrobial peptide.

21 January 2018

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Antimicrobial lipopolypeptides composed of palmitoyl Di- and tricationic peptides: in vitro and in vivo activities, self-assembly to nanostructures, and a plausible mode of action

21 January 2018

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Scope and limitations of the designer proline-rich antibacterial peptide dimer, A3-APO, alone or in synergy with conventional antibiotics

21 January 2018

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Design and activity of a 'dual-targeted' antimicrobial peptide

21 January 2018

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Characterization of the branched antimicrobial peptide M6 by analyzing its mechanism of action and in vivo toxicity.

21 January 2018

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Novel synthetic antimicrobial peptides against Streptococcus mutans

21 January 2018

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Antimicrobial dendrimeric peptides

21 January 2018

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Membrane permeabilization by multivalent anti-microbial peptides

21 January 2018

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Innate immunity and the normal microflora

21 January 2018

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The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota

21 January 2018

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Role of commensal bacteria in development of gut-associated lymphoid tissues and preimmune antibody repertoire.

21 January 2018

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Inhibition of methicillin-resistant Staphylococcus aureus by an in vitro continuous-flow culture containing human stool microflora

21 January 2018

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Bench-to-bedside review: Clostridium difficile colitis

21 January 2018

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Dissecting structural and functional diversity of the lantibiotic mersacidin

21 January 2018

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The Sushi peptides: structural characterization and mode of action against Gram-negative bacteria

21 January 2018

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Temporins and their synergism against Gram-negative bacteria and in lipopolysaccharide detoxification

21 January 2018

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Endotoxin-neutralizing peptides as gram-negative sepsis therapeutics

21 January 2018

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Design of a peptibody consisting of the antimicrobial peptide dhvar5 and a llama variable heavy-chain antibody fragment.

21 January 2018

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Targeted antimicrobial activity of a specific IgG-SMAP28 conjugate against Porphyromonas gingivalis in a mixed culture

21 January 2018

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Clavanin permeabilizes target membranes via two distinctly different pH-dependent mechanisms

21 January 2018

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Design and characterization of an acid-activated antimicrobial peptide

21 January 2018

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Molecular targeting of drug delivery systems to ovarian cancer by BH3 and LHRH peptides

21 January 2018

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Adding selectivity to antimicrobial peptides: rational design of a multidomain peptide against Pseudomonas spp.

21 January 2018

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Systematic approach to optimizing specifically targeted antimicrobial peptides against Streptococcus mutans

21 January 2018

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Targeted killing of Streptococcus mutans by a pheromone-guided "smart" antimicrobial peptide

21 January 2018

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Targeted antimicrobial therapy against Streptococcus mutans establishes protective non-cariogenic oral biofilms and reduces subsequent infection

21 January 2018

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Immunomodulatory properties of defensins and cathelicidins

21 January 2018

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What are renal defensins defending?

21 January 2018

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Chemokines meet defensins: the merging concepts of chemoattractants and antimicrobial peptides in host defense

21 January 2018

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The human beta-defensin-3, an antibacterial peptide with multiple biological functions

21 January 2018

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Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease

21 January 2018

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Minidefensins and other antimicrobial peptides: candidate anti-HIV microbicides

21 January 2018

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Design and synthesis of cyclic disulfide-bonded antibacterial peptides on the basis of the alpha helical domain of Tenecin 1, an insect defensin.

21 January 2018

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Potential therapeutic applications of the cyclotides and related cystine knot mini-proteins

21 January 2018

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Synthesis of the lantibiotic lactocin S using peptide cyclizations on solid phase

21 January 2018

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Easy strategy to protect antimicrobial peptides from fast degradation in serum

21 January 2018

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Fluorine--a new element in the design of membrane-active peptides.

21 January 2018

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Solid-phase synthesis of fullerene-peptides

21 January 2018

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The world of beta- and gamma-peptides comprised of homologated proteinogenic amino acids and other components

21 January 2018

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Beta-amino acids: versatile peptidomimetics

21 January 2018

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In vitro activity and potency of an intravenously injected antimicrobial peptide and its DL amino acid analog in mice infected with bacteria

21 January 2018

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Stability and activity in sputum of G10KHc, a potent anti-Pseudomonas antimicrobial peptide

21 January 2018

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Membrane interactions of antimicrobial beta-peptides: the role of amphipathicity versus secondary structure induction

21 January 2018

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Antimicrobial peptide therapeutics for cystic fibrosis

21 January 2018

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Retro and retroenantio analogs of cecropin-melittin hybrids

21 January 2018

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Action mechanism of PEGylated magainin 2 analogue peptide

21 January 2018

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Gramicidin S and polymyxins: the revival of cationic cyclic peptide antibiotics

21 January 2018

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Synthetic mimics of antimicrobial peptides.

21 January 2018

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Peptoid-Peptide hybrid backbone architectures.

21 January 2018

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Synthetic mimics of antimicrobial peptides--a versatile ring-opening metathesis polymerization based platform for the synthesis of selective antibacterial and cell-penetrating polymers

21 January 2018

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Antimicrobial peptide mimics for improved therapeutic properties

21 January 2018

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Peptidomimetic antibiotics target outer-membrane biogenesis in Pseudomonas aeruginosa

21 January 2018

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Antimicrobial activity of small beta-peptidomimetics based on the pharmacophore model of short cationic antimicrobial peptides.

21 January 2018

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Synthetic antimicrobial peptidomimetics with therapeutic potential.

21 January 2018

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High in vitro antimicrobial activity of synthetic antimicrobial peptidomimetics against staphylococcal biofilms

21 January 2018

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Bioactive peptides: signaling the future

21 January 2018

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Effect of preservative-free artificial tears on the antimicrobial activity of human beta-defensin-2 and cathelicidin LL-37 in vitro

21 January 2018

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In vitro aerosol delivery and regional airway surface liquid concentration of a liposomal cationic peptide

21 January 2018

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Aerosolized colistin for the treatment of nosocomial pneumonia due to multidrug-resistant Gram-negative bacteria in patients without cystic fibrosis

21 January 2018

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Evaluation of WLBU2 peptide and 3-O-octyl-sn-glycerol lipid as active ingredients for a topical microbicide formulation targeting Chlamydia trachomatis

21 January 2018

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Encapsulation of nisin and lysozyme in liposomes enhances efficacy against Listeria monocytogenes

21 January 2018

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Preparation and Characterization of Coacervate Microcapsules for the Delivery of Antimicrobial Oyster Peptides

21 January 2018

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Nanosizing--oral formulation development and biopharmaceutical evaluation

21 January 2018

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Targeted delivery of PSC-RANTES for HIV-1 prevention using biodegradable nanoparticles.

21 January 2018

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Molecularly targeted nanocarriers deliver the cytolytic peptide melittin specifically to tumor cells in mice, reducing tumor growth

21 January 2018

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Antibacterial hydrogels of amino acid-based cationic amphiphiles

21 January 2018

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Antimicrobial effectiveness of liposomal polymyxin B against resistant Gram-negative bacterial strains

21 January 2018

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The efficacy of self-assembled cationic antimicrobial peptide nanoparticles against Cryptococcus neoformans for the treatment of meningitis

21 January 2018

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Self-assembled cationic peptide nanoparticles as an efficient antimicrobial agent

21 January 2018

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Alternating release of different bioactive molecules from a complexation polymer system

21 January 2018

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Leishmanicidal activity and immobilization of dermaseptin 01 antimicrobial peptides in ultrathin films for nanomedicine applications.

21 January 2018

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Controlling the release of peptide antimicrobial agents from surfaces

21 January 2018

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Cloaking cytolytic peptides for liposome-based detection and potential drug delivery.

21 January 2018

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Effect of hydrophobicity on the interaction between antimicrobial peptides and poly(acrylic acid) microgels

21 January 2018

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Incorporation of antimicrobial compounds in mesoporous silica film monolith.

21 January 2018

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Antimicrobial peptides for detection of bacteria in biosensor assays.

21 January 2018

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Titanium immobilized with an antimicrobial peptide derived from histatin accelerates the differentiation of osteoblastic cell line, MC3T3-E1.

21 January 2018

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Immobilization reduces the activity of surface-bound cationic antimicrobial peptides with no influence upon the activity spectrum

21 January 2018

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Chewing gum of antimicrobial decapeptide (KSL) as a sustained antiplaque agent: preformulation study

21 January 2018

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Large-scale manufacture of peptide therapeutics by chemical synthesis

21 January 2018

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Development of HIV fusion inhibitors

21 January 2018

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N-Fmoc-protected(alpha-dipeptidoyl)benzotriazoles for efficient solid-phase peptide synthesis by segment condensation

21 January 2018

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Facile solid-phase synthesis of sulfated tyrosine-containing peptides: Part II. Total synthesis of human big gastrin-II and its C-terminal glycine-extended peptide (G34-Gly sulfate) by the solid-phase segment condensation approach

21 January 2018

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Use of luminescent bacteria for rapid screening and characterization of short cationic antimicrobial peptides synthesized on cellulose using peptide array technology

21 January 2018

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RAPD: a database of recombinantly-produced antimicrobial peptides

21 January 2018

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Natural products to drugs: daptomycin and related lipopeptide antibiotics

21 January 2018

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Comparative studies on the fermentative production of lantibiotics by staphylococci

21 January 2018

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Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus.

21 January 2018

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Cationic peptides: a new source of antibiotics

21 January 2018

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Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan cream

21 January 2018

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21 January 2018

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The big and small of drug discovery. Biotech versus pharma: advantages and drawbacks in drug development

21 January 2018

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Structures of the dimeric and monomeric variants of magainin antimicrobial peptides (MSI-78 and MSI-594) in micelles and bilayers, determined by NMR spectroscopy

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/FMB.11.27

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24 August 2017

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PubMed ID

21707311